• Journal of Convergence for Information Technology
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• v.11 no.6
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• pp.154-161
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• 2021

This study analyzed the characteristics of the presence of multiple chronic diseases (MCDs) in older adults who transferred from long-term care hospitals (LTCHs) to emergency departments (EDs). According to the data from the national emergency department information system from January 1, to December 31, 2019, the number of older adults transferred from LTCHs to the ED due to chronic diseases was 13,608. Among those who MCDs, 79.9% were over 75 years old, and 74.0% were hospitalized for MCDs. The length of stay in the ED differed according to the presence of MCDs (P<0.001). As for the prevalence of MCDs, the odds ratio (OR) of the ED and in the hospitalized patients was high in Gwangju (OR 8.899 vs. 8.142) and Jeonbuk (OR 13.865 vs. 10.676). As described above, the characteristics of patients regarding the presence of MCDs varied according to age and region.

• Clinical and Experimental Pediatrics
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• v.51 no.8
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• pp.886-891
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• 2008

Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud's phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.

• Journal of the Korea Convergence Society
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• v.10 no.8
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• pp.75-82
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• 2019

Many people suffers from multiple chronic diseases, leading cause of death and disability in the world. The purpose of this study was to investigate factors affecting multiple chronic diseases, hypertension, and diabetes. We analyzed the data of one metropolitan city of community health survey, 2015. 4,590 citizens were enrolled in this study. Prevalence of multiple chronic diseases, hypertension, and diabetes were 5.14%, 16.8%, and 3.89%, respectively. Educational attainment, income, salt intake, and BMI were identified as independent risk factors associated with multiple chronic diseases. Educational attainment, income, salt intake were significantly associated with hypertension and age, educational attainment, frequency of alcohol drinking, salt intake were associated with diabetes. Multiple chronic diseases, hypertension, and diabetes were associated with sociodemographic, economic, and health behavioral factors. We should consider these variables in the prevention and management programs and policies for patients with multiple chronic diseases.

• Journal of the Korea Society of Computer and Information
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• v.15 no.11
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• pp.215-224
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• 2010

Most chronic diseases are complex diseases which are caused by interactions of several genes. Studies on finding SNPs and gene-gene interactions involved in the development of complex diseases can contribute to prevention and treatment of the diseases. Previous studies mostly concentrate on finding only the set of SNPs involved. In this study we suggest a way to see how these SNPs interact using boolean expressions. The proposed method consists of two stages. In the first stage we find the set of SNPs involved in the development of diseases using mutual information based on entropy. In the second stage we find the highest accuracy boolean expression that consists of the SNP set obtained in the first stage. We experimented with clinical data to demonstrate the effectiveness of the proposed method. We also compared the differences between our method and the previous results on the SNP associations studies.

• Journal of Digital Convergence
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• v.13 no.12
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• pp.245-257
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• 2015

This study was to develop the predictive model for severity-adjusted mortality of inpatients with multiple chronic conditions and analyse the factors on the variation of hospital standardized mortality ratio(HSMR) to propose the plan to reduce the variation. We collect the data "Korean National Hospital Discharge In-depth Injury Survey" from 2008 to 2010 and select the final 110,700 objects of study who have chronic diseases for principal diagnosis and who are over the age of 30 with more than 2 chronic diseases including principal diagnosis. We designed a severity-adjusted mortality predictive model with using data-mining methods (logistic regression analysis, decision tree and neural network method). In this study, we used the predictive model for severity-adjusted mortality ratio by the decision tree using Elixhauser comorbidity index. As the result of the hospital standardized mortality ratio(HSMR) of inpatients with multiple chronic conditions, there were statistically significant differences in HSMR by the insurance type, bed number of hospital, and the location of hospital. We should find the method based on the result of this study to manage mortality ratio of inpatients with multiple chronic conditions efficiently as the national level. So we should make an effort to increase the quality of medical treatment for inpatients with multiple chronic diseases and to reduce growing medical expenses.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.497-504
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• 2015

As we enter the era Convergence, commercialized convergence contents aimed at the disabled are giving a lot of help to them. This fusion research is aimed at providing necessary basic data and practical measures for these by analyzing the effect of influencing the quality of life for women with disabilities. This research was conducted with 250 disabled women living in Jeon-nam region from Jan,1 through April, 25 in 2015. After screening women aged 20-80 who had symptoms and musculoskeletal disorders and were using convergence contents, convergence projects were implemented with total 125 patients over 16 weeks. The result of the convergence projects showed that most of these experieced the decrease of musculoskeletal pain, the decrease of depressed levels, and the improvement of quality of life. Future studies should be done in terms of a long-term perspective and continuing support, and follow-up studies should also be done to evaluate its effectiveness.

• The KIPS Transactions:PartB
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• v.15B no.4
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• pp.323-330
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• 2008

Since complex diseases are caused by interactions of multiple genes, traditional statistical methods are limited in its power to predict the onset of a complex disease. Recently new approaches using machine learning techniques are introduced. Neural nets are a suitable model to find patterns in complex data. When large amount of data are fed into a neural net, however, it takes a long time for learning and finding patterns. In this study we suggest a new model that combines the set association, which is a statistical technique to find important SNPs associated with complex diseases, and neural network. We experiment with SNP data related to asthma to test the effectiveness of our model. Our model shows higher prediction accuracy and shorter execution time than neural net only. We expect our model can be used effectively to predict the onset of other complex diseases.

• Journal of Digital Convergence
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• v.11 no.1
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• pp.431-439
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• 2013

This thesis is to research the before and after changes of physical configurations, blood components and physical strength for normal and geriatric diseased senior citizens at the end of 24 week of combined exercises constructed of aerobic and muscular strength training to create most suitable and effective complex exercise program for geriatric diseased patients. For this experiment 20 normal and 20 geriatric diseased patients in the age of 65 residing in "K" city were selected to carry out the 24 weeks of combined exercises in regularly. The result of the research showed that geriatric patients increased significantly in everything, but normal group showed significant change in only WHR. There was a slight improvement in the blood components for the average participants but it only differed slightly from the diseased participants so there were no major changes reflecting the outcomes from both before and after. After concluding the program both groups displayed positive improvements in stamina but no significant alterations in physical strength., agility, muscle endurance and balance. The positive factors for each groups could be that the norms were able to maintain their health and enhancement in stamina and diseased were able to prevent their condition from worsening. Additionally, over 50 percent of all senior citizens have one or more geriatric diseases but the participation of any physical activity is in the decrease. Henceforth, this is a field that still needs a lot of work and combined exercise programs should be created and followed through so it may enhance in the improvement of health and quality of life as well.

• Journal of agricultural medicine and community health
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• v.34 no.3
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• pp.334-345
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• 2009

Objectives: This study was performed to investigate the management status of chronic disease at community health centers. Methods: The study subjects were 450 employed persons at community health centers in Jeonlanamdo. General characteristics, status of chronic disease management and health education were collected for statistical analysis. The differences on management status among working areas were assessed with chi-square test and ANOVA. Results: The mean values of work duration were 18.7 years in rural, 14.4 years in fishing village, and 17.4 years in urban-rural, respectively. The number of management registration was highest in hypertension. The ways of disease management were medication check-up, diet stopping smoking. The contents of group health education were exercise, diet and prohibition of smoking. The place of health education was town assembling hall. The fields which officials wanted to be educated were symptom, diagnosis, treatment and complication. The most important field was early detection of chronic disease patients and health education. Finally, the field requiring support was work standardization. Conclusions: Community health workers have worked positively in chronic disease management. The barriers to work were the lack of professional and preliminary data. The support system with other health organ and health education were needed for the improvement of working ability.

• Journal of the Korean Applied Science and Technology
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• v.41 no.2
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• pp.459-471
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• 2024

In modern society, where tension and stress are ubiquitous, individuals often experience psychological imbalances. These stressors not only affect mental well-being but also manifest physically, through the skin. Consequently, a new term psychodermatology combining psychiatry and dermatology, has emerged, garnerning attention and research focus. In this study, we aimed to develop materials improving chronic skin conditions caused by stress by utilizing a compound of Cucurbita moschata, Paeonia japonica, and Prunus cerasus known to alleviate skin disorders. We sought to develop and validate the efficacy of materials alleviating chronic skin conditions induced by stress in keratinocytes..Therefore, in this study we analyzed the effects of a complex extract using Cucurbita moschata, Paeonia japonica, and Prunus cerasus on HaCaT keratinocyte cells to understand how it influences them. The complex extract on HaCaT keratinocyte cells showed a concentration-dependent decrease in the expression levels of TNF-α, IL-1β, IL-6, MDC, and TARC at concentrations of 12.5, 25, 50 and 100 ㎍/mL. Particularly noteworthy was the efficacy observed in inhibiting IL-1β, with a reduction of over 40% at a concentration of 100 ㎍/mL. Additionally, the production levels of AQP-3, HA, and filaggrin exhibited a significant concentration-dependent increase. The protein expression of p-ERK, p-JNK, and p-p38, which were elevated by TNF-α/IFN-γ, was significantly decreased with the treatment of the complex extract. These findings suggest that the compound extract may be utilized as a material for treating and preventing skin conditions, potentially mitigating the adverse effects of the mutual relationship between skin disorders and stress.