• Korean Chemical Engineering Research
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• v.61 no.1
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• pp.155-161
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• 2023

Ion concentration polarization (ICP) is one of the essential important mechanisms for biomolecule preconcentration devices as well as a fundamental transport phenomenon found in electrodialysis, electrochemical cell, etc. The ICP triggered by externally applied voltage enables the biomolecular analyte to be preconcentrated at an arbitrary position by a locally amplified electric field inside the microchannel. Conventional preconcentration methodologies using the ICP have two limitations: uncertain equilibrium position and hydrodynamic instability of preconcentration plug. In this work, a new preconcentration method in the dead-end microchannel around cation exchange membrane was numerically studied to resolve the limitations. As a result, the numerical model showed that the analyte was concentrated at a shock front developed in a geometrically confined dead-end channel. Furthermore, the electrokinetic behaviors for preconcentration dynamics were analyzed by changing microchannel's applied voltage and volumetric charge concentration of microchannel as key parameters to describe the dynamics. This work would provide an effective means for a point-of-care platform that requires ultra-fast preconcentration method.

• Proceedings of the KIEE Conference
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• 2001.11a
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• pp.69-71
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• 2001

본 논문에서는 FACS(fluorescence activated cell sorting)의 초소형화를 위한 미세 유체소자들을 플라스틱 기판에 집적하여 제작하고 전기삼투를 이용해서 세포가 일렬로 이송되는 특성을 시험한다. 제작된 미세 유체 소자는 유리 하부 기판과 플라스틱 상부 기판 및 전원장치로 구성된다. 상부기판은 세포를 주입하기 위한 샘플 측 레저버와 세포를 운반 및 일렬 이송이 가능하게 하는 버퍼를 저장할 두 개의 레저버가 있고 이들이 배출되는 레저버로 구성된다. 마이크로머시닝 기술을 이용하여 실리콘 기판 위에 미세 채널 몰드를 제작한 후 PDMS(polydimethylsiloxane)로 주물을 제작한다. $O_2$ 플라즈마를 이용하여 유리 기판과 PDMS 주물을 접합하며 제작된 채널에 적색 잉크와 bead를 샘플 측에 충전하고 버퍼 측에 sodium borate를 충전한 후 전기삼투로 구동시킨다. bead가 일렬로 이송되도록 전장을 조절하고 이때의 유속과 유량을 측정한다. 다양한 전장에 따른 실험을 통하여 채널의 구조를 최적화한다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.977-978
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• 2011

• Korean Chemical Engineering Research
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• v.52 no.1
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• pp.106-112
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• 2014

Here, we demonstrated the optimum design of pillar microstructure for efficient microdroplet merging. The microfluidic device mainly consisted of programmable microvalves and pillar microstructures. Based on the system, aqueous droplets were continuously generated at T-junction using actuating of integrated programmable microvalaves under the immiscible continuous fluid (mineral oil containing 0.5 wt% Span 80). The principle of merging process depended on the competitive correlation of hydraulic pressure of continuous phase and Laplace pressure of the droplet. We found that the design of the micropillars controls above two pressures. Finally, it was demonstrated that the microfluidic system could be able to efficient biochemical reaction. We expect that the microfluidic system is useful analytical or reaction tools in fundamental science, biotechnology, and chemical engineering.

• Clean Technology
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• v.21 no.2
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• pp.90-95
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• 2015

Digital microfluidic electroporation system was used for the transformation of microalgae and we have obtained higher transformation efficiency and viability than that of conventional method. Key parameters of electroporation such as pulse voltage, number, and duration time were systematically investigated for two different microalgal strains with and without cell wall. We have found that cell wall does not always have negative effects on the gene transformation of microalgae. Parallel processing of proposed digital microfluidic electroporation was demonstrated together with on chip culture of microalgae.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.2
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• pp.114-121
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• 2013

In order to estimate the efficiency of an evaporative heat exchanger having mini channel, the equations to calculate heat exchanger properties, those are air temperatures and water temperatures etc, are derived from the governing equations based on the Navier-Stokes equation, even though there are several assumptions to make problem simplify. There are three heat transfer zones at the mini channel heat exchanger depending on the water condition. So, there are three governing equations and solutions to calculate the properties. As the results of this study, the equations to calculate a saturation point and a dry point are derived to evaluate an evaporative heat exchanger having micro channel. It is supposed to predict and evaluate the performance of a mini channel heat exchanger with evaporation of liquid.

• Korean Chemical Engineering Research
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• v.60 no.1
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• pp.139-144
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• 2022

This study reports a microfluidic approach to produce monodisperse hydrogel microparticles in a simple and highly efficient manner. Specifically, we produce double emulsion drops with a thin oil shell surrounding an aqueous prepolymer solution, which is solidified via UV-induced free radical polymerization. When they are dispersed in an aqueous solution, the oil shell is dewetted due to the absence of surfactants, resulting in production of highly uniform hydrogel microparticles (C.V.=1%). Results show that production of monodisperse hydrogel microparticles with controllable size and composition can be achieved with minimal use of oil unlike water-in-oil (w/o) single emulsion-based approach. Furthermore, in-depth study of flow patterns in microfluidic device using a phase diagram exhibits a crucial relationship among relative flow rates while providing windows of readily controllable parameters for reliable manufacturing of hydrogel microparticles.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.505-506
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• 2010

• Journal of the Korean Society for Precision Engineering
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• v.23 no.2 s.179
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• pp.129-137
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• 2006

Polymer micro-fluidic devices were fabricated with laser processes. A UV laser and a femto laser were used to machine polymer micro-fluidic structures directly. This laser direct machining process suits the need of rapid prototyping, as in many applications changes from the original design are often required. As examples, two polymer micro-systems were developed: a micro-check valve and a micro diffuser pump. The micro fluidic devices can be applied for many applications such as clinical diagnostics and drug delivery. Advantages and disadvantages using polymers as a material for micro-fluidic applications are discussed.

• Korean Chemical Engineering Research
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• v.53 no.6
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• pp.740-745
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• 2015

This study investigated the effect of different collection methods on physical properties of pectin hydrogels in microfluidic synthetic approach. The pectin hydrogels were simply produced by the incorporation of calcium ions dissolved in continuous mineral oil. Then, different collection methods, pipetting, tubing, and settling, for harvesting pectin hydrogels were applied. The settling method showed most uniform and monodispersed hydrogels. In the case of settling, a coefficient of variation was 3.46 which was lower than pipetting method (18.60) and tubing method (14.76). Under the settling method, we could control the size of hydrogels, ranging from $30{\mu}m$ to $180{\mu}m$, by simple manipulation of the viscosity of pectin and volumetric flow rate of dispersed and continuous phase. Finally, according to the characteristics of simple encapsulation of biological materials, we envision that the pectin hydrogels can be applied to drug delivery, food, and biocompatible materials.