• Maxillofacial Plastic and Reconstructive Surgery
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• v.11 no.2
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• pp.11-18
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• 1989

Advancement of surgical techniques has made it necessary to accurately diagnose internal derangements. Arthrography and computerized tomography have been used to diagnose the majority of temporomandibular joint disorders, however, these methods have had their disadvantages. Magnetic resonance imaging utilizing surface coils has greatly improved the ability to diagnose meniscus abnormalities without using intrarticular injections or ionizing radiation. Ninety-two patients (184 joints) were evaluated by means of magnetic resonance imaging(MRI). Thirty-one patients (39 joints) were diagnosed as having meniscus perforation. Retrospective review of fifteen patients (20 joints) with a perforated meniscus diagnosed by magnetic resonance imaging pre-operatively demonstrated a sixty-five percent correlation between the radiographic diagnosis and the surgical findings.

• Journal of Genetic Medicine
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• v.6 no.1
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• pp.81-86
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• 2009

Multiple epiphyseal dysplasia (MED) is a clinically and genetically heterogeneous chondroplasia, characterized by delayed development of the ossification centers and, deformities of the extremities that involve only the epiphysis and result in mild short stature. Mutations in the cartilage oligomeric matrix protein (COMP) gene are most commonly found, and most of the mutations are located in the calmodulin-like repeats and the C-terminal domain. We report a Korean kindred of 12 family members with MED in four generations who were found to have a novel mutation in the COMP gene. A pedigree showed early onset osteoarthritis requiring arthroplasty that was an autosomal dominant inherited trait. Radiological examinations demonstrated the presence of osteochondral defects in the medial femoral condyles, and the knee and hip joints showed variable degrees of precocious degenerative changes. Mutation analysis of the COMP gene in the proband and five other affected family members identified a novel missense mutation, c.1280G>C (p.Gly427Ala) in exon 12, which was not found in three unaffected family members. Direct sequencing of the COMP gene may yield pathogenic mutations in dominantly inherited MED cases, and may provide opportunities of carrier detection among high-risk family members, leading to genetic counseling for early diagnosis and intervention before the onset of complications.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.265-270
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• 2019

Growing evidence suggests that mediating apoptotic cell death of ER stress plays an important role in pathological development of neurodegenerative diseases including Alzheimer's disease. The ethanol extract of Rodiola sacra (ERS) investigates whether ER stress protects neuroinvasive neuro-2A cells from homocysteine (Hcy) cell death and ER stress. In neuronal cells, Hcy markedly decreased the viability of the cells and induced the death of Annexin V-positive cells as confirmed by MTT assay. The Hcy cell viability and apoptotic loss pretreated with ERS were attenuated, and Hcy showed stress in the expression of C / EBP homologous protein, 78-kDa glucose regulatory protein and the junction of X-box binding protein-1 (xbp1) mRNA. ESR decreased Hcy-induced mRNA binding, GRP78 and CHOP cells induced Hcy-induced ER stress and apoptosis, and Western blotting revealed expression of heme oxygenase-1 and HO-1 enzyme activity Inhibition is indicative of therapeutic value for neurodegenerative diseases such as decreased cell death by hemin.

• The Korean Journal of Zoology
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• v.26 no.4
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• pp.253-270
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• 1983

Electron microscopic degeneration studies were carried out on the rat's interpeduncular nucleus following lesion on both habenular nuclei to clarify the morphological nature of their presynaptic endings involved in the habenulo-interpeduncular pathway. Two distinct types of interpeduncular neurons were observed: 30% of large neurons and 70% of small ones. Four types of boutons with many characteristics could be differentiated; small spherical vesicle-containing boutons (40%), large spherical vesicle-containing boutons (18%), pleomorphic vesicle-containing boutons (33%), and elongated vesicle-containg boutons (9%). Vesicle containing dendrites were observed as dendro-dendritic synapses and axo-axonal synapses were also found, though rarely. Two to four days after the lesion on both habenular nuclei, the small spherical vesicle-containing boutons were found almost exclusively in the process of degeneration, while the other types were entirely free of degeneration. Therefore, it is inferred that habenural neurons terminate in the interpeduncular nucleus as small spherical vesicle-containing boutons. The neuronal origin of the other bouton types is discussed.

• Journal of Life Science
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• v.32 no.1
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• pp.70-77
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• 2022

Endocrine disrupting chemicals (EDCs) have been attracting significant attention in modern society, owing to the increased incidence rate of various diseases along with population growth. EDCs are found in many commercial products, including some plastic bottles and containers, detergents, liners of metal food cans, flame retardants, food, toys, cosmetics, and pesticides. EDCs have a hormonal effect on the human body, which disrupts the endocrine system, notably affecting sexual differentiation and normal reproduction, and can trigger cancer as well. Recently, the association between neurological diseases and EDCs has become a hot topic of research in the field of neuroscience. Considering that EDCs negatively affect not only neuronal proliferation and neurotransmission but also the formation of the neuronal networks, EDCs may induce neurodevelopmental disorders, such as autism spectrum disorders and attention-deficit/hyperactivity disorder as well as neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. In light of these potentially deleterious outcomes, important efforts have been underway to minimize the exposure to EDCs through appropriate regulations and policies around the world, but chemicals that have not yet been associated with endocrine disrupting properties are still in wide use. Therefore, more epidemiological investigations and research are needed to fully understand the effects of EDCs on the nervous system.

• Clinical and Experimental Pediatrics
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• v.49 no.9
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• pp.1000-1004
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• 2006

Atretic cephalocele is a degenerative form of encephalocele, which is detected as a cystic mass in the head, primarily in infants. Its presentation and prognosis vary and depend on various factors, including the nature of the tissues within the cyst, other concomitant anomalies, the site of development, and the presence or absence of an embryonic straight sinus. We here report 2 cases of atretic encephalocele, that were transferred to our hospital because round tumors, misdiagnosed as dermoid cysts, were detected in their parietal lobes immediately after birth. On diagnostic and differential MRI, an embryonic straight sinus was detected while histochemical results indicated that the lesions contained cerebral tissues. Despite these structural anomalies, the two patients developed normally neurologically and no other anomalies were detected. We here discuss these two cases and present a review of the relevant literature.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.12.1-12
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• 1981

The dentigerous cyst originates through alteration of the reduced enamel epithelium after the crown of the tooth has been completely formed, with accumulation of fluid between the reduced enamel epithelium and the tooth crown. The dentigerous or follicular cyst comprises about 20% of all dental cysts. It usually occurs between 20 and 30 years of age but is occasionally seen in children or in old people. The most common sites of this cyst are the mandibular third molar and maxillary cuspid areas, since these are the most commonly impacted teeth. Many of these cysts give no clinical symptoms until noticeable asymmetry of the face develops. Rarely it develops to an ameloblastoma, epidermoid carcinoma and mucoepidermoid carcinoma, so early removal leads to better result. Roentgenographic examination of the jaw involved by a dentigerous cyst will reveal a radiolucent area. Recently the authors have experienced a giant dentigerous cyst which produced the bony deformity of the maxillary and hard palate bone. The cyst was completely removed under the local anesthesia by Caldwell-Luc approach.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.2
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• pp.87-92
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• 2015

Mucopolysaccharidosis (MPS) is an inherited disease entity associated with lysosomal enzyme deficiencies. MPS type 2, also known as Hunter syndrome, has a characteristic morphology primarily involving x-l inked recessive defects and iduronate-2-sulfatase gene mutation. The purpose of this case report is to provide important clues to help pediatricians identify Hunter syndrome patients earlier (i.e., before the disease progresses). A 30-month-old boy showed developmental delay and decreased speech ability. Physical examinations revealed a flat nose and extensive Mongolian spots. Brain magnetic resonance images (MRIs) showed bilateral multiple patchy T2 hyperintense lesions in the periventricular and deep white matter, several cyst-like lesions in the body of the corpus callosum, and diffuse brain atrophy, which were in keeping with the diagnosis. Based on these findings, the patient was suspected of having MPS. In the laboratory findings, although the genetic analysis of IDS (Iduronate-2-sulfatase) did not show any pathogenic variant, the enzymatic activity of IDS was not detected. We could confirm the diagnosis of MPS, because other sulfatases, such as ${\alpha}$-L-iduronidase, were detected in the normal range. Early enzymatic replacement therapy is essential and has a relatively good prognosis. Therefore, early diagnosis should be made before organ damage becomes irreversible, and brain MRIs can provide additional diagnostic clues to help distinguish the disorder.

• Journal of the Korean association of regional geographers
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• v.17 no.1
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• pp.17-39
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• 2011

As recent inflows of foreign immigrants to relatively advanced countries in Northeast Asia have rapidly increased, Japan in particular uses 'multicultural coexistance' as a key concept for developing both discourse and policies on them. This paper is first of all to suggest a new typology of multicultural societies in the world ill order to differentiate the case of Northeast Asian countries from those of Western countries. And this paper is to suggest that foreign immigrants in Japan have different positions in labor markets and living experiences according to historical and social backgrounds as well as their nationality. The transformation process towards multicultural society is not only historical and social but also geographical and spatial, as foreign immigrants have made different spatial distribution and regional segregation in types. In order to control this socio-spatial process towards multicultural society, Japan has developed the concept of 'multicultural coexistence' similar with that of multiculturalism in Western countries. This concept seems to be quite significant as it has been initiated by local communities for symbiotic relationship between foreign immigrants and native Japanese dwellers. But it can be regarded as a strategic ideology to control foreign immigrants as it targets mainly on Nikkeijin, and is usually concerned with the cultural aspect. Seen from a theoretical point of view, this concept can be seen as closed with liberal multiculturalism as opportunity equity, but far from corporative multiculturalism as outcome equity, and it is on the process transferring from the first stage of tolerance to the second stage of legislation of nondiscrimination, while being distant from the third stage of legislation paradigmization of recognition, and hence appears to be easily reverted to assimilationism.

• The Journal of the Korea Contents Association
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• v.13 no.1
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• pp.333-341
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• 2013

Purpose: The purpose of this study was to identify the relationship of self-differentiation, self-esteem and school adjustment among adolescents. Methods: The data were collected from 508 adolescents and analyzed using n (%), t-test, ANOVA, Scheffe test, Pearson correlation coefficient and multiple regression with the SPSS 16.0program. Results: First, School adjustment was different for grade, gender, level of mother's education, and economics level. Second, Subjects of self-differentiation was the average score 102 points, self-esteem average score 27.3 points and school adjustment average score 63.6 points.. Third, Self-differentiation and self-esteem had a significant positive correlation with school adjustment. Fourth, Stepwise multiple regression analysis showed that family regression, emotional cutoff, recognition emotional function and family projection in self-differentiation, self-esteem and gender(female), level of mother's education(above university), and grade(high) explained 46.5% of the total variance in school adjustment. Conclusion: Self-differentiation and self-esteem were confirmed as having an influence on school adjustment. We need to develop a nursing intervention program that can manage adolescent's school adjustment. When providing such programs, the family must be included.