YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

LC/MS/MS Method for the Determination of Lidocaine in Hairless Rat Plasma and Pharmacokinetic Applications of Lidocaine Patch

LC/MS/MS를 이용한 혈장 중 리도카인의 정량 및 리도카인 패치제의 약물동태학적 평가

  • Received : 2012.05.08
  • Accepted : 2012.06.16
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, pharmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a $3{\times}2cm^2$ (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, $AUC_{0-20h}$, Cmax, and Tmax of lidocaine patch were $2,926.32{\pm}335.28ng{\cdot}h/ml$, $256.86{\pm}29.63ng/ml$, and $6.00{\pm}2.31h$, respectively.

Keywords

References

  1. Lofgren, N. : Studies on local anesthetics. xylocaine, a new synthetic drug., ivar haeggstroms, stockholm (1948) reprinted by the morin press. Inc., Worcester, Mass.
  2. Bartlett, E. E. and Hutaserani, Q. : Lidocaine (xylocaine) for the relief of postoperative pain. J. Am. Med. Womens Assoc. 17, 809 (1962).
  3. Gammaitoni, A. R., Alvarez, N. A. and Galer, B. S. : Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: A review of the literature. J. Clin. Pharmacol. 43, 111 (2003).
  4. Gammaitoni, A. R., Alvarez, N. A. and Galer, B. S. : Pharmacokinetics and safety of continuously applied lidocaine patches 5%. Am. J. Health-System Pharm. 59, 2215 (2002).
  5. Galer, B. S. and Gammaitoni, A. R. : More than 7 years of consistent neuropathic pain relief in geriatric patients. Arch. Intern. Med. 163, 628 (2003).
  6. Gammaitoni, A. R. and Davis, M. W. : Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing. Ann. Pharmacother. 36, 236 (2002).
  7. Davies, P. S. and Galer, B. S. : Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia. Drugs. 64, 937 (2004).
  8. Rowbotham, M. C., Davies, P. S., Verkempinck, C. and Galer, B. S. : Lidocaine patch: Double-blind controlled study of a new treatment method for post-herpetic neuralgia. Pain. 65, 39 (1996).
  9. Peter, C. and Watson, N. : A new treatment for postherpetic neuralgia. N. Engl. J. Med. 343, 1563 (2000).
  10. Fields, H. L. and Martin, J. B. : Pain: Pathophysiology and management. Harrisons Principles of Internal Medicine. 1, 55 (2001).
  11. LaGuardia, J. J. and Gilden, D. H. : Varicella-zoster virus: A reemerging infection. J. Invest. Derma. Sym. Proc. 6, 183 (2001).
  12. Cluff, R. S. and Rowbotham, M. C. : Pain caused by herpes zoster infection. Neurol. Clin. 16, 813 (1998).
  13. Katz, N. P., Gammaitoni, A. R., Davis, M. W., Dworkin, R. H., Avery, J., Burick, T., Carns, P., Charapata, S., Clark, H., Curry, G., Drass, M., Dunbar, E., Elliot, S., Florence, I., Gessner, W. P., Gottlieb, S., Greth, W., Hart, D., Huffman, C., Johnston, K., Kassocieh, D., Kraus, T. J., Kushner, P., Lasner, J., Leong, P., Levine, J., Long, S., McMahon, R., Michie, D., Nalamachu, S., Pereira, E., Perkins, F., Peters, P., Ramundo, G., Rozanski, R., Sawada, K., Sherre, Y., Soumekh, S., Spencer, M., Stevens, D., Stewart, M., Strauss, A., Thomas, D., Trescot, A., Wadhwa, R., Warren, M. and Knight, B. : lidocaine patch 5% reduces pain intensity and interference with quality of life in patients with postherpetic neuralgia: An effectiveness trial. Pain Med. 3, 324 (2002).
  14. Devers, A. and Galer, B. S. : Topical lidocaine patch relieves a variety of neuropathic pain conditions: An open-label study. Clin. J. Pain. 16, 205 (2000).
  15. Weil, A. B., Ko, J. and Inoue, T. : The use of lidocaine patches. Compendium: Cont. Edu. Vet. 29, 208 (2007).
  16. Wilcke, J. R., Davis, L. E., Neff-Davis, C. A. and Koritz, G. D. : Pharmacokinetics of lidocaine and its active metabolites in dogs. J. Vet. Pharmacol. Ther. 6, 49 (1983).
  17. Weiland, L., Croubels, S., Baert, K., Polis, I., De Backer, P. and Gasthuys, F. : Pharmacokinetics of a lidocaine patch 5% in dogs. J. Vet. Med. Series A: Physiol. Pathol. Clin. Med. 53, 34 (2006).
  18. Lee, Y. J., Kim, Y., Lee, M., Chung, S. J., Lee, M. H. and Shim, C. K. : Analysis of bioequivalence study using a logtransformed model. Yakhakhoeji 44, 308 (2000).
  19. Ko, J. C. H., Maxwell, L. K., Abbo, L. A. and Weil, A. B. : pharmacokinetics of lidocaine following the application of 5% lidocaine patches to cats. J. Vet. Pharmacol. Therap. 31, 359 (2008).