• Title/Summary/Keyword: 다발

Search Result 1,885, Processing Time 0.038 seconds

Prediction of HLA-A*0201-Restricted Antigenic Epitopes Targeting Multiple Myeloma (다발성 골수종 적용을 위한 HLA-A*0201 제한 항원성 펩타이드 예측)

  • Kang, Yoon Joong
    • Journal of Convergence for Information Technology
    • /
    • v.10 no.6
    • /
    • pp.209-216
    • /
    • 2020
  • Protein antigens and their epitopes are targets for epitope based vaccines. There are many prediction servers which can be used for identification of binding peptides to MHC molecules. However, choosing of appropriate prediction servers is difficult. This study compared data obtained from prediction servers and evaluate them in scope of binding affinity to MHC-I molecules. Here we predicted HLA-A2-restricted cytotoxic T lymphocyte epitopes from survivin as a potential target for multiple myeloma. We suggest a procedure for prediction of antigenic peptides which could bind to MHC-I molecule. The results of this study will assist researchers in selection and prediction of noble antigenic peptides.

Multiple Cardiac Papillary Fibroelastoma of the Aortic Valve (대동맥 판막에 위치한 다발성 심장 유두상 섬유탄력종)

  • Seo, Hong-Joo;Na, Chan-Young;Yu, Jai-Kun
    • Journal of Chest Surgery
    • /
    • v.41 no.4
    • /
    • pp.496-498
    • /
    • 2008
  • Cardiac papillary fibroelastomas are the second most common primary cardiac tumor. This tumor is usually benign and it involves the cardiac valve. However, most cardiac papillary fibroelastomas originate from a single site, and the incidence of cardiac papillary fibroelastomas originating from multiple sites is very rare (5%). A 55-year-old woman who presented with momentary dizziness and syncope was evaluated by performing echocardiography. Multiple tumors attached to the aortic valve were noted. The mass was removed freely without leaving any defect on the aortic valve leaflet. After the recovery period, the patient is currently being followed up at the outpatient department.

Case of Multiple Systemic Atrophy Treated with Korean Medical Treatment and Rehabilitation Therapy (재활치료와 한방치료를 병행한 다발성 뇌신경계 위축증 1례)

  • Park, Jang-Kyung;Maeng, Yu-Sook;Lee, Seung-Bok;Kim, Dong-Il
    • The Journal of Korean Medicine
    • /
    • v.32 no.2
    • /
    • pp.118-125
    • /
    • 2011
  • Multiple system atrophy (MSA) is an idiopathic and progressive neurodegenerative disorder. Up to now, treatment of MSA patients had not been reported in Oriental medicine and only rarely reported in Western medicine. We experienced a 75-year-old female diagnosed with MSA and had quadriparesis with dysphagia. She was admitted to the hospital and received herbal medication, acupuncture, moxibustion and rehabilitation therapy. After 2 months, her motor power and swallowing function on video fluoroscopic swallowing test significantly improved. This report shows that Oriental medicine may play a role in the treatment of MSA, and further study is merited.

Tissue Specific Expression of Wound-Inducible RCaM-2 Promoter in Transgenic Tobacco Plants (상처에 의해서 유도되는 벼 calmodulin promoter의 transgenic 담배에서조직 특이적 발현)

  • Choi Young Ju
    • Journal of Life Science
    • /
    • v.15 no.2 s.69
    • /
    • pp.176-181
    • /
    • 2005
  • To study calmodulin (CaM) gene expression and its regulation, rice CaM promoter (RCaM-2) was isolated and fused to $\beta-glucuronidase$ (GUS), reporter gene. X-Glue staining patterns revealed that GUS localization is high in meristemic tissues such as the stem apex, stolen tip, and vascular regions. GUS staining in the transverse sections of stem and petiole was restricted to the inside of the vascular system, and cortex and epidermis located outside of the vascular system usually did not show GUS staining even a plant that expressed strong activity. GUS activity was found to be tissue specific expressed and exhibited a dramatic transient increase in response to wounding. These results suggest that the 5'-flanking region of RCaM gene regulates wound-inducible expression.

A Experimental Study on the Flexural Behavior of Bundle Type Polyamide Fiber Reinforced Concrete (다발형 폴리아미드섬유 보강 콘크리트의 휨거동에 관한 실험적 연구)

  • Jeon, Chan Ki;Jeon, Joong Kyu
    • Journal of the Society of Disaster Information
    • /
    • v.10 no.1
    • /
    • pp.61-70
    • /
    • 2014
  • Synthetic fiber reinforced concrete is applicable to many applications for construction material. In general, synthetic fibers have low tensile strength and elastic modulus, but they have many advantages such as high crack resistance, impact resistance, chemical resistance, flexural behavior and corrosion free in fiber reinforced concrete. Recently, fiber reinforced concrete with macro synthetic fibers has been used to improve performance of structures in tunnel shotcrete, precast segmental lining and bridge slab and precast concrete structures. This study investigated the influence of bundled type polyamide fiber reinforced concrete on the flexural behavior in accordance with ASTM C 1609 and KS F 2566 standards.

Analytic Prediction of Friction Factors for Turbulent Flow in Longitudinally Finned Rod Bundles (길이 방향 핀이 달린 봉 다발에서의 난류 마찰계수 산출을 위한 해석적 방법)

  • Kim, Nae-Hyun;Hong, Sung-Deok;Kwon, Hyuk-Sung;Lee, Sang-Keun
    • Nuclear Engineering and Technology
    • /
    • v.23 no.4
    • /
    • pp.401-409
    • /
    • 1991
  • This work is concerned with the development of an analytical model to predict the friction in longitudinally finned rod bundles. Such bundles are currently considered in KMRR design. The present model assumes the validity of the Law of the Wall over entire flow area. The flow channel area is divided into the interfin region and a number of element channels, and the algebraic form of the Law of the Wall is integrated over each element channel and interfin region to yield an analytic expression for the pressure drop. The model reasonably predicts the 6 fin KMRR data, and overpredicts the 8 fin data about 15 percent.

  • PDF

Flood Simulation and Flood damage Estimation Considering Mega Floods (거대홍수를 고려한 홍수 모의 및 홍수피해액 산정)

  • Choi, Chang Hyun;Hong, Seung Jin;Han, Dae Gun;Kim, Duck Hwan;Kim, Hung Soo
    • Proceedings of the Korea Water Resources Association Conference
    • /
    • 2015.05a
    • /
    • pp.210-210
    • /
    • 2015
  • 전 세계적으로 기후변화로 인한 자연재난은 피해의 규모에 따라 대형화 다양화 집중화 현상이 일어나고 있으며, 이로 인한 사회 경제적 피해가 과거에 비해 지속적으로 증가하고 있다. 한국에서는 이러한 자연재난 중 피해의 90%이상이 수해 풍해 설해 등으로 조사되었으며, 특히, 수해에 의한 피해가 자연재난으로 발생하는 피해 중 가장 큰 비중을 차지하고 있다. 최근에는 2014년 일본의 태풍 '판폰'과 '봉퐁', 2013년 중국의 태풍 '피토'와 '다나스', 2012년 한국의 태풍 '볼라벤', '덴빈', '산바' 등 연속적인 호우사상의 내습으로 인한 피해가 발생함에 따라 동시 다발적인 거대 호우사상의 발생에 대한 대비책이 시급한 실정이다. 국내 외적으로 단일 호우사상으로 인한 홍수 피해 대책에 관한 연구는 활발하게 이루어지고 있지만, 동시다발적 연속적인 호우사상으로 인한 홍수 피해 대책 연구는 미비한 실정이다. 이에 따라 본 연구에서는 단기간에 거대 호우사상이 동시 다발적 연속적으로 나타나는 현상을 거대홍수라고 정의하고, 거대홍수에 대응하기 위해서 거대홍수 발생에 따른 홍수범람 및 홍수피해액을 산정하였다. 홍수범람모의를 통해 거대홍수가 유역전체에 미치는 영향을 파악하고, 다차원홍수피해산정법(MD-FDA)을 통해 홍수 피해액을 산정하여 거대홍수방어 대책 수립의 참고 자료로써 활용할 수 있을 것이다.

  • PDF

Multiple Fractures in Thoracic Vertebrae after Epilepsy (뇌전증 발작 후 발생한 다발성 흉추 골절)

  • Ha, Dae-Ho;Oh, Sung-Kyun;Kim, Seung-Min
    • Journal of the Korean Orthopaedic Association
    • /
    • v.55 no.3
    • /
    • pp.266-270
    • /
    • 2020
  • The musculoskeletal system can be damaged by massive contractions of the muscles in the case of systemic attacks by epilepsy. Several studies or case reports of multiple thoracic vertebrae fractures following generalized seizures without underlying diseases or falls have been reported, but there are few domestic studies or case reports. This paper reports the case of a 42-year-old male patient without any specific underlying disease, who was diagnosed with multiple fractures of the thoracic vertebrae caused by generalized myoclonic epilepsy during sleep.

Multiple Periosteal Chondroma of the Fourth Toe (제4족지의 다발성 골막 연골종)

  • Kim, Jong-Kil;Park, Yeong-Cheol
    • Journal of the Korean Orthopaedic Association
    • /
    • v.55 no.4
    • /
    • pp.338-342
    • /
    • 2020
  • Periosteal chondroma is a rare, slow-growing, benign cartilaginous tumor that develops between the periosteum and cortex, but there are no reports of multiple periosteal chondroma of the toes. A 19-year-old male presented with a palpable mass of the right fourth toe with tenderness for one year. A radiology examination revealed multiple, radio-lucent lesions with mild cortical irregularity. The magnetic resonance imaging findings were chondrogenic tumors with multiple, well-defined T1-low and T2-high signal enhanced lesions involved in the fourth proximal, middle, and distal phalanges. The tumors were removed by a surgical resection and curettage. Histologically, the tumors were proven to be periosteal chondroma.

MRI Features of Multiple Cranial Neuropathies in Guillain-Barré Syndrome Occurring after COVID-19 Vaccination: A Case Report (COVID-19 백신 접종 후 발생한 길랑-바레증후군에서 보이는 다발성 뇌신경병증의 MRI 소견: 증례 보고)

  • Youngsoo Soh;Eun Ae Yoo;Eun-Sil Kim;Soo Jung Kim
    • Journal of the Korean Society of Radiology
    • /
    • v.84 no.4
    • /
    • pp.964-969
    • /
    • 2023
  • Guillain-Barré syndrome (GBS) is an immune-mediated demyelinating polyneuropathy characterized by progressive, ascending, and symmetrical paralysis. It is known to be triggered by an antecedent infection or vaccination. Recently, GBS development following coronavirus disease 2019 (COVID-19) vaccination has been reported. Cranial neuropathies in typical GBS patients usually involve the facial and the lower cranial nerves (from IX to XII). We report a rare case of multiple cranial neuropathies involving trigeminal, abducens, and facial nerves in a patient who developed GBS following COVID-19 vaccination on the basis of obvious MRI features.