• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.109-114
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• 2020

The aim of the study was to observe the influence and related mechanism of rebamipide on the intestinal contraction. Intestinal contraction includes the activation of thick or thin filament regulation. However, there are few reports addressing the question whether this regulation is involved in rebamipide-induced regulation. We hypothesized that rebamipide plays a role in intestinal contraction evoked by carbachol in rat intestine. Interestingly, rebamipide alone didn't inhibit and rather slightly increased the contraction in the denuded muscle. Therefore, rebamipide alone and together with indomethacin increases the ileal contraction suggesting that additional pathways might be involved in the regulation of ileal contractility. In conclusion, rebamipide has some effect on the regulation of contractility and anti-ulcer by NSAIDs.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.131-137
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• 2021

The aim of the study was to observe the influence and related mechanism of histamine and its analogues used for hypersensitivity tests and used as an indicator of impurities in drugs on the tissue-specific intestinal contraction. Intestinal contraction includes the activation of thick or thin filament regulation. However, there are few reports addressing the question whether this regulation is involved in histamine-induced regulation. We hypothesized that histamine plays a role in tissue-dependent regulation of intestinal contractility. Denuded ileal/colonic longitudinal and circular muscles of male rats were used and isometric contractions were recorded using a data acquisition system. Interestingly, histamine alone didn't increase the contraction of the circular muscle but increased the contraction of the longitudinal muscle. Histamine together with atropine (M3 receptor antagonist) didn't inhibit the contraction of the longitudinal and circular muscle. Therefore, histamine alone and together with atropine increases the ileal longitudinal muscle contraction suggesting that additional mechanisms (decreased receptor density, postreceptor signaling or distribution of agonists) might be involved in the regulation of ileal muscle contractility. In conclusion, histamine and/or atropine has some effect on the regulation of the longitudinal contractility regardless of M3 receptor and the simpler test would be preferred as the drug impurity test compared to more complicated tests.

• Korean Journal of Applied Biomechanics
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• v.19 no.1
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• pp.139-148
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• 2009

D. W. HAN. Y. R. AHN., N. J. LEE and E. J. LEE. Effects of Combined Restistance Training Program of Concentric and Eccentric Contraction Using Theraband on Shoulder Rotation Torque Max and Peak Power. Korean Joumal of Sport Biomechanics, Vol. 19, No. 1, pp. 139-148, 2009. The purpose of this study was to find out that combined concentric with eccentric resistance training program using Thera-Band was more effective than only concentric resistance training program on shoulder rotation torque max and peak power. 30 female students were randomly assigned to 3 equal group; concentric and eccentric, concentric, non training group. Subjects were tested in concentric and eccentric torque max and peak power of internal and external rotation using a CON-TERX isokinetic dynamometer. Subjects in training group participated in their regular five times a week for 4 weeks. After exercise, in concentric and eccentric training group, concentric and eccentric torque max, and peak power of internal rotator at 60 deg/sec were increased significantly. concentric peak power at 120 deg/sec were increased significantly. In concentric training group, only concentric peak power of internal rotator at 60 and 120 deg/sec was increased. In conclusion, we found out that combined concentric with eccentric resistance training program using Thera-Band was more effective than only concentric resistance training program on shoulder rotation torque max and peak power.

• Journal of Yeungnam Medical Science
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• v.5 no.2
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• pp.59-69
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• 1988

This study was designed to investigate the effect of substitution of strontium for calcium on mechanical activity in isolated perfused spontaneously beating rat hearts. The mechanical activity of the hearts of Langendorff's preparation in conditions of low calcium and strontium-substitution for calcium was compared. The effect of norepinephrine and verapamil were also observed in those conditions. The results were as follows : 1. In low calcium, the mechanical activity of the heart preparation was significantly reduced, but when the equimolar strontium was substituted for the reduced calcium, the activity was kept at similar level to the normal condition. 2. When equimolar strontium was substituted for the total calcium in perfusate, the heart preparation stopped its beating, and it was not restored in spite of reperfusion with normal calcium perfusate. 3. Norepinephrine-induced positive inotropic effect was inhibited in low-calcium condition especially with low concentration of norepinephrine, but not in strontium-substitution for calcium. 4. Verapamil reduced the activity of the heart both in low-calcium and strontium-substitution as well as in normal calcium conditions. From above results, it was concluded that strontium served as a substitute of calcium in maintaining mechanical activity and in responsiveness to norepinephrine, and the influx of strontium through cell membrane is inhibited by verapamil as the influx of calcium.

• Korean Journal of Crystallography
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• v.14 no.1
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• pp.7-12
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• 2003

The compound SrA1₂(BO₃)₂O is a good host lattice for negative thermal expansion. We have measured thermal expansion over the limited temperature range by X-ray diffraction and ceramic dilatometry. In the aluminum borate compound, a thermal contraction is observed with a coefficient -1.64×10/sup -4/ Å/℃ on the c axis in the temperature range 23∼215℃ and with a maximum change -1.75㎛ in length of a ceramic bar of 20㎜ in the temperature range 110∼170℃, respectively.

• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.119-125
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• 2022

In the study, we endeavored to investigate the effect of phenylephrine, isoprenaline and prazosin on the tissue-specific vascular contractility and to determine the mechanism involved. There were few reports addressing the question whether thin or thick filament modulation is included in phenylephrine, isoprenaline and prazosin-induced regulation. We hypothesized that isoprenaline and prazosin play a role in tissue-dependent regulation of vascular contractility. Denuded arterial muscles of Sprague-Dawley male rats were suspended in organ baths and isometric tensions were transduced and recorded using isometric transducers and an automatic data acquisition system. Interestingly, sustained continuous contraction of thoracic and abdominal aorta. Furthermore, isoprenaline and prazosin together with phenylephrine inhibited transiently and persistently vasoconstriction of thoracic and abdominal aorta suggesting that additional mechanisms (e.g. decreased receptor density, chemical interaction, postreceptor signaling or distribution of agonists) might be included in the modulation of vascular contractility.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.1
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• pp.125-132
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• 2020

The causes of concrete shrinkage are very diverse, in particular, aggregates impact the characteristics of shrinkage in concrete by constraining the shrinkage of cement paste. Meanwhile, owing to the lack of natural aggregate, various alternative aggregates are being developed, and their application in concrete also becomes more diverse. This study aimed to experimentally evaluate the drying and autogenous shrinkage in concrete that was composed of electric arc furnace slag as coarse aggregates. And, the results were compared with prediction models. From the results, the application of electric arc furnace slag can reduce the drying and autogenous shrinkage. In particular, autogenous shrinkage is greatly decreased. The predictions using GL2000 for drying shrinkage and Tazawa model for autogenous shrinkage were similar to the experimental results. However, the most prediction models do not consider the impact of aggregates, hence, the new prediction model should be developed or improved.

• The Korean Journal of Pharmacology
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• v.30 no.1
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• pp.59-65
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• 1994

The experiments were performed to determine whether lidocaine interferes with the utilization of lipid as source of energy fuel for the contractile process by the isolated rat atria. Rats were starved for two days in order to inerease the lipid content of the heart. Atria from starved rats were better able to maintain their contractility in the absence of exgenous substrate, and also were more resistant to depression by lidocaine than atria from fed rats. Starvation results in a marked loss of body weight in rats. In contrast to the starved rats, the body weight of fed rats inereased with time. The smaller reduction in contractile activity of atria from the starved rats may suggest that endogenous lipid accumulates during starvation period and is used as an energy source for the contractile process in the face of a lidocaine-induced blockade in glycolysis.

• Journal of Industrial Convergence
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• v.20 no.7
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• pp.131-137
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• 2022

In the study, we endeavored to assess the convergence effect of Silybum marianum-derived silymarin and epidemiologically-correlated alcohol intake on vascular contractility and to determine the mechanism involved. There were few reports addressing the question whether thin or thick filament modulation is included in ethanol and silymarin-induced regulation. We hypothesized that ethanol at a low concentration and silymarin play a role in agonist-dependent regulation of vascular contractility. Denuded arterial muscles of Sprague-Dawley male rats were suspended in organ baths and isometric tensions were transduced and recorded using isometric transducers and an automatic data acquisition system. Interestingly, both silymarin and ethanol didn't encourage silymarin alone-induced inhibition in agonists-induced contraction suggesting that endothelial nitric oxide synthesis might be involved in ethanol or silymarin-induced modulation of vascular contractility and additional pathways besides endothelial nitric oxide synthesis such as ROCK inactivation might be involved in the silymarin-induced modulation of vascular contractility.

• Korean Journal of Applied Biomechanics
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• v.18 no.4
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• pp.21-30
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• 2008

The purpose of this study was to investigate changes in mechanical properties of human tibialis anterior following eccentric exercise. Healthy subjects (n=12) performed 120 maximum eccentric contraction of ankle dorsiflexor. Before and 1- and 24- hour after the eccentric exercise, ankle dorsiflexion moment-angle relationships were obtained. Along with significant decrease in maximum isometric muscle strength, the shift of the optimum ankle joint angle toward the longer muscle length direction was observed, independent of the ranges of motion of the eccentric exercise. The results of this study demonstrated that eccentric exercise-induced micro muscle damage(Morgan & Allen, 1999) does rut seem to be a sole mechanism of eccentric contraction-induced muscle damage, suggesting further investigation for the better understandings of this phenomenon.