• Environmental Analysis Health and Toxicology
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• v.22 no.4
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• pp.357-366
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• 2007

To investigate the possible enhancement of genotoxicity in stress environment, we examined the of effect of genotoxic material in oxidative stress-induced condition using human tell line. Human lymphoblast cell line, TK6 was treated with hydrogen peroxide ($H_2O_2$) for induction of oxidative stress, and treated with N'-methyl-N'-nitroguanidine (MNNG), af a genetoxic material. We carried out MTS assay to set treatment doses. TK6 was treated with $H_2O_2$ at 6.75 (low dote) or $13.5\;{\mu}M$ (high dose) for 2 h, and treated with MNNG af 0.117 (low dose), 0.234 (middle dose), $0.468\;{\mu}M$ (high dose) for 2 h. As results, a treatment of MNNG induced DNA dam age as dose dependently. And TK6 treated with $H_2O_2$ at low as well as high dose followed by MNNG treatment showed higher DNA damage compared to MNNG alone treated groups. Malondialdehyde, as a marker of lipid peroxidation was increased in $H_2O_2$ and MNNG treated groups. Real-time RT-PCR analyses for expression of several antioxidative enzymes showed that catalase mRNA and glutathione peroxidase 1 mRNA expression were decreased in $H_2O_2$ and MNNG treated groups. Taken together, we conclude that genotoxicity induced by MNNG is enhanced in a condition of oxidative stress induced by $H_2O_2$ and it suggests that it should be associated with induction of lipid peroxidation and decrease of antioxidant enzymes.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.159-175
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• 1998

In order to investigate the antitumor effect by Chungsangbohahwan after B-16 cells were transplanted in C57BL/6 mice, and the immune responses in mice induced by methotrexate, the extract of Chungsangbohahwan was orally administered to the mice for 21 days. Experimental studies were performed for measurance of metastasis, cell cytotoxicity in vitro, natural killer cell activity, productivity of interleukin-2. The results were summarized as follows: 1. Inhibition of metastasis in Chungsangbohahwan-treated group was higher than control group with significance on 7th day and 14th day. 2. On the MTT assay, cell viability was significantly inhibited by $5{\mu}g/well$, $2.5{\mu}g/well$, $1.25{\mu}g/well$, and $0.625{\mu}g/well$ of Chungsangbohahwan concentration inhibited cell viability significantly(P<0.05). $IC_{50}$ for cell viability was $2.17{\mu}g/well$. 3. Natural killer cell activity in Chungsangbohahwan-treated group was significantly increased on 100:1, 50:1 E/T(effect cell/target cell) ratio(P<0.05). 4. Production of interleukin-2 in Chungsangbohahwan-treated group was significantly increased(P<0.05).

• The Journal of the Korea Contents Association
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• v.17 no.12
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• pp.104-116
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• 2017

This study was conducted in order to test a model in relation to active coping strategy, academic resilience, and subjective happiness in college students. Also, sought to test the mediating effects of academic resilience in the relationship between active coping strategy and subjective happiness. Data was collected through a self-report questionnaire which was administered to 400 college students. Correlational analysis and structure equation modeling analysis were conducted to test the research models. The results were as follows: First, as the level of active coping strategy increased, the level of academic resilience and subjective happiness increased. Second, as the level of academic resilience increased, the level of subjective happiness increased. Third, the model with active coping strategy as a prophetic variable, academic resilience as a mediating variable, and subjective happiness as a result variable showed a full mediating effect. Thus, although active coping strategy has no direct influence on subjective happiness, it has an indirect effect on subjective happiness by enhancing academic resilience. The results of this study are expected to provide basic data on research and education for the improvement of happiness in college students and to help them develop educational counseling and training programs for improving their happiness and adapting to college life.

• Journal of Korean Orthopaedic Sports Medicine
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• v.10 no.2
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• pp.54-60
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• 2011

Puropse: To evaluate the outcome of arthroscopic posterior cruciate ligament (PCL) reconstruction using fresh-frozen achilles allograft tendon with preservation of ligament remnant or elongated ligament. Materials and Methods: From October 2004 to March 2010, we performed PCL reconstruction with Achilles tendon allografts in 22 complete rupture patients. Mean age was 31.5 years. 14 cases were male and 8 cases were female. Average follow-up period was 3 years and 7 months, range from 1 year to 6 years and 4 months. Subjective and objective parameters were utilized in analyses, such as the mean range of motion, post. drawer test, Lysholm knee score, Tegner activity score, IKDC score, and second look arthroscopic examination. Results: Postoperative Lysholm knee score, IKDC scores, Tegner activity scale, and posterior displacement by the Telos stress test demonstrated statistically significant improvement compared to the preoperative state. Conclusion: Arthroscopic PCL reconstruction using fresh-frozen achilles allograft tendon with preservation of ligament remnant showed good clinical results and posterior stability.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.12
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• pp.6309-6316
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• 2013

Morbidity, mortality, mental health and problem behavior appears to be high in adolescence, but there is no proper intervention. This quasi-experimental study examined the effects of the neurofeedback training on the general health status, mental health and problem behavior, and the brain function quotient through structured questionnaires and brain waves of 11 high school students (experimental group 5, control group 6). The study was conducted at I high school in Seoul from September to December, 2012. The subjects participated in the neurofeedback training twice a week for a total of 20 sessions by trained researcher. The data was analyzed using paired t-test or Wilcoxon signed rank test depending on the normality using SPSS 20.0. Significant improvement was observed in the emotion quotient and stress resistance quotient (left, right) among the brain function quotient, but not in the general health status, mental health and problem behavior.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.40-48
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• 2017

This study investigated the relationship among emotional regulation, coping strategies and satisfaction in clinical practice, and examined factors influencing satisfaction with clinical practice in nursing students. Data were collected through structured questionnaires from May 1 to June 30, 2016. The study participants were 201 third and fourth year nursing students at four departments of nursing located in B and K metropolitan city. Data were analyzed using t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients and stepwise multiple regression with SPSS WIN v 20.0. The mean emotional regulation score was $3.73{\pm}0.48$, active coping was $2.79{\pm}0.33$, passive coping was $2.53{\pm}0.36$, and practice satisfaction was $3.58{\pm}0.46$. Statistically significant relationships were noted between emotional regulation and satisfaction with clinical practice (r=.391, p<.001), between active coping and satisfaction with clinical practice (r=.361, p<.001), between passive coping and satisfaction with clinical practice (r=.276, p<.001). Factors influencing satisfaction with clinical practice were satisfaction with the nursing major (${\beta}=-.322$, p<.001) and emotional regulation (${\beta}=.232$, p<.001). These factors explained 28.1% of variance in participant's satisfaction with clinical practice. In conclusion, effective nursing educational programs need to be developed to enhance satisfaction with clinical practice and to foster positive emotional regulation in nursing students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.406-416
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• 2017

The purpose of this study was to examine violence response, burnout, and job satisfaction according to violent episodes of emergency room workers. Methods : This Study was a descriptive survey design using convenience sampling. This study was exempt from needing an IRB approval. There were 167 emergency room workers, who agreed to participate in this study, and took a self-report questionnaire between July and August 2015. SPSS 21.0 version was used for descriptive analysis, frequency, percentage, mean, standard deviation, independent t-test, Pearson correlation coefficients, and multiple regression. The major findings of this study were as follows: 1) 84.4% of participant experienced violent episodes. The frequency of verbal violence was highest. Violent attackers were patients and guardians with drunken state. The time of violence episodes was usually during the night. Violent experience of doctors and nurses was very high. 2) There were significant differences in the emotional response according to violent episodes (t=2.528, p=0.12) 3) The correlation between \response and burnout was statistically significant, and indicates a high positive correlation (r=.616, p=<.001). The correlation between violence response and job satisfaction was statistically significant, indicating a negative correlation (r=-.512, p=<.001). There was a negative correlation between burnout and job satisfaction with statistical significance (r=-.568, p=<.001). 4) Significant factors influencing job satisfaction were emotional response to violence and burnout. Conclusion: The findings of this study provide basic information for the strategies of preventing violence, decreasing burnout, and improving job satisfaction by developing a violence management program.

• Journal of the Korean Applied Science and Technology
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• v.37 no.2
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• pp.268-278
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• 2020

This study aimed to identify the moderating effect of public health service utilization rate between public health resources and community mental health. The subjects included 144 local communities, from the data of 6th Community Health Plan and the 2015 Community Health Survey. Public health resources were measured by public health budget, public mental health budget and public mental health personnel; and mental health was measured by rate of perceived stress, rate of depressive mood and suicide rate. The hierarchical regression analysis was used to identify the moderating effects. The results were as followed. First, the effect of public mental health budget on rate of depressive mood was moderated by public health service utilization rate. Second, the effect of public mental health personnel on rate of depressive mood was moderated by public health service utilization rate. Third, the effect of public mental health personnel on suicide rate was also moderated by public health service utilization rate. Fourth, the effect of public health resources on mental health differed between the groups with high and low public health service utilization rate. In improving community mental health, the measures to improve the public health service utilization rate should be considered to ensure that reinforcing public health resources leads to the improvement of community mental health.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.477-487
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• 2016

This study attempts to comprehensively evaluate differences in sociodemographic characteristics, health behavior, disease morbidity, medical care and health-related quality of life of medical aid beneficiaries and health insurance beneficiaries. To achieve this, this study analyzes primitive data of community health survey that each health center had recently conducted in 2013. Study socioeconomic characteristics, health behavior, disease morbidity, medical care showed that various factors affecting health-related quality of life. It was found that medical aid beneficiaries showed lower health related-quality of life than health insurance beneficiaries because not good socioeconomic characteristics, health behavior, disease morbidity, and medical care and even as a comparative result after controlling socioeconomic characteristics, it was found that medical aid beneficiaries health-related quality of life was lower because of not good health behavior, disease morbidity, and medical care. Therefore, to improve health-related quality of life in medical aid beneficiaries as effectively as possible, improving mental health including managing chronic disease and stress and depression and daily living activities is above all important and our national concern with developing systematic program and policies focusing on health promotion behaviors such as moderate drinking habits and regular exercise and eating habits is required.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.623-637
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• 2016

This study examined the importance of social capital in facilitating older adults' learning and adaptation of information technology as well as alleviating depressive symptoms. At two senior community centers in South Korea, 144 adults aged 60 and older were recruited to participate in 12 week-long technology classes to learn computers, smart phone, and internet skills. At the baseline interviews were conducted to assess their health status, depression, and online social relationships. Online and offline social capital (bonding vs. bridging) was assessed (Williams, 2006). Four-step Hierarchical Linear Regression analysis was conducted to examine the effects of online social relationship on depression. Findings suggested that depressive symptoms were associated with being widowed, being unemployed, and perceiving poor health status. Adding social capital variables in the final step, older adults who perceived less stressors, greater level of subjective health and high online bonding capitals had less depressive symptoms. Only online social bonding was significant in alleviating depression. This final model explained 48% of the variance. Computer/Internet training for older adults need to consider the significant role bonding social capital can play. The findings of this pilot study provided a preliminary base of knowledge about acceptable community-based interventions for older adults.