• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.5
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• pp.697-704
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• 2013

The inhibitory effect of ethanol extracts from Curdrania tricuspidata leaves (CTL) on osteoarthritis was investigated in primary cultured rat cartilage cells and a monosodium-iodoacetate (MIA)-induced arthritis rat model. To identify the effects of CTL 80% ethanol extracts (CTL80) and CTL 10% ethanol extracts (CTL10) against $H_2O_2$ treatment in vitro, cell survival was measured by the MTT assay. Cell survival after $H_2O_2$ treatment increased with CTL80 and CTL10 close to normal up to $300{\mu}g/mL\;H_2O_2$. The mRNA expression of matrix metalloproteinases (MMPs) was determined MMP-7 and MMP-13 (known catabolic factors), were significantly inhibited by CTL 80 and CTL10; a $200{\mu}g/mL$ dose of CTL80 especially decreased MMP-13 expression. In vivo, osteoarthritis was induced by an intra-articular injection of MIA into the knee joints of rats, then CTL80 and CTL10 orally administered daily for 35 days. After the animals were sacrificed, histological evaluations of their knee joints revealed a reduction in polymorphonuclear cell infiltration and smooth synovial lining in the CTL80-500 group. Micro-CT analysis of hind paws from CTL80-500 and CTL10 showed a protection against osteophyte formation, soft tissue swelling, and bone resorption. In conclusion, CTL ethanol extracts are effective in ameliorating joint destruction and cartilage erosion in MIA-induced rats. CTL decreases and normalizes articular cartilage through preventing extracellular matrix degradation and chondrocyte injury, and could potentially serve as a therapeutic treatment for humans.

• Korean Journal of Plant Tissue Culture
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• v.25 no.4
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• pp.257-261
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• 1998

The repeated subcultures of in vitro plant materials in wasabi became highly vitrified and the capacity for multiple shoot formation from the vitrified plant materials was very low. In order to improve the quality of in vitro propagated planting materials, the experiments were carried out using culture vessels capped with membrane filter(MF). When vitrified shoots were cultured on MS medium with 0.2mg/L BA in the vessels with MF or without MF for 60 days, the shoots in the vessels with MF did not vitrified. In contrast, the shoots grown in the vessels without MF vitrified at 65%. The stomates of vitrified leaves were circular and inflated, whereas those of normal leaves acclimatizated in the vessels with MF were ovate in shape. The hardened shoots were also cultured on MS media without sucrose containing 0.01mg/L IBA in vessels with(photoautotrophic culture) or without(control) MF. Sucrose was necessary for survival of the in vitro plantlets in the vessels without MF. After 20 days of culture, the shoots in the vessels without MF on the sucrose-free media turned yellow and died. But the shoots in the vessels with MF in the sucrose-free media produced a lot of roots. When shoots were cultured on MS medium with 2% sucrose containing 0.01mg/L IBA in the vessels with(photomixotrophic culture) or without(heterotrophic culture) MF, best growth occured in photomixotrophic culture.

• Clinical and Experimental Pediatrics
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• v.48 no.3
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• pp.298-305
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• 2005

Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood; and adolescence. We measured serum levels of IGF-I, IGFBP-2 and IGFBP-3 by enzyme-linked immunosorbent assay(ELISA) and analysed the serum levels according to sex and age group. Results : For boys, the mean serum levels of IGF-I(ng/mL) in neonate, infancy, early childhood, late childhood and adolescence were $41.1{\pm}3.6$, $70.9{\pm}33.7$, $103.5{\pm}97.2$, $89.8{\pm}46.5$ and $51.4{\pm}27.8$, respectively. Those of IGFBP-2(ng/mL) were $8.2{\pm}3.4$, $5.8{\pm}0.4$, $9.3{\pm}4.0$, $9.5{\pm}1.1$ and $7.0{\pm}0.5$, respectively. Those of IGFBP-3(ng/mL) were $559.2{\pm}215.2$, $1,333.3{\pm}692.5$, $2,254.6{\pm}1,513.8$, $2,447.1{\pm}1,464.2$, $1,533.6{\pm}807.4$, respectively. For girls, the mean serum levels of IGF-I(ng/mL) according to five age groups were $53.3{\pm}9.5$, $99.3{\pm}45.8$, $69.6{\pm}51.1$, $106.2{\pm}67.0$ and $145.1{\pm}127.8$, respectively. Those of IGFBP-2 (ng/mL) were $9.1{\pm}7.4$, $5.3{\pm}0.9$, $6.9{\pm}2.0$, $10.5{\pm}3.0$ and $7.9{\pm}1.3$, respectively. Those of IGFBP-3(ng/mL) were $858.2{\pm}433.4$, $1,834.8{\pm}851.3$, $1,404.3{\pm}570.2$, $2,203.5{\pm}899.4$ and $2,029.3{\pm}1,316.7$, respectively. There were significant positive correlations observed between IGF-I and IGFBP-3 levels(r=0.589, P=0.000). Conclusion : IGF-I and IGFBP-3 levels increased as children get older. The peak level of IGFBP-3 was observed in late childhood for both boys and girls, suggesting a current trend of children reaching peak growth velocity before adolescence. The IGFBP-2 level was higher in neonates compare to infancy, suggesting that IGFBP-2 is an important substance for fetal growth.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.4
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• pp.309-316
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• 2015

Numerical analysis and experimental verification of a thermal liquid mass flow meter (LMFM) were performed. The configuration of the LMFM was the same as a gas mass flow meter (GMFM), but the opposite results in temperature difference between upstream and downstream thermistors occurred. In the case of the gas, the convection depending on the flow of thermal mass was small and comparable to the conduction through the sensor tube wall. The temperature difference was proportional to the mass flow rate due to their interaction. For the liquid flow, the convection overwhelmed the wall conduction because of the large flow of thermal mass caused by high density. The temperature difference in this case was inversely proportional to the mass flow rate. The tube diameter and heater wiring width are important design parameters, and the optimized sensor can be used to measure and control the infinitesimal liquid flow rate.

• Microbiology and Biotechnology Letters
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• v.39 no.4
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• pp.350-356
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• 2011

The purpose of this study was to investigate changes in the contents of constituents in Sipjundaebo-tang (SJ) and its fermentations (FSJ) with 8 species of lactic acid bacteria. Eight strains of lactic acid bacteria, Lactobacillus casei KFRI129, L. plantarum KFRI 144, L. curvatus KFRI 166, L. hilgardii KFRI 229, L. delbruekil subsp. lactis KFRI 442, L. casei KFRI 692, L. gasseri KCTC 3163, and Bifidobacterium breve KFRI 744, were utilized for the fermentation of Sipjundaebo-tang. As a result we identified three constituents which increased and two constituents which decreased. The increased constituents were isolated by chromatographic techniques and then their structure elucidated using NMR and MS. The decreased constituents were confirmed by comparing standard compounds. These compounds were quantitatively analyzed using the HPLC/DAD system. The increased constituents were identified to be cinnamyl alcohol (1), liquiritigenin (3), and nodakenetin (5), while the decreased constituents were liquiritin (2) and nodakenin (4). Generally, liquiritin (2) and nodakenin (4) were noted as having decreased in fermented Sipjundaebo-tangs (FSJs), while cinnamyl alcohol (1), liquiritigenin (3), and nodakenetin (5) were seen to have increased. Sipjundaebo-tang fermented by L. plantarum KFRI144 exhibited the most remarkable changes in all of fermentations. The eight lactic acid bacteria all demonstrated differing decomposable rates on the five maker compounds in fermented Sipjundaebo-tang (FSJ).

• Korean Journal of Clinical Laboratory Science
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• v.50 no.3
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• pp.297-303
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• 2018

This study investigated the effect of community-based health intervention program to improve metabolic disease in Jeju island. There were 50 obese local residents in the experimental group (body mass index, $BMI{\geq}25kg/m^2$). They participated in cooking therapy with nutrition education (4 times), exercise program with proprioceptive neuromuscular facilitation (PNF) and stretching training (9 times), and alternative medicine program with healing touch massage (3 times) during a 3-week period. To evaluate the effectiveness of the program, body composition, blood lipid profiles, blood glucose, and waist circumference were assessed before and after the intervention program. After the program, the value of total cholesterol (TC), glycosylated hemoglobin (HbA1C), diastolic blood pressure, percent body fat, and waist circumference were decreased, and became the normal value. Especially, HbA1C, percent body fat, and waist circumference were significantly decreased (P<0.001) in the experimental group, while HbA1C, percent body fat, and waist circumference were significantly increased (P<0.001) in the control group (N=50), who had no intervention. Our results suggest that metabolic syndrome associated markers need intervention program for improving them. In conclusion, although this study did not analyze the effect of the health intervention program and cooking therapy separately, considering the result of this 3-week, short term program, the effect will be more profuse if cooking therapy and exercise program were performed concurrently.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.283-304
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• 2018

mankind has evolved to stand upright a million years ago. However entering an industrial society, much has changed in only a few decades. Human beings spend more time sitting down and working, which negatively affects their bodies. Leading medical studies have shown that the prolonged working conditions have significantly affected the causes of adult illnesses that we have known. Human beings have evolved in a moving direction. So, like modern societies, sitting or standing in one space for long periods of time without movement brings various side effects to the body. Reflecting this background, this study has led to think of work in an environment that is taking the evolutionary biology perspective from a traditional standing, standing work environment. They also plan to conduct an experiment to handle work with smartphones in the hopes of expanding their mobile office environment to use smartphones in the field, which is a type of smart work. The study could help build and establish a mobile office environment, a type of smart work. In addition to using smartphones, a working environment can be created that works by moving around. Furthermore, the paradigm of the work environment of businesses and students could be changed.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.2
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• pp.95-106
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• 2007

The purpose of this study was to investigate effect of spectacle correction therapy instead of occlusion therapy for refractive amblyopia treatment. Spectacle correction were prescribed to give the same effect as a occlusion therapy by under correction for normal eye and there was no additional treatment but only spectacle correction for hyperopic amblyopia. The results can be summarized as follows: 1. In hyperopic amblyopia after correction, initial visual acuity($Mean{\pm}SD$) was $0.36{\pm}0.13$ and final visual acuity($Mean{\pm}SD$) was $0.82{\pm}0.23$. 2. Regardless with age, there was significant differences between initial acuity and final acuity, it shows improvement in visual acuity after spectacle correction treatment. 3. Initial correction age did not influence the length of treatment and success rate of treatment, so that ambyopia correction effect not related with age. 4. Compared with initial visual acuity with final visual acuity, initial visual acuity was in proportion to final visual acuity. 5. Incidence was higher in hyperopia and hyperopic astigmatism than myopia and myopic astigmatism in refractive amblyopia group and the therapy was more effective for hyperopia and hyperopic astigmatism than myopia and myopic astigmatism. 6. Treatment was effective even for children who is older than 8 years.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.93-103
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• 2006

소비자의 하이테크 서비스 가입 이후 행태를 살펴보면, 가입자들은 서비스를 실제로 사용하기도 전에 가입 해지결정을 내리기도 한다. 최근 미국의 기간통신회사에서 출시된 인터넷전화 서비스의 경우, 출시 후 1년 반 동안 이탈한 고객 중 무려 60%정도가 서비스를 실제로 사용하기 전 상태인 네트워크 및 시스템이 준비되는 동안이나 소비자가 가정에서 전화기 연결용 어댑터를 설치하는 단계에서 이탈한 것으로 나타났다. 이와 같은 가입초기 고객의 이탈은 기업에게 고객획득과정에서 지출된 마케팅비용의 손실 및 미래의 매출감소뿐만 아니라, 기 가입자를 통한 미래의 가입 희망자에게 미칠 수 있는 긍정적 구전효과와 같은 간접효과에 대한 손실을 의미한다. 하지만 하이테크 서비스에 대한 소비자의 가입 후 행태에 대한 기존연구는 고객불평 연구, 서비스 사용 후 발생하는 정상적 이탈행태(normal churn)에 대한 연구, 또는 탐색적 연구를 제외하면 매우 부족하다. 더욱이 하이테크서비스의 특성을 고려한 서비스 출시초기에 소비자의 가입직후 해지결정에 대한 결정요인 연구는 그 필요성에 비해 연구가 전무하다시피한 실정이다. 본 연구에서는 하이테크 서비스에 대한 소비자의가입시점과 실제 사용시점 사이에 발생하는 소비자의 이탈행태를 이탈시점에 따라 '가입직후 이탈(immediate churn)' 과 '가입 후 이탈(earlychurn)'로 정의한 후, 특히 가입직후 고객의 이탈행태를 설명하기 위해 하이테크 서비스에 대한 소비자의 이전 사용경험정도와 서비스에 대한 정보를 획득한 채널의 정보전달 풍부성 등을 연구모형에 포함하였다. 이 기간 동안에 기업은 서비스 제공에 필요한 부수적인 기기 제공 및 서비스 준비 등을 수행하지만, 동시에 소비자는 여러가지 이유로 가입결정을 제고할 수도 있게 된다. 제안된 연구모형에 대한 실증분석을 위해 미국 유수의 기간통신회사에서 2004년 출시된 인터넷전화(Voice over Internet Protocol: VoIP)서비스에 가입한 12,000여명 의 고객 프로파일과 서비스사용 데이터를 활용하였다. 분석결과 가입자의 하이테크 서비스에 대한 사용경험정도가 낮을수록 서비스 가입직후 바로 해지하는 경향을 보였다. 하지만 하이테크 서비스에 대한 이전 사용경험이 낮은 경우라도, 가입 후서비스를 실제로 사용하였다면 서비스에 대한 가입해지 경향은 더 이상 나타나지 않았다. 이는 가입자의 하이테크 서비스에 대한 이전 사용경험정도가 가입직후 해지에만 영향을 미치는 요인임을 보여준다. 또한 매체의 정보전달 풍부성 (media richness)이 상대적으로 높은 소매점이나 웹사이트를 통해 서비스에 가입한 소비자일수록 가입 직후뿐만 아니라 서비스사용 이후에도 낮은 해지성향을 나타냈다. 이러한 분석결과를 바탕으로 인터넷전화 서비스에 적합한 고객지원 프로그램 설계와 마케팅 매체선정과 관련한 전략적 시사점을 도출한다. 그리고 국내에서 최근 이슈가 되고 있는 차세대 무선인터넷 서비스인 와이브로 출시에 따른 마케팅 및 고객관리와 관련된 시사점을 논의한다.

• Journal of Chest Surgery
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• v.37 no.7
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• pp.570-577
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• 2004

CT angiography is now available to evaluate the early graft patency after coronary bypass surgery. We investigated whether patency or occlusion of the bypass grafts can be visualized by CT angiography and what factors effect the visuality. Material and Method: Fifty patients underwent scanning with a 4-slice computed tomographic scanner (Somatom Volume ZoomTM; Siemens, Germany) before being discharged after coronary artery bypass grafting. To evaluate graft patency and relationship between the quality of graft image and the characteristics of the diseased coronary vessels, 50 internal thoracic artery grafts, 18 radial artery grafts, and 56 vein grafts were included in this study. Result: All vein grafts (24 grafts; 32 anastomoses) to left coronary artery system were well visualized, but 3 grafts (4.7%) of 30 vein grafts (35 anastomoses) to right coronary artery system were not visualized. The latter was also occluded in invasive coronary angiographic study. Thirty-nine (78%) internal thoracic artery grafts were well visualized, 8 (16%) faintly visualized, and 3 (6%) not visualized, but all the internal artery grafts were well patent in invasive coronary angiographic study. Conclusion: Unvisualized vein grafts in CT angiography means occlusion of the grafts, but unvisualized arterial grafts in CT angiography may not mean occlusion of the graft but result from competitive flow between the graft and coronary artery. To confirm patency of the unvisualized arterial grafts, invasive coronary angiography is needed.