• Journal of Periodontal and Implant Science
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• v.24 no.1
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• pp.26-38
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• 1994

The purpose of this study was to evaluate the effects of citric acid and fibrin on the regeneration of periodontal tissues using 4 normal canines of five dogs. Mucoperiosteal flap was raised and experimental defects were made at the buccal root surfaces about $4{\times}6mm$ in length. The denuded root surfaces were covered using coronally repositioning technique after root planing alone at left lower canine, root planing plus fibrin at rigth lower canine, root planing plus citric acid at left upper canine or root planning plus citric acid and fibrin at right upper canine. All of the specimens were tangentially cut(about $3-5{\mu}m$)and available for histologic analysis 1, 3, 7, 14 and 21 days after operations. The results were as follows : At one' day after operations, the amounts of fibrin were similarly higher in the group I, II and III than control group and at 3 days after operations, the apical migrations of the long junctional epithelium were prominent in the control group and group I. At 7 days after operations, the fibrin meshworks of each group were partly changed to the collagen fibers and characteristics of the fibers were almost collagenous rather than fibrinous at 14 days after operations and at 21 days after operations, the orientation of collagen fibers were partly normal in group II and group III, but not in control group and group I. Root resorptions were visible in group II and group III at 14 days after operations and more significant in group II than group III at 21 days.

• Radiation Oncology Journal
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• v.19 no.3
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• pp.237-244
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• 2001

Purpose : To assess the tolerance, complete response rate, bladder preservation rate and survival rate in patients with muscle-invading bladder cancer treated with selective bladder preservation protocol. Method and Materials : From October 1990 to June 1998, twenty six patients with muscle-invading bladder cancer (clinical stage T2-4, N0-3, M0) were enrolled for the treatment protocol of bladder preservation. They were treated with maximal TURBT (transurethral resection of bladder tumor) and 2 cycles of MCV chemotherapy (methotrexate, crisplatin, and vinblastine) followed by $39.6\~45\;Gy$ pelvic irradiation with concomitant cisplatin. After complete urologic evaluation (biopsy or cytology), the patients who achieved complete response were planed for bladder preservation treatment and treated with consolidation cisplatin and radiotherapy (19.8 Gy). The patients who had incomplete response were planed to immediate radical cystectomy. If they refused radical cystectomy, they were treated either with TURBT followed by MCV or cisplatin chemotherapy and radiotherapy. The median follow-up duration is 49.5 months. Results : The Patients with stage T2-3a and T3b-4a underwent complete removal of tumor or gross tumor removal by TURBT, respectively. Twenty one out of 26 patients $(81\%)$ successfully completed the protocol of the planned chemo-radiotherapy. Seven patients had documented complete response. Six of them were treated with additional consolidation cisplatin and radiotherapy. One patient was treated with 2 cycles of MCV chemotherapy due to refusal of chemo-radiotherapy. Five of 7 complete responders had functioning tumor-free bladder. Fourteen patients of incomplete responders were further treated with one of the followings : radical cystectomy (1 patient), or TURBT and 2 cycles of MCV chemotherapy (3 patients), or cisplatin and radiotherapy (10 patients). Thirteen patients of them were not treated with planned radical cystectomy due to patients' refusal (9 patients) or underlying medical problems (4 patients). Among twenty one patients, 12 patients $(58\%)$ were alive with their preserved bladder, 8 patients died with the disease, 1 patient died of intercurrent disease. The 5 years actuarial survival rates according to CR and PR after MCV chemotherapy and cisplatin chemoradiotherapy were $80\%\;and\;14\%$, respectively (u=0.001). Conclusion : In selected patients with muscle-invading bladder cancer, the bladder preservation could be achieved by MCV chemotherapy and cisplatin chemo-radiotherapy. All patients tolerated well this bladder preservation protoco. The availability of complete TURBT and the responsibility of neoadjuvant chemotherapy and chemoradiotherapy were important predictors for bladder preservation and survival. The patients who had not achieved complete response after neoadjuvant chemotherapy and chemoradiotherapy should be immediate radical cystectomy. A randomized prospective trial might be essential to determine more accurate indications between cystectomy or bladder preservation.

• Radiation Oncology Journal
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• v.16 no.1
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• pp.35-41
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• 1998

Purpose : To investigate the role of adjuvant chemoradiotherapy in adenocarcinoma of the rectum, we retrospectively compared the treatment results between postoperative adjuvant radiotherapy alone and combined chemoradiotherapy. Material and Methods : From October 1989 to May 1994, 141 patients with rectal carcinoma were treated by postoperative adjuvant therapy in Yonsei Cancer Center. Sixty eight patients were treated by radiation therapy alone. Seventy three patients were treated by combined chemoradiotherapy. Radiation therapy was delivered with 10 MV linear accelerator, 180cGy fraction/5 days per week. Total radiation doses were 5400cGy in the postoperative radiotherapy alone group. Three to twelve cycles of Fluorouracil(mean dose $393.9mg/m^2$) with Leucovorin($20mg/m^2$) and 5040cGy of radiation were delivered in the combined chemoradiotherapy group. Third and 4th cycle of chemotherapy were administrated during the radiation treatment in the combined group. The median follow up was 38 months with a range of 3 to 81 months. Results : The 5 year overall survival rate of radiation alone group and combined group were $60.1\%$ and $66.3\%$, respectively. The 5 year disease free survival rate of radiation aione group and combined group were $54.2\%$ and $65.5\%$, respectively There was no significant difference of overall survival and disease free survival between RT alone group and combined group(p<0.05). But the 5 year Local failure free survival rate of combined group was significantly better than radiotherapy alone group($05.8\%\;vs.\;50.3\%.\;p=0.04$). Conclusion : There was no significant difference in overall survival, disease free survival, and distant metastasis free survival between postoperative adjuvant radiotheray alone group and combinded chemoradiotherapy group. Only the Local failure free survival rate was superior in the combined treatment group. These results confirm the radiosensitizing effect of the chemotherapeutic agent in the combined chemoradiotherapy treatment.

• Journal of Veterinary Clinics
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• v.13 no.1
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• pp.96-101
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• 1996

면역성 용혈성 빈혈증 병견은 임상적으로 허약, 황달, 발열, 침울 및 점막창백을 나타낸다. 본 병의 진단은 구상적혈구증가증, 혈구응집반응 또는 직접적 Coomb시험 양성반응을 확인함과 동시에 용혈성 빈혈의 다른 원인을 배제함으로서 확정하여야 한다. 치료방법에는 적절한 보조적 요법과 함께 면역억압제가 포함된다. 일반적으로 치료에 있어서는 일차적으로 glucocorticoids가 선택되는데 흔히 cytoxan, aziothioprin, vincristine 또는 danazole과 같은 다른 약제와 병용된다. 치료는 그 반응에 근거하여 면역억압제의 용량을 2-4주 간격으로 점차 감량하면서 6개월 또는 그 이상까지 계속한다. 면역억압제에 대한 치료반응은 지연될 수 있고 또 적혈구 보유가 골수로부터 새로운 적혈구를 유리하게될 때까지 병축을 유지시키기에 부적당할 수 있기 때문에 병축의 예후판정은 경계하여야 한다. 심급성 내지 급성 예는 일반적으로 예후가 보다더 좋지 않다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.1D
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• pp.17-23
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• 2009

Due to the rapid increase of vehicles on the street, Korean society is facing worsening traffic congestions and air pollutions. Also, the oil price pickup has led to increasing need for the use of public transportation. In particular, transfering among public transportation may be a main factor for riders who are commuting for a long distance journey. In order to ensure such connectivity, transfer stations have been actively built in Korea. However, it would be necessary to shift those vehicles, from cars to public transportations by enhancing the users' satisfaction with public transportation through strategies for minimizing the users' waiting cost by building an efficient connective system between transportation modes as well as the preparation of aforementioned transfer stations. Therefore, this study aimed to develop an algorithm for minimizing transferring passengers' waiting costs based on service intervals of linked buses within the transfer facilities. In order to adjust the service interval, we calculated the total costs, involving the wait cost of transfer passengers and bus operation costs, and produced an allocation interval, that would minimize the costs. We selected a KTX departing from Seoul station, and a No. 6014 bus route in Gwangmyeong city where it starts from the Gwangmyeong station in order to for verifying the model. Then, the transfer passengers' total waitting cost was reduced equivalent to the maximum of 212 minutes, and it revealed that the model performed very effectively.

• Journal of the Korean Magnetics Society
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• v.9 no.2
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• pp.121-126
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• 1999

This paper describes a fabrication of Fe-dispersed hydrophilic magnetic fluid and its application to oil seal in combination with the Nd-permanent magnet. The results are as follows; 1) Using silica coated iron particle of magnetization of 125.5 emu/g (at 10 kOe) and the mean particle size of 100 $\AA$, after multiple adsorption to the surface of silica coated iron particle with oleic acid ion, D.B.S. and T.M.A. ion, hydrophilic Fe-magnetic fluid [70 %(g/∝)Fe, magnetization of 52 emu/g and viscosity of 1450 cp] can be produced by dispersing the iron particle in ethylene glycol solution. 2) The oil seal apparatus consisting of six stages of Nd-permanent magnet (3200 Gauss) and Fe-magnetic fluid [70 %(g/∝) Fe] showed an excellent pressure resistance of 7400 g/$\textrm{cm}^2$ under the gap between shaft and oil seal was 0.2 mm.

• Journal of Veterinary Clinics
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• v.27 no.2
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• pp.136-141
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• 2010

The aim of this study is to investigate whether medetomidine (MED) and tiletamine/zolazepam (ZT) combination in dogs provide the sufficient analgesia during the period of the stage of surgical anesthesia determined by the response to the noxious stimuli, which were evaluated by the change of electroencephalogram (EEG) and hemodynamic values. Seven clinically healthy, adult beagle dogs were used. They were used repeatedly at interval of a week, according to a randomized design. This study had 2 experimental groups. In Group 1, dogs received $30\;{\mu}g/kg$ of medetomidine and 10 mg/kg of tiletamine/zolazepam. Both drugs were administered intramuscularly. In Group 2, dogs were medicated with the same method as in Group 1, except the pedal withdrawal reflex test was done. In Group 2, interdigital regions were grasped with a mosquito forceps for 30 seconds, every 5 min from 10 min to 45 min after ZT injection. During all recording stages, the power for each band, mean arterial pressure and heart rates were calculated. On EEG, no significant changes were observed between groups. Although mean arterial pressure and heart rate were increased 10 min after ZT injection, no significant differences were observed between groups. In conclusion, the MED and ZT anesthesia in dogs are seemed to provide a satisfactory analgesic effect during the period of surgical anesthesia based on EEG with pedal withdrawal reflex test.

• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.183-189
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• 2011

서 론: 5-FU와 cisplatin 병용항암화학요법은 국소진행성 두경부편평상피암의 유도화학요법으로 널리 사용되고 있는 요법이다. 저자들은 5-FU 대신 경구제재인 S-1을 cisplatin과 병용하는 복합항암요법의 효과와 안전성에 대해 연구하였다. 대상 및 방법: 저자들은 2007년 2월부터 2008년 12월까지 S1과 cisplatin의 복합유도화학요법을 시행받은 3/4기 구인두, 하인두, 후두, 구강 편평상피세포암 환자 52명의 치료결과를 후향적으로 분석하였다. 유도항암화학요법은 제 1일에 cisplatin(75 또는 60mg/$m^2$), 제1일부터 14일까지 S-1(40mg/$m^2$)을 1일 2회, 21일 간격으로 투여하였고 가능한 경우에는 항암방사선동시요법 또는 수술을 뒤이어 시행하였다. 결 과: 전체 52명 중 37명(71.2%)에서 부분반응을 보였으나 완전반응은 관찰되지 않았다. 2년 무진행생존율은 56.9%, 2년 전체생존율은 68.2%였다. 유도항암요법과 관련된 유해반응으로는 호중구감소증(71.2%) 및 빈혈(63.5%) 등과 같은 혈액학적 부작용이 가장 흔했다. 결 론: S-1과 cisplatin의 복합항암화학요법은 국소진행성 두경부편평상피암 환자를 대상으로 한 유도화학요법으로 적용이 가능한 것으로 판단된다.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.952-956
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• 2010

저수지에 설치된 물순환장치는 저수지 수문상황과 자연조건의 변화에 따라 유동특성이 상이하므로 연구자가 고려하는 다양한 조건에서 현장 측정하기는 불가능하다. 이런 문제를 대체하는 방안으로 전산유체유동(CFD) 모형을 적용한 모사를 실시함으로서 다양한 조건에 따른 효과를 평가할수 있게 된다. 본 연구에서는 전산유체유동을 통한 대류식 물순환장치의 유동영향범위와 수질변화 등을 평가하고, 다양한 조건에서 모사를 실시하여 최적운영방안을 도출하고 실제운영에 활용토록 하고자 한다. 수체거동을 모사하기 위해 실제 저수지를 형상화한 Domain을 3가지로 구성하였다. 첫번째는 반경 20m, 깊이 40m Domain에 물순환장치를 중앙에 설치한 것이며(D20), 두 번째는 반경 40m, 깊이 40m에 두 개의 물순환장치를 양쪽에 설치하였고(D40), 세 번째는 반경 100m, 깊이 40m로 설정(D100)하였고 양쪽에 두 개의 물순환장치를 설치한 것으로 구성하였다. CFD에 의한 개별 대류식 순환장치의 유동모사결과 D20은 시간의 경과에 따라 수온성층이 하강하는 현상이 나타났으며 이러한 결과로 판단할때 40m 간격으로 대류식 순환장치를 설치하여 운영하면 탈성층이 나타날 수 있을것으로 판단되었다. D40에 대하여 CFD에 의한 유동모사를 실시하였으며 시간의 경과에 따라 수온성층의 변화는 나타나지 않았다. 이러한 결과로 판단할때 40m 간격으로 한줄로 대류식 순환장치를 설치하여 운영하면 성층을 깨는 현상은 나타나지 않을 것으로 평가되었다. 반면 Dye테스트시 심층에서 상승한 수체는 수온성층 표면에서 수평방향으로 계속 퍼져 나가면서 옆장치에서 상승된 수체와 혼합이 활발히 이루어 지는 현상을 나타내었다. 장치간 거리가 100m인 대류식 물순환장치에 의한 유동모사시 수온성층의 변화는 전혀 나타나지 않았으며, Dye테스트시 심층에서 상승한 수체는 수온성층 위에서 수평방향으로 퍼져 나가면서 옆에서 가동되는 장치에서 상승된 수체와 혼합 현상을 나타내기는 하나 D40보다 혼합시간이 더 걸리는 것으로 나타났다.

• Clinical and Experimental Pediatrics
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• v.48 no.12
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• pp.1378-1384
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• 2005

Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy. Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n=4), ADR group(n=6), ADR+DXR group(DXR, n=5), ADR+PTX group(PTX, n=6), ADR+DXR+PTX group(DXPT, n=5). ADR(5 mg/week, twice) was administrated intravenously to rats except CNT group to induce cardiomyopathy. The PTX(50 mg/kg/day) was administered daily from day-0 to Day-21. The DXR(100 mg/kg) was administered 30 minutes before each ADR injection. On day 21, the rats were sacrificed and the degree of histopathologic changes of hypercontraction band necrosis, cytoplasmic vacuolar change and fibrosis were scored. Immunohistochemical staining for Bcl-2 expression and RT-PCR for $TNF-{\alpha}$ and CTGF were performed. Results : Histopathological scores of myocardial damage were significantly higher in ADR rats than CNT rats(P<0.05), and significantly lower in DXPT rats than ADR rats(P<0.01). Myocardial fibrosis was prevented in both PTX rats and DXPT rats. The expression of Bcl-2 was weaker in ADR rats than that in CNT rats(P<0.05), and stronger in both DXR and DXPT rats than that in ADR rats (P<0.05). $TNF-{\alpha}$ concentration of ADR rats was not different from that of treated groups. Conclusion : DXR prevented myocyte apoptosis with increased Bcl-2 expression, and PTX prevented myocardial fibrosis in ADR induced cardiomyopathic rats. The combination therapy of DXR and PTX showed prevention of cardiomyopathy in ADR induced cardiomyopathy rat model.