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http://dx.doi.org/10.7783/KJMCS.2014.22.5.331

Whitening and Anti-wrinkle Effects of Korean Native Dendrobium moniliforme Methanol Extract  

Jung, Ho Kyung (Jeollanamdo Development Institute of Korean Traditional Medicine)
Jang, Ji Hun (Jeollanamdo Development Institute of Korean Traditional Medicine)
Ko, Jae Hyung (Jeollanamdo Development Institute of Korean Traditional Medicine)
Kang, Byoung Man (Jeollanamdo Development Institute of Korean Traditional Medicine)
Yeo, Jun Hwan (Jeollanamdo Development Institute of Korean Traditional Medicine)
Cho, Jung Hee (Jeollanamdo Development Institute of Korean Traditional Medicine)
Cho, Hyun Woo (Jeollanamdo Development Institute of Korean Traditional Medicine)
Bean, Chul Gu (Research Institute, Gyeongsangnam-do Agricultural Research & Extension Services)
Kim, Seong Cheol (Namhae Sub-Station, NIHHS, RDA)
Jung, Won Seok (Jeollanamdo Development Institute of Korean Traditional Medicine)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.5, 2014 , pp. 331-338 More about this Journal
Abstract
Dendrobium moniliforme (DM) is a valuable and versatile herbal medicine with the anecdotal claims of antioxidant and anti-inflammation. In the present study, we investigated the whitening and anti-wrinkling effects of DM under various conditions with B16F10 melanoma cells and human dermal fibroblasts. The DM extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DM extract effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) and protein expression of tyrosinase were significantly attenuated by DM treatment. We also investigated the DM increased the production of type I procollagen and inhibited TNF-${\alpha}$-induced mRNA expressions of MMP-1, -3 in the human dermal fibroblast. These results indicate that DM may be a great cosmeceutical ingredient for its whitening and anti-wrinkle effects.
Keywords
Whitening; Anti-wrinkling; Dendrobium moniliforme; Melanin; Tyrosinase;
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Times Cited By KSCI : 10  (Citation Analysis)
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