• Title/Summary/Keyword: 생체적합도

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Appropriate in Vitro Culture Conditions of Growing Medium for New Ever-bearing Strawberry 'Goha' (사계성 신품종 딸기 '고하'의 기내배양을 위한 배지의 적정 조건)

  • Lee, Jong-Nam;Kim, Hye-Jin;Kim, Ki-Deog;Kwon, Young-Seok;Im, Ju-Sung;Yeoung, Young-Rok;Lim, Hak-Tae
    • Horticultural Science & Technology
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    • v.28 no.6
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    • pp.1051-1056
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    • 2010
  • This study was carried out to determine suitable in vitro culture conditions of new ever-bearing strawberry ($Fragaria$ $ananassa$ Duch.), 'Goha'. Four-week old plantlets which were derived from the meristem culture were used in this study. Three different culture media including MS, Gamborg B5 and White medium were used for the plant culture and the medium concentrations were at the 5 levels of $1/3{\times}$, $1/2{\times}$, $1{\times}$, $2{\times}$ and $3{\times}$. Sucrose content ranged at four levels of 1, 3, 5 and 8% (w/v). Crown diameter on the MS medium was thicker (2.1 mm) than in other media. Fresh weight on the MS medium was 482 mg, which was heavier than 88 mg or 260 mg of Gamborg B5 or White medium, respectively. Particularly, 1/2MS medium was found to have higher growth rate than these in other treatments (fresh weight, dry weight and D/F rate). Shoot length in the treatment of 1% sucrose concentration was 3.6 cm which was the longest. Shoot length was in inverse proportion to the increasing concentration of sucrose. Fresh weight was increased up to 3% sucrose concentration, but decreased above 5% sucrose concentration. From the results, we found that the best condition for in vitro culture of new ever-bearing strawberry 'Goha' was 1/2MS medium supplemented with 1% sucrose concentration.

Effects of SIS/PLGA Porous Scaffolds and Muscle-Derived Stem Cell on the Formation of Tissue Engineered Bone (SIS/PLGA 담체와 근육유래 줄기세포를 이용한 생체조직공학적 골재생)

  • Kim Soon Hee;Yun Sun Jung;Jang Ji Wook;Kim Moon Suk;Khang Gilson;Lee Hai Bang
    • Polymer(Korea)
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    • v.30 no.1
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    • pp.14-21
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    • 2006
  • Tissue engineering techniques require the use of a porous biodegradable/bioresorbable scaffold, which server as a three-dimensional template for initial cell attachment and subsequent tissue formation in both in vitro and in vivo. Small intestinal submucosa (SIS) has been investigated as a source of collagenous tissue with the potential to be used as biomaterials because of its inherent strength and biocompatibility. SIS-loaded poly(L-lactide-co-glicolide)(PLGA) scaffolds were prepared by solvent casting/particle leaching. Characterizations of SIS/PLGA scaffold were carried out by SEM, mercury porosimeter, and so on. Muscle-derived stem cells can be differentiated in culture into osteoblasts, chondrocytes, and even myoblasts by the controlling the culture environment. Cellular viability and proliferation were assayed by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium-bromide(MTT) test. Osteogenic differential cells were analyzed by alkaline phosphatase(ALP) activity. SIS/PLGA scaffolds were implanted into the back of athymic nude mouse to observe the effect of SIS on the osteoinduction compared with controlled PLGA scaffolds. Thin sections were cut from paraffin embedded tissues and histological sections were conducted hematoxylin and eosin (H&E), Trichrome, and von Kossa. We observed that bone formatioin of SIS/PLGA hybrid scaffold as natural/synthetic scaffold was better thean that of only PLGA scaffold. It canb be explained that SIS contains various kinds of bioactive molecules for osteoinduction.

Removal of Residual Stress and In-vitro Recording Test in Polymer-based 3D Neural Probe (폴리머 기반 3차원 뉴런 프로브의 잔류 스트레스 제거 및 생체 외 신호 측정)

  • Nam, Min-Woo;Lim, Chun-Bae;Lee, Kee-Keun
    • Journal of the Microelectronics and Packaging Society
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    • v.16 no.2
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    • pp.33-42
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    • 2009
  • A polymer-based flexible neural probe was fabricated for monitoring of neural activities from a brain. To improve the insertion stiffness, a 5 ${\mu}m$ thick biocompatible Au layer was electroplated between the top and bottom polymer layers. The developed neural probe penetrated a gel whose elastic modulus is similar to that of a live brain tissue without any fracture, To minimize mechanical residual stress and bending from the probe, two new methods were employed: (1) use of a thermal annealing process after completing the device and (2) incorporation of multiple different layers to compensate the residual stress between top and bottom layers. Mechanical bending around the probe tip was clearly removed after employing the two processes. In electrical test, the developed probe showed a proper impedance value to record neural signals from a brain and the result remained the same for 72 hours. In simple in-vitro probe characterization, the probe showed a great removal of residual stress and an excellent recording performance. The in-vitro recording results did not change even after 1 week, suggesting that this electrode has the potential for great recording from neuron firing and long-term implant performance.

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Growth Modeling of Perilla frutescens (L.) Britt. Using Expolinear Function in a Closed-type Plant Factory System (완전제어형 식물공장에서 선형지수함수를 이용한 들깨의 생육 모델링)

  • Seounggwan Sul;Youngtaek Baek;Young-Yeol Cho
    • Journal of Bio-Environment Control
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    • v.32 no.1
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    • pp.34-39
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    • 2023
  • Growth modeling in plant factories can not only control stable production and yield, but also control environmental conditions by considering the relationship between environmental factors and plant growth rate. In this study, using the expolinear function, we modeled perilla [Perilla frutescens (L.) Britt.] cultivated in a plant factory. Perilla growth was investigated 12 times until flower bud differentiation occurred after planting under light intensity, photoperiod, and the ratio of mixed light conditions of 130 μmol·m-2·s-1, 12/12 h, red:green:blue (7:1:2), respectively. Additionally, modeling was performed to predict dry and fresh weights using the expolinear function. Fresh and dry weights were strongly positively correlated (r = 0.996). Except for dry weight, fresh weight showed a high positive correlation with leaf area, followed by plant height, number of leaves, number of nodes, leaf length, and leaf width. When the number of days after transplanting, leaf area, and plant height were used as independent variables for growth prediction, leaf area was found to be an appropriate independent variable for growth prediction. However, additional destructive or non-destructive methods for predicting growth should be considered. In this study, we created a growth model formula to predict perilla growth in plant factories.

Implementation of Wearable 2-lead ECG Measurement System for Healthcare Monitoring during Daily Life (일상생활 중 모니터링이 가능한 착용형 2-Lead 심전도 계측 시스템의 구현)

  • Kim, Byung-Joo;Jeong, Do-Un
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.05a
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    • pp.358-359
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    • 2012
  • 본 연구에서는 범용적인 건강 모니터링에 활용할 수 있는 생체신호인 심전도를 일반 가정 내에서 뿐만 아니라 일상생활 중에서도 실시간으로 편리하게 측정할 수 있도록 초소형 저전력의 착용형 심전도 계측시스템을 구현하였다. 이를 위하여 표준 12-lead법이 아닌 모바일 또는 휴대용 장치에 적합한 2-lead법을 사용하여 심전도 계측부를 구현하였고, 심전도 계측부를 베이스 노드로 하여 심전도 신호를 가정 내 또는 실외에서도 무선으로 전송 할 수 있도록 구현하였다. 먼저 가정 내에서는 저 전력 무선센서노드를 이용하여 심전도 신호를 실시간으로 PC에 전송하여 모니터링이 가능하도록 구현 하였고, 실외에서는 저전력 통신 방식인 Bluetooth 2.0을 사용하여 스마트폰으로 심전도 신호를 실시간으로 전송해 모니터링 할 수 있도록 구현하였다.

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BIOCOMPATIBILITY OF FOOD COLORING AGENTS TO DEVELOP NEW DENTAL PLAQUE DISCLOSANTS (새로운 치면세균막 착색제 개발을 위한 식용색소의 생체적합성 연구)

  • Lee, Kwang-Hee
    • Journal of the korean academy of Pediatric Dentistry
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    • v.26 no.1
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    • pp.14-24
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    • 1999
  • The purpose of study was to develop new dental plaque disclosants which could replace erythrosine. Three food coloring agents(Red No.40, Blue No.1, and Mixed Green), erythrosine and fluorescein were tested for their color difference, antibacterial property, and biocompatibility. Color difference of Red No.40 was greater than that of erythrosine as concentration of solution increased. Color differences of Blue No.1 and Mixed Green were smaller than that of red dyes. Erythrosine showed obvious antibacterial property, but food coloring agents showed almost no antibacterial property. The taste and sensation of erythrosine was the worst, and the taste of Red No.40 and the sensation of Mixed Green were the most tolerable. Erythrosine stained dental plaque and oral soft tissue most deeply and long, and Blue No.1 was the next in the depth and longevity of stain.

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Tracking Hand Shape using Active Shape Model and Skin Color Information (능동형상모델과 피부색 검출을 통한 손바닥 경계 형상의 추적)

  • Lee Ju-Young;Kim Jeong-Hyun;Kang Dong-Joong
    • Proceedings of the Korea Information Processing Society Conference
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    • 2006.05a
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    • pp.681-684
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    • 2006
  • 본 논문은 능동형상모델(Active Shape Model: ASM)을 사용하여 손바닥의 형상을 추출하고 경계형상을 추적하기 위한 방법을 제안한다. 먼저, 경계추적을 위한 초기위치를 입력하기 위해 컬러영상에서 피부색영역의 위치 정보를 통해 중심점을 찾고 그 값을 통해 ASM을 이용하여 손바닥의 영역을 찾는다. ASM은 다양한 경계형상의 학습을 통해 평균값과 형상의 지배적 변형을 나타내는 형상벡터를 추출하기 위한 방법론이며 생체조직과 같은 형상이 일정하지 않고 평균형상을 기준으로 변화하는 형상의 외형을 추출, 추적하기에 적합한 기술이다. 본 논문에서는 피부색 특징을 이용하여 초기 손바닥의 위치를 찾고 이러한 위치정보를 이용하여 손 경계형상의 변화를 추적하는 방법을 실험을 통해 검증하였다

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Study on Biocompatibility and Morphology with Hydrolysis Degradation of Poly(ester amide) derived from Glycine and/or 4-Aminobutyric acid (Glycine and/or 4-aminobutyric acid로부터 유도된 Poly(ester amide)의 생체 적합성 및 분해에 따른 형태학적 고찰)

  • 한상일;임승순
    • Proceedings of the Korean Fiber Society Conference
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    • 2002.04a
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    • pp.49-52
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    • 2002
  • 합성 고분자의 생분해는 환경 보존이라는 측면에서 중요시 되고 있으며 봉합사나 bone fixation, 그리고 implant와 같은 의학적 응용면에서도 상당한 관심의 대상이 되어오고 있다 glycolic acid, L-lactic acid, $\varepsilon$-caprolactone에 근거하는 지방족 폴리에스터는 생분해성 봉합사로서 응용되고 있으나 여전히 열적, 기계적 가공특성과 같은 적정특성들이 부족하다.$^1$ 한편 폴리아마이드는 유사한 구조를 갖는 폴리에스터와 비교할 때에 상대적으로 높은 유리전이온도와 높은 융점을 가지고 있는 반면 높은 흡습성으로 인한 물성저하가 야기될 수 있다. (중략)

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모델 시스템을 이용한 생분해성 고분자의 분해거동 연구

  • 이원기;전상익;이진국
    • Proceedings of the Korean Environmental Sciences Society Conference
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    • 2004.05a
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    • pp.401-402
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    • 2004
  • 생분해성 고분자 재료들은 지구환경 보호측면에서 다양한 분야, 즉, 1회용 재료, 농업용 필름 및 생체적합성 재료(약물 방출, 봉합사) 등에서 실용화되거나 활발한 연구가 진행되고 있다. 이들 재료의 상업적응용은 물성, 분해능, 제조가격, 대량생산 등에 의해 좌우 될 수 있다. 이들 중 특히, 분해 메커니즘의 규명은 본질적인 응용에서 가장 중요한 위치를 차지하고 있다. 분해 속도의 규명 및 조절은 제품의 수명을 제어할 수 있고 응용 분야를 넓힐 수 있다. 본 연구에서는 분해매채에 따른 생분해성 고분자의 분해 메커니즘 및 속도를 단결정과 단분자막 기법을 이용하여 연구하였다. 결정성영역에서는 분해매체의 크기가 작은 알칼리 이온에 의해 표면 및 측면 분해가 일어나고 크가가 큰 효소는 비규칙성을 가진 영역에서 선호적 분해가 일어남을 두 모델 시스템으로부터 확인하였다.

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Passwordless Authentication Technology-FIDO (패스워드 없는 인증기술-FIDO)

  • Cho, S.R.;Choi, D.S.;Jin, S.H.;Lee, H.H.
    • Electronics and Telecommunications Trends
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    • v.29 no.4
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    • pp.101-109
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    • 2014
  • 패스워드 기반의 사용자 인증은 비용이 적게 들고 편리성 때문에 보안상 취약점이 있어도 현재까지 광범위하게 사용되고 있다. 이러한 패스워드 기반 인증의 보안 취약성을 개선하기 위해 생체 인증을 사용하거나 다중 요소 인증기술을 적용하려는 시도는 그동안 계속되어 왔다. 하지만 기술에 따라 사용자의 편리성이 떨어지거나 광범위하게 설치하기에 비용부담이 증가하여 응용서비스에 적용하기에는 무리가 있었다. FIDO(Fast IDentity Online)는 인증 프로토콜과 인증수단을 분리하여 패스워드 없이 인증강도를 높이면서 사용자의 편리성도 높이려는 시도를 하는 기술로 패스워드의 문제를 극복하여 스마트 모바일 환경에 적합한 인증기술로 활용될 수 있다.

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