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http://dx.doi.org/10.22156/CS4SMB.2021.11.10.131

The Convergence Effect of Histamine and Atropine on Intestinal Contractility  

Je, Hyun Dong (Dept. of Pharmacology, College of Pharmacy, Daegu Catholic University)
Min, Young Sil (Dept. of Pharmaceutical Science, Jungwon University)
Publication Information
Journal of Convergence for Information Technology / v.11, no.10, 2021 , pp. 131-137 More about this Journal
Abstract
The aim of the study was to observe the influence and related mechanism of histamine and its analogues used for hypersensitivity tests and used as an indicator of impurities in drugs on the tissue-specific intestinal contraction. Intestinal contraction includes the activation of thick or thin filament regulation. However, there are few reports addressing the question whether this regulation is involved in histamine-induced regulation. We hypothesized that histamine plays a role in tissue-dependent regulation of intestinal contractility. Denuded ileal/colonic longitudinal and circular muscles of male rats were used and isometric contractions were recorded using a data acquisition system. Interestingly, histamine alone didn't increase the contraction of the circular muscle but increased the contraction of the longitudinal muscle. Histamine together with atropine (M3 receptor antagonist) didn't inhibit the contraction of the longitudinal and circular muscle. Therefore, histamine alone and together with atropine increases the ileal longitudinal muscle contraction suggesting that additional mechanisms (decreased receptor density, postreceptor signaling or distribution of agonists) might be involved in the regulation of ileal muscle contractility. In conclusion, histamine and/or atropine has some effect on the regulation of the longitudinal contractility regardless of M3 receptor and the simpler test would be preferred as the drug impurity test compared to more complicated tests.
Keywords
Colon; Circular; Longitudinal; Ileum; Atropine; Histamine;
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1 T. Matsui, M. Amano, T. Yamamoto, K. Chihara, M. Nakafuku, M. Ito, T. Nakano, K. Okawa, A. Iwamatsu & K. Kaibuchi, (1996). Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO. J., 15(9), 2208-22016.   DOI
2 M. Suguro, H. Matsuyama, Y. Tanahashi, T. Unno, T. Kitazawa, M. Yamada & S. Komori. (2010). Muscarinic receptor subtypes mediating Ca2+ sensitization of intestinal smooth muscle contraction: studies with receptor knockout mice. J. Vet. Med. Sci., 72(4), 443-451. DOI : 10.1292/jvms.09-0458   DOI
3 N. Gao, A. N. Chang, W. He, C. P. Chen, Y. N. Qiao, M. Zhu, K. E. Kamm & J. T. Stull. (2016). Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle. J. Physiol, 594(12), 3209-3225. DOI : 10.1113/JP271703   DOI
4 P. Lieberman. (2011). The basics of histamine biology. Ann. Allergy Asthma Immunol, 106(2 Suppl), S2-5. DOI : 10.1016/j.anai.2010.08.005   DOI
5 E. Ihara, Q. Yu, M. Chappellaz & J. A. MacDonald. (2015). ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction. Neurogastroenterol. Motil, 27(1), 135-146. DOI : 10.1111/nmo.12491   DOI
6 J. Chu, C. T. Miller, K. Kislitsyna, G. A. Laine, R. H. Stewart, C. S. Cox & K. S. Uray. (2012). Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle. Neurogastroenterol. Motil, 24(3), 257-266, e109 DOI : 10.1111/j.1365-2982.2011.01855.x   DOI
7 H. D. Je, J. M. Lee & H. O. La. (2010). The Inhibitory Effect of Eupatilin on the Intestinal Contraction Induced by Carbachol. Biomol. & Thera, 18(4). 442-447. DOI: 10.4062/biomolther.2010.18.4.442   DOI
8 M. C. Gonzalez-Montelongo, R. Marin, J. A. Perez, T. Gomez & M. Diaz. (2013). Polyamines transduce the nongenomic, androgen-induced calcium sensitization in intestinal smooth muscle. Mol. Endocrinol, 27(10), 1603-1616. DOI : 10.1210/me.2013-1201   DOI
9 A. P. Somlyo & A. V. Somlyo. (1998). From pharmacomechanical coupling to G-proteins and myosin phosphatase. Acta. Physiol. Scand. 164(4), 437-448. DOI : 10.1046/j.1365-201X.1998.00454.x   DOI
10 M. C. Gonzalez-Montelongo, R. Marin, T. Gomez & M. Diaz. (2010). Androgens are powerful non-genomic inducers of calcium sensitization in visceral smooth muscle. Steroids, 75(8-9): 533-538. DOI : 10.1016/j.steroids.2009.09.012   DOI
11 M. E. Parsons & C. R. Ganellin. (2006). Histamine and its receptors. Br. J. Pharmacol, 147 Suppl 1(Suppl 1), S127-S135. DOI : 10.1038/sj.bjp.0706440   DOI
12 K. Suzuki, K. Nemoto, N. Ninomiya, M. Kuno, M. Kubota & H. Yokota. (2012). Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. J. Surg. Res., 178(1), 352-357. DOI : 10.1016/j.jss.2012.01.043   DOI
13 Y. J. Xiong, D. P. Chen, B. C. Lv, F. F. , Liu, L. Wang & Y. Lin. (2013). The characteristics of genistin-induced inhibitory effects on intestinal motility. Arch. Pharm. Res., 36(3), 345-352. DOI : 10.1007/s12272-013-0053-2   DOI
14 W. Q. He et al. (2013). Contractile Phenotypes of Intestinal Smooth Muscle in Mice Deficient in Myosin Phosphatase Target Subunit 1. Gastroenterology, 144(7), 1456-1465. e5. DOI : 10.1053/j.gastro.2013.02.045   DOI
15 C. A. Podlesnik & C. Jimenez-Gomez. (2013). Punishing and cardiovascular effects of intravenous histamine in rats: pharmacological selectivity. J. Exp. Anal. Behav., 100(3), 333-354 . DOI : 10.1002/jeab.46   DOI
16 K. M Sanders, S. J. Hwang & S. M. Ward. (2010). Neuroeffector apparatus in gastrointestinal smooth muscle organs. J. Physiol., 588(Pt 23): 4621-4639. DOI : 10.1113/jphysiol.2010.196030   DOI
17 M. Kurahashi, H. Zheng, L. Dwyer, S. M. Ward, S. Don Koh & K. M. Sanders. (2011). A functional role for the 'fibroblast-like cells' in gastrointestinal smooth muscles. J. Physiol., 589(Pt 3), 697-710. DOI : 10.1113/jphysiol.2010.201129   DOI
18 R. C. Webb, (2003). Smooth muscle contraction and relaxation. Adv. Physiol. Educ., 27(1-4), 201-206. DOI : 10.1152/advan.00025.2003   DOI