• Title/Summary/Keyword: 백수증

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Suppression of VCAM-1 Expression in Human Aortic Smooth Muscle Cells Treated with Ethanol Extracts of Cynanchum wilfordii Radix, Arctium lappa L., and Dioscorea opposita (백수오, 우엉, 마 추출물 혼합비율에 따른 혈관부착인자 VCAM-1의 발현억제 효과)

  • Cho, Young-Mi;Song, Hae-Seong;Jang, Seon-A;Park, Dae-Won;Shin, Yu Su;Jeong, Yong Joon;Kang, Se Chan
    • Korean Journal of Plant Resources
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    • v.29 no.5
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    • pp.525-531
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    • 2016
  • Cynanchum wilfordii Radix (CWR), Arctium lappa L (ALL), and Dioscorea opposite (DO) have been known to improve blood lipid profile, blood pressure, and inflammation. To find the optimal combination ratio of CWR, ALL, and DO in terms of vascular health improvement, we compared the effects of various combinations on gene expression of Vascular cell adhesion protein 1 (VCAM-1) in human aortic smooth muscle cells (HASMC). VCAM-1 mediates endothelial leukocyte adhesion and is upregulated in atherosclerosis. Cells was stimulated by TNF-α (10 ng/㎖, 2h) and treated with various combinations for 24 h. A combination (CADM5, CWR:ALL:DO = 2:1:1) showed the strongest suppression of VCAM-1 so that CADM5 was chosen for further experiments. We performed cell viability test with CADM5 (0, 3.125, 12.5, 25, 50, and 100 ㎍/㎖) and no cytotoxicity was found. We also investigated the effect of CADM5 on protein expression of VCAM-1, ICAM-1, Nrf-2, and HO-1 using western blotting. We found that CADM5 diminished the expression of VCAM-1 and increased the expression of Nrf-2 and HO-1. Therefore, we concluded that CADM5 (CWR:ALL:DO = 2:1:1) effectively improves vascular health by regulating the expression of VCAM-1.

Trends in Standards and Regulations on Hand-arm Vibration (수완계 진동에 대한 규격제정 동향)

  • 장한기
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2002.05a
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    • pp.899-902
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    • 2002
  • Effect of hand-transmitted vibration on human discomfort and health was reviewed. Since the effect by hand tool was more serious than those by any other vibration environments, western countries have protected hand tool workers by regulations. International organization for standardization legislate standard, ISO 5349, at 1979 for the measurement and evaluation of the effect. Afterwards, more than twenty standards on hand-arm vibration were enacted to Protect any damage of hand tool users. Even though Korea Standards adopted ISO 5349 in 2001, it is required an action plan should be applied to all of work environments, especially to the workers using pneumatic tool workwers such as miners, construction workers, and etc.

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SC4/Trends in Standards and Regulations on Hand-arm Vibration (SC4/수완계 진동 측정 관련 규격 제정동향)

  • 장한기
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2003.05a
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    • pp.455-458
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    • 2003
  • Effect of hand-transmitted vibration on human discomfort and health was reviewed. Since the effect by hand tool was more serious than those by any other vibration environments, western countries have protected hand tool workers by regulations. International organization for standardization legislate standard, ISO 5349, at 1979 for the measurement and evaluation of the effect. Afterwards, more than twenty standards on hand-arm vibration were enacted to protect any damage of hand tool users. Even though Korea Standards adopted ISO 5349 in 2001, it is required an action plan should be applied to all of work environments, especially to the workers using pneumatic tool workers such as miners, construction workers, and etc.

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백상지 공정수가 백상지 물성에 미치는 영향

  • 이학래;함충현;이지영
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2001.04a
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    • pp.159-159
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    • 2001
  • 용수 다소비 산업인 제지산업은 날로 심해지는 환경규제에 대처하기 위해 청수사용 량을 줄이고 백수의 재활용을 극대화하며, 궁극적으로는 폐수를 배출시키지 않는 무방류화 공정의 실현을 위해 많은 연구와 노력을 경주하고 있다. 제지공정의 폐쇄화가 성공적으로 이루어지기 위해서는 폐수의 처리를 통한 수질 개선 및 처리수의 재활용을 제고하는 방안을 채용할 수 있으나, 제지공정의 막대한 용수 사용량을 생각할 때 방출되는 공정수를 이와 같 은 방법으로 완전히 정화, 재사용한다는 것은 경제적으로 비현실적이라 할 수 있다. 따라서 공정수의 정화 및 정화된 처리수의 재활용율 제고를 통하여 제지공정의 무방류화를 실현하 더라도 공정수의 수질 악화는 필연적으로 발생하게 되며 따라서 이에 대한 다각적인 대처 가 요청된다. 제지공정의 무방류화에 따른 수질의 악화는 용수 내 미세분 및 이온성 물질의 누적 을 통해 이루어지며, 이로 인해 펠트 플러깅, 첨가제의 성능저하, 슬라임 및 악취 발생, 제품 의 품질저하 등 여러 가지 문제들이 발생하게 된다. 본 연구에서는 백상지 공정의 폐쇄화를 실험실적으로 재현하여 용수 내 미세분 및 각종 이온성 물질의 누적이 종이의 불성에 미치는 영향을 평가하고자 하였다. 백상지 공정 수 내에는 도공파지의 유입과 다량의 충전제 사용에 의하여 상당량의 회분성분이 미세분으 로 포함되어 있다. 이에 백상지 공정의 폐쇄화 단계에 따라 용수 내 누적되는 회분의 특성 변화를 파악하고, 이것이 종이 물성에 대한 영향을 살펴보았다. 또 백수의 재활용에 따른 각 종 이온성 물질의 누적이 종이의 물성에 미치는 영향도 평가하였다. 이러한 이온성 물질의 대상은 칼습 경도 및 전기전도도에 영향하는 무기 이온성 물질과 COD 및 BOD에 영향하는 유기 이온성 물질로 구분하여 평가하였다. 이후 계내에 존재하는 각 이온성 물질의 농도 증 가에 따라 종이를 제조하여 물성의 변화를 파악하였다.

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Changes of Lumbar Lordosis According to Different Heel Heights in Normal Adults and Patients with HNP (정상인과 요추 추간판 탈출증 환자에서 구두 뒷굽 높이에 따른 요추전만도의 변화)

  • Moon, Dong-Chul;Kown, Young-Shil;Song, Ju-Young;Nam, Ki-Won;Song, Ju-Min;Kim, Dong-Hyun;Baek, Su-Jeong;Ku, Hyun-Mo;Choi, Jin-Ho;Kim, Jin-Sang
    • The Journal of Korean Physical Therapy
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    • v.13 no.2
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    • pp.467-475
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    • 2001
  • The purpose of this study was to evaluate changes of static lumbar lordosis by different heel heights in normal adults and patients with herniation of nucleus pulposus(HNP). The lumbar lordosis was examined while standing on barefoot, on heel support with 4cm heel, and with 8cm heel in 10 normal adults and 10patients with HNP. Standing lumbar lateral view was performed by 20 minutes adaptation with corresponding shoe types. The angle of lumbar lordosis was taken with Wiltse and Winter's method(angles between upper margin of 1 st lumbar body and upper margin of 5th lumbar body). The results of this study were as follow: 1. Significant statistical decrease in lumbar lordosis was observed as heel heights were increased from barefoot to 8cm high heel in normal adults(p<0.05). 2. There were no significant differences in lumbar lordosis according to three different heel heights in patients with HNP(p>0.05). 3. In comparison of barefoot, There were statistically significant decrease in HNP patients compared with normal adults in terms of lumbar lordosis(p<0.05).

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Selection of Container Size and Materials Suitable for Container Cultivation of Platycodon grandiflorum (도라지 용기재배에 적합한 용기 규격 및 재료 선발)

  • Eun Suk Lee;Jeong Hyeon Yu;Chang Su Kim;Hyo Jin Kim;Young Eum Song;Sang Young Seo;Min Sil Ahn;So Ra Choi
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2022.09a
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    • pp.113-113
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    • 2022
  • 도라지(Platycodon grandiflorum)는 초롱꽃과 도라지속에 속하는 여러해살이풀로 7~8월에 보라색이나 흰색의 꽃을 피우고, 뿌리는 다육질로 원주형 또는 분지형이다. 잎은 거의 엽병이 없는 대생이며, 종자는 난형으로 3개의 모서리가 있다. 항염증 성분인 플라티코딘이 들어있어 편도염을 비롯한 후두염, 폐렴 등에 효과가 있어 우리나라 약용작물 재배면적의 상위를 차지하고 있는 주요 작물이다. 최근, 백수오, 감초 등 심근성 약용작물은 뿌리의 수확 비용 절감을 위해 용기재배가 도입되고 있다. 본 연구는 도라지 용기재배에 적합한 용기의 규격과 고온 경감을 위한 용기 재료 선발을 위해 수행하였다. 도라지 용기재배에 적합한 용기의 규격 선발은 기본 용기로 플라스틱 플륨관을 사용하였고, 높이는 40cm로 고정하여 직경을 10, 20, 30cm로 처리하였다. 2019년 4월 하순에 도라지 종자를 파종하여 용기 규격별로 각각 1주(10cm), 4주(20cm), 8주(30cm)를 남겨 두고 솎음 다음, 2020년 10월 하순에 수확하였다. 도라지의 생육 및 수량성을 조사한 결과, 용기의 직경이 증가함에 따라 근장, 근경, 근중 등 지하부 생육이 우수한 경향이었다. 또한, 10a당 수량은 노지재배 749kg에 비해 직경 10cm 778kg, 20cm 849kg, 30cm 1,156kg로 직경 30cm가 가장 우수하였다. 직경이 증가할수록 수량성이 증가하였으나 직경 30cm 이상의 용기는 수확 시 노동력이 증가하고, 배양토 비용이 증가하여 사용하지 않았다. 고온 경감을 위한 용기 재료 선발은 흰색과 검정색 플라스틱 플륨관을 높이 40cm × 직경 30cm 규격으로 절단하여 2020년 4월에 도라지 종자를 파종하였고, 2021년 10월 하순에 수확하였다. 이 중 검정색 용기는 무처리(대조), 유공, 반유공, 흰색부직포, 반사필름 처리를 하였다. 도라지의 수량성을 조사한 결과, 검정색 용기 중 유공처리가 무처리 대비 수량이 21%(1,080 → 1,304kg/10a) 증가하였다. 위의 결과로 도라지는 직경 30cm의 검정색 유공 용기가 용기재배에 적합한 것으로 판단되었다.

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Quantitative Analysis of Paeoniflorin and Paeonol in Peony Extracts and Quality Control Standards (모란 추출액에서 paeoniflorin과 paeonol 동시 정량 분석 및 화장품 원료의 품질관리 기준 설정)

  • Yun, Ki-Hun;Chi, Yong-Ha;Lee, Dong-Kyu;Paik, Soo-Heui
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.1
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    • pp.235-246
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    • 2018
  • Paeony has pharmacological activities such as anti-inflammatory, anti-allergic, anti-bacterial, central inhibitory, gastric secretion inhibition, and antispasmodic activities. In addition, its antioxidant activity and whitening effect being reported, thus it is being explored as raw materials for cosmetics. We compared the changes in the contents of paeoniflorin and paeonol in Peony extracts, depending on the changes of extracting solvents, temperature and time. The HPLC method was set up for simultaneous analysis, the system suitabilities were confirmed by using the calibration curves and the QC samples for each assay batch. Paeonol was detected only in roots, and paeoniflorin was higher in leaf and flower than root. Higher concentrations of both ingredients were extracted when the root was used after grinding to a suitable size, and when 30% 1,3-butylene glycol was used as the extraction solvent. Also the concentrations tended to increase at higher temperature and longer time, but the increase was gradual at over $75^{\circ}C$ and 4 hours. The ratio of root, leaf and flower was determined to be 2+2+1g/0.5kg of batch, reaching the contents criteria of paeoniflorin and paeonol. Finally, we selected as the best extraction condition when the raw materials are mixed with 2+2+1g/0.5kg and extracted with 30% 1,3-butylene glycol as an extraction solvent at $75^{\circ}C$ for 4 hours, considering both the concentrations of two components and the cost of raw materials and manufacturing process, The extraction units were scaled up to 10 kg under this condition.

The Distribution of Oral Candida Species in Patient with Prosthetic Appliance (보철물 장착 환자의 구강 칸디다균 분포)

  • Son, Seung Hwa;Baek, Su Min;Park, Young Min
    • Journal of dental hygiene science
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    • v.14 no.4
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    • pp.477-487
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    • 2014
  • Of the many pathogenic Candida species, Candida albicans is the main fungal pathogen of humans. The oral environmental factors considered in the Candida albicans colony forming unit test contain both host and microbial factors associated with candidiasis. In particular, Candida biofilms can develop on surfaces of prosthesis. The purpose of this study was to investigate the distribution of oral Candida species between the type of prosthesis and the situation of oral environment in patient with prosthetic appliance. The patients were 30 elderly subjects with different types of prosthesis, 7 who wore denture, 12 who wore implant and 15 who wore removable orthodontic appliance. We used Candida albicans colony forming unit test using saliva to exam the distribution of Candida albicans related with 5 oral environmental factors, gender, smoking or nonsmoking, alcohol/nonalcohol consumption, the type of prosthetic appliance and its treatment duration as well as tooth brushing frequency per day. In conclusion, for the patient's gender, site in the oral cavity and the type of prosthetic appliance and its treatment duration was associated with an increase in the distribution of Candida albicans in saliva. The distribution of Candida albicans within the oral cavity performs to be modulated to varying extents by oral environmental factors and, further investigations are required to elucidate these complex interactions.