• The Journal of Korean Medicine
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• v.39 no.2
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• pp.29-35
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• 2018

Objectives: The aim of this study is to investigate the effect of Heat-generating plaster therapy on Chronic prostatitis Methods: We searched articles from Academic Journals(CAJ) online databases. Searching keywords were '貼敷', '慢性前列腺炎', '敷貼', '慢性前列腺炎'. Results: Among the articles published until October 2017, The 18 articles were found. After reviewing the title, abstract and original article, the 3 articles were selected finally to rule out completely different prescriptions. Conclusions: The effect of Heat-generating plaster therapy on symptoms such as urinary frequency, dysuria, nocturia and sexual dysfunction due to chronic prostatitis was satisfactory. Especially the method is simple and safe, easy to use, patient-friendly, and convenient.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1164-1169
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• 2002

The purpose of this study was to examine the correlation of chronic prostatitis with sexual dysfunction and WBC counts on expressed prostatic secretion(EPS) with symptoms of sexual dysfunction. From 2001. 9. 1 to 2002. 3. 31, chronic prostatitis patients(30 examples) treated for more than 4 weeks were compared with normal group(30 examples) about hypoactive sexual desire disorder, erectile dysfunction, orgasmic disorder and hematospermia. We investigated sexual dysfunction according to the degree of prostatitis, improvement rate of prostatitis and sexual dysfunction. Chronic prostatitis patients compared with normal group were increased significantly in decreased libido(73.3%), erectile dysfunction(51.1%), orgasmic disorder(48.7%) and hematospermia(16.7%). In WBC very many/HPF group compared with others. though sexual dysfunction was highly revealed, but there was no statistic significance. In improvement rate of prostatitis, total improvement rate was 76.7%, WBC 10-30/HPF group 77.8%, WBC many/HPF group 72.8% and WBC very many/HPF group 80%. But the medical cure effect was the highest in WBC 10-30/HPF group. In the improvement rate of sexual dysfunction, total improvement rate was 68.5%, hematospermia 100%, decreased libido 90.9%, erectile dysfunction 67.4% and orgasmic disorder 60.3%. As a result of considering the relation with improvement rate of prostatitis and sexual dysfunction, there was a statistical significance at the erectile dysfunction. orgasmic disorder. The results showed the chronic prostatitis had effects on sexual dysfunction but there was no correlation between the degree of chronic prostatitis with sexual dysfunction. It also showed that the treatment of prostatitis had effects on improvements of erectile dysfunction and orgasmic disorder.

• The Korea Journal of Herbology
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• v.22 no.4
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• pp.145-153
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• 2007

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. Toosendan fructus(TOF) has been traditionally used in treatment of abdominal pain and parasite. In this study, we investigated the therapeutic effects and action mechanism of Toosendan fructus (TOF) in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Method : Eight-month-old rats were treated with $17{\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histophatological profiles. Toosendan fructus(TOF) and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histopahological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by hematological alterations of WBC, RBC, hemoglobin, hematocrit and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Toosendan fructus(TOF) showed a diminished range of the tissue damage. Epithelial score was improved in Toosendan fructus(TOF) than that of the control. The epithelio-stromal ratio was lower in Toosendan fructus(TOF) when compared to that of the control. Also, the examination of bloods were not observed hematological change. Conclusions : These findings suggest that Toosendan fructus(TOF) may protect the glandular epithelial cells and may take hematological safety. We concluded that Toosendan fructus(TOF) may could be a useful remedy agents for treating the chronic non-bacterial prostatitis.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.779-790
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• 2007

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. GLS (Gleditsiae Spina) has traditionally been used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of GLS in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Method : We observed four experimental objects of normal group, control group, testosterone group, and GLS group. Rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacteral prostatitis, which is similar to human chronic prostatitis in histophatological profiles. GLS and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histopahological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by hematological alterations of WBC, RBC, hemoglobin, hematocrit and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with GLS showed a diminished range of tissue damage. Epithelial score was improved in GLS over that of the control. The epithelial-stromal ratio was lower in GLS when compared to that of the control. Conclusion : These findings suggest that GLS may protect the glandular epithelial cells. We concluded that GLS could be a useful remedy agent for treating chronic non-bacterial prostatitis.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.91-104
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• 2011

Background : Although chronic non-bacterial prostatitis is increasing, it is hard to treat effectively. In western medicine, antimicrobials drug, ${\alpha}$-adreno-ceptor antagonists, anti-inflammatory drugs, tricyclic antidepressants and anticholinergic agents are used commonly, but chronic prostatitis/chronic pelvic pain syndromes is confusing and frustrating for urologist. IDS(Indongsoyeom-bang) is used in treatment of chronic prostatitis/chronic pelvic pain syndromes. And it is reported that GLS(Gleditsiae spina) and TOF(Toosendan fructus) components of IDS have significant effect on protection of the glandular epithelial cells. Objective : In this study was conducted to investigate the therapeutic effects and action machanism of IDS in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods : We observed six experimental objects of normal group, control group, testosterone group, and IDS 50 mg/kg, 200mg/kg, 400mg/kg group. Rats were treated with 17 ${\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histophatological profiles. IDS and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by Hematological alterations of WBC, RBC, hemoglobin and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with IDS-50 showed a diminished range of the tissue damage. Epithelial score was improved in IDS than that of the control. The epithelio-stromal ratio was lower in IDS when compared to that of the control. Also, the examination of bloods were not observed hematological change. Conclusion : These finding suggests that IDS may protects the glandular epithelial cells. We concluded that IDS could be a useful remedy agent for treating chronic non-bacterial prostatitis.

• Journal of Haehwa Medicine
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• v.11 no.1
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• pp.103-110
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• 2002

A Clinical study was done on 20 patients of chronic prostatitis who were treated by Takrisodokeum for 1 month in Dept. of Internal Medicine, Oriental Medicine Hospital, Daejon University, from 1 November. 2001 to 30 April 2002. The results were as Follows. 1. Therapeutic improvement of symptoms were distributed the voiding symptoms(81.3%), the Pain-neurological symptoms(80.0%), the others symptoms(77.6%) and the symptoms related with sexual punction(77.1%). 2. Therapeutic improvement rate of whole symptoms was 79.5%. 3. The voding symptoms was the most effectively improved and cured than any other symptoms. 4. The residual urine sensation was the most effectvely improved(93.7%) and the Urethral discharge was the less ineffectually improved(61.2%) than any other single symptoms. 5. Most symptoms of the voiding symptoms were improved over 80%. 6. According to the change of WBC counts on expressed prostatic secretion(EPS), improvement rate was 45.0% and cure rate was 15.0%.

• The Journal of Internal Korean Medicine
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• v.36 no.2
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• pp.180-188
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• 2015

Objectives: This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol. Methods: Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68. Results: Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1150-1175
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• 2023

Objectives: This study was conducted to examine the current status of traditional Korean medicine studies on chronic prostatitis in Korea, identify deficiencies, and suggest future medicine research methods to lay the foundation for traditional Korean medicine treatment. Methods: All domestic clinical research papers on the traditional Korean treatment of chronic prostatitis were selected from the literature published until October 2023 in three domestic databases. A total of 13 selected research data were classified into clinical research papers. Results: In clinical research papers, the basis for the diagnosis of cases was clinical symptoms through medical history listening and diagnosis through past visits to hospitals. The average treatment period was 7 weeks, and the duration of treatment was not significantly affected by the duration of the disease. The most widely used Korean medicine treatment intervention was herbal medicine. Conclusions: This study included all domestic clinical research papers on chronic prostatitis to identify research trends in the Korean oriental medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.271-279
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• 2014

Chronic prostatitis is a common disease among male. However, its cause and treatment are not known and it does easily come to the patients again after some treatment. Chinese has got an active research on chronic prostatitis of traditional Chinese medicine. We researched the Chinese publications from 2003 to 2013. After translating those publications, we analyzed total 64 publications by classifying those according to frequently used prescriptions, differentiation of symptoms, signs, addition and subtraction of each medicine and the quantity of frequently used medicines. Frequently used medicines were statistically analyzed. The prescription of chronic prostatitis was classified according to its stage. Paljeongsan(八正散) or Yongdamsagan-tang(龍膽瀉肝湯) was used during the early stage of chronic prostatitis, Sobokchukeo-tang(少腹逐瘀湯) or Hyeolbuchukeo-tang(血府逐瘀湯類) was used during the middle stage, and Jibaekjihwang-tang(知柏地黃湯) or Gyebujihwang-tang(桂附地黃湯) was used during the late stage. The most frequently used medicine was Phellodendri Cortex(黃柏), mentioned 43 times in the prescriptions. This analysis report would be able to provide the basis of taking a research on chronic prostatitis. In addition, it could be applied on a stereotype of chronic prostatitis as well as a variety of symptoms with frequently used prescription and addition and subtraction of each medicine.

• Journal of Haehwa Medicine
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• v.8 no.2
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• pp.245-257
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• 2000

A clinical study was done 40 patients of chronic prostatitis who was treated in Dept. of Internal Medicine, Oriental Medicine Hospital, Taejon University, from 1 Mar. 1999 to 31 Oct. 1999. The results were as follows. 1. In distribution of age, 30's and 40's were 57.5% the most, 20's and 60's were 35.0%, 50's was 7.5%. 2. In distribution of past history, the urethritis(45.0%) was the most. 3. In distribution of ocupation, a white-collar worker was 35.0%, a business man was 22.5%, a public servant was 12.5%, etc. 4. Sitting the mean time of day were distributed 5~7 hours, above 7 hours, 3~5 hours, under 3 hours, etc. 5. The resting interval of a long distance drive were distributed 2 hours(35.0%), 3 hours(32.5%), etc. 6. The habit of enduring ejaculation during sexual intercourse was showed 45.0%. 7. The habit of enduring urination was showed 20.0%. 8. Influency of mental stress was showed 90.0%. 9. Ten cases(25.0%) were showed riding horse or riding bicycle. 10. Four cases(10.0%) were showed wearing tight trousers. 11. The habit of put a wallet his hip pocket was showed 57.5%. 12. The most common symptom was distributed the others symp-tom(66.8%) and the voiding symptom(63.3%) more than pain-neuro-logical symptom(37.5%) and symptom related with sexual function (26.6%). 13. In distribution of palpation, lower abdominal pain, lumbar pain, perineal or parascrotal pain were mostly showed right side. Moreover diagnosis of pulsation was weakly showed chi pulse of right. 14. Duration of disease were distributed above 1 year(82.5%), under 1 year(17.5%). Degree of prostatitis was severe showed adove 1 year. 15. The distribution of WBC count of the prostatic secretion, com-paring with before therapy and after therapy, were showed from 5 cases to 0 case in very many/HPF, from 23 cases to 13 cases in many/HPF, from 12 cases to 13 cases in 10~30/HPF, from 0 case to 13 cases in under 10/HPF. 16. Therapeutic improvement of symptom were distributed pain-neurological symptom(94.8%), the others symptom(90.8%), the void-ing symptom(89.6%) and symptom related with sexual function(67.5%). 17. Differentiation of symptoms and signs were distributed dificiency of spleen-lung vital energy, wetness-heat of lower warmer, dificiency of spleen-kidney yang, dificiency of kidney yin, wetness-phlegm, dificiency of vital energy and blood. The prescriptions were Bojungikgitang(44.6%), Yukmijihwangtang(20.7%), Palmijihwangtang(12.0%), etc.