• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.5
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• pp.552-561
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• 2017

This study aimed to investigate glucose uptake mechanisms and metabolic mechanisms for absorbed glucose in HepG2 cells treated with Acanthopanax senticosus water extract (ASW). A colorimetric assay kit was used to measure polyphenol content, glucokinase (GK) activity, glucose uptake, glucose consumption in cell culture medium, and glycogen content. RT-PCR and western blotting were performed to examine changes in the expression levels of glucose transporter 2 (GLUT2), hepatocyte nuclear factor $1{\alpha}$ ($HNF-1{\alpha}$), phosphatidylinositol 3-kinase (PI3k), protein kinase B (Akt), phospho-AMP-activated protein kinase (AMPK), phosphoenolpyruvate carboxykinase, GK, and glycogen synthase kinase $3{\beta}$ ($GSK3{\beta}$). Increased glucose uptake upon ASW treatment was confirmed to result from increased expression of $HNF-1{\alpha}$, which is one of the transcription factors acting on the GLUT2 promoter. From the measurements of GK activity, we observed that ASW had an effect on glucose phosphorylation, and we also confirmed that increased AMPK phosphorylation promoted glycolysis and suppressed gluconeogenesis. We confirmed that the increase in glycogen upon ASW treatment was induced by activation of Akt by PI3k, followed by phosphorylation of $GSK3{\beta}$. This study demonstrates that ASW activates glucose metabolic mechanisms in liver cells and is therefore a potential candidate to alleviate diabetes.

• Journal of The Korean Association For Science Education
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• v.21 no.2
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• pp.342-356
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• 2001

Integrated science for high school is required in the present Korean National Sixth Curriculum and the Seventh Curriculum which will be effective in 2002. Currently, most science teachers in secondary school have concerns about teaching integrated science subjects and this continues to raise a significant problem for practical implementation of integrated science education in schools. In this paper, we discuss two reasons for these concerns that our analysis revealed: 1) Science teachers do not understand how to implement integrated science education and 2) there are insufficient teaching-learning materials supporting integrated science. Three different approaches to integration that have been suggested to overcome the problem of implementation are outlined here. They are the knowledge centered, social problem centered, and individual interest centered approaches. Reported here are the first two steps we undertook in preparation for testing the relative effectiveness of these approaches. First, we analyzed the content of the Korean Sixth and Seventh National Science Curricula, seven Korean integrated science text books, the American National Science Education Standards, and the American Association for the Advancement of Science Benchmarks looking for common themes. We identified in the analyzed materials the common themes: energy conservation, energy transformation, energy transport, energy degradation. We then used their energy related content to organize sets of concept structures, one set for each of the three approaches. These concept structures will provide the foundations for the development of integrated teaching-learning energy plans to be used in our research into the effectiveness of the approaches.

• Applied Biological Chemistry
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• v.47 no.2
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• pp.258-264
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• 2004

Hypoglycemic effect of Schizandrae Fructus (SF) extract containing in Okchun-san was determined on 3T3-L1 fibroblasts and adipocytes by investigating insulin-like activity, insulin sensitizing activity and ${\alpha}-glucoamylase$ suppressing activity. SF were extracted by using 70% ethanol followed by XAD-4 column chromatography with a mixture solvent of methanol and water, and the fractional extractions were utilized for assaying hypoglycemic effect. No inhibition of ${\alpha}-glucoamylase$ activity of SF was observed. Insulin-like activity 3T3-L1 adipocytes was not shown by SF. A significant insulin sensitizing activity of SF extractions was observed in 3T3-L1 adipocytes, giving SF extractions with 1 ng/ml insulin to reach glucose uptake level increased by 50 ng/ml of insulin alone. When cells were treated with SF (Fr. 4 or 5) plus 1 ng/ml insulin, glucose uptake was increased more than seven times as compared to 1 ng/ml of insulin alone, suggesting that SF extracts increased GLUT4 content by enhancing insulin signaling. These data suggest that SF extracts (especially Fr. 4 and 5) contains an effective insulin sensitizing compounds for hypoglycemic activity in 3T3-L1 adipocytes.

• Informatization Policy
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• v.25 no.4
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• pp.37-64
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• 2018

This study aims to forecast the future of the Korean society via a big data analysis. Based upon two sets of database - a collection of 46,000,000 news on 127 media in Naver Portal operated by Naver Corporation and a collection of 70,000 academic papers of social sciences registered in KCI (Korea Citation Index of National Research Foundation) between 2005-2017, 40 most frequently occurring keywords were selected. Next, their temporal variations were traced and compared in terms of number and pattern of frequencies. In addition, core issues of the future were identified through keyword network analysis. In the case of the media news database, such issues as economy, polity or technology turned out to be the top ranked ones. As to the academic paper database, however, top ranking issues are those of feeling, working or living. Referring to the system and life-world conceptual framework suggested by $J{\ddot{u}}rgen$ Habermas, public interest of the future inclines to the matter of 'system' while professional interest of the future leans to that of 'life-world.' Given the disparity of future interest, a 'mismatch paradigm' is proposed as an alternative to social forecasting, which can substitute the existing paradigms based on the ideas of deficiency or deprivation.

• Database Research
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• v.34 no.3
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• pp.148-158
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• 2018

The optical character recognition (OCR) is a technique to extract and recognize texts from images. It is an important preprocessing step in data analysis since most actual text information is embedded in images. Many OCR engines have high recognition accuracy for images where texts are clearly separable from background, such as white background and black lettering. However, they have low recognition accuracy for images where texts are not easily separable from complex background. To improve this low accuracy problem with complex images, it is necessary to transform the input image to make texts more noticeable. In this paper, we propose a method to segment an input image into text lines to enable OCR engines to recognize each line more efficiently, and to determine the final output by comparing the recognition rates of CLAHE module and Two-step module which distinguish texts from background regions based on image processing techniques. Through thorough experiments comparing with well-known OCR engines, Tesseract and Abbyy, we show that our proposed method have the best recognition accuracy with complex background images.

• The Korean Journal of Applied Statistics
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• v.34 no.3
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• pp.427-438
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• 2021

Two-stage sampling allows us to estimate population characteristics by both unit and cluster level together. Given a complex auxiliary information, integrated calibration weighting would better reflect the level-wise characteristics as well as multivariate characteristics between levels. This paper explored the integrated calibration weighting methods by Estevao and Särndal (2006) and Kim (2019) through a simulation study, where the efficiency of those weighting methods was compared using an artificial population data. Two weighting methods among others are shown efficient: single step calibration at the unit level with stacked individualized auxiliary information and iterative integrated calibration at each level. Under both methods, cluster calibrated weights are defined as the average of the calibrated weights of the unit(s) within cluster. Both were very good in terms of the goodness-of-fit of estimating the population totals of mutual auxiliary information between clusters and units, and showed small relative bias and relative mean square root errors for estimating the population totals of survey variables that are not included in calibration adjustments.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.95-106
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• 2021

The purpose of this study is to derive major topics in content R&D and provide directions for academic development by exploring research trends over the past 20 years using topic modeling targeting 9,858 papers published in the Journal of the Korean Contents Association. To secure the reliability and validity of the extracted topics, not only the quantitative evaluation technique but also the qualitative technique were applied step-by-step and repeated until a corpus of the level agreed upon by the researchers was generated, and detailed analysis procedures were presented accordingly. As a result of the analysis, 8 core topics were extracted. This shows that the Korean Contents Association is publishing convergence and complex research papers in various fields without limiting to a specific academic field. Also, before 2012, the proportion of topics in the field of engineering and technology appeared relatively high, while after 2012, the proportion of topics in the field of social sciences appeared relatively high. Specifically, the topic of 'social welfare' showed a fourfold increase in the second half compared to the first half. Through topic-specific trend analysis, we focused on the turning point in time at which the inflection point of the trend line appeared, explored the external variables that affected the research trend of the topic, and identified the relationship between the topic and the external variable. It is hoped that the results of this study can provide implications for active discussions in domestic content-related R&D and industrial fields.

• Korean Journal of Environment and Ecology
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• v.26 no.3
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• pp.463-471
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• 2012

Objective of this study is to provide basic information for developing more differentiated and targeted forest healing policy and Korean medical healing programs grounded on consumer preference for forest based Korean medical healing tourism products. The internet survey(CAWI) by percentage quota sampling with 400 Seoulite ages over 30 by the age, area, and gender was conducted, and 317 samples were used for a final analysis. 61.5% of the Seoulite associated 'forest bath/walking in the woods/tree' with an image of a forest based Korean medical healing tourism product, and preference for the product and the intention to use were positive at the percentages of 72.9% and 67.5%, respectively. Preferred areas were Seoul/Gyeonggi-do(53.5%) and Gangwon-do(38.8%). 'Stress solving and refreshment', 'taking a forest bath and a walk', and 'maintaining and promoting health' were the main purposes of the use. As for a therapy, 'walking therapy' was most preferred, and 'ergotherapy' was the next. First priority as for a use facility was 'healing trail', and 'professional medical facility' ranked second. Although important decision attributes were ' cost of use', 'food', and 'friendliness of medical staff', all the other sets of attributes related to use convenience, quality of medical service and tourism activities also recorded high, which forecasts higher consumer expectation for the product. As the result showing differences in consumer preference by the demographic segmentation, differentiated and segmented consumer needs should be considered when planing and managing a product. The scope of the study is limited to a demographic segmentation which is a basic stage of understanding consumer preference, therefore more detailed future researches on complicated and multi-dimensional consumer needs are required.

• Journal of dental hygiene science
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• v.17 no.1
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• pp.1-11
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• 2017

There are 82 dental hygiene departments and clinical training institutes across the country with a very wide range of clinical practice content and evaluation methods, making standardization difficult. Therefore, there is a need to establish a standard protocol outlining clinical practice content and evaluation methods for systematic and efficient operation of clinical practice. Thus, this study attempted to propose such a protocol for standardization of dental hygiene clinical practice in dental clinics and hospitals to examine the contents of clinical practice by reviewing relevant literature, and relating it to professional practice within the dental hygienic curriculum to facilitate enhancement of expertise. Clinical practice content was extracted from 74 cases, and was consisted of classifying mandatory and optional clinical practice, training time, and activity methods for each component. To standardize effective clinical practice, it is necessary to organize the components acquired in the course of clinical dentistry training in line with their arrangement on each university's curriculum, in order to learn all components step by step. To do this, it is necessary to present a standardized clinical practice protocol and a organic cooperation between educational institutions and clinical training institutions.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.1492-1496
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• 2006

수공구조물의 설계에 있어 가중 중요한 변수 중에 하나가 확률 강우량이다. 우리나라의 경우 매개변수적인 지점빈도해석을 통해 확률 강우량을 산정하고 있으나, 최근 들어 지점별 관측자료의 부족으로 인한 지역빈도해석을 수행하여 확률강우량을 산정하고 있는 실정이다. Index Flood 기법이나 L-moment 기법과 같은 기존의 지역빈도해석은 여러 관측 지점에서 관측된 강우자료를 이용하여 매년최대 시간강우량 자료를 추출하여 동질성 분석을 통해 이질성이 없는 것으로 분석된 연최대 강우량을 빈도해석 하여 확률 강우량을 결정한다. 그러나 이와 같은 지역빈도해석은 매개변수적 지점빈도해석과 마찬가지로 적합도 검정에 통과한 다수의 분포형이 선정되는 경우에 어떤 분포형을 사용하느냐 하는 문제점이 발생할 수 있다. 그리고 선정된 여러 강우 관측 지점의 연최대 강우량 자료에 모두 동일한 확률 분포형을 이용하므로 선정된 확률 분포형이 모든 지점의 강우 자료와 적합하지 못할 가능성을 내포하고 있으며, 또한 수문자료가 여러가지 요인으로 인하여 복합분포(mixed distribution)형태를 가질 때, 매개변수적 해석방법으로는 다중 첨두를 갖는 확률밀도함수를 해석하는데는 여러 가지 어려움이 따른다. 따라서 이러한 매개변수적 확률분포형을 이용한 빈도해석의 문제점을 해결할 수 있는 비매개변수적 빈도해석이 하나의 대안으로 제시될 수 있다. 본 연구에서는 강우자료의 선별을 통해 신뢰성 있는 자료를 구축하고, 기존의 매개변수를 갖는 확률 분포형을 이용한 지역빈도해석을 적용하여 확률 강우량을 산정하였다. 그리고 동질성분석을 통해 선정된 강우자료에 대해 비매개변수적 지역빈도해석을 적용하여 확률 강우량을 산정하고 각각의 방법에 대한 빈도해석 결과를 비교하여 확률강우량 해석에 있어 하나의 대안을 제시하고자 한다.X>${\mu}_{max,A}$는 최대암모니아 섭취률을 이용하여 구한 결과 $0.65d^{-1}$로 나타났다.EX>$60%{\sim}87%$가 수심 10m 이내에 분포하였고, 녹조강과 남조강이 우점하는 하절기에는 5m 이내에 주로 분포하였다. 취수탑 지점의 수심이 연중 $25{\sim}35m$를 유지하는 H호의 경우 간헐식 폭기장치를 가동하는 기간은 물론 그 외 기간에도 취수구의 심도를 표층 10m 이하로 유지 할 경우 전체 조류 유입량을 60% 이상 저감할 수 있을 것으로 조사되었다.심볼 및 색채 디자인 등의 작업이 수반되어야 하며, 이들을 고려한 인터넷용 GIS기본도를 신규 제작한다. 상습침수지구와 관련된 각종 GIS데이타와 각 기관이 보유하고 있는 공공정보 가운데 공간정보와 연계되어야 하는 자료를 인터넷 GIS를 이용하여 효율적으로 관리하기 위해서는 단계별 구축전략이 필요하다. 따라서 본 논문에서는 인터넷 GIS를 이용하여 상습침수구역관련 정보를 검색, 처리 및 분석할 수 있는 상습침수 구역 종합정보화 시스템을 구축토록 하였다.N, 항목에서 보 상류가 높게 나타났으나, 철거되지 않은 검전보나 안양대교보에 비해 그 차이가 크지 않은 것으로 나타났다.의 기상변화가 자발성 기흉 발생에 영향을 미친다고 추론할 수 있었다. 향후 본 연구에서 추론된 기상변화와 기흉 발생과의 인과관계를 확인하고 좀 더 구체화하기 위한 연구가 필요할 것이다.게 이루어질 수 있을 것으로 기대된다.는 초과수익률이 상승하지만, 이후로는 감소하므로, 반전거래전략을 활용하는 경우 주식투자기간은 24개월이하의 중단기가 적합함을 발견하였다. 이상의 행태적 측면과 투자성과측면의 실증결과를 통하여 한국주식시장에 있어서 시장수익률을 평균적으로 초과할 수 있는 거래전