• Korean Journal of Clinical Pharmacy
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• v.15 no.1
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• pp.41-45
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• 2005

심바스타틴은 cholesterol 생합성 과정에서 속도 조절 효소인 HMG-CoA reductase의 강력한 상경적 길항약으로서 고지혈증 치료에 널리 쓰이는 약물이다. 심바스타틴 제제인 MSD 사의 조코 20 mg정을 대조약으로 하여 시험약인 유영 제약의 엘바스타 20mg정의 생물학적 동등성 평가를 하기 위해 22명의 건강한 지원자를 모집하였다. 지원자를 두 군으로 나누어 2정씩 투여하였고 $2{\times}2$ 교차시험을 실시하였다. 심바스타틴의 혈장 중의 농도를 정량하기 위하여 발리데이션된 LC/MS/MS를 사용하였다. 채혈 시간은 투약 전 및 투약 후 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 시간에 걸쳐 총 12시점에 걸쳐 시행하였다. 생물학적 동등성을 판정하기 위한 파라미터로 12시간까지의 혈장 중 농도곡선 하 면적 ($AUC_{12hr}$)과 최고 혈중 농도($C_{max}$)를 사용하였다. 12시간 까지의 혈중 농도 곡선 하 면적의 기하 평균은 $17.30ng{\cdot}ml/hr$(시험약)과 $17.35ng{\cdot}ml/hr$(대조약)으로 나타났다. 최고 혈중 농도의 경우 각 각 5.08 ng/ml(시험약)과 5.20 ng/ml(대조약)으로 관찰 되었다. $AUC_{12hr}$의 경우 로그변환한 평균치 차의 $90{\%}$ 신뢰구간이 log0.8510 - log1.1694이었고, $C_{max}$의 경우 log0.8176 - log1.1649로 계산되어 두 항목 모두 log0.8-log1.25이어야 한다는 식품의약품 안전청과 FDA의 기준을 모두 만족시켰다. 이상의 결과를 종합하면 시험약 엘바스타 정 20mg은 대조약 조코정 20 mg에 대하여 생물학적 동등한 것으로 판정되었다.트리머 전기비저항 탐사를 수행하였다. 이를 통해 하저에 케이블을 설치하는 방식에 비해 매우 신속하고 경제적으로 하저에 분포하는 이상대의 분포범위와 발달방향을 규명할 수 있었다.대에 대해 가장 효과적이다. 모델과 현장 적용 결과들을 통해 GRM SSM 방법을 이용하여 불규칙한 굴절면을 가진 지층들에 대해 좀 더 신뢰할 수 있는 정밀한 탄성파 속도를 산출할 수 있음을 보여주고 있다.별한 주의를 기울여야 한다.EX>$\alpha/\beta$=10인 경우 $62.0\~121.9\;Gy_{10}$ (중앙값: $93.0\;Gy_{10}$)의 분포를, ${\alpha/\beta}=3$인 경우 $93.6\~187.3\;Gy_3$ (중앙값=$137.6\;Gy_3$ )의 분포를 보였다. MD-BED $Gy_3$는 직장합병증 발생과의 관계는 통계적으로 유의하였고, 방광합병증과는 유의하지 않았다. 직장합병증과의 연관성은 MD-BED $Gy_3$보다 개별 환자의 직장전벽 총 선량 BED값인 R-BED $Gy_3$가 훨씬 더 높았다. 요도카테터 풍선의 후방지점이 대변하는 방광의 총 선량 BED값인 V-BED $Gy_3$도 방광합병증과 경향성 테스트에서 통계적 유의성을 보였다. 하지만, 어떠한 방사선선량도 골반제어율과 의미 있는 상관관계를 보이지 않았다. 본 기관에서 주치의의 선호도에 따라 강내근접치료가 외부방사선치료의 중간에 시행되는 형태인 샌드위치기법과 외부방사선치료 후반부에 시행되는 순차적 기법으로 구분하였을 때, 두 방식간 치료성적 및 합병증의 차이는 없었다. 총 치료기간에 대한 분석에서는 치료기간이 길어질수록 재발 위험이 커지는 경향을 보였으나, 나이 및 병기, 종양의 크기, MD-BED $Gy_{10}$

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.3
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• pp.195-200
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• 1990

These experiments were conducted to determine the effect of high temperature and water managements on growth and yield of rice. Shoot dry weight and percent of fresh roots were decreased when rice plant was exposed to high temperature, and also high temperature treatment decreased yield components of rice through spikelet number at meiotic, filled grain ratio and percent of fertility at heading, and 1,000 grain weight at ripening stage. Nitragen content of the rice varities was decreased by high temperature treatment regardless different growth stage, although Si content increased. Grain yield of rice varieties significantly decreased due to high temperature when rice plants were treated at heading stage followed by ripening stage. meiotic, young panicle initiation, maximum tillering and tillering stage in order. Effect of the continual submerging on temperature increased by 1.1$^{\circ}C$ at daytime and by 3.7$^{\circ}C$ at nighttime, but flowing water irrigation which can maintain optimum temperature reduced plant height and increased dry weight and percent of fresh roots. Flowing water irrigation showed higher yield by 4-8% compared to continual submerging method through increment of yield components such as spikelet number, filled grain ratio and 1,000-grain weight.

• Journal of Korean Medical classics
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• v.18 no.4 s.31
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• pp.101-119
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• 2005

금원사대가적태두류완소(金元四大家的泰斗劉完素), 1110년생어하북성하간현(年生於河北省河間縣), 졸어(卒於)1200년(年), 향년(享年)90세(歲). 타통과연구(他通過硏究)${\ulcorner}$황제내경(黃帝內經)${\lrcorner}$화(和)${\ulcorner}$상한론(傷寒論)${\lrcorner}$, 저술료(著述了)${\ulcorner}$소문현기원병식(素問玄機原病式)${\lrcorner}$, ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$, ${\ulcorner}$소문병기기의보명집(素問病機氣宜保命集)${\lrcorner}$, ${\ulcorner}$상한표본심법류췌(傷寒標本心法類萃)${\lrcorner}$, ${\ulcorner}$상한직격론(傷寒直格論)${\lrcorner}$등저작(等著作). 령외, 응용운기대이론진행연구(應用運氣對理論進行硏究), 주장(主張)‘화열론(火熱論)’, 제출이한량약물치료질병적방법, 사금원시대재의학상(使金元時代在醫學上), 형성료백가쟁명적국면(形成了百家爭鳴的局面). 필자통과대류완소적방제학설급임상경험적연구(筆者通過對劉完素的方劑學說及臨床經驗的硏究), 득출여하결론(得出如下結論): 재방제학설상(在方劑學說上), ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중(中), 기사용적(其使用的)${\ulcorner}$상한론(傷寒論)${\lrcorner}$화각가급기제자문운용방제(和各家及其弟子們運用方劑), 공포괄(共包括)366개(個). 대부분주장료이용신고적한약(大部分主張了利用辛苦的寒藥), 래개통울결(來開通鬱結), 조습제열(操濕除熱). ‘상복보양(常服保養)’시인위여기소거주적중국북방(是因爲與其所居住的中國北方), 기후건조(氣候乾操), 인문다식습성강(人們多食濕性强), 차교표한적식물(且較標悍的食物), 소이유사인체장위비조적경향(所以有使人體腸胃秘操的傾向). ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$적(的)366개방중(個方中), 유산제(有散劑)126개(個), 탕제(湯劑)87개(個), 기중(其中), 지유(只有)18개방가칭지위진정적탕제, 기여도접근위자산(其餘都接近爲煮散). ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중소나열적주요방제유(中所羅列的主要方劑有)‘방풍통성산(防風通聖散)’, ‘삼화신우환(三花神佑丸)’, ‘쌍해산(雙解散)’, ‘삼일승기탕(三一承氣湯)’, ‘대금화환(大金花丸)’, ‘익원산(益元散)’, ‘대건중탕(大建中湯)’, ‘당귀룡담환(當歸龍膽丸)’, ‘비방다주조산(秘方茶酒調散)’, ‘계령감로산(桂零甘露散)’, ‘천궁석고탕(川弓石膏湯)’, ‘전성산(全聖散)’, ‘지유탕(地楡湯)’, ‘인참산(人參散)’, ‘작약탕(芍藥湯)’, ‘내통황연탕(內統黃連湯)’, ‘신궁환(神芎丸)’, ‘도환산(倒換散)’등(等). 재임상경험상(在臨床經驗上), 류씨유풍부치료경험(劉氏有豊富治療經驗), 단시유감적시몰유전하일부관우의안방면적저작(但是遺憾的是沒有傳下一部關于醫案方面的著作). 재질병적치료상(在疾病的治療上), 가간출기유독창적견해(可看出其有獨創的見解), 저일점도견우(這一點都見于)${\ulcorner}$소문현기원병식(素問玄機原病式)${\lrcorner}$등이론저작(等理論著作), 우기산견어(尤其散見於)${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중(中).

• Transactions of the Korean hydrogen and new energy society
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• v.32 no.6
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• pp.442-454
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• 2021

The porous transport layer (PTL) is essential to effectively remove oxygen and hydrogen gas from the electrode surface at high current density operation conditions. In this study, the effect of PTL with different characteristics such as pore size, pore gradient, interfacial coating was investigated by multi-layered sintered mesh. A water electrolysis single cell of active area of the 34.56 cm² was constructed, and IV performance and impedance analysis were conducted in the range of 0 to 2.0 A/cm². It was confirmed that the multi-layered sintered mesh PTL, which have an average pore size of 25 to 57 ㎛ and a larger pore gradient, removed bubbles effectively and thus seemed to improve IV performance. Also, it was confirmed that the catalytic metals such as Ni, NiMo coating on the PTL reduced activation overpotential, but increased mass transport overpotential.

• The Journal of the Korea Contents Association
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• v.22 no.4
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• pp.246-260
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• 2022

This study assumed that chef's shared leadership perceived by chefs in hotel culinary department affects self-efficacy, group efficacy, and job performance. Based on this, the causal relationship between each variable was analyzed through leadership sharing. And based on the results, we tried to suggest a manpower management plan suitable for the hotel culinary department and provide basic data. The subjects of this study were chefs working in 8 luxury hotels in Seoul and Busan. A total of 302 questionnaires were analyzed. For analysis, SPSS 23.0 and AMOS 23.0 statistical packages were used. As a result of empirical analysis, it was found that it had a positive effect on self-efficacy and job performance improvement of hotel cooks. On the other hand, it was found that the chef's shared leadership did not affect job performance through collective efficacy and collective efficacy. In conclusion, it was suggested that a differentiated and efficient manpower management plan is needed to enhance job performance by enhancing shared leadership and self-efficacy for cooks, where collaboration and division of labor are important, and individual ability is important due to the nature of their work.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.35 no.4
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• pp.352-361
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• 1990

The reducing effect of wind injury was investigated using several wind-break nets in Youngdeok province where cold-wind damage is often occurred during rice growing season. The white-head damage of rice have been often occurred by typhoon during the period between August 15 to September 10 in the cold wind area of the eastern coastal during the last 11 years (1979-1989). This may suggest that the critical period for heading will be by August 15 in the regions. High evaporation coefficient, more than 250 due to typhoon passage over the regions resulted high injury of white head. Generally, the wind injury have been caused by warm and dry westerlies through Fohn apperance in Taebaeg mountains and by cool-humid wind which blows from coast to inland. The frequency of occurrence of the two types of typhoons were 25, 20%, respectively during rice cultivation. The instalation of wind-break net significantly reduced the wind blowing speed, depending on the net mesher with the higher effect in dence net. The distances between the net and cropping area also affect the wind speed: 23% reduction at 1m distance. 34% at 10m and 28% at 20m, respectively. The reducing effect was also observed even at 10 times height of the wind-break net. The instalation of wind-break net gave several effects on climate factor, showing that temperature increased by 0.8$^{\circ}C$(maximum), 0.7$^{\circ}C$(minimum), 0.6$^{\circ}C$(average) : water temperatures increased by 0.5$^{\circ}C$(maximum), 0.6$^{\circ}C$(minimum), 0.5$^{\circ}C$(average) : soil temperature increased 0.4$^{\circ}C$. The earlier heading and increasing growth rate, use of light, culm length, panicle number per hill, spikelet number per panicle, fertility and 1,000 grain weight were observed in the fields with the wind-break nets resulting in 10-15% increase in rice yield using 0.5${\times}$0.5cm nets. The increasing seedlings per hill gave higher grain yield by 13% in the cold wind damage regions of eastern coastals. and the wind-break was more significant in the field without the wind-break net. Wind injury of rice plant in the cold wind regions of eastern coastals in korea could be reduced by selection of tolerant varieties to wind injury, adjustment of transplanting time, and establishment of wind-break nets.

• Journal of Chest Surgery
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• v.30 no.2
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• pp.172-178
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• 1997

We present a etrospective analysis of arterial embolectomies performed at the Inje University Seoul Paik Hospital. During the period of March 1987 Feburary 1996 twenty-six patients underwent embolectomies, eighteen patients were male and eight patients were female, mean age of patients was 56.8 years. Rest pain was the chief complaint in 24 patients, the remaining two patients complained of long term history of claudication after recovery of acute symtoms. But only 10 patients had sensBrylmotor symtoms. Heart was the most common source of embolization and frequent predisposing factor of embolism was ischemic heart disease in 8 cases and valvular heart disease in 11 cases. The sites of embolization were upper extremities artery in 6 cases, saddle embolism in 2 cases, lower extremities artery in 18 cases and the most common site of embolism was femoral artery in 1 1 cases. Preoperative angiography was taken in the diagnosis and planning of the embolectomy in 1) patients while in the other patient p eoperative angiography was not taken. Only two cases were operated within the golden period of 6 hours and other cases were operated in more than 6 hours after embolization. In all patients, the Fogarty embolectomy catheter was used without bypass surgery via bachial ateriotomy in the embolism of upper extremities artery, bilateral groin approaches in the saddle embolism and transfemoral approach in the embolism of lower extremities artery. However 3 patients were re-operated via transpopliteal approach in the distal poplitiotibial embolism. Eighteen patients received perioperative anticoagulation therapy by heparin or fraxiparine and wafarin was used in 17 patients at the time of discharge and the indication of anticogulation was patients of valvular heat disease andfor atrial fibrillation, peripheral artery atherosclerosis and recurrent embolism. Postoperative results of the embolectomy were as follows: fouteen pateints had excellent results, five cases had symtom improvement after re-operation, B. K. amputation in 1 case who had severe atherosclerosis of lower extremities, recurrent embolism in 1 case and death in 2 cases the cause of death were acute renal failure and cerebral artery embolism, respectively. The complications of the embolectomy were reperfusion syndrome, pseudoaneurysm and intimal dissection in one case each. Conclusively the problems of embolism is delayed diagnosis and increasing number of old aged patient who had suffered from ischemic heart diease. Preoperative angiography was not always needed for embol ectomy. Selective anticoagulation therapy can decrease incidence of re-embolism. In the distal poplitiotibial embolism, embolectomy of tibial artery was difficult.

• Journal of Preventive Medicine and Public Health
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• v.33 no.2
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• pp.208-214
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• 2000

Objectives : Face-to-face interviews were conducted to investigate the relationship between blood pressure and the impairment of cognitive function in rural elderly (N=932) aged 60-64 in Dalsung County, April to September in 1996 Methods : Impairment of cognitive function was defined as a score of less than 23 by the Korean version of the Mini-Mental State Examination (MMSEK). Blood pressure was measured once in each subject using a portable automatic sphygmomanometer. Results : By univariate logistic regression on males, no category of systolic blood pressure bore statistical significance. Groups with diastolic blood pressures of, less than 80 mmHg, 90-94 mmHg, and more than 95mmHg had odds ratios of more than one compared with the reference group (80-89 mmHg). This was most significant in the group with blood pressures lower than 80 mmHg, which had a statistically significant odds ratio of 1.68 (95% confidence interval CI; 1.02-2.75). No category of blood pressure was statistically significant in females. Multivariate logistic regression for males, with adjustment for age, educational attainment, smoking, alcoholic drinking, body mass index, atherosclerotic disease, and antihypertensive medication use, did not alter the odds ratios significantly in terms of systolic blood pressure. However, the group with diastolic blood pressure of less than 80 mmHg had an increased odds ratio of 2.01 (95% CI; 1.15-3.52) compared with the reference group. In females, systolic blood pressure did not alter the odds ratio, but the group with a diastolic blood pressure of less than 80 mmHg had a statistically significant odds ratio of 0.57 (95% CI; 0.37-0.89). Conclusions : These results suggest that the relationship between blood pressure and cognitive function status is stronger diastolic than systolic blood pressure and that there is a complex relationship between blood pressure and cognitive function by sex.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.4
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• pp.267-274
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• 2008

Purpose: Transient neurological deterioration (TND) is one of the complications after extracranial-intracranial bypass surgery, and it has been assumed to be caused by postoperative transient hyperperfusion. This study was performed to evaluate the relationship between TND and preoperative and postoperative cerebral perfusion status on brain perfusion SPECT following superficial temporal artery - middle cerebral artery (STA-MCA) anastomosis surgery. Materials and Methods: A total of 60 STA-MCA anastomosis surgeries of 56 patients (mean age: $50{\pm}16$ yrs; M:F=29:27; atherosclerotic disease: 33, moyamoya disease: 27) which were done between September 2003 and July 2006 were enrolled. The resting cerebral perfusion and cerebral vascular reserve (CVR) after acetazolamide challenge were measured before and 10 days after surgery using 99mTc-ethylcysteinate dimer (ECD) SPECT. Moreover, the cerebral perfusion was measured on the third postoperative day. With the use of the statistical parametric mapping and probabilistic brain atlas, the counts for the middle cerebral artery (MCA) territory were calculated for each image, and statistical analyses were performed. Results: In 6 of 60 cases (10%), TND occurred after surgery. In all patients, the preoperative cerebral perfusion of affected MCA territory was significantly lower than that of contralateral side (p=0.002). The cerebral perfusion on the third and tenth day after surgery was significantly higher than preoperative cerebral perfusion (p=0.001, p=0.02). In TND patients, basal cerebral perfusion and CVR on preoperative SPECT were significantly lower than those of non-TND patients (p=0.01, p=0.05). Further, the increases in cerebral perfusion on the third day after surgery were significant higher than those in other patients (p=0.008). In patients with TND, the cerebral perfusion ratio of affected side to contralateral side on third postoperative day was significantly higher than that of other patients (p=0.002). However, there was no significant difference of the cerebral perfusion ratio on preoperative and tenth postoperative day between patients with TND and other patients. Conclusion: In patients with TND, relative and moderate hyperperfusion was observed in affected side after bypass surgery. These finding may help to understand the pathophysiology of TND.