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http://dx.doi.org/10.3746/jkfn.2003.32.8.1394

Human and Animal Study on the Natural Food for Obesity and Metabolic Syndrome Risk Factors  

문근아 (한국한의학연구원 의료연구부)
최선미 (한국한의학연구원 의료연구부)
김선형 (한국한의학연구원 의료연구부)
김성수 (중앙대학교 의과대학)
강지연 (한국한의학연구원 의료연구부)
윤유식 (한국한의학연구원 의료연구부)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.8, 2003 , pp. 1394-1400 More about this Journal
Abstract
In this study a natural composition containing oriental herbs, KSH28, for reducing obesity and metabolic syndrome was constructed and its efficacy was evaluated in animal and human. To investigate the anti-obesity effect of KSH28, animal study was conducted using high fat diet-induced obese mice. KSH28 significantly decreased body weight and adipose tissue in high fat diet-fed obese mice. The mean size of fat cells in adipose tissue was significantly reduced. Glucose and triglyceride levels were also significantly decreased. To elucidate its efficacy in human, a natural food containing KSH28 with grains, vegetables, vitamins, minerals and dietary fibers was constructed and 40 subjects (8 male and 32 female) were tested for the change of body composition, blood pressure and blood lipid profile. All subjects had 2 pack (309 each) of natural food per day for 4 weeks. Compared to the baseline value, body fat was significantly reduced, however, water, protein and mineral contents in the body were not changed, suggesting selective reduction of fat tissue. Blood pressure and serum lipid profile were significantly decreased to reduce risk for metabolic syndrome. Serum GPT, a liver function indicator, was not changed and no significant side effects were detected. Therefore, it was shown that the KSH28 is a safe and effective composition for reducing obesity and metabolic syndrome.
Keywords
natural composition; natural food; obesity; metabolic syndrome; high fat diet;
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