• Journal of Food Hygiene and Safety
• /
• v.14 no.4
• /
• pp.358-364
• /
• 1999

Propolis, a natural resinous compound collected from honey bees, contains many biochemical constituents and has been used in traditional medicines as early as 300 B.C. Recently, it has been reported to possess many biological activities such as antibacterial, antiviral, fungicidal, local anaesthetic, immunostimulating, antiinflammatory and free radical scavenging properties. This study was performed to investigate the pharmacological effects of the propolis extract and fractions on the gastric lesion and ulcer. The ethanol extract was fractionated with hexane, toluene and ethyl acetate. Followed by bioassay on antigastric and antiulcer activity. Propolis ethanol extracts(500, 750, 1,000, 1,500 and 2,000 mg/kg) showed the protective effect on HCl·ethanol-induced gastric lesion and the antisecretory effect against Shay’s gastric secretion in pylorus-ligated rats in a dose related manner. In the animal models of HCl·ethanol, aspirin-induced gastric lesion and Shay’s gastric secretion, the hexane and toluene fraction of propolis significantly reduced the length of gastric lesion and the acid secretion. These data showed that the gastric protective effects of propolis might result from reduction of acid secretion through the inactivation of H+/K+ATPase activity.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.10
• /
• pp.4713-4718
• /
• 2013

Nowadays, three-dimensional computer added design(3D CAD) tool are widely and actively used for design of mechanical machine. Because using the tool is more effective to understand design concept and to collaborate with other operation than using two-dimensional design tool. In this study, the 3D CAD tool which is called I-DEAS was applied for three-dimensional modeling of main parts and assembling of modeled parts for identification the entire shape of a injection molding machine. In addition, a study was also performed regarding reduction for the weight of main plates for saving production cost and energy in the machine. A finite element method(FEM) program in I-DEAS tool was used for the improvement study. First, the current main plates were structural analysed and then the plate deformations, weak regions and stress distributions were graped. By the FEM results, the 2nd improved designing of the plates was conducted such as reinforcement or slimming of the plate wall thickness. The 2nd structural FEM was performed for verification of the redesigned plates and then the FEM results were compared with the 1st FEM's result. The weight of the main plates were averagely reduced approximately 3 - 7%. By these results, it was seemed that the improved plates have a useful availability.

• Journal of Ginseng Research
• /
• v.33 no.1
• /
• pp.1-7
• /
• 2009

Clinical and animal studies have shown that free radical overload is an important cause for a variety of diseases. Although ginseng has been recognized as antioxidant, how it modulates anti-oxidative process at the molecular level remains unknown. Free radical production is induced by tumor necrosis factor-$\alpha$ (TNF-$\alpha$) under the stress condition, and (TNF-$\alpha$) release is activated by TNF-$\alpha$-converting enzyme (TACE). Since TACE inhibitor is also well known for anti-inflammatory agent, ginseng seems to show anti-oxidative activity by repressing TACE pathway. Further studies on signal transduction would be warranted to elucidate molecular action mechanisms of ginseng on anti-oxidation and anti-inflammation.

• Journal of Korea Water Resources Association
• /
• v.38 no.9 s.158
• /
• pp.699-711
• /
• 2005

In this study, the U.S. Geological Survey's DR3M-II(Distributed Routing Rainfall-Runoff Model) was applied for small urban drainage. DR3M-II is a watershed model for routing storm runoff through a branched system of pipes and natural channels using rainfall input. The model was calibrated and verified using short term rainfall-runoff data collected from Sanbon basin. Also, the parameters were optimized using Rosenbrock technic. An estimated simulation error for peak discharge was about 7.4 percent and the result was quite acceptable. Results of the sensitivity analysis indicate that the percent of effective impervious area and ${\alpha}$ defining surface slope and roughness were the most sensitive variables affecting runoff volumes and peak discharge for low and high intensity storm respectively. In most cases, soil moisture accounting and infiltration parameters are the variables that give more effects to runoff volumes than peak discharge. Parameter ${\alpha}$ showed the opposite result.

• IMMUNE NETWORK
• /
• v.3 no.4
• /
• pp.295-301
• /
• 2003

Background: Carcinoembryonic antigen (CEA) is well-known soluble tumor marker frequently detectable in peripheral blood of carcinoma patients and considered as good target for antigen-specific immunotherapy. In this study, we used a replication-deficient adenovirus containing CEA to study CTL induction in vitro after adenovirus-mediated gene transfer into DC. Methods: DC were obtained from mouse bone marrow and cultured with IL-4 and GM-CSF. For measuring CTL activity, splenocytes were harvested from the mice, which were immunized with DC that had been infected AdV-CEA or pulsed with CEA peptide. Untreated DC was used as a control. Splenocytes were re-stimulated in vitro with DC pulsed with CEA peptide for 7 days and CTL activity with CEA peptide-pulsed EL-4 cells were assessed in a standard $^{51}Cr$-release assay. The frequencies of antigen-specific cytokine-secreting T cell were determined with $mIFN-{\gamma}$ELISPOT. Results: DC infected with recombinant adenovirus expressing CEA induced CEA-specific CTL responses in vivo. Splenocyte induced from mice immunized with AdV-CEA-infected DC increase in the number of $IFN-{\gamma}$ secreting T cells compared with those from mice immunized with CEA peptide-pulsed DC. Conclusion: These results suggested that DC infected with recombinant adenovirus has advantages over other forms of vaccination and could provide an alternative approach vaccination therapies.

• Korean Journal of Materials Research
• /
• v.2 no.6
• /
• pp.417-427
• /
• 1992

Silicon ion implantation was performed to LPCVD amorphous Si films and the low temperature annealing process followed with various conditions to find the optimal physical properties by studying recrystallization behavior. The uniformity of the recrystallized films was inspected by optical microscopy and for this purpose, new KOH: (IPA) : $H_2$O: $K_2$C${r_2}{O_7}$, etchant was developed. XRD and TEM results showed that the crystallites were grown as a form of dendrite with (111) preferred orientation, and the grain size was increased with dose concentration. The maximum grain size was obtained when the 3${\times}{10^{15}}$c$m^2$ implanted amorphous Si film was recrystallized at 55 $0^{\circ}C$for more than 40 hrs and at this condition the grain size was 3.2${\mu}$m.

• Korean Chemical Engineering Research
• /
• v.48 no.4
• /
• pp.462-469
• /
• 2010

Gas-liquid 2 phase processes are usually used in chemical, biochemical, environmental engineering and food process. For optimizing these processes, understanding bubble's precise movement and shape are needed. Bubble's movement and shape are effected by liquid's properties-viscosity, surface tension and bubble's properties-size, velocity. This paper deals with experimental data of bubble's movement and shape in high viscous silicone oil. Also, drag coefficient and deformation factor given by other researcher's papers and books are used to predicting and comparing bubble's terminal velocity, drag coefficient, deformation factor and shape with experimental value. Experimental data show that bubble moves faster when it moves in lower viscous silicone oil and it's drag coefficient is bigger when it moves in high viscous silicone oil. Bubble's shape is close to sphere when moving in high viscous silicone. Formulas proposed by Batchelor expect most accurate prediction for bubble's velocity and drag coefficient. Bubble's 2D shape predicted by Batchelor's energy balance, drag coefficient and deformation factor show excellent agreement with experimental bubble's 2D shape.

• KSBB Journal
• /
• v.20 no.4
• /
• pp.317-322
• /
• 2005

Various recovery methods were investigated to maximize hemicellulose recovery from lignocellulosic material hydrolyzed by pure water. The pretreatment conditions of water hydrolysis were $170\~180^{\circ}C$ and 1 hour of reaction time. The percentage of hemicellulose solubilized increased as the temperature increased from 170 to $180^{\circ}C$. However, significant decomposition of sugar was observed at temperature of $180^{\circ}C$. From the results of water hydrolysis, the total amount of glucan in solid residue and liquid hydrolyzate was close to the total glucan in the original biomass. For hemicellulose, however, there was a significant difference between both contents. To prove this difference, various recovery methods were proposed. From the total sugar accountability (sugar in liquid + sugar in solid), it was confirmed that hemicellulose recovery in the hydrolyzate was increased if the product including both hydrolyzate and solid residue was physically stimulated by such as heating and ultrasound irradiation. This indicated that, in commercial scale processes that much bigger substrate sizes are used and a sufficient amount of leaching solvent can not be used after pretreatment, a significant amount of oligomers could be trapped in the solid matrix.

• Composites Research
• /
• v.30 no.6
• /
• pp.350-355
• /
• 2017

The new liquid crystalline (LC) epoxy was designed by substituting the phenylcyclohexyl (PCH) mesogen moiety with an alkyl chain at the 2,5 position of the diglycidyl terephthalate. The mesomorphic properties were evaluated by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). All LC epoxy derivatives exhibited an enantiotropic smectic phase upon heating and cooling process. The LC phase temperature range was widened by mixing the eutectic mixture of LC epoxies. Interestingly, the cured LC epoxy exhibited the highest thermal conductivity of $0.4W{\cdot}m^{-1}{\cdot}K^{-1}$. The novel LC epoxy with high thermal conductivity might be used as a composite material for electronic and display devices.

• Applied Chemistry for Engineering
• /
• v.18 no.5
• /
• pp.407-414
• /
• 2007

Using the MPI (Moldflow Plastics Insight) software from Moldflow Co., the optimum conditions for producing the upper part of the automobile air cleaner were obtained for 20% talc filled polypropylene (PP). The analysis was carried out to solve the cracking problem between upper and lower parts and the improved process was proposed using the flow balance. The comparative results between the conventional process, CASE-1, with one-pin gate and the new process (CASE-2) comprising two-pin gate system are the followings. In the case of CASE-2, the shorter filling time and reduced cycle time induced an improved production and processibility. In addition, the orientation and volumetric shrinkage are similar to those observed in the lower part, but the assembly, deformation, and physical characteristics are enhanced. The problem induced by the CASE-1 did not originate from the residual stress, but from the difference in the size of the upper part air cleaner after shrinkage. Thus, the orientation problem was expected to improve by optimizing the gate structure.