• Air Cleaning Technology
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• v.23 no.3
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• pp.34-43
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• 2010

In most productive facility of pharmaceutical companies, the fumigation using formaldehyde gas has been put into operation. Because formaldehyde gas is so bactericidal as to sterilize bacterial spore which can not be sterilized with usual disinfectants, it has been used for fumigation in many facilities such as facility of experimental animals, research institute and productive facility of pharmaceutical companies which are required to be high level of biological clean. However, the use of formaldehyde is recently under the strict management because of its causing of sick house and carcinogenesis. We introduce the conditions of sterilization using formaldehyde gas, the examples of sterilization using formaldehyde gas in a pharmaceutical manufacture and the problems of use of formaldehyde against environments and health. Further, we describe the characteristics and future subjects of the sterilization method using gasified oxidants such as hydrogen peroxide, peracetic acid and chlorine oxide.

• KSBB Journal
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• v.5 no.3
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• pp.263-268
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• 1990

New methods have been developed to transform Panax ginseng with Ri plasmids of Agrobacterium rhizogenes 15834 and A. rhizogenes A4. Modified leaf disc method was made feasible to establish hairy root culture even when an axonic plantlet was not available as in the case of P. ginseng. The contents of ginsenosides (Rgl, Rf, Rc, Rbl, and Rb2) in hairy roots. were determined by HPLC. Hairy root cultures, established as liquid culture in MS medium, was produced 0.34~1.19% ginsenosides on dry weight basis, and this result is significantly higher level than that of normal P. ginseng.

• Journal of the KSME
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• v.32 no.3
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• pp.268-289
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• 1992

미크론 단위의 부유분진인 미립자를 취급하고 제어하는 초청정 공간인 클린룸 기술은, 산업의 꽃이라고 불리우는 첨단기술 분야로 주도적 역할을 담담하고 있는 반도체 제조산업의 발달과 함께 눈부시게 발달되었고 그 시장도 급속히 확대되고 있다. 반도체 산업뿐 아니라 하이테크의 파도에 편승해서 고도로 미세화, 무균화되고 있는 산업화의 추세에 따라 클린룸 필요로 하는 산업분야도 날로 넓어지고 있다. 각종 전자부품, 광학기기, 자기테이프, 정밀기계, 우주항공산업 등 산업용 클린룸과 또한 제약, 의료, 유전공학 등 바이오 클린룸의 응용범위는 점점 다양화되며 고도화되고 있다. 이러한 각종 산업분야의 요구에 부응하여 관련기술의 건축 및 공조설비, 제조 공정 설비 등의 관점에서 현재의 클린룸의 기술 및 발전현황을 살펴보고 파악하는 것이 관련분야 에서 연구 및 개발에 종사하고 있는 공학인들에게 도움이 될 것으로 사료된다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.315-317
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• 2015

Due to ageing society, health care has become a major concern. So information service for disease prevention is very important to us. Through this application, therefore, check their status after self-diagnosis such as doctor's diagnosis. With the result, it is an object to develop a function for provision of information to the precautionary.

• Korean Journal of Plant Resources
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• v.15 no.3
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• pp.221-226
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• 2002

This experiment was conducted to establish the mass propagation system of Calanthe discolor Lindley. When the Calanthe discolor seeds were sown in Murashige and Skoog medium, the percentage of germination was 65％. Seedlings grew more rapidly in the liquid medium than the solid medium. All regenerated plantlets were survived in acclimatized condition of 70% shade and more than 80％ humidity. Also, we found out that the 88% of survival ratio could be achieved in containing soil mixture of vermiculite and perlite as same as amount.

• Annals of Clinical Neurophysiology
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• v.9 no.2
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• pp.93-96
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• 2007

A 34-year-old man presented with a severe headache, fever, and cervical lymphadenopathy followed by generalized tonic-clonic seizure. Evaluations showed splenomegaly, elevated liver enzymes, and 380 white blood $cells/mm^3$ in the cerebrospinal fluid. Two weeks after admission, he developed sudden vertigo. Examination revealed spontaneous horizontal-torsional nystagmus to the right and bithermal caloric tests documented left canal paresis. A cervical lymph node biopsy disclosed subacute necrotizing lymphadenitis. We report a case of aseptic meningitis and unilateral vestibulopathy associated with histiocytic necrotizing lymphadenitis (Kikuchi's disease).

• Proceedings of the Korean Society of Life Science Conference
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• 2002.03a
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• pp.53-53
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• 2002

• Proceedings of the Korea Information Processing Society Conference
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• 2013.11a
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• pp.1495-1497
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• 2013

변화된 생활양식에 따라 최근 이명환자들이 증가하고 있지만 그에 따른 명확한 치료법이 없는 가운데 차폐기를 활용한 이명재훈련법이 가장 큰 효과를 주고 있다. 본 연구에서는 이러한 훈련을 모바일 단말기를 이용하여 손쉽게 진행할 수 있는 앱 개발에 대해 설명하고, 보다 정교한 치료 및 훈련을 위해 음원의 주파수를 조정하는데 필요한 소프트웨어 모듈의 개발에 대해 설명한다. 주파수 조정을 위해서는 공개 라이브러리인 JTransform을 활용하여 앱 개발에서 용이하게 사용할 수 있는 Java 클래스 모듈을 개발하였다.

• Journal of Life Science
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• v.22 no.7
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• pp.871-879
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• 2012

Polyploids are a potentially important germplasm source in seedless citrus breeding program. Seedlessness is one of the most promising traits of commercial mandarin breeds that mandarin triploid hybrids possess permanently. The formation of new constant triploid hybrids can be recovered through diploid species hybridization from the fusion of divalent gametes at low frequencyor intra-and inter-ploidy crosses. However, extensive breeding work based on small $F_1$ hybrid seeds developed is impossible without a very effective aseptic methodology and ploidy event. In this study, in vitro embryo culture was employed to recover natural hybrids from monoembryonic diploid, open-pollinated mandarin. Flow cytometry was used to determine ploidy level. A total of 10,289 seeds were extracted from 792 fruits having approximately 13 seeds per fruit. Average frequency of small seeds developed was 7.1%, while the average frequency of small seeds per fruit were: 8.9% for 'Clementine' 10.2% for 'Harehime' 2.6% for 'Kamja' 3.1% for 'Pyunkyool' 2.8% for 'Sadookam' and 7.0% for 'Wilking' mandarin. Average size of a perfect seed was $49.52{\pm}0.07mm^2$ ('Clementine') while the small seed measured $7.95{\pm}0.04mm^2$ ('Clementine'), which was about 1/6 smaller than the perfect seed. In total, 731 small seeds were obtained and all of them contained only one embryo per seed. The efficiency of 'Clementine' was 14 times higher than 'Wilking' and more than 109 times higher than 'Pyunkyool'. The basic information on spontaneous polyploidy provides for the hybridization of constant triploids and increases the efficiency of conventional cross.

• Pediatric Infection and Vaccine
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• v.23 no.2
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• pp.128-136
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• 2016

Purpose: This study was done to define clinical characteristics of fever without localizing signs (FWLS) in infants younger than 100 days of age with a goal of providing baseline data to establish a new diagnostic paradigm in the future. Methods: We reviewed medical records of 183 patients who admitted to Daegu Catholic University Medical Center for FWLS younger than 100 days of age from January 2013 to September 2015 retrospectively. Demographic, clinical features and laboratory findings were analyzed. Patients were divided into serious bacterial infection (SBI) and non-SBI groups, and then were compared between two groups to find risk factors for SBI. Results: Among 183 patients, lumbar puncture was performed in 98.9% and CSF pleocytosis was present in 35.9%. Sterile CSF pleocytosis was found in 43% of urinary tract infection (UTI) patients. None had concomitant bacterial meningitis in patients with UTI. As final diagnosis, febrile syndrome without source (25.7%) was most common. Among SBI, UTI was most common (99%). Birth weight, ESR, and CRP were significantly higher in SBI group compared to non-SBI group. Male sex (OR 4.93, 95% CI 1.60-15.24) and pyuria (OR 18.88, 95% CI 6.76-52.76) were identified as risk factors for SBI. Presence of sibling (OR 0.30, 95% CI 0.11-0.83) was significantly lower in SBI group. Conclusions: Our results showed UTI was the most common SBI in young infants with FWLS. Though aseptic meningitis can be coexisting with UTI, lumbar puncture may not be necessary in all patients having UTI.