• 대한한의학방제학회지
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• 제12권2호
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• pp.139-154
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• 2004

Acetaminophen은 세계적으로 널리 사용되는 해열 진통제이지만, 또한 과용 및 남용, 알코올 중독과 같은 여러 원인에 의해 간독성을 유발할 수 있는 약물이다. 이러한 acetaminophen의 간독성은 CYP에 의해 생성되는 대사산물인 NAPQI와 활성산소에 의해 유발되는 것으로 알려져 있다. 본 연구에서 5주된 수컷 백서에 acetaminophen (500 mg/kg)을 투여하기 전에 대시호탕 (500 mg/kg)를 일주일간 투여하였다. 이후 GOT, GPT, GST 그리고, 조직사진으로 대시호탕의 간보호작용을 측정하였다. 또한 대시호탕의 간보호작용 기전을 항산화작용과 CYP 2E1 발현조절을 통한 NAPQI 생성억제의 두 가지 면에서 측정하였다. GOT, GPT 그리고 조직사진에서 나타난 결과들은 대시호탕이 고용량의 acetaminophen에 대한 간보호작용이 있음을 증명할 수 있었다. 또한 LPO와 catalase, 그리고 GSH 실험에서 나타난 결과들을 통해 대시호탕이 항산화작용이 있음을 알 수 있었다. 그리고 GSH, GST, RT-PCR, western blot 실험에서 대시호탕이 CYP 2E1의 발현을 조절하여 NAPQI 생성을 억제한다는 것도 알 수 있었다. 이상의 결과들을 바탕으로 대시호탕은 항산화작용에 의한 활성산소 제거력과 CYP 2E1의 발현조절을 통한 NAPQI 생성억제로 고용량 acetaminophen에 의해 유도된 간손상에 대해 유의성 있는 보호작용을 한다는 것을 알 수 있었다.

• Journal of Animal Science and Technology
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• 제48권5호
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• pp.683-690
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• 2006

본 연구는 당밀의 첨가수준이 한약제박 사일리지의 품질에 미치는 영향을 조사하기 위하여 두 가지 실험을 실시하였다. 실험 Ⅰ에서는 당밀의 첨가수준이 대시호탕박 사일리지의 품질에 미치는 영향을 조사하기 위하여 0, 0.5 및 1.0%의 당밀 첨가수준에 3반복의 실험을 실시하였다. 실험 Ⅱ에서는 우리나라 재래산양의 대시호탕박 사일리지의 기호성을 측정하였다.본 실험에서 얻어진 결과를 요약하면 실험 Ⅰ에서, 당밀 1% 첨가구가 0.5% 첨가구 및 대조구보다 조단백질 및 유산의 함량이 유의하게(P<0.05) 높았고, pH와 낙산함량은 유의하게 낮았다. 또한 사일리지의 총균수(total microbial cell)는 당밀 첨가구가 유산균 배지인 MRS에서는 많게 나타났고, 곰팡이 배지인 PDA에서는 적은 결과를 나타내었다. 그리고 in vitro 소실율에 있어서도 당밀 첨가수준이 증가할수록 소실율이 증가하는 경향이었다.실험 Ⅱ에서는 모든 처리구에서 30분 및 6시간 동안의 섭취량은 유의한 성적은 아니지만 당밀 첨가수준이 증가할수록 많아지는 경향을 나타내었다.이상의 결과를 종합하면 대시호탕박은 열탕처리를 거침으로 인하여 수용성 탄수화물이 부족할 것으로 사료되는 바, 이에 대하여 수용성탄수화물을 보충하는 방법으로 당밀을 첨가하여 사일리지를 제조하는 것은 매우 유용한 수단이라고 생각되며, 이로 인하여 한약제박 사일리지의 보존성도 향상된다고 하겠다.

• 대한한의학회지
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• 제22권1호
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• pp.63-77
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• 2001

Objectives : In acute stage of CVA, many patients experience Bugibultong as a symptom. Daesiho-tang is one of the most useful prescriptions for constipated stroke patients. This study investigated the effects of Daesiho-tang extracts on hypoxic E18 cortical neuroblast. Methods : To evaluate the effect of Daesiho-tang extracts on enuronal death caused by hypocia the neuronal viability and protein expressions of NMDA receptor subunits, ${\alpha}CaMK$ II PDE2 PSD95 densin-180, $eEF-l{\alpha}$ and GFAP were investigated. Results : We guessed that Daesiho-tang extracts worked to protect against cell damage through effecting on the protein expression of PSD(post synatpic density), especially increase of ${\alpha}CaMK$ II, $eEF-l{\alpha}$ PDE2, PSD95 and densin-180 Conclusions : According to the above results, it is supposed that Daesiho-tang is clinically applicable to stroke patients in the acute stage.

• 생약학회지
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• 제14권1호
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• pp.9-16
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• 1983

Experimental studies were implemented to evaluate clinical efficacy of 'Daeshiho-Tang' and to validate Oriental medicine description of the recipe which has been widely used in metabolic diseases and febrile diseases. Following results were obtained; 1. Suppressive action was shown on convulsion due to cerebrocortical causes but no such action was noted either myelic or diencephatic causes in mice. 2. Analgesic and antipyretic actions were recognized in mice, rats and rabbits. 3. Antispasmodic actions were recognized on contraction of the ileum induced by $BaCl_2$ and histamine in mice and guinea-pigs. 4. Transport accelerating action of the small intestine was gained in mice.

• 사상체질의학회지
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• 제29권1호
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• pp.1-13
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• 2017

Objectives The purpose of this study is to understand the influence of Daesihog-tang on Taeeum-in's patholoy and prescription in "Donguisusebowon" of Sasang Constitutional Medicine. Methods The pathologic condition in which Daesihog-tang used and the relevant herbs and prescriptions in "Sanghanron", "Donguibogam", "Dongmuyoogo haedong", "Chobongwon", and "Donguisusebowon". Results and Conclusions 1. Daesiho-tang in "Sanghanron" was used to the symptom of Yangmyung disease merging with Soyang disease. In "Donguibogam", its indications were mainly used to the severe fever-symptom of Yangmyung disease and expanded to Onbyeong and so on. 2. The concept of Daesiho-tang in "Donguibogam" was changed into Hwanggeumdaehwang-tang in "Chobongwon", which can be used to treat Onbyeong with heat-dysenteric diarrhea, and severe fever of Taeeum-in. 3. The notion of combination between Daehwang and hwanggeum used in "Dongmuyoogo haedong" and "Chobongwon" was connected to Chungmongsukgondamhwan or Jogakhwanggeumdaehwang-tang in "Chobongwon". Especially, Jogakhwanggeumdaehwang-tang for Yeokkigammo and severe constipation was formed while the concept of Onbyeong in Hwanggeumdaehwang-tang' merged with the usage of Jogak and Daehwang or Yisunggugo-hwan. 4. Jogakhwanggeumdaehwang-tang influenced on the usage of Jogakdaehwang-tang for Yangdok and Onbyeong, while the usage of Chungmongsukgondamhwan was not found in "Donguisusebowon". 5. As a result, Daesiho-tang may be presented without usages for a specific patholoy in "Donguisusebowon" because it indirectly influenced on the concept of Yangdok and Onbyeong of Taeeum-in, and the formation of Jogakdaehwang-tang in "Donguisusebowon".

• 생약학회지
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• 제14권1호
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• pp.30-38
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• 1983

These studies were conducted in an attempt to investigate effects of 'Daeshiho-Tang' on the blood vessels, activities of liver enzyme and excretory action of bile juice in serum of $CCl_4-intoxicated$ rabbits, glucose and total cholesterol levels in serum of alloxan-induced diabetic rabbits. The result of these studies were summarized as follows; 1. Hypotensive ind vaso-dilatating actions due to vascular smooth muscle relaxation were noted in frogs, rabbits and dogs. 2. GOT, GPT and total cholesterol in serum of $CCl_4-intoxicated$ rabbits showed significant depressive effects. 3. Significantly increased biliary secretary effect was noted in $CCl_4-intoxicated$ rabbits. 4. Glucose and total cholesterol levels showed markedly decraese in alloxan-induced diabetic rabbits. Considering the experimental studies results, it is suggested that 'Daeshiho-Tang' has therapeutic efficacy to treat febrile diseses and metabolic diseases.

• 대한추나의학회지
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• 제2권1호
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• pp.177-186
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• 2001

Objectives : We experimented with Daesiho-tang in order to investigate the effects on the weight of obesity. Methods : We fed a control group of rats a high fat diet and administerd normal saline for 6 weeks. And we fed an experimental group of rats a high fat diet and administered an extracted of Daesiho-tang for 6 weeks. Results : Daesiho-tang suppressed the increasing amount of body weight in comparison with control group. The serum total cholesterol level, free fatty acid level in Daesiho-tang group showed a significant decrease in comparison with control group. The serum triglyceride, total lipid level in Daesiho-tang group showed a decrease in comparison with control group, but this result showed no efficacy. Conclusions : We concluded that the clinical application of Daesiho-tang can help the treatment of obesity.

• 대한상한금궤의학회지
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• 제9권1호
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• pp.59-73
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• 2017

Objectives : The purpose of this case report is to report the effect of Daesiho-tang on adult acne by Shanghanlun provisions with extrusion therapy. Methods : According to diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung Gyeolhyung and treated by Daesiho-tang with extrusion therapy. The result of administrations were evaluated by Korean Acne Grading System(KAGS), Korean Skindex-29, and change of clinical symptoms. Results : After administration of Daesiho-tang for 150 days with weelky extrusion therapy, KAGS improved from grade 4 to grade 1, Skindex-29 improved from 67.93 to 15.51, and patient was very satisfied with the treatment. No serius treatment-related adverse events were reported. Limitations : This case is only one case that the level of evidence is weak. Two interventions were used together and the duration of photo was uneven. Conclusions : The patient almost recovered from acne treated by Daesiho-tang according to diagnostic system based on Shanghanlun provisions with extrusion therapy. This is the first case report that suggests '熱結在裏' on the number 136 provision of Shanghanlun means fever that is always present in chronic skin lesions.

• 대한한방내과학회지
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• 제37권2호
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• pp.225-231
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• 2016

Objective: Paralytic ileus is a common complication of cerebral infarction. This study reports on the effect of Daeseunggi-tang and Daeshiho-tang on a cerebral infarction patient with paralytic ileus.Method: This patient was treated with herbal medicine (Daeshiho-tang and two applications of Bo-ryu enema), acupuncture, electro-acupuncture, and moxibustion therapy for 17 days.Results: The symptoms of paralytic ileus appeared to improve after treatment.Conclusions: Traditional Korean medical treatment may be effective in paralytic ileus.

• 대한한방내과학회지
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• 제41권5호
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• pp.761-768
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• 2020

Objectives: The prevalence of cholelithiasis is increasing in both the East and West, and this can have a great impact on the quality of life. This study reports on a patient whose cholelithiasis was improved using Daesiho-tang. Methods: A patient diagnosed with cholelithiasis was treated with acupuncture and herbal medicine. Abdominal pain due to cholelithiasis was evaluated by a numerical rating scale. Results: After 35 days of taking Daesiho-tang, the symptoms of abdominal pain and indigestion improved. Even afterwards, the patient maintained an improved quality of life without recurrence. Conclusions: Korean medicine treatment was effective in improving the symptoms of cholelithiasis. However, studies of various cases will likely be needed in the future.