• Journal of fish pathology
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• v.19 no.2
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• pp.165-172
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• 2006

This study was performed to verify the stability and efficacy of Streptococcus iniae formalin killed cells on storage at refrigerator temperature in olive flounder, Paralichthys olivaceus. The vaccines preserved for 6, 12 and 15months showed high stability of potency. The antibody titers and protection efficacy to challenge test were significantly higher in booster immunized groups than prime immunized groups during storage. Especially, above 60% of relative percent survival obtained at low antibody revel in prime immunized groups indicates that innate and non-specific immune system might act against the S. iniae challenged.

• Pediatric Infection and Vaccine
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• v.25 no.3
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• pp.141-147
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• 2018

Purpose: Despite effectiveness and safety of maternal tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination, Tdap vaccination coverage during pregnancy remains quite low. We assessed the knowledge, attitude and practice on maternal Tdap vaccination among pregnant women. Methods: This study was a cross-sectional survey of pregnant women who visited tertiary obstetrics and gynecologic units in Seoul and Gyeonggi province of Korea. Individual questionnaires were administered to assess knowledge, attitude and practice on maternal immunization with Tdap. Results: The questionnaires were completed by 184 pregnant women; 158 (86%) had not received information from doctors about pertussis and Tdap, and 166 (90%) did not know the need for Tdap vaccination. Only 7% of pregnant women unlikely to receive Tdap vaccine during current pregnancy answered 3 or more of the 5 knowledge-based questions correctly. By logistic regression analysis, recommendation by doctor (adjusted odd ratio [OR], 236.2; 95% confidence interval [CI], 12.6-4,432), belief that the vaccine is effective (adjusted OR, 40.21; 95% CI, 2.35-687.7), and belief that the vaccine is safe (adjusted OR, 19.83; 95% CI, 1.54-255.9) were significantly important factors to respondents' intention to be vaccinated. Conclusions: Most pregnant women seem to be neither recommended nor adequately informed about Tdap vaccination. Information given by health care professionals is very important to increase Tdap coverage among pregnant women.

• KOREAN POULTRY JOURNAL
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• v.33 no.3 s.377
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• pp.104-106
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• 2001

작년 6월에 인간 유전자 지도의 초안이 작성된 이후 지난 2월 11일에 신문과 방송은 사람이 게놈지도가 완성되었다고 주요뉴스로 보도하였다. 1990년 8월에 인간게놈 연구계획이 발표된지 11년여간의 연구 끝에 이룩한 연구결과이다. 최근, 학문의 급속한 발전으로 질병의 진단과 치료에 새로운 지평이 열리고 있다 수의분야에서도 예외는 아니다. 특히 질병예방에 있어 중요한 백신의 연구개발에 있어서도 괄목할 만한 발전이 있었다. 유전공학의 발전과 여러 병원체의 병원성 인자와 체내의 면역기능과의 관련성 연구결과로 여러질병이 백신으로 예방이 가능하게 되었으며 보다 안전하고 효과적인 새로운 개념의 백신도 개발되고 있다. 새로운 백신, 즉 신백신은 유전자 조작(재조합)에 의한 병원성이 약해진 백신에서부터 여러 질병을 동시에 예방하려고 공안된 벡터백신, 그리고 유전자를 접종하는 DNA 백신 등이 대표적이다. 이들 백신은 기존백신에 사용되고 있는 백신보다 안전하고 경제적이며 우수한 효능을 발휘하도록 고안되고 있다.

• 농업기술회보
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• v.48 no.6
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• pp.27-28
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• 2011

2010년 11월 28일 경북 안동에서 발생한 구제역은 2011년 4월 21일까지 144일간 전국 11개 시 도와 75개 시 군으로 확산되어 348만두의 가축을 살처분 매몰하고, 구제역 백신을 전국적으로 접종하게 되었다. 현재 구제역은 완전히 청정화된 것이 아니고 백신접종으로 관리되고 있는 상황이다. 앞으로 기온이 낮아지면 구제역 바이러스의 생존기간이 연장되고, 차단방역을 소홀히 하면 재발의 위험성이 매우 높아지므로 예방을 위해 축산농가에서 조치해야할 사항을 알아보자.

• 월간낙농육우
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• v.18 no.11 s.199
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• pp.76-76
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• 1998

최근 제주도의 한우 및 경기도, 강원도, 충청도 일부지역 젖소에서 유$\cdot$조산 발생이 부루세라 백신접종과 개연가능성이 있으나, 소의 유$\cdot$조산 발생원인은 세균성, 바이러스성, 원충성 등 그 요인이 매우 다양하여 원인규명이 쉽지 않은 실정입니다. 특별대책반에서는 정확한 발생 원인규명 중에 있으나 농가의 우선 예방치료 조치로서 향균제 치료 및 철저한 소독 등을 통하여 피해가 확산되지 않도록 예방치료를

• Clinical and Experimental Pediatrics
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• v.50 no.4
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• pp.355-362
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• 2007

Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine ($Infanrix^{(R)}$) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy infants aged 8-9 weeks. These infants were vaccinated at age 2, 4 and 6 months of age with three component DTaP vaccine. Solicited adverse events were actively monitored for 72 hours following each vaccination, and all adverse events after each vaccination were observed for three weeks. Anti-diphtheria toxoid Ab., anti-tetanus toxoid Ab., anti-pertussis toxin Ab., anti-filamentous hemagglutinin Ab., and anti-pertactin Ab. were measured using ELISA for assessing immunogenicity of study vaccine in 60 infants. Immunogenicity analysis of two component DTaP vaccine was performed with same methods in 14 infants as control. Results : The seroconversion rates of anti-diphtheria toxoid Ab, anti-tetanus toxoid Ab. anti-filamentous hemagglutinin Ab. were 100% in both group. Seroconversion rate of anti-pertactin Ab in study group was 100%, but the rate in control group was 50%. However, geometric mean concentration of anti-pertussis toxin Ab. was higher in control group. Mild local and systemic reactions were observed within three days after vaccination, and no serious adverse events related study vaccine were happened during study period. Conclusion : Our study results suggest that three component DTaP vaccine ($Infanrix^{(R)}$) is a well-tolerable and high immunogenic vaccine, especially anti-Pertactin Ab. of the study vaccine is very immunogenic. It can be available as routine DTaP vaccination in our infants.

• Pediatric Infection and Vaccine
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• v.31 no.1
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• pp.55-63
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• 2024

Purpose: A 2-dose varicella vaccination strategy has been introduced in many countries worldwide, aiming to increase vaccine effectiveness (VE) against varicella infection. In this network meta-analysis, we aimed to provide a comprehensive evaluation and an overall estimated effect of varicella vaccination strategies, via a Bayesian model. Methods: For each eligible study, we collected trial characteristics, such as: 1-dose vs. 2-dose, demographic characteristics, and outcomes of interest. For studies involving different doses, we aggregated the data for the same number of doses delivered into one arm. The preventive effect of 1-dose vs. 2-dose of varicella vaccine were evaluated in terms of the odds ratio (OR) and corresponding equal-tailed 95% confidence interval (95% CI). Results: A total of 903 studies were retrieved during our literature search, and 25 interventional or observational studies were selected for the Bayesian network meta-analysis. A total of 49,265 observed individuals were included in this network meta-analysis. Compared to the 0-dose control group, the OR of all varicella infections were 0.087 (95% CI, 0.046-0.164) and 0.310 (95% CI, 0.198-0.484) for 2-doses and one-dose, respectively, which corresponded to VE of 69.0% (95% CI, 51.6-81.2) and VE of 91.3% (95% CI, 83.6-95.4) for 1- and 2-doses, respectively. Conclusions: A 2-dose vaccine strategy was able to significantly reduce varicella burden. The effectiveness of 2-dose vaccination on reducing the risk of infection was demonstrated by sound statistical evidence, which highlights the public health need for a 2-dose vaccine recommendation.

• Monthly Korean Chicken
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• v.57 no.51 s.117
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• pp.104-108
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• 2005

농장을 방문하여 백신 프로그램을 작성해 주다 보면 느끼는 것중 하나가 농장마다 참, 상황이 다양하다는 것이다. 개별 농장별로 환경과 다발 질병이 다르고, 지역적인 차이가 있어서 어느 농장은 콕시디움이 20일령만 되면 발병하고, 어느 농장은 뉴캣슬병이 약하게 스쳐 지나가기도 하는 것을 보아 오곤 했다. 이럴 때마다 농장을 방문하여 느낀 점은 대부분 농장이 가 상황에 맞추어 백신을 접종하고는 있는데, 어떤 경우는 너무 원칙을 무시하고 편법적인 방법을 실시하여 그 효과를 기대하기 어렵게 된 경우도 많았다는 것이다. 각 농장에서 상황에 맞는 백신 프로그램을 전문 수의사와 상의하여 작성하는 것이 가장 좋으나 필치 못할 사정으로 직접 작성시 참조할 수 있도록 상황별 감보로 백신 예방 프로그램을 정리해 보았다.

• The Journal of the Convergence on Culture Technology
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• v.7 no.4
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• pp.613-621
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• 2021

This study conducted a network analysis to determine how COVID-19 vaccine-related issue spread on Twitter during the introduction stage of the COVID-19. Issue diffusion tendency is analyzed according to the time period: phase 1 (initiation of vaccine introduction: March 7 - April 3, 2021), phase 2 (stagnant period of vaccination: April 4 - April 22, 2021), and phase 3 (increase of vaccination: April 23 - May 5, 2021). NodeXL was used for data collection and analysis. Daily Twitter network data were collected by entering search terms highly related to the COVID-19 vaccine. This study found that side effects-related opinions were repeatedly formed throughout the analysis period. As the vaccination rate increased and death cases were reported on media, death-related issues also emerged on Twitter. On the other hand, vaccine safety did not receive much attention on Twitter. The results of this study highlight the role of social media as a channel of issue diffusion when a national disaster strikes. We emphasize the need for the government to monitor public opinions on social media and reflect them in crisis communication strategies.

• KOREAN POULTRY JOURNAL
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• v.32 no.2 s.364
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• pp.162-169
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• 2000