• Title/Summary/Keyword: 미드시스템

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Preparation and Characterization of Pamidronate-loaded PLGA Wafer for the Treatment of Bone Resorption (골 재흡수 치료를 위한 파미드로네이트를 함유한 이식형 생분해성 PLGA 웨이퍼의 제조와 특성결정)

  • 유제영;김상욱;강길선;성하수;정제교
    • Polymer(Korea)
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    • v.26 no.5
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    • pp.680-690
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    • 2002
  • Implantable biodegradable wafers were prepared with pamidronate -loaded poly (L-lactide-co-glycolide) (PLGA, 75 : 25 mole ratio by lactide to glycolide, molecular weight : 20000 and 90000 g/mole) by direct compression method for the sustained release of pamidronate to investigate the possibility for the treatment of bone resorption. Pamidronate-loaded PLGA powders were prepared by means of physical mixing and spray drying with the control of formulation factors and characterized by scanning electron microscope and X-ray diffractometer. The pamidronate-loaded PLGA powders fabricated into wafers by direct compression under the constant pressure and time at room temperature. These wafers were also observed for their structural characteristic, release pattern, and degradation pattern. The release rate of pamidronate increased with increasing their initial loading ratio as well as increasing wafer thickness. The molecular weight of PLGA affects the release pattern : the higher molecular weight of PLGA, the faster release rate. It can be explained that the higher viscosity of high molecular PLGA solution at same concentration tends to aggregate PLGA and pamidronate resulting in unstable pharmaceutical dosage form. This system had advantages in terms of simplicity in design and obviousness of drug release rate and nay be useful as an implantable dosage form for the treatment of aural cholesteatoma.

Input Shaping Control of a Refueling System Operating in Water (입력성형기법을 이용한 핵연료이송시스템의 수중이동 시의 진동제어)

  • Piao, Mingxu;Shah, Umer Hameed;Jeon, Jae Young;Hong, Keum-Shik
    • Journal of Institute of Control, Robotics and Systems
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    • v.20 no.4
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    • pp.402-407
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    • 2014
  • In this paper, residual sway control of objects that are moved underwater is investigated. The fuel transfer system in a nuclear power plant transfers the nuclear fuel rods underwater. The research on the dynamics of the loads transferred in different mediums (water and air) and their control methods have not been fully developed yet. The attenuation characteristics of the fuel transfer system have been studied to minimize its residual vibration by considering the effects of hydrodynamic forces acting on the fuel rod. First, a mathematical model is derived for the underwater fuel transfer system, and then experiments have been conducted to study the dynamic behavior of the rod while it travels underwater. Lastly, the residual vibration at the end point is minimized using the input shaping technique.

A study on the development of Gas-Vent Automatic Exchange Machine with Vision System (비젼 시스템을 이용한 가스벤트 자동 교환 장치)

  • Hong, Jun-Eui;Yoon, Dong-Eop;Kil, Gyung-Suk;Choo, Young-Yeol;Kwon, Jang-Woo
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • v.9 no.1
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    • pp.304-308
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    • 2005
  • 본 연구는 발포수지 공정에 사용되는 가스벤트를 신발중창 금형에 자동으로 교환하는 장치에 관한 것이다. 가스벤트는 폴리우레탄과 같은 소재를 이용한 신발 미드솔 발포시 발생되는 가스를 제거하기 위한 다공질 소자로서 신발금형 상부에 삽입된다. 가스벤트는 소모성 부품으로 일정주기마다 교환이 필요하나 작업공정상 수작업에 어려움이 많아 자동화된 교환시스템이 요구된다. 하지만 삽입되는 신발중창 금형과 가스벤트간은 유격이 거의 없으므로 본 연구에서는 신발 중창 금형의 손상을 방지하고 보다 신속한 교환을 위해 가스벤트 삽입 및 추출 홈의 위치정보를 영상을 통해서 구하고, 얻어진 영상에 대한 위치 데이터를 기계적 위치 추적 시스템의 데이터로 피드백 하여 홀의 중심 위치에서 가스벤트를 삽입 및 추출하여 자동으로 교환하는 장치를 구현하였다. 영상 처리는 패턴 매칭 기법을 이용하여 홀의 중심점을 구하였고, 이를 PLC로 전송하여 기계 작동 제어 및 XY플로터를 정밀 제어하여 공정이 진행되게 하였다.

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Analysis of Flavonoid 3',5'-Hydroxylase Gene in Transgenic Petunia (Petunia hybrida) Plants (형질 전환된 페튜니아 식물체에서의 Flavonoid 3',5' -Hydroxylase 유전자의 분석)

  • 김영희
    • Korean Journal of Plant Tissue Culture
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    • v.25 no.5
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    • pp.323-327
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    • 1998
  • The flavonoid biosynthetic pathway has been studied as a genetic model system, particularly in Petunia hybrida. In order to study the flavonoid biosynthetic pathway, we constructed a fusion gene system between Cauliflower Mosaic Virus (CaMV) 35S promoter and eggplant flavonoid 3', 5'-hydroxylase in pBI 121 plasmid. An optimal condition for plant regeneration was observed when internode explants were cultured on MS medium supplemented with IAA 0.2 mg/L plus BA 3 mg/L. For plant transformation internode explants of Petunia hybrida were precultured on BM medium supplemented with IAA 0.2 mg/L plus BA 3 mg/L. Putative transgenic plants were selected on medium containing kanamycin 50 mg/L plus cefotaxim 300 mg/L. Putative selected transformants were confirmed by amplification of selectable marker gene (nptII) by polymerase chain reaction (PCR) and Southern hybridization of flavonoid 3',5'-hydroxylase gene.

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Complete genome of a denitrifying Halioglobus sp. RR3-57 isolated from a seawater recirculating aquaculture system (순환여과양식시스템으로부터 분리된 Halioglobus sp. RR3-57의 유전체 분석)

  • Kim, Young-Sam;Noh, Eun Soo;Lee, Da-Eun;Kim, Kyoung-Ho
    • Korean Journal of Microbiology
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    • v.53 no.1
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    • pp.58-60
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    • 2017
  • Halioglobus sp. RR3-57 was isolated from a biofilter of a seawater recirculating aquaculture system and its complete genome sequence was obtained using the PacBio RS II platform. Two circular contigs were assembled and considered as a chromosome and a plasmid (size of 4,847,776 bp and 155,799 bp, and G+C content of 57.5% and 53.2%, respectively). Genomic analysis showed RR3-57 had 18 denitrification-related genes and an incomplete prophage.

Cost-efficient Fabrication of Colorless and Optically Transparent Polyimide Film for Flexible Displays (비용 효율적인 유연 디스플레이용 무색 투명 폴리이미드 필름 제작)

  • Dawoon Jo;Ji-Ho Kim;Chung-Seog Oh
    • Journal of the Semiconductor & Display Technology
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    • v.22 no.1
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    • pp.33-38
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    • 2023
  • As the demand for large flexible displays such as tablet computers continues to rise, there is an increasing need for cost-efficient colorless and optically transparent polyimide film that can meet the desired performance, particularly optical transmittance. In this study, we investigated a detailed procedure for achieving optimal optical transmittance using two different combinations of monomers: 6FDA+BAPB and 6FDA+BPA+TFDB. We employed a design of experiment method to systematically synthesize polymers, allowing for the optimization of optical transmittance. In addition, we were able to achieve uniform thickness in the films by using a doctor blade. By comparing the price and optical transmittance of four different monomer combinations, we obtained fundamental data on the production of polyimide films that can be customized to meet the specific price and performance requirements of manufacturers. This approach enables users to select the most suitable polyimide film based on their desired price and performance parameters while achieving optimal optical transmittance.

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Unknown Threats Detection by Using Incremental Knowledge Acquisition (상황 지식 축적에 의한 알려지지 않은 위협의 검출)

  • Park, Gil-Cheol;Cooke, Hamid B. M.;Kim, Yang-Sok;Kang, Byeong-Ho;Youk, Sang-Jo;Lee, Geuk
    • Convergence Security Journal
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    • v.7 no.1
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    • pp.19-27
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    • 2007
  • Detecting unknown threats is a paradox ; how do you detect a threat if it is not known to exist? The answer is that unknown threat detection is the process of making a previously unknown threat identifiable in the shortest possible time frame. This paper examines the possibility of creating an unknown threat detection mechanism that security experts can use for developing a flexible protection system for networks. A system that allows the detection of unknown threats through monitoring system and the incorporation of dynamic and flexible logics with situational knowledge is described as well as the mechanisms used to develop such a system is illustrated. The system not only allows the detection of new threats but does so in a fast and efficient manner to increase the available time for responding to these threats.

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Evaluation of Residual Strains under Pure Bending Loading for Colorless and Optically Transparent Polyimide Film for Flexible Display (유연 디스플레이용 무색 투명 폴리이미드 필름의 굽힘 잔류 변형률 평가)

  • Choi, Min-Sung;Park, Min-Seok;Park, Han-Yeong;Oh, Chung-Seog
    • Journal of the Semiconductor & Display Technology
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    • v.20 no.4
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    • pp.49-54
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    • 2021
  • The display industry is transitioning from traditional rigid products such as flat panel displays to flexible or wearable ones designed to be folded or rolled. Accordingly, colorless and optically transparent polyimide (CPI) films are one of the prime candidates to substitute traditional cover glass as a passivation layer to accommodate product flexibility. However, CPI films subjected to repetitive pure bending loads inevitably entail an accumulation of residual strain that can eventually cause wrinkles or delamination in the underlying component after a certain number of static and cyclic loading. The purpose of this study is to establish an experimental method to systematically evaluate the bending residual strain of CPI films. Films were monotonically and cyclically wrapped on mandrels of various diameters to ensure a constant strain in each. After unwrapping the wound CPI film, the residual radius of curvature remaining on the film was measured and converted into residual strain. The critical radius of curvature at which residual strain does not remain was about 5 mm, and the residual strain decreased in proportion to the log time. It is expected that flexible displays can be reliably designed using the data between the applied bending strain and the residual strain.

Optimization of Optical Performance of Colorless and Transparent Polyimide Film for Flexible Display using Design of Experiment (실험계획법을 이용한 유연 디스플레이용 무색 투명 폴리이미드 필름의 광학 성능 최적화)

  • Jo, Dawoon;Yu, Yeon-Soo;Nam, Hee-Eun;Chang, Jin-Hae;Oh, Chung-Seog
    • Journal of the Semiconductor & Display Technology
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    • v.21 no.1
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    • pp.79-84
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    • 2022
  • As various flexible display products are released, the demand for high-performance colorless and transparent polyimide (CPI) film is continuously increasing. The primary purpose of this study is to establish a systematic procedure for optimizing the optical performance of CPI films by applying the response surface method. After selecting three key factors (monomer type, stirring time for varnish synthesis, and maximum temperature of vacuum furnace for film production) affecting optical performance based on experiences and references, CPI films were manufactured according to the experimental sequence designed by the central composite design, and then the yellowness index (YI) and optical transmittance (Tr) of the films were measured. When producing a CPI film by pouring varnish into a petri dish, the change in optical properties according to thickness should be considered, and there was a meaningful linear relationship between YI and Tr. The species of monomer and the maximum temperature were the critical factors that had an influence on YI and Tr, respectively. It is expected that the procedure proposed in this study can serve as a starting point for CPI film optimization studies considering the other factors that were not considered and responses such as thermal properties.

Applications of English Education with Remote Wireless Mobile Devices (무선 원격 시스템의 모바일 장치를 이용한 영어 학습 방법 연구)

  • Lee, Il Suk
    • Journal of Digital Contents Society
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    • v.14 no.2
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    • pp.255-262
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    • 2013
  • Useful applications for English education enable immediate conversion of mobile devices into remote wireless systems for classroom computers. Once the free software has been installed in the main computers in the classroom, using powerpoint, students can operate the computers through their mobile devices by installing Air mouse on them. By using this, the students can draw or write on the "board" to manipulate the educational resources from where they are/from their seats. The study of English language encompasses not only academic study but also language training. Until recently, the issue of the English language learning has been ridden with certain problems-instead of being a tool that facilitates communication, its main purpose has been for school grades, TOEIC, and TOEFL. This study suggests English language learning methodology using various applications such as mobile, VOD English language content, and movie scripts in implementing easy and fun English language learning activities that can be studied regularly. This is operationalized by setting a specific limit on learning and by using various media such as podcast, Apps, to increase interest, motivation, and self-directed learning in a passive learning environment.