• Journal of the Korean Geosynthetics Society
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• v.17 no.4
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• pp.293-304
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• 2018

This paper described a results of field test based on plate bearing test of the restoration material, which was developed to restore the ground cavity due to sewerage damage. The analysis of bearing capacity characteristics on the restoration materials was performed by experimental results. The results showed that the load bearing capacity in the maximum stress condition of the foundation ground is about 66%-70%, when the expansion mat is embedded at the bottom of 0.1 m and 0.2 m from the ground surface. However, The load bearing capacity of expansion mat according to embedded depth was not large. The load bearing capacity of concrete mats was about 82%-90% compared with that of ground surface, and it showed about 50% of the load bearing capacity compared with the expansion mat. As a result of analysis of allowable bearing capacity according to restoration materials, it was confirmed that the allowable bearing capacity of the expansion mat and the concrete was about 130%-150% and about 160% more than the foundation ground, respectively.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.3
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• pp.103-110
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• 2019

Damage to the pavement system due to various causes will be required rapid repair work for reopening the vehicle traffic. The magnesium oxide phosphate composite(MPC) has a short curing time and is capable of early compressive strength development, is suitable for rapid repair materials. The aim of this study was to evaluate the hardening and compressive strength characteristics of MPC according to the water-binder (W / B) ratio and magnesium-phosphate(M / P) ratio in order to develop repair materials consisted with light burned magnesia and potassium dihydrogen phosphate. In order to ensure the workability in the field application, the difference of mechanical properties according to standard sand and ordinary sand and performance of retards were evaluated. The mix proportion with W/B ratio was about 35% and the M/P ratio was about 1.0 ~ 1.2 has a superior perfomance with strength and hardening condition. Especially, the strength of composite at only 1 day curing with W/B ratio of 0.35 and the M/P ratio of 1.2 was shown the higher than 25.0 MPa. Boric acid as a retarder was found to be suitable for ensuring the working time, and the purity of magnesium oxide was about 90 ~ 95%, which is effective for ensuring curing time and strength.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.235-244
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• 2019

This study examined the neurotoxicity of aluminum sulfate (AS), an environmental pollutant, and the protective effect of Phrymaleptostachya var. asiatica HARA (PLVAH) extract on the neurotoxicity induced by AS in the cultured C6 glioma cells. For this study, the cell viability and antioxidative effects, such as electron donating (ED) activity, lipid peroxidation (LP) activity, and superoxide anion-radical (SAR) scavenging activity, were analyzed. AS decreased the cell viability significantly in a dose-dependent manner and the $XTT_{50}$ value was measured at $120.0{\mu}M$ of AS. The neurotoxicity of AS was determined to be mid-toxic by Borenfreund and Puerner's toxic criteria. In addition, the catalase (CAT), antioxidant enzyme remarkably increased the cell viability injured by AS-induced neurotoxicity in these cultures. Regarding the protective effect of the PLVAH extract on AS-induced neurotoxicity, PLVAH extract significantly increased the ED ability, and the inhibitory ability of the LP and SAR scavenging ability. These findings suggest that oxidative stress is involved in the cytotoxicity of AS, and the PLVAH extract effectively protected against AS-induced neurotoxicity by its antioxidative effects. Natural resources, such as the PLVAH extract may be a putative therapeutic agent for the treatment of the toxicity induced by heavy metallic compounds, such as AS correlated with the oxidative stress.

• Journal of the Korean Institute of Gas
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• v.25 no.2
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• pp.22-27
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• 2021

This paper is a purpose to study the failure examples for LPG vehicle. The first example, the researcher certified the incongruity phenomenon decreased engine power by ignition fire leakage because of spark plug threaded part damage assembling in cylinder head. The second example, the timing mark that accurately adjusting the camshaft and crankshaft position were twisted about 0.5 block each other. Finally, the researcher seeked the disharmony phenomenon as it couldn't set ignition timing. The third example, the researcher knew the failure phenomenon by interrupted the closing period for intake valve moving with air flow in the number 3 port of cylinder head as the foreign substance in cylinder head didn't remove. Therefore, the manager of a car has to thorough going inspect and the manufacture of a car must remove the cause of failure with quality assurance.

• Journal of Life Science
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• v.31 no.2
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• pp.237-247
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• 2021

Immune responses in the central nervous system (CNS) function as the host's defense system against pathogens and usually help with repair and regeneration. However, chronic and exaggerated neuroinflammation is detrimental and may create neuronal damage in many cases. The NOD-, LRR-, and pyrin domain―containing 3 (NLRP3) inflammasome, a kind of NOD-like receptor, is a cytosolic multiprotein complex that consists of sensors (NLRP3), adaptors (apoptosis-associated speck like protein containing a caspase recruitment domain, ASC) and effectors (caspase 1). It can detect a broad range of microbial pathogens along with foreign and host-derived danger signals, resulting in the assembly and activation of the NLRP3 inflammasome. Upon activation, NLRP3 inflammasome leads to caspase 1-dependent secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. NLRP3 inflammasome is highly expressed in CNS-resident cell types, including microglia and astrocytes, and growing evidence suggests that NLRP3 inflammasome is a crucial player in the pathophysiology of several neuroinflammatory and psychiatric diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, traumatic brain injury, amyotrophic lateral sclerosis, and major depressive disorder. Thus, this review describes the molecular mechanisms of NLRP3 inflammasome activation and its crucial roles in the pathogenesis of neurological disorders.

• The Journal of Korean Society for Radiation Therapy
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• v.32
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• pp.73-83
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• 2020

Purpose: The purpose of this study is to confirm the matching of the electron density between tissue and gas due to variation of abdominal gas volume in MRgART (Magnetic Resonance-guided Adaptive Radiation Therapy) for pancreatic cancer patients, and to confirm the effect on the dose change and treatment time. Materials and Methods: We compared the PTV and OAR doses of the initial plan and the AGC(Abdominal gas correction) plans to one pancreatic cancer patient who treated with MRgART using the ViewRay MRIdian System (Viewray, USA) at this clinic. In the 4fx AGC plans, Beam ON(%) according to the patient's motion error was checked to confirm the effect of abdominal gas volume on treatment time. Results: Comparing the Initial plan with the average value of AGC plan, the dose difference was -7 to 0.1% in OAR and decreased by 0.16% on average, and in PTV, the dose decreased by 4.5% to 5.5% and decreased by 5.1% on average. In Adaptive treatment, as the abdominal gas volume increased, the Beam ON(%) decreased. Conclusion: Abdominal gas volume variation causes dose change due to inaccurate electron density matching between tissue and gas. In addition, if the abdominal gas volume increases, the Beam ON(%) decreases, and the treatment time may increase due to the motion error of the patient. Therefore, in MRgART, it is necessary to check the electron density matching and minimize the variability of the abdominal gas.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.3
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• pp.137-149
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• 2021

Cable-stayed bridges are infrastructure facilities of a highly public nature; therefore, it is essential to ensure operational safety and prompt response in the event of a collapse or damage caused by natural and social disasters. Among social disasters, impact accidents can occur in bridges when a vehicle collides with a pier or when crashes occur due to aircraft defects. In the case of offshore bridges, ship collisions will occur at the bottom of the pylon. In this research, a procedure to evaluate the structural behavior of a cable-stayed bridge for aircraft impact is suggested based on a numerical analysis approach, and the feasibility of the procedure is demonstrated by performing an example assessment. The suggested procedure includes 1) setting up suitable aircraft impact hazard scenarios, 2) structural modeling considering the complex behavior mechanisms of cable-stayed bridges, and 3) structural behavior evaluation of cable-stayed bridges using numerical impact simulation. It was observed that the scenario set in this study did not significantly affect the target bridge. However, if impact analysis is performed through various scenarios in the future, the load position and critical load level to cause serious damage to the bridge could be identified. The scenario-based assessment process employed in this study is expected to facilitate the evaluation of bridge structures under aircraft impact in both existing bridges and future designs.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.6
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• pp.25-33
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• 2020

To investigate the relationship between strain distribution and tensile properties of brittle material, five types of tensile coupon of carbon fiber reinforced polymer (CFRP) modified the tab portion in order to have a strain distribution including S0, SD1, SD2, SV1, SV2 were tested. The ultimate stress and strain of SD2 and SV2 which was intended to have larger strain distribution were smaller than those of SD1 and SV1, that was more clearly shown in the test results of the symmetric coupons (SV series) than the asymmetric coupons (SD series). In addition, the ultimate stress and strain of most coupons with strain distribution in this study were decreased when compared to the control group with uniform strain. These results were analyzed in various ways through 1) the average of the strain values directly measured by the strain gages, 2) the converted strain calculated by dividing the total deformation by the effective length, and 3) the ultimate effective strain derived from both the elastic modulus and the ultimate load. The values measured by strain gage indicates response of the local region precisely, but it does not represent the response from whole section. However, the converted strain and effective strain can supplement disadvantage of gage because they represent the average response of whole section. In particular, the effective strain can provide rupture strain conservatively, which can be utilized in practice, when the value obtained by strain gage was not effective due to gage damage or abnormal gage readings near ultimate load. This value provides a value that can be used even when partial rupture has occurred and is reasonably useful for specimens with strain distribution.

• Journal of the Korean Institute of Gas
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• v.24 no.6
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• pp.47-54
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• 2020

A brittle fracture is one of the source of structural damage and can bring a fatal accident. The inner shell of LNG storage tank should be designed and applied to construction by ensure that no brittle crack will occur under -162℃ condition. In point of view of fracture mechanics brittle fracture in the structure could be referred as crack initiation and crack arrest. It should be designed no crack initiation. However, in the unlikely event of a brittle fracture occurring, a back-up function of arresting the brittle crack should be included for the design. In this paper investigated the characteristics of 9% Ni steel thick plates of having a capability of arresting brittle cracks under the thickness of 33 mm, 37mm, 40 mm. First, charpy test has performed to evaluate the fundamental brittle impact fracture property of 9% Ni steel under the temperature of 24℃, -162℃ and -196℃. In addition, Duplex ESSO tests were also performed under -196℃ to evaluate the capability of crack arrest for 9% Ni steel. From the experiments results, it was confirmed that all the thickness of 9% Ni steel plates exhibits sufficient brittle crack arrest fracture toughness for the application of LNG storage tank as a inner shell.

• Journal of Plant Biotechnology
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• v.49 no.2
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• pp.145-149
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• 2022

Airborne fine dust (FD) particles smaller than 10 ㎛ in diameter (PM10) are one of the major causes of air pollution in East Asia, including Korea, and have become a major contributor to respiratory and skin problems. FD inordinately promotes the production of reactive oxygen species and inflammatory response in macrophages, leading to cell damage and death. Rosa rugosa, a deciduous shrub of the Rosa genus, has been used in traditional East Asian herbal medicine to treat various illnesses. The present study investigated the anti-inflammatory effects of R. rugosa organ extracts on PM10-stimulated RAW264.7 macrophages. Compared to non-treated RAW264.7 cells, treatment with 100 ㎍.ml^-1 PM10 resulted in increased nitric oxide (NO) production, similar to lipopolysaccharide treatment. Additionally, 100 ㎍/ml stem extract reduced NO production by more than 45% compared to mock treatment. Furthermore, PM10-induced expression of interleukin (IL)-1β, IL-6, inducible NO synthase, and cyclooxygenase-2 was significantly reduced by stem extract treatment, indicating that the anti-inflammatory effect of the stem extract is mediated by the inhibition of pro-inflammatory mediators in PM10-stimulated RAW 264.7 cells. These results indicate that the R. rugosa stem could be considered a natural remedy with a protective effect against inflammatory responses induced by harmful airborne dust.