• 한국광물학회지
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• 제29권4호
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• pp.191-198
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• 2016

인회석 광물 군에 속하는 녹연석($Pb_{4.85}(P_{1.02}O_4)_3Cl_{1.04}$)에 대한 상온-고압 상태방정식 연구를 시행하였다. 대칭형 다이아몬드 앤빌기기를 이용하여 33.4 GPa까지 압력을 증가시키면서 각분산 X-선 회절법과 방사광을 이용하여 회절 데이터를 검출하였으며, 시료에 가해준 압력은 루비 형광파의 파장변화를 측정하여 결정하였다. 본 고압실험에서 시행한 압력의 범위 내에서 상변이는 관찰되지 않았으며, 정압상태에서 체적탄성률($K_0$)은 $K{_0}^{\prime}=13(2)$일 때 80(7) GPa로 계산되었다. 본 연구에서 결정된 상온상태에서 녹연석의 체적탄성률 신뢰도를 정규화압력 및 정규화응력변형 분석을 하여 평가하였다.

• 약학회지
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• 제43권4호
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• pp.447-457
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• 1999

The purpose of this study is to prepare the adhesive type patch containing flurbiprofen, and to demonstrate the feasibility of flurbiprofen administration through the intact skin using adhesive type patch preparation. For this purpose, two pressure sensitive adhesives, Polyisobutylene(PIB) and $Gelva^{\circledR}737$, were selected from the chemical grade of polymers, and the adhesive type patches of flurbiprofen were prepared. The release rate of flurbiprofen from the PIB-based adhesive patch was higher than that from $Gelva^{\circledR}737$ based adhesive patch. The release rate of flurbiprofen from the PIB-based A-type patch with 1.0mm, 1.5mm or 2.0mm thicknesses followed the first order kinetics. In the skin permeation study, using male hairless mouse skin, a monophasic skin permeation profile was observed with 1% flurbiprofen loading dose. The inclusion of palmitic acid or SLS(0.25~0.5%) as an enhancer produced a remarkable enhancement in the skin permeation rate of flurbiprofen, and the percentile ratio of drug and enhancer appeared to be important for the effective enhancement. In the in vivo percutaneous absorption study, the plasma concentration of the optimal formulation was significantly (p<0.01) higher than that of the conventional cataplasma ($Bifen^{\circledR}$). These studies demonstrate a good feasibility of flurbiprofen administration through the intact skin using a transdermal patch, and show a possibility of the development of flurbiprofen patches.

• 전기학회논문지
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• 제64권8호
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• pp.1207-1211
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• 2015

Various laser systems have been widely used in almost all industrial technologies because they have high energy density, directivity and coherence. Recently the clinical application is becoming wider in medical parts such as incurable disease, diagnosis and so on. Generally, ruby laser beam has the greatest efficacy for removing tattoos, freckle and other skin problem. But current medical ruby laser system has the maximum repetition rate of 2Hz and optical output beam energy of 1J. Many medical doctors really want to have a high repetition ruby laser system because that can reduce the operation time. We investigated a new ruby laser system with high repetition rate of 4Hz using double cavities. Furthermore, we develop a new power supply system adopting zero voltage switching(ZVS) to minimize switching loss by LLC resonant converter designed as 2kW class.

• 약학회지
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• 제42권3호
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• pp.275-283
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• 1998

Aclarubicin(ACL)-entrapped freeze dried liposomes were prepared using Microfludizer to attain a sustained release at targeted organs in a prolonged time so that it can reduce th e side effect and maximize the therapeutic effect. The freeze-dried liposomes were evaluated for pharmacokinetics, antitumor activity against Sarcoma 180, cytotoxicity against L1210 and A549 tumor cells, spleen toxicity and myelosuppressive action. The $AUC_{0{\rightarrow}8hr}$ values were $122{\pm}42,\;382{\pm}140,\;419{\pm}171,\;835{\pm}206\;and\;443{\pm}309{\mu}g{\cdot}min/ml$ for free ACL. ACL-liposome formulation I, II, III and IV, respectively. Cytotoidcity of ACL-entrapped liposomes against L1210 and A549 tumor cells was 2-4 times higher than that of free aclarubicin. ACL-liposome formulation I(PC/CHOL/TA) showed the most potent antitumor activity against Sarcoma 180 in mice. The loss of body weight was much smaller with ACL-entrapped liposomes than free ACL after I.p. injection at a dose of 2 mg/kg/day. Compared to free ACL, ACL-entrapped liposomes expressed a lower and delayed spleen toxicity up to 5th day after I.v. administration. Myelosupperssion seemed to be lower with ACL-entrapped liposome of PC/PC-hydrate/CHOL/TA (formulation III) than free aclarubicin.

• 약학회지
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• 제42권3호
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• pp.265-274
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• 1998

In order to attain a sustained release at targeted organs in a prolonged time which can reduce the side effects and maximize the therapeutic effect, aclarubicin (ACL) was entrap ped into liposomes of different lipid compositions using Microfluidizer, and dry liposomes were prepared by lyophilization. The dry aclarubicin-entrapped liposomes were evaluated in terms of mean particle size and size distribution, entrapment efficiency and in vitro drug release profile. The Entrapment efficiency of liposome, when the concentration of aclarubicin and lipid were 0.5 to 1.0mg/ml and $200{\mu}mol$/ml, respectively, was over 80% using Microfluidizer, in contrast to 70% of entrapment efficiency using hand-shaking method. Mean particle size and size distribution of aclarubicin-entrapped liposomes of various lipid compositions did not change considerably by the freeze drying. The range of particle size was between 80 and 200nm. Among aclarubicin-entrapped liposomes, ACL-liposome of PC/DPPC/CH0L/TA displayed the most significant sustained release. The addition of DPPC appeared to be favorable for the control of release. In general, aclarubicin entrapped in liposomes was less stable than free aclarubicin either in pH 7.4 phosphate buffer or in human plasma. Formulation I($t_{1/2}$, 20.3 hr) devoid of lipid additive was the most unstable in the phosphate-buffer solution while formulation II($t_{1/2}$, 40.7 hr) with cardiolipin was the most stable. Half lives of aclarubicin-entrapped liposomes in human plasma were 43.2, 50.7, 35.9 and 35.3 hr for formulation I. II, III and IV, respectively, in contrast to 57.8 hr for free aclarubicin.

• 한국수소및신에너지학회논문집
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• 제24권3호
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• pp.255-263
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• 2013

Carbon dioxide reduction technologies using photosynthetic microorganism were suggested to overcome environmental destruction caused by $CO_2$ in flue gases from power plant and other industries. However, there are many toxic constituents in flue gas including CO, NOx, SOx. Continuous and Excessive supply of these noxious gases to cells will leads to inhibition of microalgal growth along with partial cell death. In this study, we tested the noxious effect of SOx and NOx on the pH and microalgal growth under photoautotrophic culture in three microalgae of Neochloris oleoabundans, Chlorella vulgaris and Haematococcus pluvialis. As a result, SOx concentration more than 50 ppm led to the rapid reduction of pH, thereby inhibiting of the growth in Neochloris oleoabundans and Chlorella vulgaris. NOx concentration more the 100 ppm reduced the exponential growth of N. oleoabundans and C. vulgaris. And H. pluvialis exhibited low sensitivity to SOx and NOx. Consequently, the three microalgae of N. oleabundas, C. vulagaris and H. pluvialis showed the normal vegetative growth in 25 ppm of NOx and SOx. Above all, H. pluvialis was useful for the $CO_2$ sequestration of the flue gas including high concentrations of NOx and SOx.

• 한국의상디자인학회지
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• 제8권3호
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• pp.59-71
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• 2006

This study contemplates Croatian traditional costumes with focus on its geographical characteristics and acculturation with neighbor countries as a member of old Yugoslavian Union. Therefore, it contains the information from field works based on Croatian language, native costumes and folk materials wildly. Men usually wear wide linen pants ($ga\'{c}$), shirt ($ko\v{s}ulje,\;rnbina)$, vest (lajbek), hat and jacket ($kro\v{z}et$). Also they sometimes wear scarves or aprons. Women put on blouse, long skirt, apron, headgear with various decoration and scarf ($pe\v{c}a$), shawl (tibetui robe) or necklace together. Croatian folk dresses fall into three different styles by provinces, such as Pannonia, Dinar and Adria, according to the basic environmental and racial characteristics of each province. People of Pannonia plain generally wear white linen clothing and often use flounce and lace, which are influenced by Serbia and Hungary. In the Dinar mountain province, aprons with tassel, knitted vests made of leather and fur are very popular. The clothing of Dinar province has much commonness with those of Bosnia - Herzegovina and Montenegro which have metal buttons and belts. And the clothing of Adria coast is influenced by Italy a lot. There are many splendid silk clothes in its folk dress code. As mentioned above, there are a lot of foreign influences in Croatian history. Although there were severe cultural invasions in many times through its history, Croatians didn't just surrender to these cultural influences. People in Croatia comply with these new coming culture and reconcile these into their own tradition and dress code in their own way.

• 디지털콘텐츠학회 논문지
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• 제18권1호
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• pp.9-16
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• 2017

최근 경제의 장기적 불황으로 저렴하게 좋은 상품을 구매하려는 소비자의 욕구가 급증하고 있다. 저렴하게 좋은 상품을 구매하는 방법으로는 중고거래가 각광을 받고 있으며, 중고거래가 활성화됨에 따라 소비자가 느끼는 중고거래에 대한 심리적 거리감도 줄어들고 있다. 특히 대학교의 전공서적 같은 고가의 도서의 경우 각 대학마다 중고도서 전용의 커뮤니티가 생길 정도로 활발한 거래가 이루어지고 있다. 하지만, 대학 중고도서 거래 전용 사이트의 경우 실시간 거래 현황을 한눈에 알아보기 힘들고, 단방향적인 판매자의 가격 설정으로 인해 합리적 도서 구매가 불가능하다. 본 논문에서는 누구나 손쉽게 중고도서 거래를 할 수 있는 경매 방식 기반 중고도서 거래 웹 서비스를 설계 및 구현하였다. 본 서비스는 웹 기반으로 설계되었으며 편리하고 효율적인 도서 등록 및 검색 기능을 통해 사용자에게 편리함을 제공한다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1995년도 춘계학술대회논문집; 전남대학교, 19 May 1995
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• pp.313-317
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• 1995

최근 환경오염이 심각한 사회문제로 대두됨에 따라 환경오염원을 제거하기 위한 여러 가지의 집진장치가 개발되고 있는데 화력발전소에서는 건식정전집진장치(dry electrostatic precipitator)를 이용하고 있다. 건식정전집진장치는 햄머(hammer) 방식의 충격장치를 설치하여 집진극과 방전극에 충격을 가함으로써 충격력을 극대화시키고 높은 분진박리 효과를 꾀하고 있는데 환경오염원이 되고 있는 집진판의 분진의 분리율을 높이기 위해서는 집진판의 전체 영역에서 분진을 동일하게 떨어뜨릴 수 있는 충격장치가 설계되어야 하는데, 이를 위해서는 충격하중에 따른 집진판의 진동 형태를 정확하게 분석하여야 한다. 본 연구에서는 집진판의 충격하중에 따른 진동의 형태를 분석하기 위해 펄스 레이저를 이용한 2중 노출 홀로그래피 시스템을 구성하였다. 홀로그래픽 간섭계는 이미 오래 전에 개발된 레이저 응용 계측기법으로서 주로 정현적인 진동을 하는 진동체의 진동 현상을 연구하는 데에 많이 사용되어 왔는데 그 기술 개발은 상당한 수준에 있다. 그러나 종래의 기술들은 주로 헬륨-네온(He-Ne)레이저와 같은 연속 레이저(continuous wave laser)를 이용한 기술들인데 최근에는 루비(ruby) 레이저와 같은 펄스 레이저 (pulse laser)를 이용한 기술이 많이 응용되고 있다. 이 펄스 레이저 홀로그래픽 간섭계를 Gottenberg는 응력파에 의해서 발생된 변형을 측정하기 위해 사용하였고 Aprahamian등은 보(beam)와 평판의 굽힘파(bending wave)의 전파 특성 연구에 이용하였다. 그 실험적 결과는 수치적 해석 결과와 비교되어 매우 좋은 일치성을 보였는데 이러한 펄스 레이져 홀로그래픽 간섭계 기법의 주요 장점은 어떠한 특정한 순간에 관찰하고자 하는 시험편의 전체 영역의 파동 전파 형상을 관찰할 수 있다는 것이다. 따라서 본 연구에서는 펄스 레이저를 응용한 2중 노출 홀로그래피법(double exposure holography method)을 이용해서 집진판에 충격하중이 가해졌을 때 발생하는 진동이 발생과 전파 특성을 충격하중의 방향에 따라서 분석하였다.

• 한국세라믹학회지
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• 제42권2호
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• pp.110-116
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• 2005

본 연구는 $BaO-B_{2}O_3-ZnO$계에서 저온소성이 가능한 조성을 탐색하고, 여기에 $Al_{2}O_3$를 filler로 첨가하여 복합체를 제조할 경우의 소결거동과 물성에 미치는 영향을 조사하였다. 이때 첨가하는 알루미나 분체는 입자크기가 서로 다른 두 종류를 이용함으로서 알루미나 입자 크기의 효과도 동시에 조사하였다. 알루미나 첨가량이 증가하는 경우 복합체의 치밀화정도, 유전상수, 열팽창계수, 그리고 경도 값이 감소하였다. 또한 첨가되는 알루미나 입자의 크기가 미세할 경우 그 감소율은 증가되었다. 한편 파괴인성값은 알루비나 첨가량이 많을수록, 알루미나 입자 크기가 작을수록 오히려 증가하였는데 이는 기공과 filler의 crack전파 억제 효과에 의한 것으로 해석하였다.