• The Journal of Internal Korean Medicine
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• v.32 no.4
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• pp.599-609
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• 2011

Objectives : The aim of this study was to evaluate the single oral dose toxicity and safety of Bojungikgi-tang (Buzhongyiqi-tang) and fermented Bojungikgi-tang (Buzhongyiqi-tang) extracts in male and female ICR mice. Methods : In the single oral dose toxicity study, non-fermented and fermented Bojungikgi-tang (Buzhongyiqi-tang) were administered to male and female ICR mice as an oral dose of 1250, 2500 and 5000 mg/kg. Changes of body weights, general behaviors, adverse effects and mortality were determined throughout the experimental period. Hematological parameters, serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There was no mortality or sign of toxicity in the single oral dose toxicity study. There were also no significant differences in body weights, organ weights, and hematological parameters, serum chemistry values between treatment and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of fermented Bojungikgi-tang (Buzhongyiqi -tang) in both female and male mice can be considered as well over 5,000 mg/kg, so these medicines can be safe in clinics.

• The Journal of Internal Korean Medicine
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• v.36 no.3
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• pp.391-399
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• 2015

Objectives This case series reports the efficacy of Baenong Ickki San, a Bojungikki-tang -modified formula, in treating chronic prostatitis/chronic pelvic pain syndrome. Methods Patients diagnosed with chronic prostatitis/chronic pelvic pain syndrome (n=11) were treated with Baenong Ickki San. Changes in their condition were measured using the National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI). Results NIH-CPSI scores showed a significant improvement in the disease. The mean NIH-CPSI total score significantly decreased from 37.6±5.8 at baseline to 7.5±3.9 at end point (p<0.001), i.e., a 30.2±7.3 mean decrease was noted. Conclusions Baenong Ickki San may be a potential new medicine for chronic prostatitis/chronic pelvic pain syndrome.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.590-595
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• 2005

The following conclusions are produced by the consideration of Bojungikki-tang(補中益氣湯) from the view point of Hyungsang medicine. A review on the explanation and provisions of Bojungikki-tang stipulated in 'Donguibogam(東醫寶鑑)' results in the idea that the main purpose of Dongwon(東垣) and various application in clinic by Jeesan(芝山) cannot be understood without the deep comprehension of ki(especially Jungki and Wonki) and the fire. Jungki(中氣, the middle warmer ki) is the ki of stomach. Wonki(元氣, the original ki) is a combination of innate Jung(先天之精, Ki stored between the two kidneys) and acquired Jung(後天之精, Ki of the stomach) and the sources of five Jang and six Bu, twelve meridians and triple warmer. Yin fire is referred to the ministerial fire of spleen, liver and kidney. Excess or lack of the ministerial fire can cause a disease and especially the excess of it is harmful to original ki. Deficiency of original ki is thought to be a cause of allergic diseases. Damages on the original ki by the abdominal surgery lead to a disease. Pale complexion, long face and the long limbs are considered as the Hyungsang of deficiency of Jung ki by Jeesan. Clinical cases of Bojungikki-tang in Hyungsang medicine draw the following conclusions ; Bojungikki-tang is usually prescribed to the person who has one of the following Hyungsang : Bangkwang type, pale complexion, long face, short-sight, astigmatism and wrinkles on face. Bojungikki-tang can be applied to the every disease caused by the deficiency of original ki regardless of name and symptoms of disease.

• Journal of Sasang Constitutional Medicine
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• v.25 no.4
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• pp.396-405
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• 2013

Objectives The purpose of this study was to evaluate the effects of Soeumin's Bojungikgi-tang, which is based on the Sasang constitutional medicine, for the patient who has suffered from Urinary Disturbance. Methods A 29 year-old woman who suffered from Urinary Disturbance but had no significant organic lesion, was enrolled in this study. The patient had the symptoms including urinary incontinence, pollakiuria, painful urination, discomfort after urinating, general body weakness, chilling sign, and abdominal pain. We diagnosed her as Soeumin Yang Depletion pattern and treated with Soeumin's Bojungikgi-tang. Results After 12 days of admission treatment with Soeumin's Bojungikgi-tang, remarkable improvement was seen on her total number of urination and the Qualiveen Questionnaire score. Conclusions This clinical case indicates that Soeumin's Bojungikgi-tang is effective in treatment of a Soeumin Mang-yang Syndrome, including Urinary Disturbance.

• The Journal of Internal Korean Medicine
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• v.38 no.2
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• pp.235-239
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• 2017

This case study describes the effect of Bojungikki-tang on chemotherapy-induced alopecia. Alopecia is a well-documented cause of distress to patients undergoing cancer treatment, but no approved pharmacological treatment exists for chemotherapy-induced hair loss. A 70-year-old female diagnosed with a cholangiocarcinoma and liver metastasis received chemotherapy, including gemcitabine and cisplatin, every three weeks. As a result of the continuous chemotherapy, she suffered various toxicity-related side effects, including bone marrow suppression, general weakness, nausea, peripheral numbness, and hair loss. Bojungikki-tang was initially administered to improve the patient's general weakness and fatigue. After three months of treatment, the patient's hair loss and general condition improved, and the color of the new hair was dark, despite the chemotherapy. The treatment did not improve other symptoms, such as bone marrow suppression and peripheral numbness. This case suggests that Bojungikki-tang could have a beneficial effect on chemotherapy-induced alopecia.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.2
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• pp.191-197
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• 2008

Objective : This study is to investigate the effect of Bojoongikki-tang on Acne patients Methods : We treated 3 acne patients diagnosed as the deficiency of Qi with Bojoongikki-tang(Buzhongyiqitang), comedon extraction by needle and stamp acupunctures. After treatments we compared the before and after photos, and estimated by Korean Acne Grading System(KAGS1-4). Results & Conclusions : After taking Bojoongikki-tang(Buzhongyiqi-tang) and extruding comedones by needle, the acne was improved. After stamp acupuncture, the acne scar was improved. This study shows that the acne can possibly be diagnosed as the deficiency of Qi. So further studies are needed continuously.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.784-789
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• 2010

Syndrome of asthenia of spleen gi usually caused by improper diet, overstrain, emotional upsets, followed by syndrome of sinking of splenic gi. There are several pathologic categories of splenic gi deficiency syndrome. These include failure to nourish the body, failure to astringe liquid substances, failure of splenic gi to rise, gi stagnation in which gi can't disperse normally, failure of transportation. In the splenic gi deficient situation, body fluid is usually stagnated because the rest of the water absorbed from the food is transported to every part of the body by the action of splenic gi. In addition, there is abnormal sinking of clear gi, followed by fever due to gi deficiency. Bojungikgi-tang is composed of restoratives which are invigorating splenic gi and herbs which uplift splenic gi. It is mainly applicable to splenic gi deficiency syndrome accompanied by gi stagnation and fluid accumulation.

• Korean Journal of Pharmacognosy
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• v.15 no.3
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• pp.115-120
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• 1984

'Bojungikgi-tang' consists of Astragali Radix, Ginseng Radix, Atractylodis Rhizoma alba, Glycyrrhizae Radix, Angelicae gigantis Radix, Aurantii nobilis Pericarpium, Cimicifugae Rhizoma and Bupleuri Radix. It has been widely prescribed in oriental medicine for controlling digestive functions and for health. Experimental studies were implemented on analgesic, sedative and antipyretic actions. The results showed significant analgesic and antipyretic actions were recognized. Sedative actions were significantly noted.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.233-241
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• 2006

Background : Bojungikgitang is a typical prescription that helps to replenish the spleen and stomach, and its effect proved positive on allergic rhinitis by experiment. But there is only a few clinical thesis on allergic rhinitis to which Bojungikgitang was administered. Objective : The prevalence of allergic rhinitis appear to be increasing. The experimental study on allergic rhinitis has occasionally been reported, but the clinical study on various cases on treatment of using herbal medicine is not many. The aim of this study was to investigate effect of Bojungikgitang-Gamibang on allergic rhinitis. Methods : The treatment effect was analyzed over fifty patients who visited and had treatment with Bojungikgitang-Gamibang on allergic rhinitis in the hospital of Sangji University from June, 2003 to September, 2005. Result : After we analyzed 50 cases of allergic rhinitis by administering Bojungikgitang-Gamibang, we concluded that the shorter duration of disease and high dosage were the main factors which improved the symptoms effectively. Conclusion : Bojungikgitang-Gamibang was the effective treatment of allergic rhinitis.

• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.205-212
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• 2005

Korea has recently seen reduction in Gihyeolbujog(氣血不足)-related woman disease due to low birth rate and elevated nutritional intake. In particular Uterine Prolapse usually result from malnutrition in days of need and also from earlier resumption of social activity after childbirth. Nowadays some women still develop Uterine Prolapse, of which the reasons are earlier resumption of social activity after childbirth, malnutrition due to harsh diet, contaminated food, and Gihyeolbujog by stress. This research has determined that GamibojungiggiTang would be effective for the treatment of those diseases. This research found that the combination of BojungiggiTang with Sugjihwang(熟地黃)and Noggaggyo(鹿角膠), which were used for Sinsubujog(腎水不足) and IghyeolbojeongJe(益血保定劑). Respectively, produced satisfactory treatment outcomes for prolapse.