• Title/Summary/Keyword: 수요 활성화

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Toxic action of benfuracarb via oxidative bioactivation process by cytochrome $P_{450}$ (Procarbamate계 살충제 benfuracarb의 산화적 활성화 과정을 통한 독성발현)

  • Yu, Yong-Man;Kim, Eun-H.;Kim, Song-Mum;Hur, Jang-Hyun
    • The Korean Journal of Pesticide Science
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    • v.7 no.1
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    • pp.45-50
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    • 2003
  • This study was conducted to understand the role of oxidative enzyme cytochrome $P_{450}$ in the bioactivation of benfuracarb and to know metabolites of benfuracarb by cytochrome $P_{450}$. The bimolecular imhibition rate constant $(k_i)$ of benfuracarb on acetylcholinesterase (AChE) was as low as $1.1{\times}10^3\;M^{-1}\;min^{-1}$, suggesting that benfuracarb should be activated for its toxic action. The potency of benfuracarb on AChE in the oxidase system (cytochrome $P_{450}$ + NADPH) in vitro was 10-fold higher than that of control (cytochrome $P_{450}$). Such a similar result was also found in the oxidase + PBO system. In vivo the $I_{50}$ of benfuracarb was 22.7mg $kg^{-1}$, but pie-treatment of piperonyl butoxide (PBO) reduced the $I_{50}$ by >100mg $kg^{-1}$. This result suggests that cytochrome $P_{450}$ was involved in the activation of benfuracarb. Using microsomal oxidase system, metabolites of benfuracarb were elucidated. Fifty-eight percent of benfuracarb was converted to carbofuran, a major toxic metabolite, in the oxidase system, while only less than two percent of benfuracarb was converted to carbofuran in the oxidase + PBO system. These results also suggest that cytochrome $P_{450}$ was involved in the activation of benfuracarb. Overall results indicate that cytochrome $P_{450}$ could be involved in the bioactivation of benfuracarb to carbofuran.

Local Revitalization Movement through Revival of Traditional Ceramic Industry in Japan - A Case of Mashiko-cho in Tochigi-ken (전통 도자기산업의 부활과 지역활성화운동 -일본 토치기현(栃木縣) 마시코정(益子町)의 사례-)

  • Hong, Sung-Heup
    • Journal of the Economic Geographical Society of Korea
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    • v.12 no.4
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    • pp.597-612
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    • 2009
  • This paper is an anthropological study on the regional revitalization movement by the traditional ceramic industry in Mashiko-cho, Japan. It especially deals with the issues like history of revitalization based on ceramics, idealogical features and roles of core activist group, and adaptive strategies of local society to the ever-changing circumstances. The ceramic industry of Mashiko-cho had developed vigorously in 19C, and had passed many critical points in 20C. In 1960s, the ceramic industry of Mashiko-cho developed stably through introducing of Mingei(民藝) ideology and artists. This is evaluated as a 'bottom-up' regional revitalization movement and a active utilization of traditional cultural resources. In Mashiko-cho, the ideological leadership of cultural artist groups have been central roles in the regional revitalization movement. The representative cases are transformation of production of ordinary ceramics to production of Mingei ceramics from the middle of 1950s, official organization of core activist group and establishment of direct sale system by the producers in the middle of 1960s, and full-scale cooperation of private sector and public sector from the beginning of 1980s. Nonetheless the regional revitalization movement by the traditional ceramic industry in Mashikocho have come out well up to now, it should make new tradition which is well-matched to the ever-changing circumstances as seeing various and complex differentiation on the inside of local society.

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Electrochemical Studies on the Corrosion Performance of Steel Embeded in Activated Fly Ash Blended Concrete (활성화된 플라이애쉬 혼입콘크리트의 철근부식거동에 관한 전기화학적 연구)

  • Song, Ha-Won;Lee, Chang-Hong;Lee, Kewn Chu;Velu, Saraswathy
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.12 no.6
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    • pp.97-108
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    • 2008
  • The use of fly ash to replace a portion of cement has resulted significant savings in the cost of cement production. Fly ash blended cement concretes require a longer curing time and their early strength is low when compared to ordinary Portland cement(OPC) concrete. By adopting various activation techniques such as physical, thermal and chemical method, hydration of fly ash blended cement concrete was accelerated and thereby improved the corrosion-resistance of concrete. Concrete specimens prepared with 10-40% of activated fly ash replacement were evaluated for their open circuit potential measurements, weight loss measurements, impedance measurements, linear polarization measurements, water absorption test, rapid chloride ion penetration test and scanning electron microscopy (SEM) test and the results were compared with those for OPC concrete without fly ash. All the studies confirmed that up to a critical level of 20-30% replacement; activated fly ash cement improved the corrosion-resistance properties of concrete. It was also confirmed that the chemical activation of fly ash better results than the other methods of activation investigated in this study.

Examination of Validity of Motivation Activation Tendency as a Target Group in Delivering Anti-drug Advertisements (마약퇴치 광고의 표적 집단 활용을 위한 동기 활성화의 타당도 조사)

  • Lee, Seungjo
    • The Journal of the Korea Contents Association
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    • v.17 no.8
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    • pp.301-311
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    • 2017
  • The current study investigated whether individual variation in motivational activation would predict the drug-use and interacts with discrete emotions to influence the responses to anti-drug advertisements. Motivational activation tendency indicates an individual's level to approach life-sustaining elements and defend life-threatening stimuli. Discrete emotion represents joy, sadness, and fear elicited by the advertisements. The experiment proceeded using both self-reports and physiological responses with 80 subjects. Results showed that approach motivation activation can be a target for anti-drug advertisements and in order to target individuals higher in approach activation, it is necessary to use the appeal type to elicit positive emotions such as joy.

A Study on the Factors affecting Cyber-Career-Counseling-Activation based on Structural Equation Model(SEM) (구조방정식 모형을 이용한 사이버진로상담 활성화 영향요인에 관한 연구)

  • Lee, Young-Ja;Baek, Hyeon-Gi
    • Journal of Digital Contents Society
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    • v.9 no.3
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    • pp.379-388
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    • 2008
  • This paper is to redefine the concept of Cyber Career Counseling Activation(=C-C-C-A) and verify the effects of the factors affecting the C-C-C-A at Korean academic high school level in Kyunggi Province. In this research, we hypothesize that the three independent variables increase the effects of Cyber Career Counseling Activation.. To discuss the hypothesis, we analyzed survey data of 322 students who had taken Cyber Career Counseling in December 2007 based on Structural Equation Model. The results are as follows: First, the three crucial factors(Expanding C-C-C Opportunities, Improving C-C-C Service, Establishing C-C-C Service System) increase the C-C-C-A effectiveness. Second, as a result of Confirmatory Factor Analysis(CFA), the goodness of fit indices(GFI, AGFI, CFI, RMSEA) demonstrate statistical significance and fitness of the C-C-C-A Model. Therefore, the outcomes show that the three factors are the significant ones of Cyber Career Counseling Activation Model.

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Economic Growth by Arts Activities Case Study on Nagahama Story in Shiga Pregecture, Japan (문화할동을 통한 지역활성화: 일본 시가현(滋賀縣) 나가하마(長浜市) 이야기)

  • Shin, Dong-Ho
    • Journal of the Economic Geographical Society of Korea
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    • v.9 no.3
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    • pp.431-440
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    • 2006
  • In many countries of the world, cultural activities are introduced as a popular means of promoting local economies and identities. In many places of Japan, a traditional cultural activity, "Machtskuri" (meaning "Vilige Making," literally) has been practiced in the past several decades. A small town, Nagahama of Shiga Prefecture, with 50,000 people, started restoring an old castle and historical build, art exibition, traditional fashion festivals, etc. Based on the successful experience from the cultural activities, community leaders of Nagahama made success in creating other projects, such as construction of a baseball stadium, a hotel and a community college. It can be concluded that Nagahama has been successful in creating making the place famious and the people confident.

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Brain Correlates Associated with Negative Emotions (부적 정서와 관련된 뇌 활성화 영역)

  • Lee Ok-Hyeon;Seok Ji-A;Park Mi-Suk;Eom Jin-Seop;Gwon Ae-Ran;Son Jin-Hun
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2006.05a
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    • pp.351-354
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    • 2006
  • 시청각 동영상을 이용하여 정서의 뇌 활성화 영역을 규명하는 뇌 영상 연구들은 심상이나 슬라이드와 같은 정서유발도구를 사용한 연구들이 가지지 못한 장점을 가지고 있다. 그러나 시청각 동영상을 이용하여 정서와 관련된 뇌 활성화 영역을 밝히는 연구들은 미미한 실정이다. 본 연구는 시청각 동영상 자극을 이용하여 부적정서에 해당하는 공포, 분노, 혐오정서의 뇌 활성화 영역을 밝히도록 하겠다. 실험참가자로 11명의 오른손잡이 여대생이 선정되었다. fMRI 실험을 위한 패러다임은 block design으로, 각 정서당 통제자극 30초와 정서자극 1분 30초로 구성되었다. 개발된 공포자극에 의해 유발된 공포정서를 경험하는 동안, 공포자극에서는 우측 Amygdala와 양측 Fusiform Gyrus, 좌측 Middle Occipital Gyrus, 우측 Superior Temporal Gyrus가, 분노자극에서는 좌측 Thalamus와 양측 Anterior Cingulate Gyrus, 혐오자극에서는 좌측 Insula, 우측 Putamen, 우측 Fusiform Gyrus, 우측 Middle Occipital Gyrus, 우측Superior Temporal Gyrus 가 활성화되는 것으로 나타났다. 본 연구 결과에서는 시청각 자극을 사용하여 부적 정서에 따른 뇌 활성화 영역을 규명할 수 있었다.

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Relations of multilingual's L1, L2, L3 lexical processing and cerebral activation areas in fMRI (fMRI에 반영된 다중언어화자의 L1, L2, L3 어휘 정보처리 특성과 대뇌 활성화 영역의 관련성)

  • Nam Kichun;Lee Donghoon;Oh Hyun-Gum;Ryu Jaeook
    • Proceedings of the Acoustical Society of Korea Conference
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    • spring
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    • pp.313-316
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    • 2002
  • 본 연구에서는 기능적 자기공명 영상법(functional magnetic resonance imaging)을 이용하여, 한국어, 일어, 프랑스어, 영어 등 여러 언어를 구사할 수 있는 다중언어화자들을 대상으로 각 언어에 따른 대뇌 언어처리 과정을 알아보고, 그 처리과정이 해당언어의 유창성, 습득시기에 따라 어떻게 달라지는지를 알아보았다. 실험 결과, 언어처리에 있어 핵심적인 역할을 하는 것으로 보고되는 Broca 영역은 언어의 이해와 산출 과정에 모두 관계된 것으로 보이며, 언어의 산출과정에는 언어의 이해과정에 관계되는 영역외에 조음과정에 따른 영역의 활성화가 보고되었다. 또한 언어습득시기와 유창성에 따른 각 언어의 활성화를 살펴보면, 유창성이 높을수록 대뇌 활성화는 줄어들며, 유창성이 낮은 언어조건에서는 언어처리 영역의 활성화 수준이 높아지며 또한 우반구 및 전전두회(prefrontal gyrus)의 활성화가 높아지는 것이 보인다.

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Manufacture of Activated Carbon based on Solid Residue after Lignin Pyrolysis (리그닌 열분해 잔류고형물을 원료로 한 활성탄의 제조)

  • Lee, Jong-Jib;Yoon, Sung-Wook;Lee, Byung-Hak
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.1
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    • pp.133-139
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    • 2000
  • In this study, activated carbon was prepared from solid residue after lignin pyrolysis by using zinc chloride as an activation agent. The steam activation method was adopted to manufacture activated carbon from solid residue after lignin pyrolysis. The effect of process operation variables such as activation temperature, activation time and mass of activation agent added to char on the pore structure and specific surface area of the activated carbon was investigated. Activated carbon with high surface area and well-developed pore structure could be prepared, when solid residue after lignin pyrolysis was mixed with zinc chloride of 300 wt% and then the mixture was activated for 1 hour at $1000^{\circ}C$ in a stream of nitrogen.

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Estimation of Activation Energy for the Free Radical Polymerization by Using Isoconversional Analysis (등전환 분석(Isoconversional Analysis)를 이용한 자유라디칼 중합의 활성화 에너지 계산)

  • Chung, I.
    • Elastomers and Composites
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    • v.39 no.4
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    • pp.281-285
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    • 2004
  • In this paper, the simple way to evaluate the value of the activation energy for the overall rate of free radical polymerization by using DSC thermograms was studied using free radical polymerization or butylacrylate as a model. Activation ehergies were determined at heating rates of 1, 2, 5, and $10^{\circ}C/min$ by applying the multiple scanning-rate methods of Kissinger, Osawa, and half-width methods as well as the single rate method of Barrett. The value of the overall activation energy measured was closely matched with the values calculated from individual data. This work also demonstrated that the use of the isoconversional method was a simple and effective way to estimate the activation energy for the overall free radical polymerization.