• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.5
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• pp.242-250
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• 2013

In this paper, R-wave detection algorithm using refractory period to reflect the depolarization and repolarization of the myocardial cells of the heart is proposed. The proposed algorithm detects R-peaks using the features of R-wave and variable refractory period. First, the proposed algorithm extracts candidate R-peaks that have a relatively high potential and calculates the refractory period based on the kurtosis and potential for candidate R-peaks. Next, R-peak is determined by morphological features of the R-wave within the refractory period. In addition, due to less computation in the proposed algorithm, real-time processing is possible. The algorithm is applied to all records of the MIT-BIH arrhythmia database and the obtained results show a competitive detection rate of over 99.7%.

• Journal of Advanced Marine Engineering and Technology
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• v.41 no.3
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• pp.182-190
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• 2017

All liquids contain a small amount of gaseous components and the amount of gases dissolved in a liquid is in accordance with Henry's Law. In a multi-stage thermal-type seawater desalination plant, as the supplied seawater undergoes variations in temperature and pressure in each evaporator, the gases dissolved in the seawater are discharged from the liquid. The discharged gases are carbon dioxide, nitrogen, oxygen, and argon, and these emitted gases are non-condensable. From the viewpoint of convective heat transfer, the evaluation of non-condensable gas released during a vacuum evaporation process is a very important design factor because the non-condensable gases degrade the performance of the cooler. Furthermore, in a thermal-type seawater desalination plant, most evaporators operate under vacuum, which maintained through vacuum system such as a steam ejector or a vacuum pump. Therefore, for the proper design of a vacuum system, estimating the non-condensable gases released from seawater is highly crucial. In the study, non-condensable gases released in a thermal-type seawater desalination plant were calculated quantitatively. The calculation results showed that the NCG releasing rate decreased as the stage comes getting a downstream and it was proportional to the freshwater production rate.

• Journal of Advanced Marine Engineering and Technology
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• v.24 no.1
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• pp.25-30
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• 2000

In present paper, mass transfer over a flat plate with film condensation including noncondesable gas is analyzed with the help of similarity methods. Couette flow was assumed in liquid film and boundary-layer approximation was used in the ambient flow. Governing equations were transformed into the ordinary differential equtions by the similarity methods. Runge-Kutta and shooting method were used in order to fine the effect of mass transfer on the velocity and concentrations at the liquid-vapor interface.

• Pediatric Infection and Vaccine
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• v.21 no.3
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• pp.225-230
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• 2014

Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.

• Journal of the Korea Society of Computer and Information
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• v.18 no.1
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• pp.93-101
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• 2013

The accurate detection of R-wave is important for other feature extraction in ECG, and R-wave has a lot of medical information about heart. Numerous R-wave detection algorithms have been studied on the ECG signal shape analysis, but it was difficult to find accurate R-wave when the shape of R-wave is similar to the shape of P-wave. This paper presents an R-wave detection method based on the refractory period that is the period of depolarization and repolarization of the cell membrane after excitation. And we also use the shape of kurtosis in the refractory period. The proposed method is validated using the ECG records of the MIT-BIH arrhythmia database. Experimental results show that the proposed method significantly outperforms other method in case of 105 and 108 record that have R-wave similar to P-wave, as well as other records.

• Korean Journal of Biological Psychiatry
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• v.2 no.1
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• pp.131-139
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• 1995

Clozapine, on atypical antipsychotic drug, has been estimated to be a major improvement in the treatment-refractory schizophrenic patients. We evaluated the clozapine efficacy in the treatment of schizophrenic patients who are refractory to classic neuroleptics. The patients were assigned in a prospective, open, comparative trial for 12 weeks. Following an dose titration, 33 inpatients with treatment-refractory schizophrenia diagnosed according to DSM-III-R were given a clozapine(N=17, approximate 300-600mg/day) or haloperidol(N=16, approximate 20-30 mg/day) for 12 weeks. The clinical state was assessed before treatment, and 1st, 4th, 8th and 12th week during treatment using Brief Psychiatric Rating Scale(BPRS) and Positive and Negative Syndrome Scale(PANSS). Assessment of side effects were mode weekly using Simpson-Angus Scale for Extrapyramidal Side Effects and Adverse Events-Somatic Symptoms. Clozapine produces significant improvement than haloperidol on the BPRS and PANSS scores. 77% (13/17) of the clozapine-treated patients were categorized as responders, who showed at least 20% decrease in total BPRS scores, compared with 31% (5/16) of haloperidol-treated patients. Extrapyramidal side effects occurred in only one patient in clozapine group, but nine patients in haloperidol group. Salivation, sleepiness, constipation and hypotension were most frequent adverse effects observed in clozapine group. There was no significant changes in total WBC and neutrophil during clozapine treatment. These findings suggest that clozapine is on effective antipsychotic drug for the Korean treatment-refractory schizophrenic patients, who are nonresponsive to or unable to tolerate classcal antipsychotic drugs due to extrapyramidal side effects.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.180-187
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• 2008

Purpose : We wanted to determine the characteristics of patients with Kawasaki disease (KD) who were unresponsive to intravenous immunoglobulin (IVIG). Methods : The patients with KD were divided into two groups: the IVIG responsive group (25 cases) and the IVIG unresponsive group (14 cases). We analyzed various parameters before and after the administration of IVIG, including the complete blood cell count with the differential count (%), the erythrocyte segmentation rate (ESR), the C-reactive protein (CRP) level and the protein and lipid profiles. Results : The IVIG unresponsive group had a prolonged duration of fever and a higher incidence of CAL compared to the IVIG responsive group (P<0.001, respectively). Before IVIG infusion, the neutrophil differential, the ESR and the CRP values were higher (P<0.001), and the total protein and albumin values were lower in the IVIG unresponsive group (P=0.01) compared to the IVIG responsive group. After IVIG infusion, there were no significant changes in the WBC count and CRP levels in the IVIG unresponsive group. The reduction of the HDL-cholesterol levels by IVIG was more significant in the unresponsive group (P=0.02). Conclusion : A more severe and prolonged inflammatory response occurred in the IVIG unresponsive group at an early stage, and this finding can be detected by such inflammatory parameters as the neutrophil count and the CRP and HDL-cholesterol levels after IVIG infusion.

• Bulletin of Korea Environmental Preservation Association
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• v.21 no.11_12
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• pp.41-44
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• 1999

• 발명특허
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• v.13 no.4 s.146
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• pp.19-19
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• 1988

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.4
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• pp.510-518
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• 1996

The study presents experimental and theoretical analysis focusing on the infulence of a noncondensable gas upon the absorption enhancement that is obtained by Marangoni convection generated by the addition of the surfactant. The shadowgraph method is adopted in this visualization. As a result of absorption phenomena with shadowgraph photos, the different patterns of Marangoni convection cells are observed in accordance with the various amounts of noncondensable gas. Furthermore, non dimensional number K(Ma/Ra) is introduced to calculate the value of surface tension difference theoretically for the comparison with the various amount of non condensable gas in absorber.