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http://dx.doi.org/10.7742/jksr.2014.8.7.389

Development of Glioblastoma In Vivo Model for the Research of Brain Cancer Diagnosis and Therapy  

Kang, Seonghee (Lab of Radiation Convergence Science)
Kang, Bosun (Department of Radiological Science, College of Medical Science, Konyang University)
Publication Information
Journal of the Korean Society of Radiology / v.8, no.7, 2014 , pp. 389-395 More about this Journal
Abstract
The research was carried out to develop a animal model of malignant brain tumor for the researches in glioblastoma multiform (GBM) diagnosis and therapy. C6 cells were transplanted into the right striatum of SD rat using stereotactic instrument for the development. The developed animal model was verified by MRI and H&E stain assay of anatomicohistological examination. The MRI observations showed that the tumor developed at the injection site at the 7 days after glioblastoma inoculation. At 14 days post inoculation, the tumor grew to a large volume occupying almost a half of the right cerebral hemisphere. It was confirmed that the expression of excessive mitosis and pleomorphism in anatomicohistological examination. The developed animal model must be necessary and useful tool for the in vivo level research in the development of the new modality for the diagnosis and therapy of brain cancer.
Keywords
Glioblastoma multiform; in vivo model; allograft; C6 cell; stereotactic inoculation;
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Times Cited By KSCI : 1  (Citation Analysis)
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