• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.383-387
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• 2015

Bowel and rectal diseases are on the increase by irregular life and westernized eating habits of modern people, especially rectal cancer, which accounts for 50% of the entire colon cancer. For the initial rectal cancer, because there is no portion projecting on the surface, if not see inside the tissue with ultrasound, you make an errors that misdiagnosis as rectal abscess. However there is a need for more accurate diagnosis, because it is sometimes difficult to distinguish abscess from rectal cancer depending on staging, in spite of the ultrasonic diagnosis. Therefore, this study was performed quantitative analysis by using a computer algorithm for rectal cancer and abscess image. Each of 20 cases about normal, abscess and cancer by setting analysis region ($50{\times}50$ pixels) applies to GLCM algorithm and Autocorrelation, Max probability, Sum average, Sum variance in each image were analyzed by comparing the 4 single parameter. Consequently, The high lesion detection efficiency was presented 100% by the 3 parameter of Autocorrelation, Max probability, Sum variance and the parameter of Sum average presents 95% in cancer, more than 90% in abscess. Those parameters are valuable in distinction standard about normal, cancer and abscess in rectum. It is sufficient availability as a computer assisted diagnosis system depended on clinical using.

• Journal of Life Science
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• v.27 no.10
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• pp.1215-1224
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• 2017

Until now, various oncogenic pathways were idenfied. The accumulation of DNA mutation induces genomic instability in the cell, and it makes cancer. The development of bioinformatics and genomics, to find the precise and reliable biomarker is available. This biomarker could be applied the early-dignosis, prediction and convalescence of cancer. Recently, Transposable elements (TEs) have been attracted as the regulator of genes, because they occupy a half of human genome, and the cause of various diseases. TEs induce DNA mutation, as well as the regulation of gene expression, that makes to cancer development. So, we confirmed the relationship between TEs and colon cancer, and provided the clue for colon cancer biomarker. First, we confirmed long interspersed nuclear element-1 (LINE-1), Alu, and long terminal repeats (LTRs) and their relationship to colon cancer. Because these elements have large composition and enormous effect to the human genome. Interestingly, colon cancer specific patterns were detected, such as the hypomethylation of LINE-1, LINE-1 insertion in the APC gene, hypo- or hypermethylation of Alu, and isoform derived from LTR insertion. Moreover, hypomethylation of LINE-1 in proto-oncogene is used as the biomarker of colon cancer metastasis, and MLH1 mutation induced by Alu is detected in familial or hereditary colon cancer. The genes, effected by TEs, were analyzed their expression patterns by in silico analysis. Then, we provided tissue- and gender-specific expression patterns. This information can provide reliable cancer biomarker, and apply to prediction and diagnosis of colon cancer.

• Spatial Information Research
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• v.20 no.6
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• pp.23-32
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• 2012

This study applied an exploratory analysis based on Self Organizing Map and GIS to cause specific age-standardized regional death rates data related to ten types of male cancers to find meaning patterns in the data. Then the patterns revealed from the exploratory analysis was evaluated to investigate possible relationship between these patterns and regional socio-economic status represented by regional educational attainment levels of head of household. The results from this analysis show that SI-GUN-GUs in Korea can be clustered to eighteen unique clusters in the stand point of male cancer death rates and these clusters are also spatially clustered. Also, the results reveal that regions with higher socio-economic status show lower level of the death rates compared with the regions with lower socio-economic status. However, for some cancer types, the regions with higher socio-economic status show relatively higher death rates. These patterns imply that the prevention, detection, and treatment of male cancers might be strongly affected by regional factors such as socio-economic status, environmental factors, and cultures and norms in Korea. Especially, one of the eighteen clusters, which includes Gangnam-Gu and Seocho-Gu, shows lower death rates in many of male cancer types. This implies that socio-economic status may be one of the most influential factors for regional cancer control.

• Journal of Hospice and Palliative Care
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• v.7 no.1
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• pp.64-72
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• 2004

Purpose: This research aims to assess the effect of a single session of group education of hospice program at Seoul National University Hospital for the advanced and terminal cancer patients and their family members. Methods: Response to questionnaires from 89 participants were evaluated using SAS and CHISQ analysis. The questionnaires included the following items: 1) the characteristics of participants; 2) the characteristics of patients; 3) the difficulties of patient care; 4) the satisfaction with the program Results: The participants consist of 33 patients (37.5%) and 56 family members (56.2%). Diagnosis included mainly stomach, lung, breast, and colon cancer. Participants of family members consisted of spouse, parent, children, daughter-in-law, and siblings (in decreasing order). The participants were interested in the medical information, nutrition, pain and symptom management, and psychosocial adaptation. They had difficulties in emotional problem, nutrition and symptom management. Even though it was a single session of group education, the level of satisfaction was high (95%). Conclusion: This research shows that even the single session of the group education for the advanced and terminal cancer patients and their family members is very helpful by giving them the necessary information. In order to develop comprehensive care-giving services, more specific informations, more opportunities to participate in such sessions and longer question-answer time is required.

• Journal of Life Science
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• v.17 no.9 s.89
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• pp.1232-1236
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• 2007

Growth and DNA synthesis inhibitory effects of extracts from root bark of Ulmus parvifolia on MG-63 human osteosarcoma cells, HT-29 human colon cancer cells and K-562 leukemia cancer cells were studied. The root bark extract of Ulmus parvifolia was extracted with methanol, hot water and juice. The methanol extract showed the highest inhibitory effect on growth of MG-63, HT-29 and K-562 cancer cells by >85%. The treatment of hot water and juice extracts from root bark of Ulmus parvifolia also inhibited growth of the above cancer cells with increasing concentration. DNA synthesis of MG-63 and HT-29 cancer cells was significantly inhibited by adding methanol, hot water and juice extracts from root bark of Ulmus parvifolia with increasing concentration, showing that the inhibitory effect of growth was more effective on HT-29 cancer cells. These results suggest that the methanol extract from root bark of Ulmus parvifolia may have specific active com-pounds on anticancer effect. The hot water extract also showed a strong inhibitory effect on growth of cancer cells, indicating that the active compounds may be stable to heat.

• Explosives and Blasting
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• v.18 no.4
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• pp.43-54
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• 2000

본 연구에서는 계단식 발파에서 파쇄입도에 영향을 미치는 변수들로부터 대괴를 줄이는 새로운 발파패턴을 제시하고자 하였다. 광주 제2순환도로 대절토 구간에서 천공경, 1회발파공수, 화약의 종류 등의 영향을 파쇄암의 평균입자의 크기와 상위 5개의 대괴 평균치로 나타내었다. 그 결과 대괴의 크기는 평균 파쇄암의 크기와 선형적인 추이를 나타내었으며 평균파쇄도는 저폭속 폭약인ANFO가 NewMITE 보다 좋은 결과를 보였다. 또 천공경 65 mm와 75 mm로 ANFO즉 사용했을 때 파쇄도는 약포의 직경이 작은 경우에 파쇄도가 양호하게 나타났고 총공수와 파쇄도를 살펴본 결과 평균파쇄도와 대괴의 크기는 대제적으로 총공수의 증가에 비례하여 커지는 경향이었으며 평균파쇄도 보다는 대괴의 크기가 증가의 폭이 컸다. 한편 첫째 열을 2단 분리장약했을 때가 일반 발파나 1열 소단벤치발파 때보다 파쇄도가 좋았다.

• Proceedings of the Korea Information Processing Society Conference
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• 2013.11a
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• pp.1113-1116
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• 2013

유전체에 대한 관심이 크게 증가하면서, 이에 따른 다양한 연구가 이루어졌다. 그 결과 유전체와 관련된 다양한 종류의 데이터가 얻어졌으며, 그것을 해석하고 다른 데이터와 통합하는 것이 중요한 연구과제 중 하나가 되었다. 본 논문은 유전자 상호작용(genetic interaction) 데이터, 유전자 발현 데이터, 문헌으로부터 텍스트마이닝 기술을 통해 얻은 이종(heterogeneous) 데이터를 통합하여 암과 관련이 있는 유전자를 찾는 실험을 수행하였다. 또한, 단순히 질병(disease)-정상(normal)의 대조가 아니라 암의 단계(stage)를 고려한 실험을 수행하였다. 데이터를 통합하지 않거나 암의 단계를 고려하지 않았을 경우에 비하여 제안하는 방법이 더 높은 유전자 예측 성능을 나타냈다.

• Journal of Preventive Medicine and Public Health
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• v.25 no.2 s.38
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• pp.115-126
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• 1992

To estimate the cancer mortality rates among Koreans, a mortality survey was carried out in the province of $Ky{\breve{o}}ngsangnam-do$. The study population are the beneficiaries of Korea Medical Insurance Corporation(KMIC), $Ky{\breve{o}}ngsangnam-do$ area, among which the 3,867 deaths occurred from January, 1989 to December, 1990, were reviewed to confirm the cancer deaths. These were based upon the death certificates and medical utilization records before dying which were available through the computerized databases on medical care utility of KMIC. The survey was conducted along three steps. At first, the death certificates were examined, as a second step medical utilization records were reviewed, and finally direct contacts to the family members of the deceased were done. As a result, 990 deaths were found due to cancer. Using them, age and sex specific cancer(all sites and several sites) mortality rates were estimated. Overall cancer mortality rate in the area was estimated 138.7 per 100,000 person-years in males, and 65.7 in females, respectively. And the orders of site-specific cancer mortality rates were the cancers of stomach, liver, lung, esophagus, and cancers of the hematopoietic system among males, In females, followed by gastric cancer, cancers of lung and liver are the 2nd and 3rd in rank, respectively and cancers of breast and uterine cervix are the 4th and the 5th in rank.

• Tunnel and Underground Space
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• v.21 no.2
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• pp.145-150
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• 2011

Variations of physical properties such as weight loss rate, wave velocity and uniaxial compressive strength after performing freeze-thaw cyclic test were measured in order to define weathering characteristics of sandstone and andesite. Weight change in specimens of the two rocks decreased with increasing the repetition number of freeze-thaw cyclic test. In particular, weight loss of andesite specimens was very irregular. P-wave velocity of sandstone specimens decreased more than 5%. On the other hand, P-wave velocity of andesite specimens do not vary up to 500 cycles and decreased more than 5% after 1000 cycles. This implies that the sandstone are easily weakened and loosened by weathering processes, while the andesite are relatively strong. In addition, the wave velocity changes of the andesite specimens coincident with the weight change. Uniaxial compressive strengths of the sandstone specimens slightly decreased at the early stage of the freezing-thawing cyclic test, then tended to be irregular after 64 cycles. In conclusion, the rock specimens showed smaller weight loss, less had lower strength reduction rate.

• The Journal of the Petrological Society of Korea
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• v.28 no.2
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• pp.71-83
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• 2019

The volcanic rocks in Saryangdo area are composed of Witseom Andesite, Punghwari Tuff, Araetseom Andesite, Obido Formation, Namsan Rhyolite and Saryangdo Tuff in ascending order. The volcanic rocks has a range of andesite-rhyodacite-rhyolite, which indicates calc-alkaline series and volcanic arc of orogenic belt. In Harker diagrams for trace element and REE pattern, these are also distinguished into so three groups(Witseom Andesite, Araetseom Andesite and Saryangdo Tuff) that each unit is interpreted to have originated in different magma chamber. The Saryangdo Tuff exhibits systematically(chemical zonations that gradually change) from lower dacite to upper rhyolite in section. The systematic sequence of compositional variations suggests that the tuffs were formed by successive eruptions of upper to lower part of a zoned magma chamber in which relatively dacitic magma is surrounded around rhyolitic magma of the central part. The zoned magma chamber was formed from marginal accretion and crystal settling that resulted form magmatic differentiations by fractional crystallization.