• Title/Summary/Keyword: 변이분석

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SARS-CoV-2 Variant Prediction Algorithm Using the Protein-Protein Interaction Model with BERT Mask-Filling (BERT Mask-Filling과 단백질-단백질 상호작용 모델을 이용한 SARS-CoV-2 변이 예측 알고리즘)

  • Kong, Hyunseung
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2021.07a
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    • pp.283-284
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    • 2021
  • 최근 SARS-CoV-2 백신들의 예방접종이 진행됨에 따라 코로나 19 팬데믹의 종결이 예상되고 있다. 하지만 계속해서 출현 중인 변종 바이러스들은 팬데믹 종결의 위험요소로 남아있다. 본 논문에서는 사전학습된 단백질 BERT와 단백질-단백질 상호작용 모델을 활용한 SARS-CoV-2 스파이크 단백질의 변이 예측 분석 알고리즘을 제안한다. 제안하는 기술은 변이 단백질 서열의 예측과 변이 단백질과 human ACE2 수용체의 친화도에 따른 자연선택으로 이루어진다. 이를 통해 시간이 지나며 나타날 수 있는 변종 바이러스들을 시뮬레이션 할 수 있어 변종 바이러스들의 해결에 기여할 것으로 기대된다.

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Morphological Analysis on the Kalopanax pictus (Araliaceae) of Korean Populations (한국 음나무(두릅과) 집단의 형태적 분석)

  • Jung, Sang-Duk;Hong, Jung-Hee;Bang, Kyung-Hwan;Huh, Man-Kyu
    • Journal of Life Science
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    • v.14 no.3
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    • pp.400-405
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    • 2004
  • Morphological characteristics of Kalopanox pictus Nakai were studied to examine population differentiation of this species. Based on a phenogram of using 23 morphological characteristics, differentiation of regions were distinct. Collections of 138 specimens from nine populations served as operational taxonomic unit (OTU's) were examined for phenotypic similarity and morphological variation using clustering (Ward's minimum variance method) and principal component analysis (PCA). The first three principal components were responsible for 77.0% of the total variance. Principal component 1 explained 52% of the total variance and was contributed to by the number of palmately parted, the number of pinnately lobed, and width between two lateral lobe apex.

Eco-friendly vehicle preferences by consumer characteristics (운전자 특성에 따른 친환경 자동차에 대한 선호도 분석)

  • Won, Doohwan
    • Environmental and Resource Economics Review
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    • v.23 no.2
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    • pp.281-304
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    • 2014
  • This research presents that exogenous characteristics of consumers affect eco-friendly vehicle preference. The car consumers are classifies into two groups by their characteristics - sex, age, and fuel expense. To find differences in the preference for eco-friendly vehicle, marginal utilities and compensate variations of vehicle attributes are estimated. The results suggest that there are significant differences in marginal utilities and compensate variations. However, the compensate variation is more reliable standard to test the preference differences because utility is a subjective measure. Men and old people have stronger preference for the fuel efficiency than women and young people. High fuel expense people have more preference for short time charging vehicles than low fuel expense people. In addition, gasoline vehicles are more attractive to young people than old people.

Development of Variation Marker of Myzus persicae by Altitude (고도에 따른 지역별 복숭아혹진딧물 집단 변이 마커 개발)

  • Kim, Ju-Il;Kwon, Min
    • Korean journal of applied entomology
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    • v.50 no.4
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    • pp.325-333
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    • 2011
  • This study focused on the green peach aphid, Myzus persicae, as an indicator pest in Chinese cabbage cultivation to develop a genetic marker. We hypothesized that M. persicae gene flow is related to climate change. Genetic variation was analyzed using five local populations collected at different altitudes (157 m, 296 m, 560 m, 756 m and 932 m above sea level) in Hoengseong, Pyeongchang, and Gangneung areas, plus a laboratory strain used as an outgroup. There were no differences in ecological characteristics among strains. Esterase isozyme pattern and inter-simple sequence repeat (ISSR) PCR results showed significantly different bands between laboratory and wild, local populations. However, there was no difference among local populations. Partial fragments of ribosomal RNA (rRNA) and mitochondrial cytochrome oxidase I (mtCO I) were amplified and their nucleotide sequence was analyzed. Single nucleotide polymorphisms (SNPs) were detected in internal transcribed spacer-2 (ITS-2) and mtCO I regions among the five local populations. These SNPs can be use to discriminate different populations of M. persicae to monitor gene flow.

Edge-Preserving Directional Regularization Technique for Disparity Estimation and Intermediate View Reconstruction of Stereoscopic Images (경계-보존 방향성 평활화를 이용한 양안 영상의 변이 추정과 중간 시점 영상의 재구성)

  • 김미현;강문기;이철희;최윤식;손광훈
    • Journal of Broadcast Engineering
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    • v.4 no.1
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    • pp.59-67
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    • 1999
  • In this paper, we study two important topics in stereoscopic image communication system. One is a disparity estimation (DE) method to obtain the depth information of a scene at the transmitter and the other is an intermediate view reconstruction(IVR) method at the receiver. We propose a new DE method using an edge-preserving directional regularization technique. The proposed DE method smooths disparity vectors in smooth regions and preserves edges without over-smoothing problem. It provides better reconstructed stereoscopic images and improved coding efficiency than the existing regularization techniques. In addition. we propose a new IVR method using interpolation and extrapolation techniques. The proposed IVR method preserves edge regions as well as occlusion regions well. Thus. it gives better intermediate views than the existing IVR methods.

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Development and Characterization of Sporulation Mutants for Overexpression of Recombinant Protein of Bacillus subtilis (재조합 단백질 과발현을 위한 Bacillus snbtilis 포자형성 변이주의 개발 및 특성 분석)

  • 오민규;박승환김병기
    • KSBB Journal
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    • v.9 no.1
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    • pp.16-25
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    • 1994
  • Sporulation mutants of Bacillus subtilis were developed for overproduction of heterologous proteins. The strains spoOJ spoIIG, and spoOJ spoIIG double mutant were constructed from two pretense-delfted mutant (DB104). The vector containing aprE gene was integrated in the chromosome of each strain, then the morphology of each strain was observed by TEM (trasmission electron microscopy). The morphology of spoOJ mutant and spoIIG mutant coincides with the description of the previous reports, respectively. The sporulating cells of spoOJ SpoIIG double mutation resemble spoIIG mutant more similarly, but with a little rougher cell wall membrane. The spoOJ mutation in B. subtilis gives negative effect on aprE activity with only a decreased sporulation frequency. On the contrary spoIIG mutation increases the aprE activity twice with an undetectable sporulation frequency. In the case of spoOJ and spolIG, i. e. double mutation, the effect of spoOJ on aprE activity seems to be relieved and the double mutant shows more or less the same aprE activity compared to spoIIG mutant.

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Interregional Variant Factor Analysis of Hypertension Treatment Rate in COVID-19 (코로나19에서 고혈압 치료율의 지역 간 변이요인 분석)

  • Park, Jong-Ho;Kim, Ji-Hye
    • Journal of Digital Convergence
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    • v.20 no.4
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    • pp.469-482
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    • 2022
  • The purpose of this study is to analyze regional variation factors of hypertension treatment rate in COVID-19 based on the analysis results based on ecological methodology. To this end, data suitable for ecological analysis were collected from the Korea Centers for Disease Control and Prevention's regional health statistics, local government COVID-19 confirmed cases, National Health Insurance Corporation, Health Insurance Review and Assessment Service's welfare statistics, and Korea Transport Institute's traffic access index. Descriptive statistics and correlation analysis were conducted using SPSS Statistics 23 for regional variation and related factors in hypertension treatment rate, and geographical weighted regression analysis was conducted using Arc GIS for regional variation factors. As a result of the study, the overall explanatory power of the calculated geo-weighted regression model was 27.6%, distributed from 23.1% to 33.4% by region. As factors affecting the treatment rate of hypertension, the higher the rate of basic living security medical benefits, diabetes treatment rate, and health institutions per 100,000 population, the higher the rate of hypertension treatment, the lower the number of COVID-19 confirmed patients, the lower the rate of physical activity, and the alcohol consumption. Percentage of alcohol consumption decreased due to COVID-19 pandemic. It was analyzed that the lower the ratio, the higher the treatment rate for hypertension. Based on these results, the analysis of regional variables in the treatment rate of hypertension in COVID-19 can be expected to be effective in managing the treatment rate of hypertension, and furthermore, it is expected to be used to establish community-centered health promotion policies.

An Analysis of the Concentration Ratios and the Shift Effect of Korean Container Ports (우리나라 컨테이너항만의 집중도와 변이효과 분석)

  • Kim, Eun-Soo;Lee, Su-Young
    • Journal of Korea Port Economic Association
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    • v.32 no.1
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    • pp.135-149
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    • 2016
  • This study analyzes the concentration ratios (CR) and the shift effect in the system of Korean container ports that concern the export and import of container cargos, especially from/to 5 overseas origin/destination (O/D) regions, using the Hirshmann-Herfindahl Index (HHI) and the Shift-Share Method. The results shows that the CR has decreased during the last 20 years, from 0.86 to 0.44, mainly because cargos from/to the Far-East/South-East Asian regions have become more dispersed to several domestic container ports, especially from the Port of Busan. This study also indicates that there has been little change in the CR for all cargos, like the value of -0.3%, in the last 5 years. However the change in CRs for the cargos from/to the North America and Europe is positive, with the value of 7.6% and 6.6%, respectively. It can be inferred that the future development of medium- and small-sized container ports in Korea is not very likely. The study also suggests that the CR and the shift effect of the Korean container ports for the cargos by the domestic O/D regions should be analyzed in the future to suggest policy implications in great detail.

A Systematic Study on Polygonum sect. Tovara (Polgonaceae) : Analysis of Morphological Variation (여뀌속 Tovara절 식물의 분류학적 연구 : 형태변이 분석)

  • 박종욱
    • Journal of Plant Biology
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    • v.35 no.4
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    • pp.385-392
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    • 1992
  • 여뀌속 Tovara절 식물은 매우 복잡한 양상의 형태변이를 나타내기 때문에 각 분류군의 한계 및 위치 성정, 계통적 유연관계 해석에 있어 많은 혼란이 나타나고 있다. 따라서 본 연구에서는 본 절 분류군에서 나타나는 형태 변이의 양상을 수리분류학적으로 분석하여, 각 분류군의 한계를 명확히 설정하고 그 분류학적 타당성을 검토하고자 하였다. 본 절 분류군의 주요 식별형질에 대한 주성분 분석을 수행한 결과, 본 절은 형태적으로 크게 P. virginianum, P. filiforme, P. neofiliforme의 3분류군으로 구분되며, 이들은 주로 잎의 형태에 의해 식별되는 것으로 밝혀졌다. 또한 P. virginianum var. glaberrimum은 그 분류학적 타당성이 없는 것으로 나타났으며, Tovara (=Polygonum) virginiana var. kachina는 형태적으로 볼 때 P. neofiliforme의 변종으로 취급하는 것이 타당한 것으로 판명되었다. Polygonum virginianum, P. filiforme, P. neofiliforme는 그 flavonoid 조성에 있어서도 명확한 차이를 나타내며, 이러한 결과를 종합해 볼 때 이들은 각각 독립된 종으로 인식하는 것이 타당한 것으로 판단된다.

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공간통계분석에서 이상점 수정을 위한 방법비교

  • Lee, Jin-Hui;Sin, Gi-Il
    • Proceedings of the Korean Statistical Society Conference
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    • 2003.05a
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    • pp.275-280
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    • 2003
  • 공간 자료에서 이상점이 존재할 경우 변이도(Variogram)를 추정함에 있어 그 효과를 줄이기 위한 방법으로 로버스트(robust) 변이도를 이용한다. 그러나 이상점이 존재하는 자료분석에서 로버스트 변이도를 사용하기에 앞서 이상점을 수정한 자료를 사용하였을 경우 그 효율성 또한 좋다고 알려져 있다. 본 논문에서는 이상점이 존재하는 자료를 분석함에 있어 기존의 이상점 수정법 및 새로운 이상점 수정법의 효율성을 비교하였다.

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