• Proceedings of the Korean Institute of Industrial Safety Conference
• /
• 2003.05a
• /
• pp.452-455
• /
• 2003

마이크로캡슐화 기술은 심물질, 캡슐의 벽재재료 및 후가공과 관련한 응용기술로 구성되어 있으며, 심물질로서는 다양한 종류의 기능성 물질을 적용할 수 있다. 벽막재료 또한 목적하는 마이크로캡슐의 용도에 따라서 고분자 물질이나 무기재료 등 적합한 재료를 쓸 수 있다. 이러한 기술을 통하여 심물질 자체의 단점들 예를 들면 열안정성, 광안전성, 분산성, 등을 대폭 개선할 수 있고, 또한 이 심물질의 이용시 가공방법의 한계 등을 보완할 수 있으며, 특히 서방성을 목적으로하는 경우에 적당한 가공방법이라고 할 수 있다.(중략)

• Proceedings of the KAIS Fall Conference
• /
• 2002.05a
• /
• pp.124-126
• /
• 2002

폴리우레탄의 특징을 이용하여 폴리우레탄에 흡습능력 과 탈취능력을 향상시키고 향의 서방성 능력을 첨가하여 장루 환자들이 사용하기에 적합한 패드의 특징을 테스트 후 분석하였다. 수분의 흡습능력, 변의 냄새제거 정도의 탈취 능력 , 향의 지속성을 측정하였다. 폴리우레탄만의 특징으로도 흡습능력과 탈취능력이 있지만 주흡습제 보조흡수제를 첨가하고, 소취 제와 보조제를 첨가하여 더욱 개선된 흡습능력과 탈취능력을 확인하였다.

• Journal of the Korean Society for Precision Engineering
• /
• v.6 no.3
• /
• pp.7-14
• /
• 1989

본 논문은 생산자동화 운동이 고조되어가고 있는 현 한국제조산업에서 자동화운동에 대한 올바른 이해와 필요성을 강조하고 선진국의 자동화기술에 단시일내에 효율적으로 접근할 수 있는 추진 대책 및 준비사항을 서술함을 목적으로 한다. 한국의 제조업은 일본, 미국 등 서방국가의 자동화 수준에는 기술적이나 규모면에서 크게 뒤지고 있다. 그러나 여러 서방국가들이나 일본이 겪은 과오와 시행착오를 면밀히 조사 분석함으로써 그들이 겪은 과오와 시행착오를 미연에 예방하여 급속도로 그들의 자동화기술수준에 접근 할 수 있는 유리한 입장에 서 있다. 본문에서는 자동화의 필요성, 미래의 제조분야에서의 영향, 그리고 한 국적인 자동화 추진대책에 대하여 간단히 서술하려 한다.

• Journal of Pharmaceutical Investigation
• /
• v.15 no.4
• /
• pp.221-227
• /
• 1985

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.3
• /
• pp.215-222
• /
• 2020

Metformin is a recommended first-line therapy drug for type 2 diabetes patients. However, compared to other oral antidiabetic drugs (OAD), metformin has a large unit dosage, with bioavailability of 40-60%. This limiting bioavailability is because metformin is absorbed only in the upper gastrointestinal tract as a BCS class 3 drug. Hence, we propose that applying the Gastroretentive Drug Delivery System (GRDDS) and extending drug release time in the stomach will result in improved bioavailability. We selected the swelling type delivery system, as it is considered the most stable gastroretention technology compared to other GRDDSs. We modified the swelling excipient by using a natural swelling excipient to form a swelling tablet made of carrageenan and hydroxypropyl methylcellulose (HPMC). Our results indicate that the swelling complex tablet made of carrageenan and HPMC has a good swelling ability and shows required sustained release in a dissolution pattern. In addition, the carrageenan complex has a better swelling ability than the marketed metformin tablet, as determined by the ratio, (swelling ability)/(excipient weight). Taken together, our results indicate that the carrageenan complex can be developed as a good swelling excipient. Further optimizations are required for the commercialization of the carrageenan complex.

• Polymer(Korea)
• /
• v.38 no.6
• /
• pp.760-766
• /
• 2014

Bead type super-absorbent resins to be used for release-control were prepared by modification of the inverse suspension polymerization, and their physical properties were characterized. Acrylic acid and acrylamide were used as monomers, and N,N-methylenebisacrylamide was used as crosslinker, controlling the viscosity of monomer solution by adding hydroxyethylcellulose (HEC). SEM studies of the synthesized beads verified that the bead surfaces had many pores with their diameters of several tens nm. The bead sizes were in the range of $500{\sim}3000{\mu}m$, depending on the viscosity of the monomer solution. Both absorbent amount and absorbent rate of the beads were inversely proportional to the bead size, and the maximum water absorbent amount of 1 g beads was determined to be ca. 170~200 g for 5 hrs. The absorbent rate was also dependent on pH change of the aqueous solution, exhibiting the maximum rate in pH ranging from 5 to 11. The absorbent rate decreased as the concentration of salt (NaCl and $MgCl_2$) or ethanol and ethylene glycol increased. Release time of the water absorbed into the bead resins was 700 hrs, confirming the usefulness of the resin for the good release-control materials.

• Economic and Environmental Geology
• /
• v.48 no.3
• /
• pp.247-253
• /
• 2015

Natural halloysite is mostly found in the form of a tubular structure with a 15-125 nm internal lumen. This kaolin clay can be used for encapsulating a liquid ingredient of cosmetics and for immobilizing an inorganic solid-phase ingredient. In this paper, the encapsulation and immobilization procedures are introduced and two example applications are reviewed to demonstrate the usefulness of halloysite as a cosmetics substrate. It may help attract more interest in cosmetic applications of halloysite and thus spur more research on the utilization of natural clays.

• Polymer(Korea)
• /
• v.29 no.3
• /
• pp.260-265
• /
• 2005

The initial burst of drug release is an important role in the controlled delivery of drug having hish toxicity and narrow therapeutic ranges. Nanosphere composed of monolayer could not achieve precisely controlled drug release because of the initial burst of drug on surface. In this study, double layered nanosphere was prepared for sustained drug delivery without initial burst. Double layered nanosphere composed of dextran and PLGA was fabricated by using conventional W/O/W double emulsion method. To control surface tension on the outer layer of nanospheres, PVA was used as a surfactant. Release behavior of dextran as model drug was observed as the $3{\times}1$mm wafers formed by compression mould in the deionized water for 7 days. Double layered nanosphere has sustained release behavior, in contast to single layered nanospheres. such as mechanical mixture and dextran nanospheres. Especially, nanosphere containing PVA $0.2\%$ has shown nearly the zero-order release profile. As a result of this study, double layered nanospheres has more sustained release profile of drug without the initial burst and the release behavior of dexoan on tile double layered nanospheres was controlled by the contents of PVA as a surfactant.

• Korean Journal of Clinical Pharmacy
• /
• v.1 no.1
• /
• pp.23-30
• /
• 1991

The sustained-release beads containing terbutaline sulfate (TBS) were prepared by rotogranulation method. The drug was dusted on the non-pareil seeds in a CF-granulator. The sustained-release beads were obtained by coating the active beads with ethylcellulose or $Eudragits^{(R)}$, using in any case the same granulator employed for active beads preparation. The release characteristics of sustained-release beads were examined in vitro by rotating basket method applied to $Bricanyl^{(R)}$ durules which is a sustained-release TBS matrix tablet. The release of terbutaline from the beads in vitro was first-order, and the release rate was dependent on both the coat weight ratio and membrane hydrophilicity. Both surfaces of the beads before and after dissolution were smooth. The drug release pattern from the beads could be thought the diffusion through the polymer membrane. The release rate and the surface of the beads stored for 3 years at room temperature were the same with those of the initial beads.

• Journal of Pharmaceutical Investigation
• /
• v.32 no.2
• /
• pp.95-101
• /
• 2002

Matrix tablets of nifedipine (NP) were prepared with Eudragit, diluent (lactose or Ca. phosphate) and Mg. stearate employing two different preparation methods (wet granulation and direct compression) to develop its sustained-release dosage forms. The effects of various formulation factors on the dissolution rate of the drug were investigated. Dissolution test was studied in pH 6.8 phosphate buffer containing 1% sodium lauryl sulfate using the paddle method. Formulation factors were the type and content of Eudragit, the type of diluent and the tablet preparation method. The optimum formula of NP matrix tablet, which resulted in a similar dissolution profile to that from Adalat Oros used as a reference, was 30 mg NP, 10% Eudragit RS, 2% Mg. stearate and an adequate quantity of lactose to yield 500 mg weight using the wet granulation method.