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Application of Glucuronic Acid with New Cosmetic Active Ingredient  

Lee Geun-Soo (R&D Center, Hanbul Cosmetics Co.)
Kim Jin-Wha (R&D Center, Hanbul Cosmetics Co.)
Lee Chun-Il (R&D Center, Hanbul Cosmetics Co.)
Pyo Hyeong-Bae (R&D Center, Hanbul Cosmetics Co.)
Lee Kong-Joo (College of Pharmacy, Ewha Womans University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.4, 2004 , pp. 471-477 More about this Journal
Abstract
Exposure to elevated temperatures, chemical (active oxigen), or physical stress (UV light) induces immediate physiological response, the expression of heat shock proteins in cells. Thus, cells with elevated Heat Shock Protein levels become more tolerant to stress conditions that are otherwise lethal. First, we studied on the new function of glucuronic acid (GA) as preventive material of skin aging. The application of the GA shows significant induction of Heat Shock Protein 70 kDa (HSP 70 kDa) in contrast to cells without it. GA at the concentration which can induce HSP 70 kDa, protects the cell death induced by second stress (heat shock and hydrogen peroxide) in NIH3T3 cells. Second, we studied on in vitro transdermal permeation characteristic of GA through the excised mouse skin. In this study, we compared the skin permeability of GA in water with O/W emulsion. As a result, skin permeation parameters of GA shows lag time 1.2 h, partition coefficient 0.114, permeation flult rate $0.83114 mg/cm^2/h.$ In case of lag time, O/W emulsion containing GA increase 2.48 h. Also, the total accumulation permeation content decreased in contrast to GA solution after 24 h. But it has long-term permeability of glucuronic acid. These results suggest that glucuronic acid could be a good cosmetic active ingredient.
Keywords
glucuronic acid; heat shock protein; anti-aging; o/w emulsion; long-term permeability;
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