Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Canine Immune-Mediated Hemolytic Anemia

개의 면역성 용혈성 빈혈

  • Published : 1996.03.01
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Abstract

면역성 용혈성 빈혈증 병견은 임상적으로 허약, 황달, 발열, 침울 및 점막창백을 나타낸다. 본 병의 진단은 구상적혈구증가증, 혈구응집반응 또는 직접적 Coomb시험 양성반응을 확인함과 동시에 용혈성 빈혈의 다른 원인을 배제함으로서 확정하여야 한다. 치료방법에는 적절한 보조적 요법과 함께 면역억압제가 포함된다. 일반적으로 치료에 있어서는 일차적으로 glucocorticoids가 선택되는데 흔히 cytoxan, aziothioprin, vincristine 또는 danazole과 같은 다른 약제와 병용된다. 치료는 그 반응에 근거하여 면역억압제의 용량을 2-4주 간격으로 점차 감량하면서 6개월 또는 그 이상까지 계속한다. 면역억압제에 대한 치료반응은 지연될 수 있고 또 적혈구 보유가 골수로부터 새로운 적혈구를 유리하게될 때까지 병축을 유지시키기에 부적당할 수 있기 때문에 병축의 예후판정은 경계하여야 한다. 심급성 내지 급성 예는 일반적으로 예후가 보다더 좋지 않다.

Keywords

References

  1. Ann Intern Med v.300 Harrington. Danazol therapy for autoimmune hemolytic anemia Ahn YS
  2. J Clin Invest v.52 Effect of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes Atkinson JP;Schuber AD;Frank MM
  3. Physicians Desk Reference Barnhart ER
  4. J Am Vet Assn v.173 Cold agglutination hemolytic anemia and Hemobartonella Canis infection in a dog Bellamy J(et al)
  5. Br J Haematol v.8 Microangiopathic hemolytic anemia. The possible role of vascular lesion pathogenesis Brain Mc(et al)
  6. J Pediatrics The acute and transient nature of idiopathic immune hemolytic anemia in children Buchanan GR;Boxer LA;Nathan DC
  7. J Am Anim Hosp Assoc v.13 Autoimmune hemolytic disease and other cause of immune mediated anemia. An overview Dodds WJ
  8. Textbook of Veterinary Internal Medicine, (5th ed) Ettinger SJ;Feldman EC
  9. J. Am Vet Med Assoc v.187 Splenectomy as adjunctive therapy for immune-mediated thrombocytopenia and hemolytic anemia in the dog Feldman BP;Handagam P
  10. Am J Pathol v.71 Heriditary hemolytic anemia and chondroplasia in the dog Fletch SM(et al)
  11. J Am Vet Med Assn v.170 Cold hemaglutin disease in a dog Green C(et al)
  12. Adv Vet Sci Comp Med v.22 Autoimmune disease in a dog Halliwell REW
  13. J Am Vet Med Assoc v.176 Canine hemolytic anemias Harvey JW
  14. Am J pediatric Hematol Oncol v.9 Exchange transfusion for severe autoimmune hemolytic anemia Heideman SM;Sarnaik SA;Sarnaik AP
  15. J Am Anim Hosp Assoc v.14 Microangiopathic hemolytic anemia in a pupply: Grand Rounds Conference Israel E(et al)
  16. Can. Vet J. v.26 Immune-mediated hemolytic anemia and thrombocytopenia in the dog. A retrospective study of 55 cases diagnosed from 1967-1983 at the Western College of Veterinary Medicine Jackson ML;Kurth SA
  17. J Am Vet Med Assoc v.14 Occurence of adult heartworm in the vena cavae of dogs Jackson RF(et al)
  18. J Am Vet Med Assoc v.202 Idiopathic immune-mediated hemolytic anemia in dogs: 42 cases (1986-1990) Klag AR(et al)
  19. Am J Med v.83 Efficacy of intravenous gamma globulin in autoimmune mediated pediatric blood dyscrasias Kurtzkerg J;Freidman HS
  20. Blood v.69 Variability of erythropoetic response in autoimmune hemolytic anemia. Analysis of 109 cases Lievsveld JL;Rowe JM;Lichtman MA
  21. Aust NZ N Med v.17 Danazol therapy in patients with immune cytopenia Manoharan A
  22. Yonsei Med J v.28 Autoimmune hemolytic anemia in children Park D;Yang C;Kim K
  23. Current veterinary therapy. Ⅷ Therapy of immune mediated disease Pederson NC;Kirk RW(ed)
  24. Veterinary Hematology. (3rd ed) Schalm OW;Jain NC;Carrol EJ
  25. Immunological Disease, (4th ed) Acquired hemolytic anemias Schreiber A;Frank M;Sauter M(ed)
  26. N Engl J Med v.316 Effect of danazol in immune thrombocytopenia purpura Schreiber AD;Chein P;Tomaski A;Clines DB
  27. Prog. Clin Immunol v.3 Clinical immlunology of the corticosteroids Schreiber AD
  28. Summary of Ph.D. thesis, Cornell University Congenital Hemolytic Anemia in the Basenji Dog dut to Erythrocyte Pyruvate Kinase Deficiency Search GP
  29. Vet Immunol Immunopathol v.1 The diagnositic significance of the direct antiglobulin test (DAT) in anemic dos Slappendale RJ
  30. Compend Contin Educ Prac Vet v.15 no.11 Immune-mediated hemolytic anemia. Part Ⅱ: Clinical entity, diagnosis and treatment theory Stewart AF;Feldman BF
  31. Critical Reviews in Oncology/Hematology v.9 Immune hemolytic anemia in children Warren RW;Collins ML
  32. Inflammation v.38 Methylprednisilone inhibits alternative and amplification pathways of complement Weiler JM;Pacland BD
  33. Compend Contin Educ Prac Vet v.2 no.2 Coomb's positive anemias in the dos and cat Werner LL
  34. Ann Inter Med v.108 Danazol for the treatment of refractory autoimmune thrombocytopenia in systemic lupus erythmatosis West SG;Johnson SC
  35. J Am Vet Med Assoc v.185 Canine idiopathic thrombocytopenia: clinical obseervations and long term follow-up 54 cases Williams DA;Maggio-Price L
  36. Hematology Erythrocyte disorders-anemias due to increased erythrocyte destruction mediated by antibodies Williams WJ;Beutler E;Erslev AJ;Rundles RW;Williams WJ(et al.)