• 한국한의학연구원논문집
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• 제18권2호
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• pp.17-24
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• 2012

Research on Seokgok(石谷), Lee Gyu Jun(李圭晙, 1855~1923)'s thought and medicine was progressed from various angles. There is no research on Chinese poem(漢詩) accounting for the half of his collection of literary works, "Seokgoksango(石谷散稿)" yet. Hence, the article reviewed concerns on his life and what life he lived as a Confusion(儒家) writer through his Chinese poem. Should read "Seokgoksango", Seokgok's spiritual orientation and attitude to life were found to have its core in the Confusion(儒家的), especially ethical(道學的) aspect. Seokgok's Chinese poem materialized his spiritual composition more, able to access up to general emotional state, representing concerns and frustration of intellectuals in the latter era of the Choson Dynasty. Anxiety consciousness(憂患) of patriotism and love of the people which traditional intellectuals implicated enough at the turbulent era of early modern time appeared strongly in his works. Also works seeking for devotion(歸依) toward the clean world(淸明世界) staring at the corrupt world losing the national sovereignty at the same time and the expansion(擴散) was able to be found many. The latter half of the 19th century and the early 20th century when Seokgok lived was the period of changeover in the history of civilization called intersection between traditional era and modern times. His Chinese poem showed traditional intellectuals' anxiety, frustration, conflict, and hope based on such times. Along with the status of an Oriental, medical doctor and thinker, up to discussion on the quality of a writer, the intensified research on him is expected.

• Applied Biological Chemistry
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• 제51권3호
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• pp.228-232
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• 2008

본 연구에서는 항산화 황성을 가지면서 신경세포 보호 효과를 가지고 있는 석곡, 형개, 감초 및 작약 추출물을 대상으로 GST 유도 활성 효과를 실험하였다. 그 결과, 감초 추출물이 가장 높은 GST 유도 활성을 나타내었다. 감초를 methanol, ethanol, acetone으로 분획 추출한 뒤 GST 유도 활성을 살펴본 결과, 감초의 methanol 추출물을 50 ${\mu}g/ml$ 농도로 처리 시 대조구에 비해 2.23배로 가장 논은 GTS 유도환성이 나타났다. 그리고 감초의 각 추출물들은 처리 농도에서 세포의 형태학적인 변화를 유도하지 않았으며, 이는 LDH release assay 결과를 통해서도 매우 낮은 세포 독성을 확인할 수 있었다. 감초의 GST 유도 활성 물질들의 용매특성을 알아보기 위하여 methanol 추출물을 극성도에 따라 용매 분획하여 GST 유도 활성을 확인한 결과, diethyl ether층 분획물에서 가장 높은 GST 유도 활성을 나타냄을 확인하였다.

• 대한한의학원전학회지
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• 제19권3호
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• pp.432-438
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• 2006

${\ulcorner}$소문대요(素門大要)${\lrcorner}$는 한국의 이규준(李圭晙)이 편저한 중의문헌과 임상이론이 결합된 중요한 저작물이다. 이 책은 광무갑진팔년(光武甲辰八年)(1904년) 음력 3월 16일에 완성되었고, 광무병오(光武丙午)(1906년) 초여름 밀양(密陽) 금천(琴川)에서 조판간행(雕版刊行)되었다. 이 책의 저자인 석곡(石谷) 이규준(李圭晙)(1855-1923)은 경상북도 영일군 사람으로 ${\ulcorner}$소문(素問)${\lrcorner}$ 뿐만 아니라 ${\ulcorner}$영추(靈樞)${\lrcorner}$ ${\ulcorner}$상한론(傷寒論)${\lrcorner}$ ${\ulcorner}$금궤요략${\lrcorner}$ ${\ulcorner}$잡경(難經)${\lrcorner}$ ${\ulcorner}$맥경(服經)${\lrcorner}$ 및 김원사대가(金元四大家)의 저작 등에 대해서도 심도 깊은 연구를 하였다. ${\ulcorner}$소문대요(素門大要)${\lrcorner}$의 중요 공헌은 ${\ulcorner}$소문(素問)${\lrcorner}$의 중요 문장을 회집(匯集)하였을 뿐만 아니라, 이규준(李圭晙) 자신의 의학이론과 임상사상이 표현되어 있다는 것이다. 이규준(李圭晙)은 ${\ulcorner}$소문(素問)${\lrcorner}$의 여러 편(篇) 가운데 특히 ${\ulcorner}$생기통천론(生氣通天論)${\lrcorner}$의 문장을 통해 '양비급고(陽秘乃固)'의 사상을 중요시 하여, 양기(陽氣)의 작용을 강조하면서 '양상유여음상부족(陽常有餘陰常不足)'의 편면성(片面性)을 극복하였다. 이러한 과정에서 그가 제시한 이론은 바로 '부양론(扶陽論)'으로, 그는 ${\ulcorner}$내경(內經)${\lrcorner}$ 십팔권(十八卷)의 내용을 한 마디로 요약하면 '양밀급고(陽密乃固)'라고 주장하였다. 한편 그가 ${\ulcorner}$소문대요(素門大要)${\lrcorner}$를 저술하면서 저본(底本)으로 삼았던 것은 명대(明代)에 간행(刊行)된 고종덕목(顧從德本)이라고 할 수 있다. 이규준(李圭晙)은 고종덕목(顧從德本)을 저본(底本)으로 하여 ${\ulcorner}$소문(素問)${\lrcorner}$의 문장을 해석하였고, 아울러 교감(校勘)을 병행하였는데 그의 교감법(校勘法)은 일정한 판본(版本)에 근거한 것이 아니라 자신의 ${\ulcorner}$소문(素問)${\lrcorner}$ 에 대한 이해를 중심으로 교감(校勘)을 하였다. 또한 그는 훈고학 방면에서도 일정한 식견을 갖추고 있는 것으로 확인되었다. 마지막으로 ${\ulcorner}$소문대요(素門大要)${\lrcorner}$ 는 간행본(刊行本)과 수초본(手抄本)이 유행되고 있는데, 수초본(手抄本)의 경우 와전(訛傳)된 글자가 많으니 간행본(刊行本) 및 ${\ulcorner}$소문(素問)${\lrcorner}$의 원문과 대조하여 잘못된 글자를 바로잡을 필요가 있다.

• 대한한의학원전학회지
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• 제22권4호
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• pp.177-188
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• 2009

In the chapter "Cheonwon-gidaeron(天元紀大論)" of "Hwangjenaegyeong(黃帝內經)", Lee-Gyujun(李圭晙) corrected "heaven has the rule of six and earth has the rule of five[天六地五]" to "heaven has the rule of five and earth has the rule of six[天五地六]", and "sovereign fire is bright[君火以明]" to "sovereign fire is summoning[君火以召]", which changes the meaning of the rule of circulation of the heaven and earth. Considering the context and many scholars' opinions, it was suggested that "sovereign fire naming[君火以名]" which was noted from Tang dynasty to Jin & Wen dynasty was corrected to "sovereign fire is bright[君火以明]" over Ming dynasty. In the corrections of Wangbing(王冰)'s Plain Questions, the sentence is written as "sovereign fire naming[君火以名]". The two characters, '明' and '名' are hardly similar in both shape and meaning, that it is only plausible to assume that it was mistaken for '召'. Consequently, we corrected "sovereign fire is bright[君火以明]" to "sovereign fire is summoning[君火以召]". And "sovereign fire is summoning, ministerial fire is locating[君火以召, 相火以位]", it raise "the rule of five and six is combined together[五六相合]". "The rule of five and six is combined together' means 'heaven's number of five" coincide "earth's number of six", and it says former times before dividing up and down.

• 농업과학연구
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• 제5권2호
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• pp.145-148
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• 1978

우리나라의 최남서단(最南西端)에 위치(位置)하는 전라남도(全羅南道) 신안군(新案郡) 흑산면(黑山面)에 속(屬)하는 소흑산도(小黑山島)와 홍도(紅島)의 식물자원(植物資源)을 조사(調査)하였다. 소흑산도(小黑山島)의 식물상(植物相)은 매우 다양(多樣)하였으며, 이중 출현빈도(出現頻度)가 많고 관상식물(觀賞植物)로도 개발(開發) 가능(可能)한 27과(科) 54종(種)을 보고(報告)하였다. 그중 난과식물(蘭科植物)은 새우난(Calanthe discolor)등(等) 8종(種)이었다. 홍도(紅島)의 식물상(植物相)은 소흑산도(小黑山島)와 매우 유사(類似)하였으나 덜 풍부(豊富)해 보였으며, 아직 미기록(未記錄)된 1종(種)을 추가보고(追加報告)하였다. 풍란(風蘭), 석곡 등(等) 기호도(嗜好度)가 높은 관상식물(觀賞植物)은 이미 절종상태(絶種狀態)에 이르고 있어 이의 보호(保護)가 절실(切實)히 요청(要請)되었다.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.11-32
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• 2010

Objective : The aim of this study is to determine the effects of Dendrobii herba extract and Punica granatum extract on skin disease and skin beauty. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH radical, xanthine oxidase activity. In the next experiment, to investigate anti-inflammatory activity assay, examined by relations in NO synthesis, IL-$1{\beta}$, IL-6, TNF-${\alpha}$, NF-${\kappa}B$, COX-2, MAP kinase. To study Skin wrinkle formation effect, we were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Dendrobii and Punica granatum extract showed high radical scavenging activity. 2. In an anti-inflammatory test, Dendrobii herba and Punica granatum extract weakly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from RAW 246.7 macrophage cells. Dendrobii herba and Punica granatum extract also inhibited LPS-induced IL-$1{\beta}$ and COX-2 expressions. The inhibitory effect of Dendrobii herba and Punica granatum extract on macrophage activation were via the inhibition of NF-${\kappa}B$, evidenced by transient transfection assay. however, Dendrobii herba and Punica granatum extract did not have any effects about activation of Jun-N-terminal kinase(JNK) and inhibition of p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Dendrobii herba and Punica granatum extract weakly inhibited collagenase and elastase, however it was not statistically significant. 4. In the skin whitening assay, Dendrobii herba and Punica granatum extract weakly inhibited tyrosinase activity, however, it was not statistically significant. They did not have any effect on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : Dendrobii herba extract and Punica granatum extract may play a significant role in skin disease and skin beauty.

• 대한한의학원전학회지
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• 제22권3호
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• pp.161-185
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• 2009

This article looks into Lee Gyujun(李圭晙)'s life course, Confucian thoughts, and philosophical ideas on the Medicine of Boosting Yang by translating selectively his "Seokgoksango(石谷散稿)". Translating his works is a pre-requisite in order to fully understand the significance of boosting-yang theory in the historical landscape of Korean medicine, not just to comprehend the Medicine of Boosting Yang. First, it is found through the translation that a previous version of "Seokgoksango" had been probably printed before its existing version 1981. Secondly, there are numerous resistants to the Japanese ruling of Korea among his friendship. Thirdly, his academical root came from the Gihohakpa(畿湖學派) - the Giho school of Korean Seongli Confucianism[朝鮮性理學]. Its genealogy in Gyeongsang(慶尙) province is as follows: Lee Yi(李珥), Song Siyeol(宋時烈), Hong Jikpil(洪直弼), Seo Changyu(徐贊奎) and Lee Gyujun(李圭晙), and last, he kept contact with the Toegyehakpa(退溪學派), the Toegye school of Korean Seongli Confucianism, even though his academic root was closely linked to the Giho school. If the entire parts of "Seokgoksango" is translated, it will serve as invaluable historical document to understand a medical unfolding around the 20th century in Korea.

• 한국약용작물학회지
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• 제22권5호
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• pp.331-338
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• 2014

Dendrobium moniliforme (DM) is a valuable and versatile herbal medicine with the anecdotal claims of antioxidant and anti-inflammation. In the present study, we investigated the whitening and anti-wrinkling effects of DM under various conditions with B16F10 melanoma cells and human dermal fibroblasts. The DM extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DM extract effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) and protein expression of tyrosinase were significantly attenuated by DM treatment. We also investigated the DM increased the production of type I procollagen and inhibited TNF-${\alpha}$-induced mRNA expressions of MMP-1, -3 in the human dermal fibroblast. These results indicate that DM may be a great cosmeceutical ingredient for its whitening and anti-wrinkle effects.

• 동의생리병리학회지
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• 제21권2호
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• pp.414-424
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• 2007

Adenophorae Radix (AR), Liriopis Tuber (LT), Dendrobii Monile (DM), Polygonati Officinalis (PO), Polygonati Rhizoma (PR) have been used to treated a variety condition/diseases in traditional oriental medicine. The present study was conducted to investigate the immunmodulatory effects of the water-extracted AR, LT, DH, PO and PR. In spleen cell proliferation assay, DH was significantly enhanced mitogenic activity compared with control group. In RT-PCR, DH ad PO induced IL-2 and IFNr cytokine gene expression in mouse spleen cells. Methotrexate(MTX), immune supression agent, was significantly inhibited mouse spleen cell proliferation(1600 mg/ml). In spite of MTX treatement, DH and PO sustained the spleen cell proliferation, In the flow cytometry analysis, DH stimulated mouse spleen cells showed an increase in B-cell phenotype (CD45R/B220). The water-extracted DH and PO inhibited NO production and iNOS expression in LPS-stimulated RAW 264.7 macrophage cell. DH induced IL-2 and IFNg gene expression in human peripheral mononuclear cells. The GC-MS analysis show that the main component of water-extracted DH was b-Nitroethyl alcohol. The main components of water-extracted PO were Dipirartril-tropico, Methyl sulfoxide and Demsodrox. These data suggest that among these extracts, DH has a protective effcet of immune suppression caused by MTX. DH may be enhance cellular and humoral immune response by the regulation of cytokine gene expression, NO production and B cell production.

• 식물분류학회지
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• 제49권2호
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• pp.179-197
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• 2019

전라남도 고흥군에 위치하는 외나로도의 관속식물상을 조사하고 분포가 확인된 주요식물에 대해 논의하였다. 2015년 3월부터 2017년 10월까지 3년 동안 총 21회의 현지조사에서 확보된 표본에 근거하여 관속식물목록을 작성하였고, 국립생물자원관 표본관(KB)과 대전대 생물학과 표본실(TUT)에 수장하였다. 본 조사에서 생육이 확인된 관속식물은 122과 364속 538종 6아종 41변종 2품종의 총 587분류군이다. 멸종위기야생생물로는 혹난초, 지네발란, 대흥란, 석곡 4분류군을 확인하였다. 한반도고유종은 변산바람꽃, 해변싸리, 거제물봉선 등 14분류군이었고, 식물구계학적 특정식물로는 V등급 4분류군, IV등급 4분류군, III등급 47분류군, II등급 18분류군, I등급 64분류군으로 총 137분류군이 조사되었다. 적색식물목록종으로는 위급종(critically endangered) 꽃꿩의다리를 포함하여16분류군을 확인하였다. 귀화식물로는 가시상추, 물참새피 등 46분류군이 조사되었다.