• Journal of Veterinary Clinics
• /
• v.28 no.5
• /
• pp.473-478
• /
• 2011

The study evaluated the antioxidant effects of ascorbic acid (AA) against oxidative stress during laparotomy in dogs under general anesthesia using isoflurane. Twelve dogs were randomly assigned to either the ascorbic acid group (AAG) or the sham group (SG). AAG received intravenous dosage of 100 mg/animal of standard AA 10 minutes before anesthesia. Plasma levels of cortisol, glucose, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were measured. Cortisol level increased significantly with time in both groups (p < 0.05). The change of glucose levels was not significantly different between both groups. TOS and OSI increased significantly with time in the SG (p < 0.05), whereas it did not significantly change with time in the AAG. The TOS and OSI of the AAG were significantly lower than in the SG (p < 0.05). However, TAS did not significantly change between both groups. The results suggest that the decrease of TOS in the AAG might be related to the conversion of antioxidants to oxidants. The decrease of OSI indicates that the decrease of reactive oxygen species (i.e., oxidative stress) produced at the site of injury is able to decrease surgical side effects of abnormal blood circulation, organ failure, and inflammation. Therefore, AA can be used to protect a surgical patient from oxidative stress in canine laparotomy.

• The Journal of Internal Korean Medicine
• /
• v.30 no.1
• /
• pp.144-152
• /
• 2009

Background : Ephedra (Ephedra sinica) has been widely used to treat respiratory disease in traditional medicine of East Asia for over a hundred years. Despite safety concerns raised by some, the use of ephedra in traditional medicine is documented over more than 1,800 years. It is well established that ephedra is one of the central medicines in Korean 'Seseng constitution' medicine. In Sasang constitution medicine, all humans can be divided into one of four types: Soeumin, Soyangin, Taeumin or Taeyangin, and each constitution type has their own typical characteristics. Accordingly, it is hypothesized that the adverse effects of ephedra differ depending on the Sasang constitution classification. Objectives : The aim of this study was to determine adverse effects of ephedra which is classified as a Taeumin herb, and to observe whether the response differs or not. according to Sasang constitution classification. Methods : The study design was a double-blind randomized controlled trial. The subjects were healthy adults 20 - 50 years old who agreed to participate in this study. They were allocated through randomization to either ephedra group (N=55) or placebo group (N=24). where ephedra extract (6 g of dried ephedra) and placebo with similar opaque capsules were given twice for one day. To compare the adverse events of ephedra according to Sasang constitution classification, we analyzed blood pressure (systolic and diastolic), pulse rate, the morning questionnaire, and patient's global assessment scale score for well known adverse events: palpitation, headache, sweating, tiredness, dyspepsia, and dry mouth. Results : After ingestion of ephedra, the pulse rate had a significant increase in all constitution types. The changes of diastolic pressure in Soeumin and the changes of pulse rate in Soeumin, Soyangin and Taeumin had a significant increase in the ephedra over the control group. In the ephedra group, the palpitation and dyspepsia score of the patients' global assessment scale had a significant increase in Soeumin, with palpitation and sweating score increasing in Soyangin. Others observations were insignificant results. Conclusion : The results of this study may confirm that the physical responses or adverse effects of herbs differ for each type of Sasang constitution. Future studies using other herbs will be required to ascertain the herbal drug reaction of Sasang constitutions.

• Korean Journal of Acupuncture
• /
• v.30 no.2
• /
• pp.135-142
• /
• 2013

Objectives : This study aimed to investigate the general effects of low-frequency electrical stimulation of the ankle joint acupuncture points(BL62 and KI6) on the brain waves of elderly women as a pilot study to figure out the possibility of candidate non-invasive and non-chemical stimulation method for the enhancing the brain function. Methods : A randomized, controlled, double-blinded clinical trial was performed in 31 healthy women(mean age, 54.5 years) within a treatment duration of 12 sessions. In the experimental group, low-frequency electrical stimulation was applied using the maximum range of the individual insensible strength(mean current, $0.04{\mu}A$). The control group received sham stimulation. The background electroencephalographic activity was measured before and after the12 sessions. Results : After 12 sessions of stimulation, the relative power of the alpha wave increased(32 of 32 channels: significant difference in 11 channels, p<0.05); the theta(30 of 32 channels: significant difference in 10 channels, p<0.05), beta(31 of 32 channels), and gamma(30 of 32 channels: significant difference in 7 channels, p<0.05) powers were also decreased compared with the sham group. Conclusions : Electrical stimulation on the ankle joint acupuncture points(BL62 and KI6) seemed to stabilize the elderly women brain by inducing the alpha power and reducing beta, theta, and gamma powers. These results provide insight into the action mechanism of the stimulation and can assist the future developement of a non-invasive and non-chemical treatment technique for stressor related cognitive problems.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.8 no.4
• /
• pp.380-391
• /
• 2003

Surface sediments were collected from Gwangyang and Yeosu Bays to evaluate their sedimentological characteristics and geochemical aspects of both the benthic environment and heavy metal pollution. The grain size distribution includes both sandy and muddy sediments. Sand-rich sediments occur mainly near the POSCO and the channel between Namhedo and Yeosu Bando, while elsewhere mud-dominated sediments are present. TOC content ranges from 0.2 to 2.1 % and C/N ratios indicate that the range arises from the mix of organic matter. The C/S ratios of this organic matter show that parts of the study area are anoxic or have sub-anoxic bottom conditions. The hydrogen sulfide content of the sediment has a range of 0.7 to 301 ppm, with a high content occurring inshore of Myodo Island, where it indicates a polluted environment. The enrichment factor (Ef) and index of accumulation rate (Igeo) of ten heavy metals (Co, Ni, Cu, Cd, Pb, Li, Zn, V, Cr, Ba) show that parts of the study area contain from one to seven times more Pb and Ba, and from 0.8 to 3.5 times more of the other elements than the mean sediment value. The Igeo values of V and Cd show that different parts of the area can be classified as heavily polluted, heavily to moderately polluted, or more or less unpolluted. Those areas that have both high levels of enrichment and high accumulation rates of heavy metals contain predominantly fine sediments with a high organic matter and hydrogen sulfide content.

• Korean Journal of Ecology and Environment
• /
• v.36 no.2 s.103
• /
• pp.172-180
• /
• 2003

For a biological assessment of Pyeongtaek Reservoir and its major influent streams, an algal growth potential test (AGPT) was conducted with the blue-green algae Microcystis aeruginosa in March, June, September and December, 2000. The range and average value of AGPT were from 0 to 463 mg dw/l and 90 mg dw/l, respectively. For the influent streams in particular, the average of AGPT was the in the Hwangguchi Stream (343 mg dw/l). It decreased to 158, 66, 29, 21, and 21 mg dw/l in the Sojong Stream, Songhwan Stream, Osan Stream, Chinwi Stream, and Ansong Stream, respectively. The AGPT values in the reservoir ranged from 0 to 138 mg dw/1(mean 54 mg dw/1) with a tendency to increase in the upstream, which was close to the influent streams. In general, the AGPT values decreased further in the downstream. Immediately after the abrupt increase in influent discharge in summer, the AGPT value in the downstream almost doubled due to the proliferation of blue-green algae. The water quality of Pyeongtaek Reservoir and its influent streams further deteriorated during the drought period. Similarly, the AGPT value was the highest during this period. The AGPT values showed the closest correlation with the content of P (r = 0.999, p<0,001). Thus, it could be concluded that the content of P is highly effective in the growth of algae. In the Pyeongtaek Reservoir Watershed, the AGPT values varied in space and time. It was also closely related to the nutrient content of influent streams. The AGPT values revealed that the water quality state was hypertrophic (> 20 mg dw/1). Thus, control of the aquatic environment is essential. AGPT is very useful in evaluating the fertility and pollution state of the water as well as determining the nutrients that limit the growth of algae.

• Journal of Life Science
• /
• v.13 no.4
• /
• pp.473-480
• /
• 2003

We analyzed the patterns of mineral ions and growth responses among symbiotic nitrogen fixing legumes by external nitrogen applications under salt gradients. Glycine max, Phaseolus angularis and Albizzia julibrissin showed remarkable growth inhibition above 40 mM NaCl treatments, but Cassia tora did not exhibit any visible injury symptom up to 100 mM NaCl treatments. As to ionic pattern, the $Na^+$ and $Cl^-$contents in leaves of G. max, P. angularis and A. julibrissin progressively increased with higher contents of external salinity. Compared to other plants, C. tora excluded $Na^+$more efficiently and maintained rather constant ionic contents in spite of high salt levels. With a few exception, these 4 legume plants exhibited better growth by the external nitrogen supply rather than the contribution of symbiotic nitrogen fixation only under saline condition.

• Korean journal of food and cookery science
• /
• v.4 no.2
• /
• pp.21-30
• /
• 1988

To study the optimum fermentation and aging conditions for preparation of Andong Sikhe which is consumed in the northern Kyungbuk province as a traditional beverage, Sikhe were fermented and aged at $12^{\circ}C$ for 48, 60 and 72hrs and fermented at 40, 50. and $60^{\circ}C$ for 2, 3, and 4hrs and then aged at $12^{\circ}C$ for 20 hrs, Non-volatile organic acids and free sugars were analyzed by GC and HPLC, respectively, and sensory test was performed. Sikhe fermented at $40^{\circ}C$ for 3hrs and aged at $12^{\circ}C$ for 20hrs was evaluated the most favorable one by sensory test. This Sikhe had the lowest pH 4.6~4.7 among sample and 14.6% of sugar. The sugar content was lower than those of Sikhe Fermented at $50^{\circ}C$ and $60^{\circ}C$. In organic acid analysis, the concentration of malate 67.53%/mg in this Sikhe was the highest. Lactate, succinate and maleate were produced more in this Sikhe than in any other ones. Oxalate which was existed before fermentation was not found in the Sikhe, and a small amounts of citrate and fumarate were produced. In sugar analysis, maltose was dominant 11.56%, glucose 1.25% and fructose 0.45%.

• Korean Journal of Food Science and Technology
• /
• v.32 no.6
• /
• pp.1358-1364
• /
• 2000

A mixed culture of bacteriocin-producing lactic acid bacteria and yeast was used to prepare unique fermented fruit and vegetable beverage which contains bacteriocin. Fruit and vegetable broth fermented by Lactococcus lactis 11454 showed inhibitory activity against foodborne pathogens such as Listeria monocytogens and Staphylococcus aureus, and Streptococcus mutans which is a major causative agent for dental caries. Bacteriocin was detected at the end of fermentation of fruit and vegetables and its antimicrobial activity was stable for 5 weeks during storage at $4^{\circ}C$. These results suggest that the presence of bacteriocin in beverages during fermentation and storage will provide a safeguard against foodborne pathogens and spoilage bacteria. To improve flavor of the fermented broth, post-fermentation of the fermented broth was carried out at $4^{\circ}C$ by using yeast isolated from raw material mixture. Total acidity of the post-fermented broth was slightly decreased, but significant increase in the concentration of succinic acid was observed in the post-fermented broth. It was also observed that bitter and disagreeable taste compounds such as phthalates were decreased, and mild acidic and fruity flavor esters and alcohols were increased by the post-fermentation of the fermented broth with yeast.

• Proceedings of the KSCN Conference
• /
• 2003.11a
• /
• pp.1073-1074
• /
• 2003

본 연구는 고학력 중년 여성을 대상으로 취업 여부에 따른 영양섭취 상태의 차이를 분석하여 고학력 중년 여성의 영양 및 건강관리를 위한 대책 마련의 기초자료로 활용하고자 시행되었다. 연구 대상자의 선정은 유의추출 방법으로 전업 여성은 고학력자 비율이 높은 대전시의 일정 지역에 거주하는 기혼여성으로 하였고, 취업여성은 여러 직업의 특성으로 인한 교란(confounding)을 줄이기 위하여 고학력 여성의 비율이 높은 기혼의 교사로 한정하였다. 연령에 의한 교란을 방지하기 위하여 연령대별로 동일 비율로 무작위 추출하여 전업여성 250명, 취업여성 236명을 대상으로, 24시간 회상법을 이용하여 조사 전일 하루동안의 식이 섭취 내용을 개별 면담으로 조사하였다. 1일 영양소 섭취 조사 결과 취업여성은 전업여성에 비해 인, 비타민 B$_1$, B$_2$를, 전업여성은 취업여성에 비해 지방 및 동물성 지방, 나트륨, 비타민 C, 엽산을 많이 섭취하고 있었다. P/M/S비는 전업여성 1/1.19/1.05, 취업여성 l/l.05/0.87로 나타나 취업여성이 전업여성에 비해서, 그리고 한국인 영양권장량의 기준(1/1/1)에 비해서 포화지방의 비가 낮았다. 또한 지방 에너지 구성비도 전업여성(24.38%)이 취업여성(23.29%)에 비해 높았고, 총 열량에 대한 동물성 지방의 섭취비율이 전업여성 12.44%, 취업여성 11.46%으로 나타나 전업여성이 취업여성에 비해 동물성 지방, 포화지방비, 지방에너지 구성비가 모두 높았다. 영양권장량에 대한 영양소 섭취 백분율에서 전업여성과 취업여성 모두 칼슘과 아연을 권장량에 비해 낮게 섭취하고 있었고, 질적 영양지수(INQ)도 두 군 모두에서 칼슘이 가장 낮게 나타났다. 인의 영양밀도(Nutrient Density)가 취업주부에서 높았던 점 외에는 영양밀도와 영양소 적정섭취비(NAR) 모두에서 비타민 B$_1$, B$_2$가 전업여성에 비해 취업여성이, 비타민 C가 취업여성에 비해 전업여성이 더 높았다. 한편 두 군 모두 INQ가 가장 높은 영양소는 인이었고, INQ가 가장 낮은 영양소는 칼슘으로 나타났으며, INQ가 1 미만인 영양소는 칼슘과 함께 철분으로 나타났다. 이는 1998년도 국민건강영양조사 결과에서 45세 이상 여성의 경우 관절염, 요통.좌골통, 디스크 등 근골격계질환 유병률이 남자보다 3배정도 높게 나타난 결과에 비추어볼 때 이들 관련 영양소에 대한 섭취 방안 지도의 필요성을 제시하고 있다. 결론적으로 고학력 중년 여성중 전업여성에 대해서는 지방 특히 동물성 지방 식품 섭취에 대한 적절한 영양교육과 식사관리 지도가 요구된다 하겠다. 또한 고학력 중년 여성은 취업 여부에 관계없이 칼슘과 철분이 많이 함유된 식품으로 식사량을 증가시켜 주는 영양 지도 및 영양 보강 대책이 요구되며, 칼슘과 인의 적정섭취비가 되도록 인의 섭취를 낮추는 식생활 지도가 필요하다.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.12 no.11
• /
• pp.5094-5101
• /
• 2011

In order to investigate recurrence rate and risk factors for recurrence of gastric cancer after curative resection, we examined blood biochemical profile and clinicopathological features of 386 gastric cancer patients by using medical charts and data of hospital cancer registry from September 2010 to May 2011. Chi-square test and logistic regression analyses were performed to identify risk factors. The recurrence rate of all gastric cancer patients was 2.6%; The recurrence rate by gender was 3.45% in male and 0.89% in female, and that was 4 times higher in male than in female. On univariate logistic regression analyses, lymph node metastases(OR=8.793), Helicobactor pylori infecton(OR=6.495), abnormal total cholesterol(OR=14.333) were related to recurrence. On multivariate logistic regression analyses, lymph node metastases and H. pylori infection were very important risk factors for recurrence of gastric cancer. In conclusion, lymph node metastases, H. pylori infection, and total cholesterol control were very important to prevent recurrence of gastric cancer, and it needs to monitor blood biochemical (C-reactive protein, carcinoembryonic antigen, etc) for the early detection of gastric cancer recurrence.