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http://dx.doi.org/10.22156/CS4SMB.2020.10.10.109

The Effect of Rebamipide on the Regulation of Intestinal Contractility  

Je, Hyun Dong (Dept. of Pharmacology, College of Pharmacy, Daegu Catholic University)
Min, Young Sil (Dept. of Pharmaceutical Science, Jungwon University)
Publication Information
Journal of Convergence for Information Technology / v.10, no.10, 2020 , pp. 109-114 More about this Journal
Abstract
The aim of the study was to observe the influence and related mechanism of rebamipide on the intestinal contraction. Intestinal contraction includes the activation of thick or thin filament regulation. However, there are few reports addressing the question whether this regulation is involved in rebamipide-induced regulation. We hypothesized that rebamipide plays a role in intestinal contraction evoked by carbachol in rat intestine. Interestingly, rebamipide alone didn't inhibit and rather slightly increased the contraction in the denuded muscle. Therefore, rebamipide alone and together with indomethacin increases the ileal contraction suggesting that additional pathways might be involved in the regulation of ileal contractility. In conclusion, rebamipide has some effect on the regulation of contractility and anti-ulcer by NSAIDs.
Keywords
Colon.ileum; Contraction; Rebamipide; Anti-ulcer; Smooth muscle;
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