• Journal of Chest Surgery
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• v.41 no.2
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• pp.247-252
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• 2008

Background: We compared the analgesic effects of an intravenous infusion of remifentanil with local lidocaine injection during endovenous laser treatments (EVLT) for varicose veins. Material and Method: In order to compare the efficacy of analgesia between the lidocaine group (n=15) and the remifentanil group (n=15), we measure the pain intensity of the patients, with using the visual analogue scale, during EVLT and at the first week, the second week, the third week and the fourth week after EVLT. Result: The remifentanil group showed significantly less pain intensity during EVLT (p<0.01), but there were no differences of pain intensity between the two groups from the first week to the fourth week after EVLT (p>0.3). Conclusion: The result showed that the intravenous infusion of remifentanil during EVLT can be a good option to reduce pain during EVLT for treating varicose veins.

• YAKHAK HOEJI
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• v.56 no.3
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• pp.158-163
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• 2012

Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, pharmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a $3{\times}2cm^2$ (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, $AUC_{0-20h}$, Cmax, and Tmax of lidocaine patch were $2,926.32{\pm}335.28ng{\cdot}h/ml$, $256.86{\pm}29.63ng/ml$, and $6.00{\pm}2.31h$, respectively.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2003.05a
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• pp.183-184
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• 2003

어류를 채란채정, 표지, 계측 및 수술하기 위하여 공기 중에서 취급할 때 받는 스트레스를 최소화하기 위해서나, 일정 용기로 다량의 어류를 장시간에 걸쳐 효율적으로 운반하기 위하여 마취는 매우 중요시 된다. 본 연구는 쥐노래미 Hexagrammos otakii (Jordan and Starks)의 공기중에서의 효과적인 취급과 쥐노래미를 대상으로 한 양식생물학적 연구시 간편한 취급을 위하여, 쥐노래미를 대상으로 인체에 무해하여 안전성이 높은 염산리도카인-중탄산나트륨(lidocaine HCl/NaHCO$_3$)을 사용시 그 수온별 마취 효과를 조사하였으며, 일정 마취수온에서의 염산리도카인-중탄산나트륨과 MS-222(methanesulfonate)의 마취 효과를 비교 평가하였다. (중략)

• Restorative Dentistry and Endodontics
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• v.28 no.6
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• pp.475-484
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• 2003

동통조절을 위해 국소마취제는 치과임상에서 광범위하게 사용되어진다. 가장 널리 쓰이는 국소마취제는 리도카인이고 이는 마취효과의 지속 및 지혈효과 등의 목적으로 혈관수축제를 포함하고 있다. 대표적 혈관수축제인 에피네프린은 임상에서 1:300,000에서부터 1:50,000의 농도로 다양하게 사용되어진다. 수복치료를 위해서는 통상적으로 1:100.000농도의 에피네프린이 사용되고 있고 외과적 근관치료시 지혈효과를 위해서는 1:50,000농도의 에피네프린이 추천되고 있다. 이들 농도의 에피네프린을 포함한 리도카인으로 국소마취시 에피네프린의 농도가 치수의 혈류 및 치은의 혈류에 미치는 영향을 이해할 필요가 있고 그 영향이 전기치수검사에 대한 치수의 반응성에 미치는 영향도 이해할 필요가 있다. 따라서 혈관수축제를 포함한 국소마취제에 의한 치수혈류의 변화와 치수신경의 반응성을 이해하는 것은 중요하다 하겠다. 본 연구의 목적은 두 가지 농도의 에피네프린을 포함한 국소마취제로 마취시 나타나는 치수 및 치은의 혈류 변화를 치수신경의 반응성과 비교, 관찰함으로써 국소마취제가 치수 및 치은에 미치는 영향을 파악하고자 함에 있다. 24세에서 27세까지의 10명의 피검자의 건전한 상악중절치를 시험에 이용하였다. Laser Doppler flowmeter의 probe을 고정하기 위한 splint를 간접법으로 인상용 putty를 이용하여 제작하고 치수 및 치은의 혈류량, 그리고 전기치수검사에 대한 반응성을 측정하기 위한 3개의 구멍을 만들었다. 피검자를 10분간 안정시킨 후 마취 전 10분간 정상 혈류량과 전기검사치를 측정하고 1:50,000 epinephrine과 1:100,00 epinephrine이 각각 함유된 2% 리도카인 용액 0.9 ml를 상악 좌측 중절치 치근단부위 협점막에 침윤마취하였다. 마취 후 70분간 치수 및 치은 혈류량을 laser Doppler flowmeter를 이용해 연속적으로 측정하여 그 수치를 컴퓨터에 저장하였고, 매 5분 간격으로 전기치수검사를 시행하여 그 측정치를 기록하였다. 매 시간 간격의 평균 혈류량을 정상 혈류량에 대한 백분율로 나타내고, 각각의 농도에서 최소 치수 및 치은 혈류량을 Paired t-test, Wilcoxon's signed rank test. Duncan's multiple range test. Fisher's exact test등을 이용. 통계분석 하여 다음과 같은 결과를 얻었다. 에피네프린이 함유되어 있지 않은 리도카인을 협점막에 주사시 혈류변화가 거의 나타나지 않았으나 1:50,000 및 1:100.000 에피네프린이 함유된 2% 리도카인을 협점막에 침윤마취시 치수 및 치은 혈류 공히 현저히 감소하였다(p<0.01). 1:50,000 에피네프린군은 1:100,000 에피네프린군에 비해 치수 혈류량이 현저히 억제되어 나타났으나(p<0.01), 치은 혈류량에서는 유의성 있는 차이를 나타내지 않았다(p>0.05). 두 농도의 에피네프린 군 공히 치은혈류는 치수혈류에 비해 유의하게 많은 감소를 나타내었다(p<0.05). 1:100,000 에피네프린 군에서 마취액 주입 후 치수혈류 최대감소가 가장 먼저 나타났고 이어서 전기검사에 대한 치수의 반응성 소실 및 치은혈류 최대 감소의 순으로 나타났다(p<0.05). 1:50,000 에피네프린군의 경우가 1:100,000 에피네프린군의 경우에 비해 마취지속시간이 길게 나타났으나 유의성은 없었다(p>0.05).

• Journal of fish pathology
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• v.1 no.2
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• pp.123-130
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• 1988

General anaesthetics have been usually used for a long time because handling and transportation of live fish constitutes an important aspect in fisheries science. Numerous investigations, however, have shown that the majority of fish anaesthetics cause strong toxic effect to marine fishes. Therefore, less toxic and more effective anaesthetics are essential for marine fishes. Lidocaine belongs to a group of anaesthetics which are used as a local anaesthetic in human medicine. This chemical was tested for 11 commercially important marine fishes. Anaesthetic effects were clearly dose dependent and acute or chronic toxicities were not observed within clinical doses. The recovery time in the tested fish after anaesthetization was 3 to 4 minutes.

• Journal of Aquaculture
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• v.18 no.4
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• pp.272-279
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• 2005

The efficacy of lidocaine hydrochloride and Clove oil as anaesthetics was evaluated in the Korean rose bitterling, Rhodeus uyekii (Mori, 1935) and oily bitterling, Acheilognathus koreensis (Kim and Kim, 1990) at four different temperatures of $10^{\circ}C,\;15^{\circ}C,\;20^{\circ}C$ and $25^{\circ}C$. When complete anaesthesia was acquired less than 3 min and recovery was acquired less than 10 min, the optimal dose range of lidocain hydrochloride at $20^{\circ}C$ was 250${\~}$550 ppm in Korean rose bitterling, and 150${\~}$550 ppm in oily bitterling, respectively. In case of Clove oil, the optimal dose range at $20^{\circ}C$ was 40${\~}$200 ppm in Korean rose bitterling and 80${\~}$240 ppm in oily bitterling, respectively. Both of lidocaine hydrochloride and Clove oil resulted in a negatively dose-dependent manner for anaesthesia induction time in these two species. Recovery times were more variable in relation to anaesthetic doses, but in general higher anaesthetic doses resulted in similar or longer recovery time. As expected, the lower temperature resulted in longer anaesthesia induction and recovery time. The study demonstrated that lidocaine hydrochloride and Clove oil can be used as effective anaesthetics in these two species. The results from this study could be useful for aquaculturists industry and other related husbandry practices that require anaesthesia of Korean rose bitterling and oily bitterling.

• The Korean Journal of Malacology
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• v.19 no.1
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• pp.71-79
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• 2003

After the juvenile octopus individuals being discharged, it is hard to separately capture them because they attach strongly to the wall of the aquarium by the suckers on the arms. Therefore, anaesthetics (MS-222 or lidocaine-HCl) are usually used for capture from attachment. The anaesthetized time of the octopus by lidocaine-HCl was more faster 1.6 to 4.5 times under 200 ppm and 6.0 to 6.5 times in 300 to 500 ppm than those in MS-222. In the anaesthetized and recovery rates (%) by the exposed time, the juvenile octopuses were anesthetized by lower concentrations of lidocaine-HCl within the short time, and rapidly recovered from anesthesia. In the secondary anesthesia of the juvenile octopuses exposed with lidocaine-HCl by the elapsed time after the primary anesthesia, the anesthetized time was later in case of lower concentrations and long elapsed times, However, the anesthetized time was faster when their concentrations were higher and the elapsed time after anesthesia were shorter. Recovery from the secondary anesthesia was faster when the elapsed time was long in lower concentration, and was later when the elapsed time was shorter. In case of Octopus ocellatus, anaesthetic effects by lidocaine-HCl concentrations were better than those of MS-222. Doses of lidocaine-HCl and critical time for works at the indoor laboratory were proper in concentration of 100 ppm within 15 min.

• Restorative Dentistry and Endodontics
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• v.31 no.4
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• pp.257-262
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• 2006

The aims of the study were to evaluate the effect of epinephrine-containing local anesthetics on pulpal blood flow (PBF) and to investigate its effect on cavity preparation-induced PBF change. PBF was recorded using a laser Doppler flowmeter (Perimed Co., Sweden) from canines of nine cats under general anesthesia before and after injection of local anesthetics and after cavity preparation. 2% lidocaine hydrochloride with 1 : 100,000 epinephrine was administered by local infiltration given apical to the mandibular canine at the vestibular area and the same volume of isotonic saline was injected on the contralateral tooth as a control. A round carbide bur was operated at slow speed with isotonic saline flushing to grind spherical cavities with increasing depth through the enamel and into the dentin on both teeth. The obtained data was analyzed with paired t-test. Cavity preparation caused significant increase of PBF (n = 9, p < 0.05). Local infiltration of lidocaine with epinephrine resulted in decreases of PBF (n = 9, p < 0.05), whereas there was no significant change of PBF with the physiologic saline as a control. Cavity preparation on tooth anesthetized with lidocaine with epinephrine caused significantly less increase of PBF than in control tooth (p < 0.05). Therefore, the result of the present study demonstrates that local infiltration of 2% lidocaine with 1 : 100,000 epinephrine effectively reduces PBF increase caused by cavity preparation.

• Korean Aquaculture
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• v.15 no.1
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• pp.91-99
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• 2003

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.817-818
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• 2012

본 연구에서는 치과에서 마취 시 환자들의 고통을 최소화 하기위하여 무통마취를 위한 치과용 약물주입기를 구현하였다. 약물의 주입 시 통증을 최소화하기 위해서 온도를 $36{\pm}2^{\circ}C$ 범위로 제어하여 체온과 유사한 온도로 유지하였다. 이를 위하여 필름히터 방식을 이용한 치과범용국소약물(36mg, 2% 리도카인) 앰플 가열부를 설계하였다. 또한 약물이 주입되는 양을 능동적으로 제어하기 위하여 약물주입 환부의 환자별 흡수 속도 차이에 차등 주입을 위한 압력 측정 시스템을 구현하였다. 필름 형태의 압력 센서를 통하여 전달 압력을 측정하였으며 측정된 압력을 바탕으로 능동적으로 모터의 동작을 제어함으로써 약물주입시 환자의 고통을 최소화 할 수 있도록 구현하고자 하였다.