• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.1
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• pp.35-43
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• 2012

In general, load carrying capacity, one of the load & resistance capacities in bridges, has more margins than the load carrying capacity evaluated with theoretical methods, unless there are severe damages, defects or material deterioration phenomena that can have a great impact on the behavior of bridges. However, errors have been already included in the current processes of loading tests and structural analysis for measuring load carrying capacity, thus devaluing the reliability of response adjustment factor. Therefore, this study found out the problems of existing electric resistance strain and displacement sensors in sensor suite to solve the problems with sensors and the errors in the appropriateness of structural analysis model, thereby leading to the changes into an optical fiber smart sensor with excellent performance. Besides, the study attempted to ensure the accuracy of response adjustment factor by selecting the optimal models through the interpretation of various structural analysis models.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.727-732
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• 2022

Applying the calculated cross-sectional reduction due to the corroded rebar investigated in the field to the numerical analysis model, the damage pattern and delamination of concrete in the field showed a tendency relatively similar to the numerical analysis results. It was analyzed that when the expansion pressure due to corrosion of the reinforcing bar is greater than the tensile stress of the concrete, cracks are generated and the concrete cover can be fracture. As a result of this study, the correlation between the corrosion rate of reinforcing bars and the crack occurrence of the concrete cover of the subway box structure was verified based on the numerical analysis and field test results. To prevent rebar corrosion, the corrosion rate can be reduced by applying rust prevention to the reinforcing bar and changing the material. In the case of exposed to a corrosive environment, the tensile strength of the concrete is improved by adjusting the concrete compressive strength to secure durability against the expansion pressure caused by the corroded rebar.

• Journal of the Korean Geotechnical Society
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• v.22 no.8
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• pp.107-118
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• 2006

Among a variety of influencing components, time-variant seepage and long-term underground motion are important to understand the abnormal behavior of tunnels. Excessiveness of these two components could be the direct cause of severe damage on tunnels, however, it is not easy to quantify the effect of these on the behavior of tunnels. These parameters can be estimated by using inverse methods once the appropriate relationship between inputs and results is clarified. Various inverse methods or parameter estimation techniques such as artificial neural network and least square method can be used depending on the characteristics of given problems. Numerical analyses, experiments, or monitoring results are frequently used to prepare a set of inputs and results to establish the back analysis models. In this study, a back analysis method has been developed to estimate geotechnically hard-to-known parameters such as permeability of tunnel filter, underground water table, long-term rock mass load, size of damaged zone associated with seepage and long-term underground motion. The artificial neural network technique is adopted and the numerical models developed in the first part are used to prepare a set of data for learning process. Tunnel behavior, especially the displacements of the lining, has been exclusively investigated for the back analysis.

• Journal of Korean Society of Steel Construction
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• v.9 no.2 s.31
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• pp.193-204
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• 1997

In order to quantify the relationships of the important physical factors relating failure to strong earthquake loading, the plastic fatigue problems for structural components under repeated loading were reviewed first. A new concept of very low cycle fatigue failure for structural components under severe cyclic excitations as in strong earthquakes was represented. Also, an experimental study was made of the very low cycle fatigue failure of structural steel elements. It was attempted to realize the ultimate failure in the course of loading repetitions of the order of several to twenty. The test specimen had a form of rectangular plate, representing a thin-plated element in a steel member as wide-flange cross section. It was subjected to uniaxial loading repeatedly, until complete failure takes place after undergoing inelastic buckling, plastic elongation and/or their combination. It was seen as a result that the state of the ultimate failure is closely related to the maximum strain at the extreme fiber in the cross section.

• Proceedings of the Korean Society of Computer Information Conference
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• 2014.07a
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• pp.21-24
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• 2014

본 연구는 뇌손상(뇌졸중, 외상성 뇌손상, 뇌성마비 등)으로 인하여 손의 능동적 움직임이 결여되어 발생하는 관절의 구축, 근육의 단축, 근육의 탄력성 저하 등의 문제점을 분석하여 인체 역학적 모델에 따른 과학적 설계를 기반으로 환자의 손 기능 회복을 위하여 로봇 기술과 스마트폰의 융합을 통한 재활 로봇 보조 치료기를 설계하고 구현하였다. 제안된 시스템은 일반적인 근 경직을 치료하는 방법을 응용하여 IT 기술과 로봇기술을 융합하여 치료사들의 부담을 덜어 주고, 환자들에게 오랫동안 정확한 운동을 반복적으로 할 수 있도록 하는데 목적이 있다. 하나의 구동기로 2자유도의 움직임을 조절 할 수 있는 링크 매커니즘과 링크의 길이를 조절하여 신전(extension)과 과신전(Hyperextension)의 범위 조절이 가능하도록 로봇 플랫폼을 설계하였다. 또한 환자의 재활정도 및 상태에 적합한 운동속도, 운동반복횟수 등을 손쉽게 조작할 수 있는 등의 개인 맞춤형 재활훈련이 가능한 사용자 인터페이스를 설계 및 구현하였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.241-251
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• 2019

In the present study, we investigated the effect of microcurrent against cognitive impairment in Alzheimer's disease (AD) mice model. The cognitive impairment was induced by intracerebroventricularly injection of amyloid beta ($A{\beta}$) to ICR mouse brain, and four kinds of micorocurrent wave were applied to AD mice. We observed the improved cognitive ability in microcurrent-applied AD mice through novel object recognition test and Morris water maze test, compared to $A{\beta}$-injected control group. The contents of malondialdehyde generated by $A{\beta}$ in the brain were also reduced by microcurrent application. These effects of microcurrent were related to the modulation of $A{\beta}$ producing and brain-derived neurotrophic factor (BDNF). Microcurrent down-regulated ${\beta}$-secretase, presenilin 1, and presenilin 2 which were related amyloidogenic pathway, and up-regulated human brain-derived neurotrophic factor in the mice brain, especially Wave4 group [STEP FORM wave form (0, 1.5, 3, 5V), wave superposition]. These results suggest that microcurrent application could provide help for improvement learning and memory ability, at least partly.

• Korean Journal of Veterinary Research
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• v.41 no.4
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• pp.571-578
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• 2001

To evaluate if the apoptotic fragment assay could be used to estimate the dose prediction after radiation exposure, we examined apoptotic mouse crypt cells per 1,000 cells after whole body $^{60}Co$ $\gamma$-rays and 50MeV ($p{\rightarrow}Be^+$) cyclotron fast neutron irradiation in the range of 0.25 to 1 Gy, respectively. The incidence of apoptotic cell death rose steeply at very low doses up to 1 Gy, and radiation at all doses tigger rapid changes in crypt cells in stem cell region. These data suggest that apoptosis may play an important role in homeostasis of damaged radiosensitive target organ by removing damaged cells. The curve of dose-effect relationship for the data of apoptotic fragments was obtained by the linear-quadratic model $y=0.18+(9.728{\pm}0.887)D+(-4.727{\pm}1.033)D^2$ ($r^2=0.984$) after $\gamma$-rays irradiation, while $y=0.18+(5.125{\pm}0.601)D+(-2.652{\pm}0.7000)D^2$ ($r^2=0.970$) after neutrons in mice. The dose-response curves were linear-quadratic, and a significant dose-response relationship was found between the frequency of apoptotic cell and dose. These data show a trend towards increase of the numbers of apoptotic crypt cells with increasing dose. Both the time course and the radiation dose-response curve for high and low linear energy transfer (LET) radiation modalities were similar. The relative biological effectiveness (RBE) value for crypt cells was 2.072. In addition, there were significant peaks on apoptosis induction at 4 and 6h after irradiation, and the morpholoigcal findings of the irradiated groups were typical apoptotic fragments in crypt cells that were hardly observed in the control group. Thus, apoptosis in crypt cells could be a useful in vivo model for studying radio-protective drug sensitivity or screening test, microdosimetric indicator and radiation-induced target organ injury. Since the apoptotic fragment assay is simple, rapid and reproducible in the range of 0.25 to 1 Gy, it will also be a good tool for evaluating the dose response of radiation-induced organ damage in vivo and provide a potentially valuable biodosimetry for the early dose prediction after accidental exposure.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.149-154
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• 2008

Service life of bridges should be evaluated by physical life considering damage/deterioration. But it is difficult to identify optimal maintenance scenario due to insufficient research related to that. To identify optimal maintenance scenario, it is needed to develope life cycle profile model of condition state variation by deterioration factor. The LCP model has been developed in consideration of regression analysis and survey in this study. It is expected that the LCP model could help to achieve HBMS system improvement.

• Journal of the Korean Institute of Gas
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• v.9 no.4 s.29
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• pp.57-61
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• 2005

The objective of paper is to carry out a comparative Quantitative Risk Assessment (QRA) of two KOGAS tank designs using a fault tree methodology, a standard 'Full Containment' tank and a 'Membrane' tank. For the membrane tank, both the initial KOGAS design and 4 modified KOGAS designs have been assessed, giving six separate cases. In this paper, the frequencies of releases are quantified using a fault tree approach. For clarity in the analysis, and to ensure consistency, all cases have been quantified using the same fault tree. Logic within the fault tree is used to select each of the cases. Full quantification of risks is often difficult, owing to a lack of relevant failure data, but the aim of this study has been to be as quantitative as possible, with full transparency of failure information. The most significant general cause of external LNG leaks is predicted to be a seismic event, which has been quantified nominally. 4modified KOGAS desiens to Prevent damage of bottom membrane panels that was shown in preparatory estimation could quantitively confirm safety improvement. According to result, the predicted frequencies of an external LNG leak for the full containment and modified membrane tanks are very similar, failures due to dropped pumps are predicted to be significantly greater for the membrane tank with thickened plate than for the full containment tank.

• Korean Journal of Organic Agriculture
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• v.29 no.1
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• pp.85-96
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• 2021

Reflux esophagitis (RE) is a common gastrointestinal disease observed at all ages, which seriously affects the quality of life. In this study, we investigated the anti-inflammatory effects of Pomacea canaliculata extract (PCE) using the experimental RE rat model. RE was induced by a surgical procedure. The rats were randomly divided into 4 groups: normal group, RE group, PCE group (RE treated with PCE, 100 mg/kg), positive control group (RE treated with ranitidine, 40 mg/kg). We performed the histological examination and measured the expression of tight junction complex and inflammatory mediators using western blot analysis. The phenotypes of RE were attenuated by PCE treatment. PCE administration significantly reduced esophageal mucosal damage and protected tight junction confirmed by claudin-5. Furthermore, PCE treatment reduced inflammatory reaction by inhibiting the expression of COX-2 and TNF-α. PCE treatment, also, reduced translocation of NF-κB into nuclear and IκB-α phosphorylation at the same time. Our findings indicate that PCE has the potential as a novel therapeutic agent to inhibit RE by protecting mucosal damage and regulating inflammatory reactions mediated by NF-κB signaling.