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LC/MS/MS Method for the Determination of Lidocaine in Hairless Rat Plasma and Pharmacokinetic Applications of Lidocaine Patch  

Hwang, Ji-Yeon (College of Pharmacy, Kyungsung University)
Kim, Chul-Jun (TDS Pharm. Co. Ltd.)
Shin, Young-Hee (College of Pharmacy, Kyungsung University)
Publication Information
YAKHAK HOEJI / v.56, no.3, 2012 , pp. 158-163 More about this Journal
Abstract
Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, pharmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a $3{\times}2cm^2$ (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, $AUC_{0-20h}$, Cmax, and Tmax of lidocaine patch were $2,926.32{\pm}335.28ng{\cdot}h/ml$, $256.86{\pm}29.63ng/ml$, and $6.00{\pm}2.31h$, respectively.
Keywords
LC/MS/MS assay; lidocaine patch; pharmacokinetics; hairless rat;
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