• Journal of Nutrition and Health
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• v.42 no.8
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• pp.673-681
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• 2009

Diabetes mellitus is a multifactorial disease. Particularly, diabetic nephropathy is a serious complication for diabetic patients, yet the precise mechanisms that underline the initial stage of diabetic renal inflammation remain unknown. However, oxidative stress induced by hyperglycemia in diabetes is implicated in diabetic renal disease. We hypothesized that dietary supplementation of antioxidants either VCE (0.5% VC + 0.5% VE) or Comb (0.5% VC + 0.5% VE + 2.5% N-acetylcysteine) improves acute diabetic renal inflammation through modulation of blood glucose levels and antioxidant and anti-inflammatory responses. Experimental animals (5.5 weeks old female ICR) used were treated with alloxan (180 mg/kg) once. When fasting blood glucose levels were higher than 250 mg/dL, mice were divided into 3 groups fed different levels of antioxidant supplementation, DM (diabetic mice fed AIN 93G purified rodent diet); VCE (diabetic mice fed 0.5% vitamin C and 0.5% vitamin E supplemented diet); Comb (diabetic mice fed 0.5% vitamin C, 0.5% vitamin E and 2.5% N-acetylcysteine supplemented diet), for 10 days and then sacrificed. Body weights were measured once a week and blood glucose levels were monitored twice a week. Lipid peroxidation products, thiobarbituric acid reacting substances were measured in kidney. NF-${\kappa}B$ activation was indirectly demonstrated by pI${\kappa}B$-${\alpna}$ and expressions of selective inflammatory and oxidative stress markers including antioxidant enzymes were also determined. Dietary antioxidant supplementation improved levels of blood glucose as well as kidney lipid peroxi-dation. Dietary antioxidant supplementation improved NF-${\kappa}B$ activation and protein expression of HO-1, but not mRNA expression levels in diabetic mice fed Comb diet. In contrast, the mRNA and protein expression of CuZnSOD was decreased in diabetic mice fed Comb diet. However, antioxidant supplementation did not improve mRNA and protein expressions of IL-$1{\beta}$ and MnSOD in diabetic mice. These findings demonstrate that acute diabetic renal inflammation was associated with altered inflammatory and antioxidant responses and suggest that antioxidant cocktail supplementation may have beneficial effects on early stage of diabetic nephropathy through modulation of blood glucose levels and antioxidant enzyme expressions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.452-459
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• 2017

In recent years, to reduce self-weight of structural elements, the use of SCP (Steel Concrete Plate) instead of prestressed concrete is increasing. Because SCP has a complicated sectional shape and includes a large number of studs, the use of high-fluidity concrete is required. Therefore, in this study, to prevent the restrained shrinkage behavior by the stud, the effects of using an expansive agent (EA) and shrinkage reducing agent (SRA) were investigated, and the optimal mixture proportions to maximize the filling capacity were determined based on the fine aggregate ratio. The test results indicated that the combined use of EA and SRA exhibited the smallest shrinkage. The ratio of the crushed sand and washed sea sand was determined to be 5:5, and the proper fine aggregate ratio was found to be 55.6%, because when the ratio was too high, a decrease in strength and an increase in shrinkage strain were expected. The high-fluidity concrete effectively filled the large-sized SCP module.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.205-217
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• 2016

The objective of this study was to understand the fundamental aspects of the laughter therapy using the Van Manen's hermeneutic phenomenological method. Participants of this study included twelve elderly people-four men and eight women-who agreed to participate in this study underwent laughter therapy at a senior citizen's center. Data were collected through focus interviews, a literary work, and a work of art. The essential themes of this study are a healthy life (restoration of health, refreshed feeling), a happy life (stress relief, put idle thoughts out of one's mind, vitality in daily routine, double pleasure through laughter, re-juvenescence with reminiscence), and a wishful life (became optimistic while leaving behind suffering, look forward to things). Healthy life was defined as experiencing the basic motive power of life, happy life was defined as experiencing delightfulness through relationships with others and empathy, and wishful life was defined as experiencing an affirmative life integration through overcoming suffering from losses. In conclusion, laughter therapy showed to improve health, personal relations and life integration for elderly people. Therefore, utilization of laughter therapy will help to improve independence and self-esteem in elderly people.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.242-252
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• 2016

This study seeks to verify the effect size of the variables relating to job satisfaction through a meta-analysis focusing on previous papers over the last 20 years that have examined the job satisfaction of kindergarten teachers and verified the trend by publication year through a meta-regression analysis. The study results are as follows. First, the results demonstrated that the total effect size of the variables relating to kindergarten teachers was large. Second, the organization's internal variable and organization's external variable groups, except for the individual characteristics variable group, showed a large effect size at similar levels. Third, the status of teachers in the individual characteristics variable group showed a meaningfully large effect size and the interpersonal relationship variable in organization's internal variable group showed a relatively larger effect size than the organizational climate variable did. Finally, the results of the verification of the trend by publication year showed that job satisfaction increased for all variables, except for the individual characteristics variable in more recent publications. This study highlights the imperative of making every effort to improve the organization's internal and external environment. In particular, measures to reduce job stress and work load are required. Furthermore, the atmosphere that is devoted to the teaching profession and teacher efficacy is important.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.308-317
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• 2017

This study aims to determine the current status of experiences of suicidal attempts of Korean women and to evaluate related factors and provide basic sources for distinguishing high risk group. The primary data of the 6th period of national health and nutrition survey by KCDC, between 2013 and 2015,wereutilized in this study.Women were selected;general characteristics, psychological characteristics, and relevant information of daily activities were collected. The collected data wereanalyzed by applying the complex sample analysis method,using the SPSS 20.0 program with an application of weighted values. The resultsof this study revealed that 1% of the study population had previously attempted suicide; the suicidal attempts in subjects with prior psychological counselling within 1 year was 5.25 times higher than those without prior counselling.Subjectswith too much stress were 14.92 times more likely to attempt suicide than those without stress. Moreover, subjects with higher-intensity work in daily lives was 4.85 times more likely to attempt suicide than those with less intense work. In addition, subjects who sat for longer period of time was 3.76 times more likely to attempt suicide. All of these were statistically significant. Therefore, these subjects should be considered as high risk for suicidal attempt.In order to prevent female suicide, guidelines that considers the psychological health status and daily activities are required. In addition, it is necessary to approach this issuewith individualized prevention programs as part of social policies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.382-390
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• 2017

This study was conducted to identify the factors affecting the quality of life of cancer patients based on demographic characteristics, health status, and mental health using the results of the 6th National Health and Nutrition Survey. The research tool used the demographic characteristics, health status, mental health, and quality of life of the KNHANES VI-2. Data analysis was conducted using SAS 9.3 version. There were significant differences in the quality of life in the study results by age, gender, economic activity, individual income quartile, subjective health status, mental health status, activity limitation, stress perception, and experience of depression symptoms. Factors influencing the quality of life of cancer patients included age, sex, income quintiles(individual), subjective health status, activity limitation, and experience of depression symptoms, which together explained 39.1% of the quality of life. To improve the quality of life of cancer patients, comprehensive management is required from diagnosis to treatment to return to society. It is also necessary to develop and apply long-term programs including multidimensional approaches and improvement of quality of life, early screening of cancer and cancer prevention education, management of depression symptoms, and social support.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.4
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• pp.245-253
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• 2018

This study investigated 2,088 economically active workers aged 20 to 65 years selected from the sixth Korea National Health and Nutrition Examination Survey to evaluate the relationship between chronic diseases and oral health behaviors among economic workers and examine the risk factors for oral diseases. The results of the study were as follows. Dental caries were related to subjective oral health status, toothache experience, orthodontic treatment experience, chewing problems, speaking problems, oral examination, and dental clinic use. Periodontal disease was associated with oral health status, toothache experience, orthodontic experience, and chewing and speaking problems. The risk factors for chronic diseases and oral health behavior were as follows. Hypertension, 1.37 times; obesity, 1.48 times; diabetes, 1.5 times; low HDL-cholesterol, 1.31 times; hepatitis A antibody, 1.53 times higher. Health status was found to be 1.70 times higher in dental caries and 2.10 times higher in periodontal disease. The tooth experience was 1.30 times higher in dental caries and 1.35 times higher in periodontal disease. Problems chewing were 1.76 times for dental caries and 1.78 times for periodontal disease. The possibility of dental caries and periodontal disease was 1.44 times higher. Smokers were 1.61 times more likely to have dental caries and 1.63 times more likely to have periodontal disease. These results suggest that periodontal diseases increase the risk of chronic diseases and oral health behavior increases the risk of dental caries and periodontal disease. Although dental caries seem to have a lower risk of becoming a chronic disease if only oral health care is good, it is considered that both chronic disease and oral health care are important for periodontal disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.4
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• pp.293-300
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• 2018

The purpose of this study is to investigate the educational needs for career development according to the job type of nursing college students. In order to achieve the purpose of the study, 146 nursing college students from K and P universities in the Busan and Kyungnam areas were analyzed using a career anchor questionnaire. In addition, 28 nursing college students who showed a higher level of tendency among job types were selected and divided into 4 teams, and a focus group interview was conducted based on the contents of the created map. Its purpose is to investigate the educational needs of nursing college students to enhance their career development. First, the career anchor types of the nursing college students showed the highest score in the areas of lifestyle, security and stability, while the lowest types of career anchor were pure challenge and general managerial competence. Second, the educational needs for career development were categorized into four areas, namely major competence, practical competence, personality competence, and resource management competence. The major competences are nursing expertise and skills. The practical competences consisted of ward task management, communication, crisis coping ability and personality competence and these were divided into cooperation and responsibility recognition. The resource management competence consists of time management ability and stress management ability. The results of this study are meaningful in that they can be used as the basic educational data for the career development of nursing college students in the future. In addition, it is expected that they can be applied to the development of a curriculum for the improvement of nursing practice.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.471-477
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• 2004

Exposure to elevated temperatures, chemical (active oxigen), or physical stress (UV light) induces immediate physiological response, the expression of heat shock proteins in cells. Thus, cells with elevated Heat Shock Protein levels become more tolerant to stress conditions that are otherwise lethal. First, we studied on the new function of glucuronic acid (GA) as preventive material of skin aging. The application of the GA shows significant induction of Heat Shock Protein 70 kDa (HSP 70 kDa) in contrast to cells without it. GA at the concentration which can induce HSP 70 kDa, protects the cell death induced by second stress (heat shock and hydrogen peroxide) in NIH3T3 cells. Second, we studied on in vitro transdermal permeation characteristic of GA through the excised mouse skin. In this study, we compared the skin permeability of GA in water with O/W emulsion. As a result, skin permeation parameters of GA shows lag time 1.2 h, partition coefficient 0.114, permeation flult rate $0.83114 mg/cm^2/h.$ In case of lag time, O/W emulsion containing GA increase 2.48 h. Also, the total accumulation permeation content decreased in contrast to GA solution after 24 h. But it has long-term permeability of glucuronic acid. These results suggest that glucuronic acid could be a good cosmetic active ingredient.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.4
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• pp.321-330
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• 2014

Ultraviolet B (UVB) is a primary environmental factor that induces adverse effects on skin such as photoaging, skin burn and cancer. UVB also increases the expression of $11{\beta}$-hydroxysteroid dehydrogenase type 1 ($11{\beta}-HSD1$), which converts inactive cortisone to active cortisol in response to a variety of stressors in target tissues. Thus, we have screened new herbal extracts that suppress $11{\beta}-HSD1$ expression induced by UVB in human dermal fibroblasts. We also investigated whether Trapa japonica (TJ) extract and its fractions inhibit UVB-induced photoaging in Hs68 cells and 3D skin model. Results showed that TJ extract inhibited the increase of $11{\beta}-HSD1$ expression in UVB-exposed Hs68 cells significantly. TJ extract and its fractions not only inhibited $11{\beta}-HSD1$ expression, but also suppressed the increase of matrix metalloproteinases (MMP-1, 3, 9) and proinflammatory cytokines (IL-6, 8) in UVB-irritated Hs68 cells. TJ extract also inhibited MMP-1 expression in UVB-irritated 3D skin model. In addition, TJ extract recovered UVB-induced decreases of epidermal thickness and PCNA-positive cells in 3D skin model. Taken together, these results suggest that TJ extract and its fractions inhibit UVB-induced skin photoaging by interfering with $11{\beta}-HSD1$ and MMPs.