• Journal of radiological science and technology
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• v.23 no.1
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• pp.77-80
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• 2000

전신 ${\gamma}$-선 조사전 Grifola umbellata(Gu) 추출물의 단일 투여가 생쥐의 생존율, 체중, 기관 무게 및 혈액세포에 미치는 효과를 조사하였다 ${\gamma}$-선 조사 24시간 전에 Gu 추출물을 복강 투여하였을시, ${\gamma}$-선을 조사한 생쥐의 40-day 생존율을 65.5%에서 78.6%로 증가시켰다. Gu 추출물의 투여는 ${\gamma}$-선 조사에 의한 비장과 흉선의 무게 감소를 완전히 막아주었다(P<0.05, P<0.01) 또한 이와 유사하나 다소 적은 방사선 방호효과가 Gu 투여군의 고환에서도 관찰되었다(P<0.05). Gu 추출물의 투여는 ${\gamma}$-선 조사시 나타나는 조사 후 7일째까지의 백혈구와 림프구수의 현저한 감소를 지연시켰고, 회복속도를 촉진시켰다. 또한 21일째후의 적혈구수의 회복을 촉진시켰다. 이와 같은 결과에서 Gu 추출물의 방사선 방호효과를 알 수 있다.

• Journal of the Korean Society of Radiology
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• v.7 no.3
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• pp.239-244
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• 2013

Radiation were seriously damaged on liver functions. Blueberry was fruits that contains Vit A, Vit c, Vit E, follic acid, ${\beta}$-carotene, and anthocyanin. The purpose of this study was to evaluate the protection effects of blueberry the liver functions. Irradiation dose was used to 4 Gy (Linac 6 Mev) X-ray Treatment device Experiment animals was used to 7 rats in each groups. It was investigated liver functions that contains TP, ALB, GLOB, ALT, ALKP and CHOL. We showed that Blueberry was not recovery effects on radiation-induced liver functions. But, Statistically significant value was showed ALB (p>0.01) and ALT (p>0.1). It was concluded that blueberry was not used to recovery materials on radiation-induced liver functions.

• Journal of Radiation Protection and Research
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• v.26 no.1
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• pp.13-18
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• 2001

We performed this study to determine the effect of Baizhu (Atractylodes japonica), Chuanxiong (Cnidium officinale), Shanyao (Discorea japonica) and Shengma (Cimicifuga heracleifolia), as Oriental rhizomata herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}$-radiation. Shengma was effective in intestinal crypt survival(p<0.05). The frequency of radiation induced apoptosis was also reduced by pretreatment with Chuanxiong and Shengma(p<0.05). Although the mechanisms of this effort remain to be elucidated, these results indicated that Shengma might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Journal of the Korean Society of Radiology
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• v.15 no.3
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• pp.313-320
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• 2021

This study evaluates the radiation protection effects of Schizonepeta tenuifolia water extract on white rat by gender. Schizonepeta tenuifolia contains polyphenol and flavonoid, which are typical substances that remove free radical. Thus, to determine the effectiveness of radiation protection, the Schizonepeta tenuifolia water extract was administered to Sparaqu-Dawely (SD) rat males and females for two weeks, followed by hematological analysis, analysis of changes in the length of the small intestine villi length, and SOD activity evaluation. The male rat in ST+IR group showed a slightly greater recovery of platelets than the IR group. The ST+IR group also showed a higher platelet recovery capability than the IR group. lymphocyte showed that male and female rat ST+IR groups have higher resilience than IR groups likewise platelet. After irradiation, the villi length of the male rat and female rat decreased less in ST+IR group than in the IR group, indicating that the villi length of all genders was less damaged. This result confirmed that the Schizonepeta tenuifolia water extract had a radiation protection effect.

• Journal of Radiation Protection and Research
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• v.7 no.1
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• pp.11-16
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• 1982

Cysteamine(Mercaptoethyiamine, MEA), S,2-Aminoethylisothiouronium Bromide. HBr (AET), and S-(2-Aminoethyl) Dihydrogen Phosphorothioate (WR-638) were prepared and radioprotective effects of these chemicals and their combinations against $^{60}Co$ ${\gamma}-ray$ radiation were studied ,in irradiated ICR mice. Intraperitonially administered chemicals or their combinations resulted drug deaths in cases of MEA, AET, and their combinations, whereas there were a slight or no drug death in cases of WR-638 and the combination of AET with WR-638. All tested chemicals and their combinations yielded radioprotective effects against $^{60}Co$ $\gamma-ray$ radiation. An additive radioprotection effect was observed in case of the combination of AET with WR-638.

• Journal of radiological science and technology
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• v.40 no.2
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• pp.317-322
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• 2017

High-tech medical equipment has increased the utilization of radiation in the medical field. As a result, research on radiation protection using natural materials has become an important social issue. Selenium is a natural substance that is highly expressed in prostate known that an essential role in prostate cells. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the prostate tissue w as used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium through changes of blood components, Superoxide Dismutase and histological changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet) in the group irradiated with selenium(p<0.05). the observation of tissue changes selenium is an effective component to increase Superoxide Dismutase activity, and it was confirmed that it has an effect of inhibiting the expression of hypertrophy of prostate by irradiation. Therefore, it is considered that selenium can be utilized as a radioprotective agent by inducing prevention of prostate-related diseases.

• Journal of Radiation Protection and Research
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• v.27 no.3
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• pp.181-188
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• 2002

We investigated the effect of Paeonia japonica (PJ) on radiation-induced oxidative damage to macromolecules in vitro and in vivo. The PJ reduced the tail moment (TM) which was a marker of DNA strand break in single-cell gel electrophoresis (SCGE; comet assay) in the human peripheral blood lymphocytes. Lipid peroxidation in the liver of the ICR mouse, measured as malondialdehyde (MDA), was also reduced by PJ administration. Ethanol fraction of PJ was more effective than polysaccharide fraction of that on reduction of TM in SCGE and lipid peroxidation. Also, Their activities to scavenge DPPH radicals and hydroxyl radicals were observed in vitro, and the activities were due to its ethanol fraction. It is plausible that scavenging of flee radicals by PJ extract may have played an important role in providing the protection against the radiation-induced damage. These results indicated that Paeonia japonica might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Journal of radiological science and technology
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• v.22 no.1
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• pp.67-71
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• 1999

Effect of single intraperitoneal administration of Cordyceps sinensis (Cs) extract at 24 hour before whole-body ${\gamma}$ - irradiation on the survival ratio, body weight, organ weight changes and serum metabolites in the irradiated mice were investigated. The single pre-administration of Cs extract increased the 40-day survival ratio of irradiated mice from 66.7% to 83.4%. The administration of Cs extract completely prevented weight reductions of spleen and thymus produced by ${\gamma}$ - irradiation (P<0.05, P<0.01). Similar but somewhat less radioprotective effect was also found in the testis of the Cs treated mice. The administration of Cs inhibited the serum hyperglycemia produced by irradiation on the day 7th(P<0.01). However, it did not influence the serum cholesterol and protein levels on the days examined. The present study is the first report regarding Cs which was tested and found to be radioprotective.

• Journal of the Korean Society of Radiology
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• v.14 no.6
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• pp.755-762
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• 2020

This study is desinged to examine the effects of Taheebo(Tabebuia avellanedae) extract on the prostate of male rats as a natural radiation protection agent. Taheebo extract is well known to inhibit cell growth for the cell lines of breast and prostate cancer. In this study, the X-ray 7 Gy was irradiated in the prostate of male rat to identify radiation protection effects by Taheebo Extracts, 1, 7, and 21 Days later, hematological changes, external toxicity assessments(LDH), antioxidant enzyme(SOD) activity changes and tissue change were observed. IR+TH group showed greater lymphocyte levels than the irradiation group, which is believed to affect the hematopoietic immune system's resilience. As a results of the external toxicity assessment, Taheebo extract's toxicity is maximum 18.128±5.16%, minimum 13.6945±4.43%. Taheebo is considered to be of little toxicity. The composition of prostate cell nuclei and cytoplasm in Control and TH group was honogeneous, whereas the cell nucleus cohesion in the prostate in irradiation group and inflammatory reactions in cytoplasm were shown. IR+TH group showed less inflammatory reactions of cytoplasm in the prostate than in the radiation irradiation group, but showed a cohesive phenomenon of cell nuclei. It is judged that Taheebo extract has radiation protection against prostate cells.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.506-512
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• 2000

건조 농산물을 비롯한 식품에 대한 방사선 조사가 허가, 시행되고 있으며, 그 적용 범위도 확대되고 있다. 이에 따라 건조 생약재의 위생화의 대체방법으로 방사선 조사 기술의 적용이 산업계로부터 요구되고 있다. 본 연구는 감마선 조사 생약재의 효능 변화 유무를 확인하기 위한 일환으로 수행되었다. 저자 등은 사물탕, 보중익기탕 및 삼령백출산 등이 방사선 방호 효과를 보이는 것으로 이미 보고한 바 있다. 본 실험에서는 감마선 조사(10 kGy)한 이들 한약제 각각의 방사선 방호 효과를 비조사 시료와 비교 평가하였다. 효과평가를 위하여 방사선 조사 마우스에서 소장움 생존시험, 내재성 비장집락 형성시험 및 apoptosis 측정을 시행하였다. 각 한약제의 감마선 조사 시료는 3가지 시험 모두에서 비조사 시료와 유사한 효과를 나타내었으며(p<0.05), 생체내 독성도 나타내지 않았다. 이는 생약재의 여러 가지 고유 효능 중 일부의 안정성으르 확인한 것으로 생각되며, 이 결과로 미루어 보아 감마선 조사 생약재의 효능 안정성은 한의학적 고유의 효능 비교 평가를 통하여 확인될 수 있을 것으로 사료된다. 한편, 저자 등은 감마선 조사 생약재의 유효성분 안정성 및 유전 독성학적 안전성을 확인하여 보고한 바 있다. 이들 결과를 토대로 향후 감마선 조사 행약재의 고유 효능의 안정성에 관한 체계적인 연구결과를 얻는다면 생약재의 위생화 수단으로 감마선 조사기술의 이용이 실용화될 수 있을 것으로 사료된다.