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http://dx.doi.org/10.7742/jksr.2020.14.6.755

The Radiation Protection effect of Tabebuia Avellanedae Extract on the Prostate in Male Rats  

Jeon, Chan-hee (Department of Emergency and Disaster Management, Inje University)
Kim, Jang-Oh (Department of Emergency and Disaster Management, Inje University)
Lee, Yoon-Ji (Department of Emergency and Disaster Management, Inje University)
Lee, Ji-Eun (Department of Emergency and Disaster Management, Inje University)
Lee, Chang-Ho (Department of Emergency and Disaster Management, Inje University)
Min, Byung-In (Department of Nuclear Applied Engineering, Inje University)
Publication Information
Journal of the Korean Society of Radiology / v.14, no.6, 2020 , pp. 755-762 More about this Journal
Abstract
This study is desinged to examine the effects of Taheebo(Tabebuia avellanedae) extract on the prostate of male rats as a natural radiation protection agent. Taheebo extract is well known to inhibit cell growth for the cell lines of breast and prostate cancer. In this study, the X-ray 7 Gy was irradiated in the prostate of male rat to identify radiation protection effects by Taheebo Extracts, 1, 7, and 21 Days later, hematological changes, external toxicity assessments(LDH), antioxidant enzyme(SOD) activity changes and tissue change were observed. IR+TH group showed greater lymphocyte levels than the irradiation group, which is believed to affect the hematopoietic immune system's resilience. As a results of the external toxicity assessment, Taheebo extract's toxicity is maximum 18.128±5.16%, minimum 13.6945±4.43%. Taheebo is considered to be of little toxicity. The composition of prostate cell nuclei and cytoplasm in Control and TH group was honogeneous, whereas the cell nucleus cohesion in the prostate in irradiation group and inflammatory reactions in cytoplasm were shown. IR+TH group showed less inflammatory reactions of cytoplasm in the prostate than in the radiation irradiation group, but showed a cohesive phenomenon of cell nuclei. It is judged that Taheebo extract has radiation protection against prostate cells.
Keywords
irradiation; Taheebo; Tabebuia avellanedae; LDH; SOD; prostate;
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