• Title/Summary/Keyword: 방사선학적 변화

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Dose Reduction According to Geometric Parameters of Digital Cerebral Angiography (두개부 혈관 조영검사 시 기하학적 특성에 따른 선량 감소 방안)

  • Park, Chan Woo;Cho, Pyong Kon
    • Journal of the Korean Society of Radiology
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    • v.13 no.3
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    • pp.399-406
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    • 2019
  • This study aims to find geometric parameters that the radiologist can change from time to time to reduce dose in angiography examinations. Depending on the geometric characteristics, the values calculated by effective dose were compared, while filming in fluoroscopy mode and Digital subtraction angiography, respectively. The study found that the lower the dose was in FPS mode, the lower the dose was reduced to 30-40%. Doses according to the X-ray angle were measured highest in AP View and lower as the angle went in the head direction. The greater the FOV, the higher the dose was 1.2-1.6 times, and the closer the distance between the X-ray tube and the table, the greater the dose was about 10%. Source-image intensifier distance (SID) get longer to 100 mm, dose of each fluoroscopy and Digital subtraction angiography increase up to 25-30%. In conclusion, various geometric characteristics in angiography examinations are parameters that can be applied by radiographers as frequently as possible, and appropriate geometric properties can be considered and applied in various situations, resulting in appropriate dose reduction.

Development of Glioblastoma In Vivo Model for the Research of Brain Cancer Diagnosis and Therapy (뇌암 진단 및 치료 연구를 위한 교모세포종 동물모델 개발)

  • Kang, Seonghee;Kang, Bosun
    • Journal of the Korean Society of Radiology
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    • v.8 no.7
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    • pp.389-395
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    • 2014
  • The research was carried out to develop a animal model of malignant brain tumor for the researches in glioblastoma multiform (GBM) diagnosis and therapy. C6 cells were transplanted into the right striatum of SD rat using stereotactic instrument for the development. The developed animal model was verified by MRI and H&E stain assay of anatomicohistological examination. The MRI observations showed that the tumor developed at the injection site at the 7 days after glioblastoma inoculation. At 14 days post inoculation, the tumor grew to a large volume occupying almost a half of the right cerebral hemisphere. It was confirmed that the expression of excessive mitosis and pleomorphism in anatomicohistological examination. The developed animal model must be necessary and useful tool for the in vivo level research in the development of the new modality for the diagnosis and therapy of brain cancer.

Analysis of dosimetric leaf gap variation on dose rate variation for dynamic IMRT (동적 세기조절방사선 치료 시 선량률 변화에 따른 선량학적엽간격 변화 분석)

  • Yang, Myung Sic;Park, Ju Kyeong;Lee, Seung Hun;Kim, Yang Su;Lee, Sun Young;Cha, Seok Yong
    • The Journal of Korean Society for Radiation Therapy
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    • v.28 no.1
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    • pp.47-55
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    • 2016
  • To evaluate the position accuracy of the MLC. This study analyzed the variations of the dosimetric leaf gap(DLG) and MLC transmission factor to reflect the location of the MLC leaves according to the dose rate variation for dynamic IMRT. We used the 6 MV and 10 MV X-ray beams from linear accelerator with a Millennium 120 MLC system. We measured the variation of DLG and MLC transmission factor at depth of 10 cm for the water phantom by varying the dose rate to 200, 300, 400, 500 and 600 MU/min using the CC13 and FC-65G chambers. For 6 MV X-ray beam, a result of measuring based on a dose rate 400 MU/min by varying the dose rate to 200, 300, 400, 500 and 600 MU/min of the difference rate was respectively -2.59, -1.89, 0.00, -0.58, -2.89%. For 10 MV X-ray beam, the difference rate was respectively ?2.52, -1.69, 0.00, +1.28, -1.98%. The difference rate of MLC transmission factor was in the range of about ${\pm}1%$ of the measured values at the two types of energy and all of the dose rates. This study evaluated the variation of DLG and MLC transmission factor for the dose rate variation for dynamic IMRT. The difference of the MLC transmission factor according to the dose rate variation is negligible, but, the difference of the DLG was found to be large. Therefore, when randomly changing the dose rate dynamic IMRT, it may significantly affect the dose delivered to the tumor. Unless you change the dose rate during dynamic IMRT, it is thought that is to be the more accurate radiation therapy.

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Serum enzymes as indicators of radiation exposure in rat (흰쥐의 방사선 피폭후 생물학적 지표로서의 혈액효소)

  • Kim, In-Gyu;Kim, Sang-Bok;Kim, Jin-Gyu;Kim, Kug-Chan;Chun, Ki-Chung;Park, Hyo-Kook;Lee, Kang-Suk
    • Journal of Radiation Protection and Research
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    • v.18 no.2
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    • pp.37-45
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    • 1993
  • Enzyme activity changes in rat blood as biochemical indicator useful for evaluating exposure dose were experimentally studied. The experimental results obtained are as follows: 1) Alkaline phosphatase activities increased in the blood serum until 24 hours after 0.1, 0.25, 0.5, 2 and 4Gy irradiation and its activities returned normal condition after 72 hours of post-irradiation. Creatine kinase activities increased in the blood serum until 72 hours after 2 and 4Gy irradiation but any significant activity changes were not detected after 0.1, 0.25Gy irradiation. 2) Malate dehydrogenase activities did not reveal available changes after 0.1, 0.25, 0.5 Gy irradiation and lactate dehynrogenase activities decreased in the blood serum after 0.1, 0.25, 0.5 Gy irradiation.3) Glutamate oxaloacetate transaminase activity changes were detected in the blood serum after 0.1, 0.25, 0.5, 2, 4Gy(0.1Gy/min.) and GOT activities increased after 0.5, 1, 1.5, 2, 3, 5, 7Gy(0.5Gy/sec.). Any acid phosphatase activities were detected in the blood serum after 0.1, 0.25, 0.5, 2, 4Gy(0.1Gy/min.) and 0.5, 1, 1.5, 2, 3, 5, 7Gy(0.5 Gy/sec.) irradiation. Potentially some of these enzymes can be used as indicator protein for radiation injury. Futher investigation is needed to find better biochemical indicators utilizing recent know-ledge and techniques of biochemistry.

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CLINICAL AND RADIOLOGIC STUDY OF ODONTOGENIC KERATOCYST (치원성 각화 낭종의 임상 방사선학적 연구)

  • Kim Sung Rae;Park Tae Won
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.14 no.1
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    • pp.27-38
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    • 1984
  • 치원성 각화 낭종의 임상적 방사선학적 양상을 연구하였다. 32명의 환자(21명의 남자, 11명의 여자)를 이 연구를 위하여 사용하였다. 환자들의 기록과 방사선사진을 통하여 성별 및 연령의 분포, 호발부의 방사선사진의 양상, 재발율 임상적 소견들을 조사하였던 바 아래와 같은 결과를 얻었다. 1. 남성이 여성에 비해 약 2배 호발하였고, 10대와 20대에서 가장 많이 발생하였다. 2. 호발부위는 하악의 구치에서 하악지에 이르는 부위였고 하악골이 상악골에 비해 호발하였다. 3. 원기성 낭종에서 각화성 변화를 일으킨 것이 가장 많았다. 4. 치근의 흡수를 많이 보였으며, 하악골에서 경계는 원형과 부채형(scalloped)이 거의 동등히 나타났고 상악골에서는 대부분 원형의 단발형 낭종이었다. 5. 높은 재발율을 보였다. 6. 감염이 되어 있는 경우가 많았다.

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Manufacture and Image Characteristic Changes Observation by Temperature of Ultrasound Tissue Mimicking Phantom (초음파 Tissue Mimicking 팬텀의 제작과 온도 변화에 따른 영상 특성 변화 관찰)

  • Ma, Sang-Chull
    • Journal of radiological science and technology
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    • v.39 no.2
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    • pp.157-161
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    • 2016
  • The purpose of this study is that in measures the acoustic propagate characteristics and temperature sensitivity of ultrasound tissue mimicking phantom(TM phantom). TM phantom manufacture according to the International Electronical Committee(IEC) guidelines for acoustic propagate characteristics of soft tissue. TM phantom was observed to have the image brightness and the image depth penetration decreases changes convergence which was the subject of ultrasound image characteristics in accordance with an external temperature that the change is reduced in temperature below $22^{\circ}C$. This study provide a basis t o create another TM Phantom and TM Phantom has been determined that it is appropriate for use in more than $22^{\circ}C$.

Studies on the Radiation Induced Apoptosis by Morphological and Biochemical Analysis in A431 Cells (방사선에 조사된 인체세포주(A431)에서 형태학적 분석법과 생화학적 분석법을 이용한 방사선 유도 세포고사에 관한 연구)

  • Choi, Keun-Hee;Bom, Hee-Seung;Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
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    • v.33 no.3
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    • pp.306-315
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    • 1999
  • Purpose: We performed this study to evaluate the process of radiation induced apoptosis in A431 skin epithelial cancer cell line. Materials and Methods: Low to high dose radiation (0, 2, 5, 10, 25 Gy) was given to A431 cells by Cs-137 cell irradiator. Apoptosis was evaluated by cell morphology, dye exclusion test, and DNA laddering. Results: Cell viability decreased as the radiation dose increased. Number of apoptotic bodies increased as radiation dose increased. It increased most significantly at 12 hours after irradiation. Lactate dehydrogenase activity in culture medium increased according to radiation dose and time after irradiation. DNA ladders could be identified in irradiated cells, but, it had no correlation with radiation dose or time after irradiation. Conclusion: Radiation-induced apoptosis which was the main course of cell death in A431 cells could be analyzed quantitatively by counting apoptotic bodies under microscope. Apoptosis increased as radiation dose increased.

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