• Clinical and Experimental Pediatrics
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• v.48 no.1
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• pp.13-20
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• 2005

Purpose : Obesity is, along with metabolic syndrome, closely related with nonalcoholic fatty liver disease. This study tried to evaluate the prevalence of nonalcoholic liver disease in obese children and verify the factors associated with the disease. Methods : Two hundred and seventy nine children who showed a body mass index of 95 percentile over the baseline in health examinations of surrounding schools were evaluated. Questionnaires, body measurements, blood examinations, and ultrasonographic measurements of abdominal fat were examined. Results : Out of 279 children enrolled for the study, 27 children were found to possess nonalcoholic liver disease(9.7%). Among those found to be positive for nonalcoholic liver disease, it's prevalence increased to 15.2%(22 out of 144 children) among children with severe obesity. Factors known to be involved with metabolic syndrome, namely waist/hip circumference ratio and thickness of abdominal fat, were found to be closely related to nonalcoholic fatty liver as well. Conclusion : The prevalence of nonalcoholic fatty liver in obese children was 9.7%, with higher incidence observable in severer obesity. Factors responsible for metabolic syndrome were closely associated with nonalcoholic fatty liver disease, and the level of insulin resistance, which is an useful index in both diseases, can be utilized in evaluation of the effect of treatment and control of risk factors.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1394-1400
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• 2003

In this study a natural composition containing oriental herbs, KSH28, for reducing obesity and metabolic syndrome was constructed and its efficacy was evaluated in animal and human. To investigate the anti-obesity effect of KSH28, animal study was conducted using high fat diet-induced obese mice. KSH28 significantly decreased body weight and adipose tissue in high fat diet-fed obese mice. The mean size of fat cells in adipose tissue was significantly reduced. Glucose and triglyceride levels were also significantly decreased. To elucidate its efficacy in human, a natural food containing KSH28 with grains, vegetables, vitamins, minerals and dietary fibers was constructed and 40 subjects (8 male and 32 female) were tested for the change of body composition, blood pressure and blood lipid profile. All subjects had 2 pack (309 each) of natural food per day for 4 weeks. Compared to the baseline value, body fat was significantly reduced, however, water, protein and mineral contents in the body were not changed, suggesting selective reduction of fat tissue. Blood pressure and serum lipid profile were significantly decreased to reduce risk for metabolic syndrome. Serum GPT, a liver function indicator, was not changed and no significant side effects were detected. Therefore, it was shown that the KSH28 is a safe and effective composition for reducing obesity and metabolic syndrome.

• The Korean Journal of Food And Nutrition
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• v.29 no.5
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• pp.595-604
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• 2016

It has been reported that the increased uric acid level is associated with metabolic syndrome risk factors in both male and female. However, there has not been enough studies to investigate gender differences of this association in Korea. To evaluate relation between serum uric acids and metabolic syndrome markers, anthropometric and biochemical analyses data was obtained from National Health Examination 2005 and 5,523 (M=3,097; F=2,426) data was analyzed. Results by quartile of serum uric acid levels in females showed that increased serum uric acid level was associated with elevated levels of total-. LDL-cholesterol, and triglycerides, whereas association between serum uric acid and total cholesterol levels was not observed in male subjects. In both female and male, higher quartile of serum uric acid level were linked with lower levels of HDL-cholesterol. In regression analysis, association of serum uric acid levels with fasting glucose levels was significant in female subjects only. In conclusion, higher serum uric acid levels were associated with metabolic syndrome indices, however gender differences were existed for total cholesterol.

• Journal of Information Technology Applications and Management
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• v.30 no.1
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• pp.71-80
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• 2023

The purpose of this study is to promote understanding of physical activity and metabolic syndrome in middle-aged adults and to provide basic data of interventions development for the prevention and management of metabolic syndrome. Using the 2020 data for Korea National Health and Nutrition Examination Survey, 1,786 middle-aged adults between the ages of 40 and 64 with no missing data were analyzed. As a result of the study, 56.5(±2.1)% of men and 52.9(±1.81)% of women were sufficient activity group among physical activity, and the proportion of men was higher than that of women, but it was not statistically significant(t=1.27, p=.207). The prevalence of metabolic syndrome was 38.9(±2.1%) of men and 25.4(±1.5)% of women, the prevalence of men was significantly higher than that of women(t=5.12, p<.001). Compared to the insufficient activity group, the sufficient activity group had a 0.71(95% CI: 0.57~0.88) times the risk of developing low HDL(high density lipoprotein)- cholesterol(p=.002), and this pattern was maintained even after adjusting for age, education level, body mass index, smoking status, and drinking status(p=.002). Based on the results of this study, a physical activity and metabolic syndrome risk group in middle-aged adults should be selected, and physical activity promotion program to improve high density lipoprotein-cholesterol among metabolic syndrome indicators should be developed.

• Korean Journal of Community Nutrition
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• v.19 no.2
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• pp.133-141
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• 2014

Objectives: The purpose of this study was to estimate the prevalence of metabolic syndrome (MS), metabolic abnormalities, and nutrient intakes in Korea children and adolescents using the Korea National Health and Nutrition Examination Survey from 2008. Methods: A sample of 838 children and adolescent males (n=442) and females (n=396) aged 10-18 was used from the 2008 Korea National Health and Nutrition Examination survey. The diagnosis of the metabolic syndrome subjects was adapted from modified National Cholesterol Education Program-Adult Treatment Panel III by Ford. To compare nutrient intakes, we used a judgment sampling. The first group was composed of all children and adolescents (n=46) with MS. The second one along with the first group had children and adolescents with the same age, sex, and body mass index (BMI) but without MS (n=46). The control group like the first two had children and adolescents with same sex and same age but with normal BMI and without MS (n=46). Results: In this randomized controlled controlled trial, the prevalence of the metabolic syndrome was 5.8%. The risk factors was associated with the MS were abdominal obesity 9.4%, hypertriglyceridemia 25.0%, low HDL-cholesterol 10.3%, hypertension 23.4%, and hyperglycemia 7.1%. Among metabolic abnormalities, blood pressure was significantly affected by sex, age and obesity. On the other hand, HDL-cholesterol, triglycerides, and waist circumference were directly linked to obesity. There were no significant differences in nutrient intakes among the three groups. Conclusions: The prevalence of MS was higher in children (10-11 years old) than in adolescents (12-18 years old). There was a difference in hypertension among risk factors by gender, and there were no significant differences in nutrient intakes.

• Journal of the East Asian Society of Dietary Life
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• v.23 no.3
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• pp.282-296
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• 2013

The study classified 83 obese adults by constitution and had them follow a strict diet according to their constitution in order to see if the Yin-Yang method would be effective on the metabolic syndrome, which is one of the main causes of death in Korea. Overall, the application of both Yin and Yang methods improved the following factors: weight, body fat percentage, systolic blood pressure, diastolic pressure, neutral fats and total cholesterol. In particular, the Yin constitution group of men showed more improvements than the Yang constitution group. Furthermore, waist circumference and the prevalence rate of systolic blood pressure, diastolic pressure, total cholesterol and metabolic syndrome were decreased noticeably. Total energy intake was increased in both men and women after the constitutional diet, along with the increase of nutrient intake, such as dietary fiber, vitamins and minerals, among others. Among various nutrients, vitamin A, vitamin C, thiamine, vitamin B6, folic acid, calcium, phosphorus, potassium, magnesium and iron intake were increased noticeably after the constitutional diet. In addition, subjects' intake of all nutrients, except for magnesium, satisfied the nutrition intake standards. Further, the nutrients adequacy ratio (NAR) and the mean adequacy ratio (MAR) improved for both men and women. The intake of potatoes, starch, greens and mushrooms increased noticeably, whereas the intake of meat, dairy, drinks and alcohol decreased after the constitutional diet. For the Yin constitution, the intake of Yin foods noticeably decreased, where as the intake of Yang foods decreased for the Yang constitution. In conclusion, the constitutional diet effectively improves the metabolic syndrome. Among many nutrients, the intake of dietary fiber, vitamins A, C and E, potassium and magnesium is positively associated with the improvement of metabolic syndrome biomarkers.

• Culinary science and hospitality research
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• v.23 no.8
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• pp.184-194
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• 2017

The purpose of this study was to investigate the relationship between coffee intake and metabolic syndrome, which has increased the burden of social illness, based on the data of the $6^{th}$ National Health and Nutrition Survey in 2015. The subjects' coffee intake level was divided into <1 cup/a day, 1~2 cups/a day, and ${\geq}3cups/a\;day$ and the general characteristics of the subjects were examined according to the classification. The effect of coffee consumption on the risk factors of metabolic syndrome was evaluated by OR value. The age of the subjects was higher than that of the other groups in the < 1 cup/day group and the TG in the prediabetic group was above the normal level in the ${\geq}3cups/day$ group. In the normal group of blood glucose, coffee intake was the highest in <1 cup/day group and BP was significantly different according to intake. In the multiple regression analysis conducted to identify the causal relationship between the risk of metabolic syndrome and coffee intake, BP was significantly decreased in ${\geq}3cups/day$ coffee group in normal group. In order to control the level of blood lipids in pre-diabetic subjects, it is necessary to establish dietary guidelines for foods that are frequently consumed, and various situations and long-term studies are needed to determine the precise effect of coffee intake on BP.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.1
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• pp.103-111
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• 2016

Objectives The waist circumference has been known as an obesity index reflecting the visceral fat. This study was conducted to investigate the obesity index of what can be predicted visceral fat obesity. Methods 121 test subjects who have $BMI{\geq}30$ or BMI 27~29.9 with having more than one high blood pressure, diabetes, and hyperlipidemia were gathered in the Gachon University Korean medical hospital. The relationship between obesity index, the abdominal fat area, and the metabolic syndrome component analyzed using Pearson correlation analysis. The obesity indices, that are largely used in clinics such as waist circumference (WC), HC (hip circumference), body mass index (BMI), waist-hip ratio (WHR) and waist-height ratio (WHtR). Total fat area (TFA), visceral fat area (VFA), subcutaneous area (SFA) and visceral fat/subcutaneous fat ratio (VSR) that was measured from CT. Results 1. Total fat area (TFA) was positively correlated WC, BMI, HC. 2. The subcutaneous fat area (SFA) was positively correlated HC, WC, BMI. 3. The visceral fat area (VFA) did not show a strong correlation with obesity indicators. Conclusions It was found indices of obesity and visceral fat area is a high correlation. BMI, WC was the obesity index showed a high correlation as the SFA, TFA.

• Clinical and Experimental Pediatrics
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• v.52 no.7
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• pp.766-771
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• 2009

Purpose : The objective of this study was to compare the levels of adipocytokines in obesity group with those in control group and examine their correlation with insulin resistance. Methods : We enrolled 36 obese children (male:female [M:F]=17:19; age, $9.3{\pm}1.9yrs$) with ${\geq}95^{th}$ percentile body mass indexes (BMIs) (obesity group) and 35 healthy children (M:F=16:19; age, $9.1{\pm}2.1yrs$) with $25^{th}-75^{th}$ percentile BMIs (control group). We measured the serum leptin, adiponectin, and resistin levels and insulin resistance in both the groups. Results : The weights, heights, BMIs, fasting sugar levels, insulin levels, and homeostasis model assessment for insulin resistance (HOMA-IR) values were higher in the obesity group than in the control group. As compared to the control group, the obesity group showed significantly higher leptin levels and lower adiponectin levels; no significant difference was observed in the resistin levels. The leptin/adiponectin (L/A) ratio was higher in the obesity group than in the control group. In the obesity group, HOMA-IR showed significant positive correlations with weight, height, BMI, and leptin level. However, it was not correlated with age and adiponectin and resistin levels. In the obesity group, leptin level showed significant positive correlations with age, weight, height, and BMI, while adiponectin and resistin levels showed no such correlations with the other variables. Conclusion : We suggest that adiponectin plays an important protective role against weight gain in obese children. Further, L/A ratio can be used as a parameter for predicting the prognosis of obese children.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.4
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• pp.1-9
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• 2011

Hemorrhagic shock is a clinically widespread syndrome characterized by inadequate oxygenation and supply. It is important to diagnose hemorrhagic shock in its early stage for improving treatment effects and survival rate. However, an accurate diagnosis and treatment could be delayed in the early stage of hemorrhagic shock by evaluating only vital signs such as heart rate and blood pressure. There have been many studies for the early diagnosis of hemorrhagic shock, reporting that lactate concentration and perfusion were useful variables for tissue hypoxia and metabolic acidosis. In this study, we measured both perfusion using a laser Doppler flowmeter and lactate concentration from the volume controlled hemorrhagic shock using rats. We also proposed a new shock index which was calculated by dividing lactate concentration by perfusion for early diagnosis. As a result of the survival prediction by the proposed index with the receiver operating characteristic curve method, the sensitivity, specificity, and accuracy of survival were 90.0, 96.7 and 94.0%, respectively. The proposed index showed the fastest significant difference among the other parameters such as blood pressure and heart rate. It could offer early diagnosis and effective treatment for human hemorrhagic shock if it is applicable to humans.