• IMMUNE NETWORK
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• v.5 no.3
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• pp.163-171
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• 2005

Background: To perform the successful dendritic cell-based cancer immunotherapy one of the main issues to be solved is the source of antigen for DC pulsing. Limitations occur by using auto-tumor lysate due to the difficulties obtaining enough tumor tissue(s) quantitatively as well as qualitatively. In this study the possibility of allogeneic tumor cell lysate as a DC pulsing antigen has been tested in mouse melanoma pulmonary me tastasis model. Methods: B16F10 melanoma cells $(1{\timeS}10^5/mouse)$ were inoculated intra venously into the C57BL/6 mouse. Therapeutic DCs were cultured from the bone marrow myeloid lineage cells with GM-CSF and IL-4 (1,000 U/ml each) for 7 days and pulsed with lysate of either autologous B16F10 (B-DC), allogeneic K1735 (C3H/He origin; K-DC) or CloneM3 (DBA2 origin; C-DC) melanoma cells for 18 hrs. Pulsed-DCs $(1{\times}10^6/mouse)_{[CGP1]}$ were injected i.p. twice with one week interval starting from the day 1 after tumor cell inoculation. Results: Without observable toxicity, allogeneic tumor cell lysate pulsed-DC induced the significantly better anti-tumor response (tumor scale: $2.7{\pm}0.3,\;0.7{\pm}0.3\;and\;0.3{\pm}0.2$ for saline, B-DC and C-DC treated group, respectively). Along with increased tumor specific lymphocyte proliferations, induction of IFN-${\gamma}$ secretion against both auto- and allo-tumor cell lysates was observed from the DC treated mice. (w/B16F10-lysate: $44.97{\pm}10.31,\;1787.94{\pm}131.18,\;1257.15{\pm}48.27$, w/CloneM3 lysate: 0, $1591.13{\pm}1.83,\;1460.47{\pm}86.05pg/ml$ for saline, B-DC and C-DC treated group, respectively) Natural killer cell activity was also increased in the mice treated with tumor cell lysate pulsed-DC ($8.9{\pm}_{[CGP2]}0.1,\;11.6{\pm}0.8\;and\;12.6{\pm}0.7%$ specific NK activity for saline, B-DC and C-DC treated group, respectively). Conclusion: Conclusively, promising data were obtained that allogeneic-tumor cell lysate can be used as a tumor antigen for DC-based cancer immunotherapy.

• The Journal of Korean Academy of Prosthodontics
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• v.45 no.4
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• pp.457-468
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• 2007

Statements of problem: The fracture of acrylic resin dentures remains an unsolved problem. Therefore, many investigations have been performed and various approaches to strengthening acrylic resin, for example, the reinforcement of heat-cured acrylic resin using glass fibers, have been suggested over the years. Silane is important for bonding between glass fiber and resin. Purpose: The aim of the present study was to investigate the effect of various silane on the strength of PMMA resin and roughness of resin-glass fiber complex after abrasion test. Material and methods: 3mm glass fiber (Chopped strand, Hankuk fiber Co., Milyang, Korea) was treated with 3 kinds of silane (MPS, EPS, APS) (Sila-ace, Chisso chemical, Tokyo, Japan) and mixed with PMMA resin(Vertex RS, Vertex Dental B.V., Zeist, Netherlands). Transverse strength and Young's modulus was measured using Instron (Instron model 4466, Instron, Massachusetts, USA). After abrasion test (The 858 Mini Bionix II Test System, MTS System Co., Minnesota, USA) surface roughness was evaluated using tester (Form Talysurf plus, Taylor Hopson Ltd., Leicester England). Examination of scanning electron microscope was also performed. Results: Within this study, the following conclusions were drawn. 1. Surface treatment of glass fiber with MPS and APS increased transverse strength of PMMA resin complex, but surface treatment with EPS decreased transverse strength of PMMA resin complex (p<0.05). 2. Silane treated glass fiber increased Young's modulus of PMMA resin complex compared to desized glass fiber (p<0.05). 3. Roughness increased after abrasion test in case of PMMA resin reinforced with desized glass fiber (p<0.05). 4. Roughness change was not observed after abrasion test in case of PMMA resin reinforced with silane treated glass fiber (p>0.05).

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.4
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• pp.653-658
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• 2004

Oxidative stress is currently suggested as a mechanism underyling diabetes. Accordingly, the present study was designed to evaluate the effect of Aralia elate water extracts (AEW) on activities of hepatic oxygen free radical generating and scavenging enzymes in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats divided into nondiabetic group, diabetic group, and diabetic-AEW supplemented group. The extract was supplemented in 1.14% of raw Aralia elata/kg diet for 7 weeks. Diabetes was induced by injecting STZ (55 mg/kg BW, ip) once 2 weeks before sacrifying. The hepatic cytochrome P-450 content, xanthine oxidase and aminopyrine N-demethylase activities were significantly lowered in the diabetic group compared to the nondiabetic group. Whereas, the activities of aniline hydroxylase and oxygen free radical scavenging enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and glutathione S-transferase, were significantly higher in the diabetic group than in the nondiabetic group. However, the supplementation of AEW normalized these enzyme activities in STZ-induced diabetic rats. When the AEW was supplemented with the diabetic rats, hepatic glutathione content was markedly elevated as well as lipid peroxide level was significantly lowered compared to those of the diabetic group. Thus, these results suggested that AEW supplement enhanced the activities of oxygen species metabolizing enzymes in STZ-induced diabetic rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.4
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• pp.411-418
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• 2007

Oxidative stress can play a key role in cadmium (Cd)-induced dysfunction. The present study examined the effect of pine needle water extract (PN) on Cd-induced oxidative stress in rats. Sprague-Dawley male rats were divided into three groups: normal group, Cd control group (Cd) and PN-administered Cd group (Cd-PN). $CdCl_2$ in 0.9% NaCl was administered orally with a dose of 5mg/kg of body weight/week, while the PN was administered orally with a dose of 1.26g/kg of body weight/day. Body weight gain was not different between groups, whereas food intakes were significantly lower in the Cd-PN group than in normal or Cd group. Relative liver weight was significantly increased by cadmium administration compared to the normal group. Hepatic cytochrome P450 was significantly lower in Cd and Cd-PN groups than in normal group, while xanthine oxidase and alcohol dehydrogenase activities were significantly higher in the Cd-PN group than in normal or Cd group. Increased hepatic superoxide dismutase, monoamine oxidase, catalase, and glutathione peroxidase activities by cadmium administration were significantly decreased by PN supplement. PN did not affect the hepatic glutathione content in cadmium-administered rats; however, PN significantly lowered the hepatic lipid peroxide level and plasma alanine transferase activity compared to the Cd control group. These results suggest that the PN may alleviate Cd-induced oxidative stress without hepatotoxicity.

• Journal of Dental Rehabilitation and Applied Science
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• v.25 no.3
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• pp.255-265
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• 2009

Recently many studies have been published on application of immediate loaded implants. However, the immediate loading protocol has not been well documented. The purpose of the present study was to evaluate the stress distribution between bone-implant interfaces and the effect of implant length in the anterior maxilla using 3 dimensional finite element analyses. The diameter 4.0 mm threaded type implants with different length(8.5 mm, 10.0 mm, 11.5 mm, 13.0 mm, 15.0 mm) were used in this study. The bone quality of anterior maxillary bone block was assumed to D3 bone. Bone-implant interfaces of immediately loaded implant were constructed using a contact element for simulating the non osseointegration status. For simplification of all the processing procedures, all of the material assumed to be homogenous, isotropic, and linearly elastic. The 178 N of static force was applied on the middle of the palatoincisal line angle of the abutment with $120^{\circ}$ angle to the long axis of abutment. Maximum von Mises stress were concentrated on the labial cortical bone of the implant neck area, especially at the cortical-cancellous bone interfaces. Compared the different length, highest peak stress value was observed at the 8.5 mm implants and the results indicated a tendency towards favorable stress distribution on the bone, when the length was increased. Presence of cortical bone was very important to immediate loading, and it appears that implants of a length more than 13 mm are preferable for immediate loading at the anterior maxilla.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2010.06a
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• pp.183-183
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• 2010

위치기반서비스(Location Based Service)는 갈수록 고도화 되어 가고 있다. 특히 최근의 대형 포털을 중심으로 지오웹 서비스가 활성화 되어 있고 이를 스마트폰과 같은 개인용 이용기기를 통해 연속적으로 제공하려는 경향이 뚜렷하다. 이와 같은 시점에서 정부와 민간에서 구축 중이거나 보유 중인 전국적 규모의 데이터 간 상호 연동과 융합을 도모하려는 시도 또한 불가결하다. 이는 고도화된 LBS를 위하여 반드시 필요한 과정이기 때문이다. 이에 따라 몇 가지 주요한 전국 데이터를 대상으로 상호 연동과 융합을 위한 기술개발을 시도하였다. 우선 도로명주소기본도와 수치지형도 간 POI의 연계를 위한 연구를 수행하고 있다. 이 연구에서는 두도면 내의 POI를 대상으로 다양한 매칭과 이에 기반 한 의사결정 방법론을 이용하여 자동으로 상호 인식 및 연계가 될 수 있도록 하고 있다. 다음으로 지적도와 수치지형도 간의 객체 매칭에 관한 연구이다. 수치지형도와 지적도의 불부합으로 인하여 그 동안 지적도를 수치지형도에 맞춘 형태의 편집지적도를 지속적으로 생산하여 왔고 앞으로도 그럴 것이다. 문제는 여기에 필요한 많은 예산이다. 만일 수치지형도와 지적도를 자동으로 매칭하여 편집지적도를 자동으로 생산할 수 있게 된다면 많은 예산 절감과 함께 편집지적도의 현시성을 확보할 수 있게 될 것이다. 다음으로 항공사진과 도로망도의 매칭이다. 현재 주요 포털에서 제공하고 있는 항공사진 기반의 도로망도는 기복변위와 같은 문제로 인하여 시각적으로 많은 위치오차를 보이고 있다. 만일 항공사진의 도로영역을 자동으로 추출하여 벡터 도로망도와 매칭을 할 수 있다면 보다 시각적으로 안정된 항공사진 상의 도로망도를 제공할 수 있게 되고 나아가 이는 차량이나 보행자 네비게이션에 매우 요긴하게 이용될 수 있을 것이다. 다음으로 서로 LOD가 다른 도로망도의 매칭 문제이다. 많은 기관에서 독자적으로 생산한 도로망도는 LOD의 상이에 기인한 문제가 많아 서로 연계 활용되지 않는다. 이를 자동으로 매칭하여 서로 연계할 수 있다면 두 도로망도가 보유하고 있는 속성정보를 공동으로 이용할 수 있는 이익을 얻게 된다. 다음으로 지도 일반화 기술이다. 지도일반화는 지적도내 수치지형도와 같은 대규모 데이터를 스마트폰과 같은 저용량 사양의 기기에 서비스 할 때 불가결한 기술이다. 지도상 객체들의 기하학적 정보 손실을 최소화하면서 메모리 측면에서 경량의 지도를 자동으로 만들어 낸다면 이는 매우 요긴하게 이용될 것이다. 마지막으로 보행자 네트워크의 생성기술이다. 보행자 네트워크는 그 상세함과 정보용량에 있어서 차량용 네트워크에 견줄 수 없다. 이를 현행의 차량용 네트워크와 같이 수동으로 생성하는 데에는 경제적으로나 시간적으로 막대한 투자가 필요하다. 따라서 이를 기존의 공간정보들을 활용하여 자동으로 생성해 낼 수 있다면 그 파급효과는 매우 크리라 판단된다. 본 발표에서는 위와 같은 주제에 관하여 그간의 연구 성과를 개략적으로 소개해본다.

• The Journal of Korean Academy of Prosthodontics
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• v.30 no.1
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• pp.55-64
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• 1992

This study investigated the effect of porcelain primer on bonding of coomposite resin to porcelain surface. In order to test the bond strength between porcelain and composite resin, porcelain cylinders were embedded in acrylic resin, and polished with 240grit silicone caqrbide paper. The specimens were divided into twelve groups. All specimens were treated with three porcelain primers and bonded with five composite resins. All test groups were stored in $37^{\circ}C$ distilled water for 48hours. Shear bond strengths were measured with Instron(Model 4201) at a cross-head speed of 1mm/min. The obtained results were as follows : 1. Scotchprime/Silux II group and BISCO Porcelain Primer/Bisfill group showed significant higher bond strengths than Clearfil Porcelain Primer/photo Clearfil Bright group(p<0.05). And there was no significant differences in bond strengths between Scotchprime/Silux II group and BISCO Porcelain Primer/Bisfill group(p>0.05). 2. When composite resins were used with Scotchprime, the bond strengths were decresed Silux II$(16.68{\pm}3.35MPa)$, Bisfil$(16.23{\pm}4.54MPa)$, Poly-Fill$(14.74{\pm}4.08MPa)$, Photo Clearfil Bright$(13.75{\pm}2.89MPa)$ and Pekalux$(14.74{\pm}4.08MPa)$ in order, but there was no statistical significance(p>0.05). 3. When composite resins were used with BISCO Porcelain Primer, the bond strength were decreased Bisfil$(16.17{\pm}1.60MPa)$, Silux II$(12.13{\pm}2.37MPa)$, Poly-Fill$(10.78{\pm}1.99MPa)$, Photo Cleafil Bright $(9.91{\pm}4.59MPa)$ and Pekalux$(7.36{\pm}2.16MPa)$ in order, but there was no statistical significance(p>0.05). 4. Silux II, Photo Clearfil Bright and Poly-Fill used with Scotchprime showed significant higher bond strengths than BISCO Porcelain Primer(p>0.05).

• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.231-240
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• 2010

The major purpose of this study is to examine how the perfectionism of dance majors affect self-efficacy and performance satisfaction. The sampling of this study was done in 2009, by using purposive sampling method with the subjects who are currently the students of an arts high school and dance majors of a college in Daejeon and Chungcheongnam-do. Specifically, by dividing the district in Chungnam and Daejeon, one arts high school and one college were selected from each district, and 75 dance majors from 4 schools respectively, total 300 students were examined for the study. Among these 300 students, the number of students' questionnaires used in the final analysis is 274, excluding the questionnaires containing inadequate answers. The adequacy of the questionnaire was verified by factor analysis, and the reliability of the questionnaire by reliability analysis. In the matter of reliability, Cronbach's ${\alpha}$ turned up to be over .602. In this study, factor analysis, reliability analysis, regression analysis, and course analysis were done by using SPSS16.0. With the above research method and results, I could come to a conclusion as following. Above all, perfectionism affects the subordinate variable of self-efficacy, the self-control efficacy. That is, with the higher self-oriented perfectionism and the other-oriented perfectionism, self-efficacy increases more as well. Secondly, perfectionism affects performance satisfaction. In other words, the higher self-oriented perfectionism, the higher performance satisfaction. Thirdly, self-efficacy affects performance satisfaction. That is, higher self-control efficacy makes the performance satisfaction higher. Lastly, perfectionism affects self-efficacy and performance satisfaction either directly or indirectly. Now it is obvious that self-efficacy is the variable that intermediate performance satisfaction.

• Journal of Society of Preventive Korean Medicine
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• v.7 no.1
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• pp.123-132
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• 2003

It is considered to be important to create aesthetically beautiful style through the change of external shape, however for the hair stylists, whose beauty expression is through hair, the role of hair doctor is becoming even more important with focus to improve the hair healthiness. Hair clinic is management of hair and scalp. It is the management process of preventing damages, while improving and cultivating healthy and shiny hair. The current concept in hair management is moving from simple hair styling to emphasis at hair management. As far as hair management is concerned, it usually includes treatment tools such as shampoo, conditioner, hair treatment and scalp scaling system, which is used for diagnosis of hair condition in order to treat the scalp. As the interest of hair healthiness becoming more wide spread, so does the breadth of clinic menu. The wide choice is to fulfill the profound desire of people, whose demands are simply to have variety in their choice. This is resulting in faucets of new value-added and differentiated products. The values that make-up the hair styles consist of mainly design (trend, preference), function(styling, management convenience) and clinic(hair quality improvement, damage repair). Shampoo and conditioner have gone beyond their original function of cleansing to providing combinational functions of treatment, to care and remedy, and advanced massage effectiveness. These are, to name a few that seem to go beyond their original function to satisfy the mental healthiness in people, the King Kong shampoo of shampooings in forward-backward manner, 5-minute shampoo massage that applies sports and relaxation massage, scalp acupunctural message and aural(ear) massage. More and more people are complaining about the damaged hair and hair loss problems due to perms, dyeing and bleaching of hair, in addition to natural scalp and hair damaging factors. Such complaints have stimulated many beauty products and various hair treatment systems being introduced with focus to provide nutrition and prevent damages to scalp and hair. As the living standards improve and the desire of people is to pursue differentiated lives, their demand also increases in hair styling products to fulfill the needs of healthy and aesthetical aspects of their lives.

• Pediatric Infection and Vaccine
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• v.17 no.2
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• pp.130-136
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• 2010

Purpose : The purpose of this study is to identify the viral etiology of acute respiratory illnesses and to determine epidemiology in outpatients in Busan, Korea. Methods : We collected nasal wash samples from 990 patients who visited the hospital for acute respiratory illnesses between January 2007 and December 2008. Extracted DNA or RNA from specimens was used for viral detection by an RT-PCR method. Results : Of a total of 990 samples, viruses were detected in 351 cases (35.5%). The ratio of male to female was 1.6:1 and 93.7% were less than 5 years old. Rhinovirus was detected year-round in 202 cases (57.5%), respiratory syncytial virus from October to March in 57 cases (16.2%), adenovirus year-round in 37 cases (10.5%), influenza virus from December to April in 21 cases (6%), bocavirus from January to August in 15 cases (4.3%), parainfluenza virus from April to July in 9 cases (2.6%), coronavirus from January to July in 7 cases (2%), and enterovirus from June to September in 3 cases (0.9%). Conclusion : We identified the etiology and epidemiology of viruses that caused the acute respiratory diseases that were prevalent in Busan, 2007-2008. Further surveillance will be necessary.