Browse > Article

Effects of Paljeong-san (八正散, Bazheng-san) on Chronic Nonbacterial Prostatitis Induced in Rats by Estradiol  

Lee, Seung-wook (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Na, Hyun-young (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Yoo, Jeong-hwa (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Ahn, Young-min (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Ahn, Se-young (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Kim, Young-ock (Dept. of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration)
Lee, Byung-cheol (Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.36, no.2, 2015 , pp. 180-188 More about this Journal
Abstract
Objectives: This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol. Methods: Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68. Results: Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.
Keywords
Paljeong-san; prostatitis; inflammation; estradiol;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Naslund MJ, Strandberg JD, Coffey DS. The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J Urol 1988;140:1049-53.
2 Okuyama E, Nishimura S, Ohmori S, Ozaki Y, Satake M, Yamazaki M. Analgesic component of Notopterygium incisum Ting. Chem Pharm Bull 1993;41:926-9.   DOI
3 생약학교재 편찬위원회. 생약학. 개정2판. 서울: 동명사; 2014, p. 368, 658.
4 Robinette CL. Sex-hormone-induced inflammation and fibromuscular proliferation in the rat lateral prostate. The Prostate 1988;12:271-86.   DOI
5 Seethalakshmi L, Bala RS, Malhotra RK, Austin-ritchie T, Menon M, Miller-Graziano C, Luber-Narod J. 17β-Estradiol induced prostatitis in the rat is an autoimmune disease. J Urol 1996;156:1838-42.   DOI
6 Lundgren R, Holmquist B, Hesselvik M, Muntzig J. Treatment of prostatitis in the rat. The Prostate 1984;5:277-84.   DOI
7 McNeal JE. Normal histology of the prostate. Am J Surg Pathol 1988;12:619-33.   DOI
8 Muntzing J, Sufrin G, Murphy GP. Prostatitis in the rat. Scand J Urol Nephrol 1979;13:17-22.   DOI
9 Steenkamp V, Gouws MC, Gulumian M, Elgorashi EE, van Staden J. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol 2005;22.
10 Turner JA, Ciol MA, Von Korff M, Berger R. Prognosis of patients with new prostatitis/pelvic pain syndrome episodes. J Urol 2004;172:538-41.   DOI
11 Kim SM, Yoo DY. A Case Report of the Effects of paljeongsan on the Female Urethral Syndrome. Journal of Oriental Obsterics & Gynecology 2007;20:225-33.
12 Angwafo FF 3rd, Zaher A, Befidi-Mengue R, Wonkam A, Takougang I, Powell I, Murphy G. The National Health Survey Team for The National Epidemiology Board of Cameroon. High-grade intra-epithelial neoplasia and prostate cancer in Dibombari, Cameroon. Prostate Cancer Prostatic Dis 2003;6:34-8.   DOI
13 Andriole VT. Use of quinolones in treatment of prostatitis and lower urinary tract infections. Eur J Clin Microbiol Infect Dis 1991;10:342-50.   DOI
14 Ahn YM, Ahn SY, Cho DH, Doo HK. The study of oriental and accidental benign prostste hypertrophy. J of Oriental Chr Dis 1995;1: 85-112.
15 Lee MS, Lee SH, Song MD. Two cases of Cystitis Patients Trated with Paljung-san. J of Oriental Chr Dis 2000;6(1):102-5
16 Effects of androgen deprivation on chronic bacterial prostatitis in a rat model. Int J Urol 2003;10:485-91.   DOI
17 Lee EB, Keum HJ. Pharmacological studies on Forsythiae Fructus. Kor J Pharmacogn 1988;19(4) :262-9
18 Ozaki Y, Rui J, Tang YT. Antiinflammatory effect of Forsythia suspensa V(AHL) and its active principle. Biol Pharm Bull 2000;23(3): 365-7.   DOI
19 두호경. 東醫腎系學, 서울: 東洋醫學硏究院; 2003, p. 1056-9.
20 彭懷仁. 中國方劑大辭典精選本. 北京: 人民衛生出版社; 1999, p. 52-3.
21 Koo HJ, Song YS, Kim HJ, Lee YH, Hong SM, Kim SJ, Kim BC, Jin C, Lim CJ, Park E. Antiinflammatory effects of genipin, an active principle of gardenia. Eur J Pharmacol 2004;495(2-3):201-8.   DOI   ScienceOn
22 Jeun DJ, Cha YY, Lee E. Inflammatory Effect of Rheum undulatum L. J Oriental Rehab Med 2011;21(1):35-46.
23 대한비뇨기과학회. 비뇨기과학. 제4판. 서울: 고려의학; 2007, p. 150-61.
24 Ryu JW, Hong ES, Choi YH, Lee YT, Choi BT. Effects of Talc on Cyclophosphamide-Induced Cystitis in the Rat. Korean J Oriental Physiology & Pathology 2005;19(2):429-33.