Browse > Article
http://dx.doi.org/10.9713/kcer.2014.52.1.106

Stagnation of Droplet for Efficient Merging in Microfluidic System  

Jin, Si Hyung (Department of Chemical Engineering, Chungnam National University)
Kim, Jongmin (Department of Chemical Engineering, Chungnam National University)
Jang, Sung-Chan (Department of Chemical Engineering, Chungnam National University)
Noh, Young Moo (Department of Chemical Engineering, Chungnam National University)
Lee, Chang-Soo (Department of Chemical Engineering, Chungnam National University)
Publication Information
Korean Chemical Engineering Research / v.52, no.1, 2014 , pp. 106-112 More about this Journal
Abstract
Here, we demonstrated the optimum design of pillar microstructure for efficient microdroplet merging. The microfluidic device mainly consisted of programmable microvalves and pillar microstructures. Based on the system, aqueous droplets were continuously generated at T-junction using actuating of integrated programmable microvalaves under the immiscible continuous fluid (mineral oil containing 0.5 wt% Span 80). The principle of merging process depended on the competitive correlation of hydraulic pressure of continuous phase and Laplace pressure of the droplet. We found that the design of the micropillars controls above two pressures. Finally, it was demonstrated that the microfluidic system could be able to efficient biochemical reaction. We expect that the microfluidic system is useful analytical or reaction tools in fundamental science, biotechnology, and chemical engineering.
Keywords
Microfluidics; Droplet; Microvalve; Pillar; Merging;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Whitesides, G. M., "The Origins and the Future of Microfluidics," Nature, 442(7101), 368-373(2006).   DOI   ScienceOn
2 Jeong, H. H., Lee, S. H. and Lee, C. S., "Pump-less static Microfluidic Device for Analysis of Chemotaxis of PseudomoNas Aeruginosa Using Wetting and Capillary Action," Biosens. Bioelectron., 47, 278-84(2013).   DOI   ScienceOn
3 Jang, S. C., Jeong, H. H. and Lee, C. S., "Analysis of Pseudomonas Aeruginosa Motility in Microchannels," Korean Chem. Eng. Res.(HWAHAK KONGHAK), 50, 743-748(2012).   과학기술학회마을   DOI
4 Min, S. K., Lee, B. M., Hwang, J. H., Ha, S. H. and Shin, H. S., "Mathematical Analysis of Colonial Formation of Embryonic Stem Cells in Microfluidic System," Korean J. Chem. Eng., 29(3), 392-395(2012).   과학기술학회마을   DOI   ScienceOn
5 Huh, Y. S., Jeon, S. J., Lee, E. Z., Park, H. S. and Hong, W. H., "Microfluidic Extraction Using Two Phase Laminar Flow for Chemical and Biological Applications," Korean J. Chem. Eng., 28(3), 633-642(2011).   DOI   ScienceOn
6 Utada, A. S., Lorenceau, E., Link, D. R., Kaplan, P. D., Stone, H. A. and Weitz, D. A., "Monodisperse Double Emulsions Generated From a Microcapillary Device," Science, 308(5721), 537-541(2005).   DOI   ScienceOn
7 Choi, C. H., Weitz, D. A. and Lee, C. S., "One Step Formation of Controllable Complex Emulsions: From Functional Particles to Simultaneous Encapsulation of Hydrophilic and Hydrophobic Agents into Desired Position," Adv. Mater., 25(18), 2536-2541 (2013).   DOI
8 Kang, S. M., Choi, C. H., Hwang, S., Jung, J. M. and Lee, C. S., "Microfluidic Preparation of Monodisperse Multiple Emulsion using Hydrodynamic Control," Korean Chem. Eng. Res.(HWAHAK KONGHAK), 50, 733-737(2012).   과학기술학회마을   DOI   ScienceOn
9 Churski, K., Kaminski, T. S., Jakiela, S., Kamysz, W., Baranska- Rybak, W., Weibel, D. B. and Garstecki, P., "Rapid Screening of Antibiotic Toxicity in an Automated Microdroplet System," Lab Chip, 12(9), 1629-1637(2012).   DOI
10 Hung, L. H., Choi, K. M., Tseng, W. Y., Tan, Y. C., Shea, K. J. and Lee, A. P., "Alternating Droplet Generation and Controlled Dynamic Droplet Fusion in Microfluidic Device for CdS Nanoparticle Synthesis," Lab Chip, 6(2), 174-178(2006).   DOI   ScienceOn
11 Frenz, L., El Harrak, A., Pauly, M., Begin-Colin, S., Griffiths, A. D. and Baret, J. C., "Droplet-based Microreactors for the Synthesis of Magnetic Iron Oxide Nanoparticles," Angew. Chem.-Int. Edit., 47(36), 6817-6820(2008).   DOI
12 Niu, X. Z., Gielen, F., Edel, J. B. and deMello, A. J., "A Microdroplet Dilutor for High-throughput Screening," Nat. Chem., 3(6), 437-442(2011).   DOI
13 Link, D. R., Grasland-Mongrain, E., Duri, A., Sarrazin, F., Cheng, Z. D., Cristobal, G., Marquez, M. and Weitz, D. A., "Electric Control of Droplets in Microfluidic Devices," Angew. Chem.-Int. Edit., 45(16), 2556-2560(2006).   DOI   ScienceOn
14 Kohler, J. M., Henkel, T., Grodrian, A., Kirner, T., Roth, M., Martin, K. and Metze, J., "Digital Reaction Technology by Micro Segmented Flow - Components, Concepts and Applications," Chem. Eng. J., 101(1-3), 201-216(2004).   DOI   ScienceOn
15 Mazutis, L., Baret, J. C., Treacy, P., Skhiri, Y., Araghi, A. F., Ryckelynck, M., Taly, V. and Griffiths, A. D., "Multi-step Microfluidic Droplet Processing: Kinetic Analysis of an in vitro Translated Enzyme," Lab Chip, 9(20), 2902-2908(2009).   DOI
16 Baroud, C. N., de Saint Vincent, M. R. and Delville, J. P., "An Optical Toolbox for Total Control of Droplet Microfluidics," Lab Chip, 7(8), 1029-1033(2007).   DOI
17 Tan, Y. C., Fisher, J. S., Lee, A. I., Cristini, V. and Lee, A. P., "Design of Microfluidic Channel Geometries for the Control of Droplet Volume, Chemical Concentration, and Sorting," Lab Chip, 4(4), 292-298(2004).   DOI   ScienceOn
18 Fidalgo, L. M., Abell, C. and Huck, W. T. S., "Surface-induced Droplet Fusion in Microfluidic Devices," Lab Chip, 7(8), 984-986(2007).   DOI   ScienceOn
19 Niu, X., Gulati, S., Edel, J. B. and deMello, A. J., "Pillar-induced Droplet Merging in Microfluidic Circuits," Lab Chip, 8(11), 1837-1841(2008).   DOI   ScienceOn
20 Guo, F., Liu, K., Ji, X. H., Ding, H. J., Zhang, M., Zeng, Q. A., Liu, W., Guo, S. S. and Zhao, X. Z., "Valve-based Microfluidic Device for Droplet On-demand Operation and Static Assay," Appl. Phys. Lett., 97, 233701 (2010).   DOI
21 Unger, M. A., Chou, H. P., Thorsen, T., Scherer, A. and Quake, S. R., "Monolithic Microfabricated Valves and Pumps by Multilayer Soft Lithography," Science, 288(5463), 113-116(2000).   DOI
22 Zeng, S. J., Li, B. W., Su, X. O., Qin, J. H. and Lin, B. C., "Microvalve- actuated Precise Control of Individual Droplets in Microfluidic Devices," Lab Chip, 9(10), 1340-1343(2009).   DOI   ScienceOn