Browse > Article

Preparation and Characterization of Pamidronate-loaded PLGA Wafer for the Treatment of Bone Resorption  

유제영 (전북대학교 유기신물질공학과)
김상욱 (전북대학교 유기신물질공학과)
강길선 (전북대학교 유기신물질공학과, 전북대학교 유기신물질공학과)
성하수 (한국화학연구원 생체의료고분자팀)
정제교 (삼천당제약 중앙연구소)
Publication Information
Polymer(Korea) / v.26, no.5, 2002 , pp. 680-690 More about this Journal
Abstract
Implantable biodegradable wafers were prepared with pamidronate -loaded poly (L-lactide-co-glycolide) (PLGA, 75 : 25 mole ratio by lactide to glycolide, molecular weight : 20000 and 90000 g/mole) by direct compression method for the sustained release of pamidronate to investigate the possibility for the treatment of bone resorption. Pamidronate-loaded PLGA powders were prepared by means of physical mixing and spray drying with the control of formulation factors and characterized by scanning electron microscope and X-ray diffractometer. The pamidronate-loaded PLGA powders fabricated into wafers by direct compression under the constant pressure and time at room temperature. These wafers were also observed for their structural characteristic, release pattern, and degradation pattern. The release rate of pamidronate increased with increasing their initial loading ratio as well as increasing wafer thickness. The molecular weight of PLGA affects the release pattern : the higher molecular weight of PLGA, the faster release rate. It can be explained that the higher viscosity of high molecular PLGA solution at same concentration tends to aggregate PLGA and pamidronate resulting in unstable pharmaceutical dosage form. This system had advantages in terms of simplicity in design and obviousness of drug release rate and nay be useful as an implantable dosage form for the treatment of aural cholesteatoma.
Keywords
pamidronate; PLGA wafers; implantable dosage from;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
연도 인용수 순위
1 /
[ S.A. Seo;H.S. Choi;G. Khang;J.M. Rhee;H.B. Lee ] / Macromol.Res.
2 /
[ S.H. Ralston;M.D. Gardner;F.J. Dryburgh;A.S. Jenkins ] / Lancet
3 /
[ J.C. Cho;G. Khang;J.M. Rhee;Y.S. Kim;J.S. Lee;H.B. Lee ] / Korea Polym.J.
4 /
[ H.B. Lee;G. Khang;J.C. Cho;J.M. Rhee;J.S. Lee ] / Polymer Preprints
5 /
[ A. Fitton;D. McTavish ] / Drugs   DOI   ScienceOn
6 /
[ K. Adachi;R.A. Chole ] / Ann.Otol.Rhinol.Alryngol.   DOI
7 /
[ H.S. Choi;G. Khang;H. Shin;J.M. Rhee;H.B. Lee ] / Int.J.Pharm.   DOI
8 /
[ H.J. Kim;I.S. Park;J.L. Lim ] / Korean J.Otolaryngol.
9 /
[ J. den Jartigh;R. Langebrook;P. Vermeji ] / J.Pharm.Biomed.Anal.   DOI   ScienceOn
10 /
[ C.A. Mautalen;C.A. Casco;D. Gonzalez;G.R. Ghiringhelli;C. Massironi ] / Br.Med.J.
11 /
[ G. Khang;I. Lee;J.M. Rhee;H.B. Lee ] / Polym.Sci.Tech.
12 /
[ T.K. An;H.J. Kang;D.S Moon;J.S. Lee;H.S. Seong;;J.K. Jeong;G. Khang;H.B. Lee ] / Polymer(Korea)
13 /
[ S.J. Lee;G. Khang;Y.M. Lee;H.B. Lee ] / J.Biomater.Sci.Polym.Ed.   DOI   ScienceOn
14 /
[ J.C. Cho;G. Khang;H.S. Choi;J.M. Rhee;H.B. Lee ] / Polymer(Korea)
15 /
[ G. Khang;J.H. Lee;H.B. Lee ] / Polymer Sci.Tech.
16 /
[ G.A. Rodan;H.A. Fleisch ] / J.Clin.Invest.   DOI   ScienceOn
17 /
[ H.S. Seong;D.S. Moon;G. Khang;H.B. Lee ] / Macromol.Chem.Symp.
18 /
[ D.J. Dodwell;A. Howell;J. Ford ] / Br.J.Cancer.   DOI   ScienceOn
19 /
[ S.A. Seo;H.S. Choi;G. Khang;J.M. Rhee;H.B. Lee ] / Int.J.Pharm.   DOI
20 /
[ R.W. Sparidans;J. den Hartigh;J.H. Beijnen;P. Vermeij ] / J.Chromatogr.B.   DOI
21 /
[ G. Khang;J.C. Cho;J.W. Lee;J.M. Rhee;H.B. Lee ] / Bio-Med.Mater.Eng.
22 /
[ D.S. Moon;G. Khang;H.S. Seong;J.M. Rhee;J.S. Lee;H.B. Lee ] / Biomater.Res.
23 /
[ G. Khang;H.S. Choi;J.M. Rhee;S.C. Yoon;J.C. Cho;H.B. Lee ] / Korea Polym.J.
24 /
[ S.A. Seo;H.S. Choi;D.H. Lee;G. Khang;J.M. Rhee;H.B. Lee ] / Polymer(Korea)
25 /
[ H.S. Choi;S.W. Kim;D.I. Yun;G. Khang;J.M. Rhee;Y.S. Kim;H.B. Lee ] / Polymer(Korea)
26 /
[ G. Khang;I. Jo;J.H. Lee;I. Lee;H.B. Lee ] / Polymer Sci.Tech.
27 /
[ C.S. Kim;H.W. Hong;B.H. Nam;S.H. Oh;I.T. Kim ] / Korean J.Otolaryngol.
28 /
[ S.H. Ralson;S.J. Gallacher;U. Patel;F.J. Dryburgh;W.D. Fraser ] / Lancet
29 Controlled Drug Delivery : Designing Technologies for the Future /
[ H.B. Lee;G. Khang;J.C. Cho;J.M. Rhee;J.S. Lee;K. Park(ed.);R.J. Mrsny(ed.) ] / ACS Symp.Series 752
30 /
[ R.W. Sparidans;J. den Hartigh;J.J. Beijnen;P. Vermeij ] / J.Chromatogr.A.   DOI
31 /
[ A.C. Richardson;S.P. Tinling;R.A. Chole ] / Otolaryngol.Head Neck Surg.   DOI
32 /
[ G. Khang;J.M. Rhee;J.S. Lee;H.B. Lee ] / Polymer Sci.Tech.
33 /
[ G. Khang;H.B. Lee;A. Atala(ed.);R. Lanza(ed.) ] / Methods of Tissue Engineering
34 /
[ G. Khang;C.S. Park;J.M. Rhee;S.J. Lee;Y.M. Lee;I. Lee;M.K. Choi;H.B. Lee ] / Korea Polym.J.
35 /
[ G. Khang;H.B. Lee ] / Biomedical Polymer
36 /
[ R.W. Sparidans;J. den Hartigh;J.H. Beijnen;P. Vermeij ] / J.Chromatogr.B.   DOI
37 /
[ G. Khang;J.H. Lee;J.W. Lee;J.C. Cho;H.B. Lee ] / Korea Polym.J.
38 /
[ W.B. Frijink;O.L.M. Bijvoet;J. Te Velde;G. Heynen ] / Lancet
39 /
[ H.S. Seong;D.S. Moon;G. Khang;H.B. Lee ] / Polymer(Korea)
40 /
[ W.I. Son;D.I. Yun;G. Khang;B.S. Kim;H.B. Lee ] / Biomater.Res.
41 /
[ J.C. Cal;P.T. Dalzy-Yates ] / Toxicology   DOI
42 /
[ S.J. Gallacher;S.H. Ralston;U. Patel;I.T. Boyle ] / Lancet.
43 /
[ A.R. Moron;J.A. Cantrill;A.E. Craig;A. Howell;M. Davies ] / Br.Med.J.   DOI
44 /
[ G. Khang;I. Lee;J.M. Rhee;H.B. Lee ] / Polymer Sci.Tech.