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http://dx.doi.org/10.3345/kjp.2008.51.8.886

A case of mixed connective tissue disease presenting initially with Raynaud's phenomenon  

Kim, Soo Young (Department of Pediatrics, School of Medicine, Chonnam National University)
Choi, Young Seok (Department of Pediatrics, School of Medicine, Chonnam National University)
Kim, Young Ok (Department of Pediatrics, School of Medicine, Chonnam National University)
Woo, Young Jong (Department of Pediatrics, School of Medicine, Chonnam National University)
Publication Information
Clinical and Experimental Pediatrics / v.51, no.8, 2008 , pp. 886-891 More about this Journal
Abstract
Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud's phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.
Keywords
Mixed connective tissue disease; Raynaud's phenomenon; Antibody to ribonucleoprotein;
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Times Cited By KSCI : 1  (Citation Analysis)
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