Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance |
Park, Min Young
(Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Ahn, Sun A (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Cho, Won Kyoung (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Cho, Kyoung Soon (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Park, So Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Hahn, Seung Hoon (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Jung, Min Ho (Department of Pediatrics, College of Medicine, The Catholic University of Korea) Suh, Byung Kyu (Department of Pediatrics, College of Medicine, The Catholic University of Korea) |
1 | Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986-1998. JAMA 2001;286:2845-8 DOI ScienceOn |
2 | Chang JH, Kim DH, Kim HS, Choi IK, Cheong MY, Kim DK. Prevalence of metabolic syndrome in obese children. Kor J Pediatr 2004;47:1149-56 |
3 | Inoue M, Yano M, Yamakado M, Maehata E, Suzuki S. Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia. Metabolism 2006;55:1248-54 DOI ScienceOn |
4 | Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001;86:3815-9 DOI ScienceOn |
5 | Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 2003;149:331-5 DOI ScienceOn |
6 | Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003;26:2442-50 DOI ScienceOn |
7 | Bjørbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59: 305-31 |
8 | Cutfield WS, Jefferies CA, Jackson WE, Robinson EM, Hofman PL. Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Pediatr Diabetes 2003;4:119-25 DOI ScienceOn |
9 | Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997;3:1029-33 DOI ScienceOn |
10 | Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997;3:1029-33 DOI ScienceOn |
11 | Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-61 DOI |
12 | Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901 DOI ScienceOn |
13 | Blum WF. Leptin: the voice of the adipose tissue. Horm Res 1997;48 Suppl 4:2-8 DOI |
14 | Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002; 147:173-80 DOI ScienceOn |
15 | Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 2002; 103:137-42 DOI ScienceOn |
16 | Ahn GH, Kim SH, Yoo EG. The relationship between leptin adiponectin ratio and insulin resistance in healthy children. Kor J Pediatr 2008;51:256-61 DOI ScienceOn |
17 | Punthakee Z, Delvin EE, O'loughlin J, Paradis G, Levy E, Platt RW, et al. Adiponectin, adiposity, and insulin resistance in children and adolescents. J Clin Endocrinol Metab 2006;9:2119-25 DOI ScienceOn |
18 | Galler A, Gelbrich G, Kratzsch J, Noack N, Kapellen T, Kiess W. Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study. Eur J Endocrinol 2007;157:481-9 DOI ScienceOn |
19 | Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. Plasma concentrations of a novel, adipose- specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-9 PUBMED ScienceOn |
20 | Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-12 DOI ScienceOn |
21 | Dez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003;148:293-300 DOI ScienceOn |
22 | Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003;157:821-7 DOI ScienceOn |
23 | Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, et al. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 1999;48:94-8 DOI ScienceOn |
24 | Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 2001;98:502-6 DOI ScienceOn |
25 | Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7:947-53 DOI ScienceOn |
26 | Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998;83: 1407-13 DOI ScienceOn |
27 | Byun SH, Jeon JD, Kim HS, Kim SY. A study of serum adiponectin and insulin resistance in children and adolescents. J Kor Soc Pediatr Endocrinol 2007;12:63-70 |
28 | Banerjee RR, Lazar MA. Resistin: molecular history and prognosis. J Mol Med 2003;81:218-26 ScienceOn |
29 | Zou CC, Liang L, Hong F. Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity. Indian Pediatr 2007;44:275-9 PUBMED ScienceOn |
30 | Kershaw EE, Flier JS. Adipose Tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-56 |
31 | Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005;42:987-1000 DOI ScienceOn |
32 | Zou CC, Liang L, Hong F, Fu JF, Zhao ZY. Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children. Endocr J 2005;52:519-24 DOI ScienceOn |
33 | Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-70 DOI ScienceOn |
34 | Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-6 PUBMED ScienceOn |
35 | Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, et al. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 2003;88:2014-8 DOI ScienceOn |
36 | Morales A, Wasserfall C, Brusko T, Carter C, Schatz D, Silverstein J, et al. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care 2004;27:2010-4 DOI ScienceOn |
37 | Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83 DOI ScienceOn |
38 | Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996;221:286-9 DOI ScienceOn |
39 | Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 2002;51:2734-41 DOI ScienceOn |
40 | Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002;87:4652-6 DOI ScienceOn |
41 | Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978;14: 141-8 DOI |
42 | Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001;108:1875-81 PUBMED ScienceOn |
43 | Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, et al. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes 2002;51: 1005-15 DOI ScienceOn |